Shifted‐excitation Raman difference spectroscopy for the detection of SERS‐encoded gold nanostar probes

Register, Janna; Maiwald, Martin; Fales, Andrew; Strobbia, Pietro; Sumpf, Bernd; Vo‐Dinh, Tuan

doi:10.1002/jrs.5482

Title: Shifted‐excitation Raman difference spectroscopy for the detection of SERS‐encoded gold nanostar probes

Journal Article · 16 September 2018 · Journal of Raman Spectroscopy

DOI: https://doi.org/10.1002/jrs.5482 · OSTI ID:1472161

^[2]; Fales, Andrew ^[1];

^[1];

^[2];

^[3]

Fitzpatrick Institute for Photonics Duke University Durham NC USA, Department of Biomedical Engineering Duke University Durham NC USA
Ferdinand‐Braun‐Institut Leibniz‐Institut für Höchstfrequenztechnik Berlin Germany
Fitzpatrick Institute for Photonics Duke University Durham NC USA, Department of Biomedical Engineering Duke University Durham NC USA, Department of Chemistry Duke University Durham NC USA

Abstract In vivo applications of surface‐enhanced Raman spectroscopy (SERS) have limited sensitivity due to the intense background signal from real‐life complex samples such as plants and tissues. To overcome this issue, this work investigates the combination of shifted‐excitation Raman difference spectroscopy (SERDS) with SERS nanoprobes to generate background‐free SE‐SERDS spectra. The SERDS technique was performed with a dual‐wavelength diode laser with two emission lines at 785.40 and 785.02 nm. The SERS nanoprobes used for these studies are SERS‐encoded nanostars. The use of the SERDS technique in the detection of SERS nanoprobes was demonstrated by recovering full Raman spectra from a 1 pM concentration of nanoprobes, which only show few peaks in the pure SERS spectra. Background‐free SE‐SERDS spectra were collected from SERS nanoprobes injected in pig skin ex vivo. Pig skin is considered a good model of human skin and was previously used in testing the performance of our SERS nanoprobes when implanted subcutaneously. In this study, we show the application of SERDS for background removal and signal recovery in spectra of SERS nanoprobes. In addition, the detection of SERS plasmonic nanoprobes implanted into animal skin further illustrates the usefulness of the SE‐SERDS technique and how the combination of SERS with SERDS provides a powerful tool for in vivo biosensing.

View Accepted Manuscript (Publisher)

Cite

Export

Save

Sponsoring Organization:: USDOE

Grant/Contract Number:: NONE; SC0014077

OSTI ID:: 1472161

Journal Information:: Journal of Raman Spectroscopy, Journal Name: Journal of Raman Spectroscopy Journal Issue: 12 Vol. 49; ISSN 0377-0486

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Netherlands

Language:: English

References (39)

