Achieving the desired outcome

Richerson, Joan T.; Glass-Mattie, Dana

doi:10.1038/s41684-018-0068-x

Title: Achieving the desired outcome

Full Record
Other Related Research

Abstract

We present the scenario states that buprenorphine is administered to rodents as a negative control in a study evaluating the efficacy of certain new synthetic opioids; however, a nationwide shortage of buprenorphine has occurred. The IACUC is faced with the challenge of trying to decide if it is acceptable for Dr. Rosenfeld to use outdated buprenorphine or a buprenorphine reference standard to complete her study. The IACUC’s policy on veterinary verification and consultation (VVC) is not provided in this scenario, but it seems unlikely that the policy would address the use of either a reference standard or an expired drug, so the Attending Veterinarian was correct in referring the request to the full committee.

Authors:

Richerson, Joan T. ^[1];

^[1]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Publication Date:: 2018-05-23

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1471855

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Accepted Manuscript

Journal Name:: LabAnimal

Additional Journal Information:: Journal Volume: 47; Journal Issue: 6; Journal ID: ISSN 0093-7355

Publisher:: Springer Nature

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Richerson, Joan T., and Glass-Mattie, Dana. Achieving the desired outcome.  United States: N. p., 2018. 
Web.  https://doi.org/10.1038/s41684-018-0068-x.

Copy to clipboard


                    Richerson, Joan T., & Glass-Mattie, Dana. Achieving the desired outcome.  United States.  https://doi.org/10.1038/s41684-018-0068-x

Copy to clipboard


                    Richerson, Joan T., and Glass-Mattie, Dana. Wed .  
"Achieving the desired outcome".  United States.  https://doi.org/10.1038/s41684-018-0068-x.  https://www.osti.gov/servlets/purl/1471855.

Copy to clipboard


                    
@article{osti_1471855,

  title        = {Achieving the desired outcome},

  author       = {Richerson, Joan T. and Glass-Mattie, Dana},

  abstractNote = {We present the scenario states that buprenorphine is administered to rodents as a negative control in a study evaluating the efficacy of certain new synthetic opioids; however, a nationwide shortage of buprenorphine has occurred. The IACUC is faced with the challenge of trying to decide if it is acceptable for Dr. Rosenfeld to use outdated buprenorphine or a buprenorphine reference standard to complete her study. The IACUC’s policy on veterinary verification and consultation (VVC) is not provided in this scenario, but it seems unlikely that the policy would address the use of either a reference standard or an expired drug, so the Attending Veterinarian was correct in referring the request to the full committee.},

  doi          = {10.1038/s41684-018-0068-x},

  journal      = {LabAnimal},

  number       = 6,

  volume       = 47,

  place        = {United States},

  year         = {2018},

  month        = {5}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (DOE)

Publisher's Version of Record

https://doi.org/10.1038/s41684-018-0068-x

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

A question of authority

Journal Article Morgan, Earl W - Lab Animal

A Question of Authority. This article deals with a certain scenario and several reviewers are to give their opinion. This one is in regards to - Suspending an IACUC approved animal use activity is about the last thing a research institution wants to do. Consider the predicament that the Great Eastern University IACUC faced when Dr. Janet Jenkins, the Attending Veterinarian, suspended all animal use activity on an approved protocol of Dr. Roy Maslo. Jenkins had the IACUCs authority to temporarily suspend a protocol, subject to review by a quorum of the full committee. She alleged that Maslo used micemore »« less
https://doi.org/10.1038/laban1003-18b
Effect of waste anesthetic gas and vapor exposure on reproductive outcome in veterinary personnel

Thesis/Dissertation Johnson, J A

This study was designed to investigate potential adverse reproductive outcome in veterinary personnel who are exposed to waste anesthetic gas and vapor at levels near the NIOSH recommended standards. Subjects for this case-control study of births with congenital abnormalities and spontaneous abortion, selected from the American Veterinary Medical Association roster, were contacted by mail and asked to complete a screening questionnaire regarding reproductive history. Crude prevalence rates for spontaneous abortion, births with congenital abnormalities and stillbirths, determined on the basis of the responses to the screening questionnaire, showed no excess rates when compared with national statistics. All pregnancies resulting inmore »« less
Evaluation of a Subunit Vaccine to Infectious Hematopoietic Necrosis Virus, July 31, 1988 to September 20, 1989 Annual Report.

Technical Report Leong, JoAnn Ching

A recombinant DNA vaccine to IHNV was prepared and tested in field trials at Clear Springs Trout Company's Box Canyon Hatchery in Buhl, Idaho this year in Phase III of the project. The vaccine under consideration in these field trials consisted of lysed bacteria that contained a plasmid which expressed an antigenic portion of the IHNV glycoprotein. In addition, laboratory trials with a bacterial expressed viral nucleoprotein indicated that this served as an immune adjuvant. Therefore, a decision was made to conduct these field trials on a vaccine containing both IHNV glycoprotein and IHNV nucleoprotein. Original plans to conduct themore »« less
https://doi.org/10.2172/758123

Full Text Available
Adverse reproductive outcomes among female veterinarians

Journal Article Schenker, M B ; Samuels, S J ; Green, R S ; ... - American Journal of Epidemiology; (USA)

Because female veterinarians are exposed to several known reproductive hazards, the authors conducted a reproductive survey of all female graduates of a US veterinary school (n = 537) and law school (comparison group, n = 794). Analysis was confined to pregnancies completed after the second year of professional school and from 1966 to 1986. Based on one randomly chosen eligible pregnancy per woman (veterinarians, n = 176; lawyers, n = 229), spontaneous abortion rates, adjusted for elective abortions, were 13.3% for the veterinarians and 15.1% for the lawyers; these did not differ significantly. A Cox life table regression model controllingmore »« less
Report on the third international workshop on chromosome 9

Conference Povey, S ; White, J A ; Armour, J

The Third International Workshop on human chromosome 9 was held at Queens` College, Cambridge 9-11 April, 1994. The meeting was attended by 74 participants from 12 countries. On the morning of 12 April a satellite meeting was held on Tuberous Sclerosis, and because of its relevance to chromosome 9 a summary of this meeting is also presented within this report. The division consisted of a group with global interests, four regional groups 9p, 9q11-q21, 9q22-q33 and 9q33-qter, a group interested in mapping putative suppressor genes in ovarian and bladder cancer and a comparative mapping group. There was also discussion ofmore »« less
Full Text Available

Similar Records