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Title: Achieving the desired outcome

Abstract

We present the scenario states that buprenorphine is administered to rodents as a negative control in a study evaluating the efficacy of certain new synthetic opioids; however, a nationwide shortage of buprenorphine has occurred. The IACUC is faced with the challenge of trying to decide if it is acceptable for Dr. Rosenfeld to use outdated buprenorphine or a buprenorphine reference standard to complete her study. The IACUC’s policy on veterinary verification and consultation (VVC) is not provided in this scenario, but it seems unlikely that the policy would address the use of either a reference standard or an expired drug, so the Attending Veterinarian was correct in referring the request to the full committee.

Authors:
 [1]; ORCiD logo [1]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1471855
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
LabAnimal
Additional Journal Information:
Journal Volume: 47; Journal Issue: 6; Journal ID: ISSN 0093-7355
Publisher:
Springer Nature
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Richerson, Joan T., and Glass-Mattie, Dana. Achieving the desired outcome. United States: N. p., 2018. Web. https://doi.org/10.1038/s41684-018-0068-x.
Richerson, Joan T., & Glass-Mattie, Dana. Achieving the desired outcome. United States. https://doi.org/10.1038/s41684-018-0068-x
Richerson, Joan T., and Glass-Mattie, Dana. Wed . "Achieving the desired outcome". United States. https://doi.org/10.1038/s41684-018-0068-x. https://www.osti.gov/servlets/purl/1471855.
@article{osti_1471855,
title = {Achieving the desired outcome},
author = {Richerson, Joan T. and Glass-Mattie, Dana},
abstractNote = {We present the scenario states that buprenorphine is administered to rodents as a negative control in a study evaluating the efficacy of certain new synthetic opioids; however, a nationwide shortage of buprenorphine has occurred. The IACUC is faced with the challenge of trying to decide if it is acceptable for Dr. Rosenfeld to use outdated buprenorphine or a buprenorphine reference standard to complete her study. The IACUC’s policy on veterinary verification and consultation (VVC) is not provided in this scenario, but it seems unlikely that the policy would address the use of either a reference standard or an expired drug, so the Attending Veterinarian was correct in referring the request to the full committee.},
doi = {10.1038/s41684-018-0068-x},
journal = {LabAnimal},
number = 6,
volume = 47,
place = {United States},
year = {2018},
month = {5}
}

Journal Article:
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