Surface-enhanced Raman spectroscopy: a brief retrospective Moskovits, Martin Journal of Raman Spectroscopy, Vol. 36, Issue 6-7 https://doi.org/10.1002/jrs.1362	journal	January 2005
Application of surface-enhanced Raman scattering (SERS) for the identification of anthraquinone dyes used in works of art Chen, Kui; Leona, Marco; Vo-Dinh, Kim-Chi Journal of Raman Spectroscopy, Vol. 37, Issue 4 https://doi.org/10.1002/jrs.1426	journal	January 2006
Spectral characterization and intracellular detection of Surface-Enhanced Raman Scattering (SERS)-encoded plasmonic gold nanostars: Nanostars SERS characterization Yuan, Hsiangkuo; Fales, Andrew M.; Khoury, Christopher G. Journal of Raman Spectroscopy, Vol. 44, Issue 2 https://doi.org/10.1002/jrs.4172	journal	October 2012
SERS signal response and SERS/SERDS spectra of fluoranthene in water on naturally grown Ag nanoparticle ensembles: Fluoranthene on naturally grown Ag nanoparticle ensemble Ossig, Robert; Kolomijeca, Anna; Kwon, Yong-Hyok Journal of Raman Spectroscopy, Vol. 44, Issue 5 https://doi.org/10.1002/jrs.4270	journal	March 2013
In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models Register, Janna K.; Fales, Andrew M.; Wang, Hsin-Neng Analytical and Bioanalytical Chemistry, Vol. 407, Issue 27 https://doi.org/10.1007/s00216-015-8939-0	journal	September 2015
Naturally grown Ag nanoparticles on quartz substrates as SERS substrate excited by a 488 nm diode laser system for SERDS Ossig, R.; Kwon, Y. -H.; Hubenthal, F. Applied Physics B, Vol. 106, Issue 4 https://doi.org/10.1007/s00340-011-4866-8	journal	February 2012
Surface raman spectroelectrochemistry: Part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode Jeanmaire, David L.; Van Duyne, Richard P. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, Vol. 84, Issue 1, p. 1-20 https://doi.org/10.1016/S0022-0728(77)80224-6	journal	November 1977
Multiplex detection of endothelial cell activation biomarkers using surface enhanced raman spectroscopy (sers) Noonan, Jonathan; Grassia, Gianluca; Macritchie, Neil Atherosclerosis, Vol. 263 https://doi.org/10.1016/j.atherosclerosis.2017.06.080	journal	August 2017
Fiber-optic remote sensor for in situ surface-enhanced Raman scattering analysis Bello, Job M.; Narayanan, V. Anantha.; Stokes, David L. Analytical Chemistry, Vol. 62, Issue 22 https://doi.org/10.1021/ac00221a005	journal	November 1990
Surface-enhanced Raman spectrometry for trace organic analysis Vo-Dinh, Tuan.; Hiromoto, M. Y. K.; Begun, G. M. Analytical Chemistry, Vol. 56, Issue 9 https://doi.org/10.1021/ac00273a029	journal	August 1984
Transcutaneous Glucose Sensing by Surface-Enhanced Spatially Offset Raman Spectroscopy in a Rat Model Yuen, Jonathan M.; Shah, Nilam C.; Walsh, Joseph T. Analytical Chemistry, Vol. 82, Issue 20 https://doi.org/10.1021/ac101951j	journal	October 2010
Online Fluorescence Suppression in Modulated Raman Spectroscopy De Luca, Anna Chiara; Mazilu, Michael; Riches, Andrew Analytical Chemistry, Vol. 82, Issue 2 https://doi.org/10.1021/ac9026737	journal	January 2010
Rapid Identification by Surface-Enhanced Raman Spectroscopy of Cancer Cells at Low Concentrations Flowing in a Microfluidic Channel Pallaoro, Alessia; Hoonejani, Mehran R.; Braun, Gary B. ACS Nano, Vol. 9, Issue 4 https://doi.org/10.1021/acsnano.5b00750	journal	February 2015
Folate Receptor-Targeted Theranostic Nanoconstruct for Surface-Enhanced Raman Scattering Imaging and Photodynamic Therapy Fales, Andrew M.; Crawford, Bridget M.; Vo-Dinh, Tuan ACS Omega, Vol. 1, Issue 4 https://doi.org/10.1021/acsomega.6b00176	journal	October 2016
Ultrastable Substrates for Surface-Enhanced Raman Spectroscopy: Al ₂ O ₃ Overlayers Fabricated by Atomic Layer Deposition Yield Improved Anthrax Biomarker Detection Zhang, Xiaoyu; Zhao, Jing; Whitney, Alyson V. Journal of the American Chemical Society, Vol. 128, Issue 31 https://doi.org/10.1021/ja0638760	journal	August 2006
The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment Kelly, K. Lance; Coronado, Eduardo; Zhao, Lin Lin The Journal of Physical Chemistry B, Vol. 107, Issue 3 https://doi.org/10.1021/jp026731y	journal	January 2003
Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering Fales, Andrew M.; Yuan, Hsiangkuo; Vo-Dinh, Tuan The Journal of Physical Chemistry C, Vol. 118, Issue 7 https://doi.org/10.1021/jp4091393	journal	February 2014
Gold Nanostars For Surface-Enhanced Raman Scattering: Synthesis, Characterization and Optimization Khoury, Christopher G.; Vo-Dinh, Tuan The Journal of Physical Chemistry C, Vol. 112, Issue 48 https://doi.org/10.1021/jp8054747	journal	November 2008
Plasmonic Nanoparticles and Nanowires: Design, Fabrication and Application in Sensing Vo-Dinh, Tuan; Dhawan, Anuj; Norton, Stephen J. The Journal of Physical Chemistry C, Vol. 114, Issue 16 https://doi.org/10.1021/jp911355q	journal	March 2010
Reproducible Surface-Enhanced Raman Quantification of Biomarkers in Multicomponent Mixtures De Luca, Anna Chiara; Reader-Harris, Peter; Mazilu, Michael ACS Nano, Vol. 8, Issue 3 https://doi.org/10.1021/nn406200y	journal	February 2014
