Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications
Abstract
Lanthanide phosphate nanomaterials are appealing as multifunctional platforms for biomedical applications because of their low toxicity, radiation resistance, and unique luminescence and magnetic properties. Lanthanide phosphate nanoparticles (NPs) radiolabeled with 156Eu were synthesized by an aqueous route using sodium tripolyphosphate as a phosphate source and complexing agent. GdPO4 was used as a host matrix, while synthetic concentrations of Ce3+/Tb3+ and Eu3+ were varied between 5–40% and 10–30%, respectively, and yielded spherical NPs with hexagonal crystal system and particle size < 5 nm. Luminescence emission and magnetic susceptibility were influenced by lanthanide concentrations where characteristic 5D0-7FJ and 5D4-7FJ transitions were observed for Eu3+- and Tb3+-doped NPs, respectively. Chemical yield of > 90% was achieved for GdPO4 and Gd0.6Ce0.3Tb0.1PO4 NPs intrinsically radiolabeled with 156Eu. Lastly, in vitro retention of 156Eu within LnPO4 NPs was > 97% over 3 weeks. Intrinsically radiolabeled LnPO4 NPs have the potential to combine the luminescence and magnetic properties of Ln3+ ions with lanthanide radioisotopes for biomedical and environmental applications.
- Authors:
-
- Virginia Commonwealth Univ., Richmond, VA (United States). Dept. of Mechanical and Nuclear Engineering
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1471921
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Nanoparticle Research
- Additional Journal Information:
- Journal Volume: 20; Journal Issue: 9; Journal ID: ISSN 1388-0764
- Publisher:
- Tsinghua University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY; Multifunctional nanomaterials; lanthanide phosphate; luminescence; magnetic susceptibility; intrinsically radiolabeled nanoparticles; europium-156
Citation Formats
Toro Gonzalez, Miguel T., Clifford, Dustin M., Copping, Roy, Mirzadeh, Saed, and Rojas, Jessika V. Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications. United States: N. p., 2018.
Web. doi:10.1007/s11051-018-4338-8.
Toro Gonzalez, Miguel T., Clifford, Dustin M., Copping, Roy, Mirzadeh, Saed, & Rojas, Jessika V. Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications. United States. https://doi.org/10.1007/s11051-018-4338-8
Toro Gonzalez, Miguel T., Clifford, Dustin M., Copping, Roy, Mirzadeh, Saed, and Rojas, Jessika V. Thu .
"Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications". United States. https://doi.org/10.1007/s11051-018-4338-8. https://www.osti.gov/servlets/purl/1471921.
@article{osti_1471921,
title = {Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications},
author = {Toro Gonzalez, Miguel T. and Clifford, Dustin M. and Copping, Roy and Mirzadeh, Saed and Rojas, Jessika V.},
abstractNote = {Lanthanide phosphate nanomaterials are appealing as multifunctional platforms for biomedical applications because of their low toxicity, radiation resistance, and unique luminescence and magnetic properties. Lanthanide phosphate nanoparticles (NPs) radiolabeled with 156Eu were synthesized by an aqueous route using sodium tripolyphosphate as a phosphate source and complexing agent. GdPO4 was used as a host matrix, while synthetic concentrations of Ce3+/Tb3+ and Eu3+ were varied between 5–40% and 10–30%, respectively, and yielded spherical NPs with hexagonal crystal system and particle size < 5 nm. Luminescence emission and magnetic susceptibility were influenced by lanthanide concentrations where characteristic 5D0-7FJ and 5D4-7FJ transitions were observed for Eu3+- and Tb3+-doped NPs, respectively. Chemical yield of > 90% was achieved for GdPO4 and Gd0.6Ce0.3Tb0.1PO4 NPs intrinsically radiolabeled with 156Eu. Lastly, in vitro retention of 156Eu within LnPO4 NPs was > 97% over 3 weeks. Intrinsically radiolabeled LnPO4 NPs have the potential to combine the luminescence and magnetic properties of Ln3+ ions with lanthanide radioisotopes for biomedical and environmental applications.},
doi = {10.1007/s11051-018-4338-8},
journal = {Journal of Nanoparticle Research},
number = 9,
volume = 20,
place = {United States},
year = {Thu Sep 06 00:00:00 EDT 2018},
month = {Thu Sep 06 00:00:00 EDT 2018}
}
Web of Science
Figures / Tables:
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