Control of enhanced Raman scattering using a DNA-based assembly process of dye-coded nanoparticles Graham, Duncan; Thompson, David G.; Smith, W. Ewen Nature Nanotechnology, Vol. 3, Issue 9 https://doi.org/10.1038/nnano.2008.189	journal	July 2008
Surface-enhanced Raman spectroscopy for in vivo biosensing Laing, Stacey; Jamieson, Lauren E.; Faulds, Karen Nature Reviews Chemistry, Vol. 1, Issue 8 https://doi.org/10.1038/s41570-017-0060	journal	August 2017
Direct Detection of Unamplified Pathogen RNA in Blood Lysate using an Integrated Lab-in-a-Stick Device and Ultrabright SERS Nanorattles Ngo, Hoan T.; Freedman, Elizabeth; Odion, Ren Abelard Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-21615-3	journal	March 2018
Tissue factor-specific ultra-bright SERRS nanostars for Raman detection of pulmonary micrometastases Nayak, Tapas R.; Andreou, Chrysafis; Oseledchyk, Anton Nanoscale, Vol. 9, Issue 3 https://doi.org/10.1039/C6NR08217C	journal	January 2017
Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy Vo-Dinh, Tuan; Fales, Andrew M.; Griffin, Guy D. Nanoscale, Vol. 5, Issue 21 https://doi.org/10.1039/c3nr03633b	journal	January 2013
Microanalysis of organic pigments and glazes in polychrome works of art by surface-enhanced resonance Raman scattering Leona, M. Proceedings of the National Academy of Sciences, Vol. 106, Issue 35 https://doi.org/10.1073/pnas.0906995106	journal	August 2009
Review of Fluorescence Suppression Techniques in Raman Spectroscopy Wei, Dong; Chen, Shuo; Liu, Quan Applied Spectroscopy Reviews, Vol. 50, Issue 5 https://doi.org/10.1080/05704928.2014.999936	journal	January 2015
Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging Yuan, Hsiangkuo; Khoury, Christopher G.; Hwang, Hanjun Nanotechnology, Vol. 23, Issue 7 https://doi.org/10.1088/0957-4484/23/7/075102	journal	January 2012
How the localized surface plasmon became linked with surface-enhanced Raman spectroscopy Moskovits, Martin Notes and Records of the Royal Society, Vol. 66, Issue 2 https://doi.org/10.1098/rsnr.2011.0024	journal	November 2011
Recent advances in plasmonic nanostructures for sensing: a review Strobbia, Pietro; Languirand, Eric; Cullum, Brian M. Optical Engineering, Vol. 54, Issue 10 https://doi.org/10.1117/1.OE.54.10.100902	journal	October 2015
Surface regeneration and signal increase in surface-enhanced Raman scattering substrates Farrell, Mikella E.; Strobbia, Pietro; Pellegrino, Paul M. Applied Optics, Vol. 56, Issue 3 https://doi.org/10.1364/AO.56.00B198	journal	January 2017
Multi-excitation Raman spectroscopy technique for fluorescence rejection McCain, Scott T.; Willett, Rebecca M.; Brady, David J. Optics Express, Vol. 16, Issue 15 https://doi.org/10.1364/OE.16.010975	journal	January 2008
Automated Fluorescence Rejection Using Shifted Excitation Raman Difference Spectroscopy Zhao, Jun; Carrabba, Mike M.; Allen, Fritz S. Applied Spectroscopy, Vol. 56, Issue 7 https://doi.org/10.1366/000370202760171491	journal	July 2002
Remote Pulsed Raman Spectroscopy of Inorganic and Organic Materials to a Radial Distance of 100 Meters Sharma, S. K.; Misra, A. K.; Lucey, P. G. Applied Spectroscopy, Vol. 60, Issue 8 https://doi.org/10.1366/000370206778062110	journal	August 2006
Effective Rejection of Fluorescence Interference in Raman Spectroscopy Using a Shifted Excitation Difference Technique Shreve, Andrew P.; Cherepy, Nerine J.; Mathies, Richard A. Applied Spectroscopy, Vol. 46, Issue 4 https://doi.org/10.1366/0003702924125122	journal	April 1992
Fluorescence Rejection in Raman Spectroscopy by Shifted-Spectra, Edge Detection, and FFT Filtering Techniques Mosier-Boss, P. A.; Lieberman, S. H.; Newbery, R. Applied Spectroscopy, Vol. 49, Issue 5 https://doi.org/10.1366/0003702953964039	journal	May 1995
Dual-Wavelength Y-Branch Distributed Bragg Reflector Diode Laser at 785 Nanometers for Shifted Excitation Raman Difference Spectroscopy Maiwald, Martin; Eppich, Bernd; Fricke, Jörg Applied Spectroscopy, Vol. 68, Issue 8 https://doi.org/10.1366/13-07331	journal	August 2014
Surface-enhanced Raman scattering-active nanostructures and strategies for bioassays Jun, Bong-Hyun; Kim, Gunsung; Noh, Mi Suk Nanomedicine, Vol. 6, Issue 8 https://doi.org/10.2217/nnm.11.123	journal	October 2011
A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy Liu, Yang; Ashton, Jeffrey R.; Moding, Everett J. Theranostics, Vol. 5, Issue 9 https://doi.org/10.7150/thno.11974	journal	January 2015

Similar Records

Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS)

Journal Article · 2021 · Theranostics · OSTI ID:1817030

Strobbia, Pietro; Cupil-Garcia, Vanessa; Crawford, Bridget M.; +6 more

Sensing trace levels of molecular species in solution via zinc oxide nanoprobe Raman spectroscopy

Journal Article · 2017 · Journal of Raman Spectroscopy · OSTI ID:1533185

Cook, Andrew L.; Carson, Carcia S.; Marvinney, Claire E.; +2 more

In vivo nucleic acid detection and imaging within whole plants using plasmonic nanosensors

Conference · 2019 · OSTI ID:1573916

Crawford, Bridget M.; Strobbia, Pietro; Wang, Hsin-Neng; +7 more

Title: Shifted‐excitation Raman difference spectroscopy for the detection of SERS‐encoded gold nanostar probes

Citation Formats

References (39)

Similar Records

Related Subjects