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Title: Maternal consumption of fish oil programs reduced adiposity in broiler chicks

Abstract

We report that maternal intake of eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (22:6 n-3) has been associated with reduced adiposity in children, suggesting the possibility to program adipose development through dietary fatty acids before birth. This study determined if enriching the maternal diet in fish oil, the primary source of EPA and DHA, affected adipose development in offspring. Broiler chickens were used because they are obesity-prone, and because fatty acids provided to the embryo can be manipulated through the hen diet. Hens were fed diets supplemented (2.8% wt:wt) with corn oil (CO; n-6) or fish oil (FO; n-3) for 28 d. Chicks from both maternal diet groups were fed the same diet after hatch. Maternal FO consumption enriched chick adipose tissue in EPA and DHA and reduced adiposity by promoting more, but smaller, adipocytes. This adipocyte profile was paralleled by lower expression of the adipogenic regulator PPARG and its co-activator PPARGC1B, and elevated expression of LPL. Proteomics identified 95 differentially abundant proteins between FO and CO adipose tissue, including components of glucose metabolism, lipid droplet trafficking, and cytoskeletal organization. Lastly, these results demonstrate that the maternal dietary fatty acid profile programs offspring adipose development.

Authors:
 [1];  [1];  [1];  [2];  [2];  [3]; ORCiD logo [4];  [5]; ORCiD logo [6]
+ Show Author Affiliations
  1. Univ. of Tennessee, Knoxville, TN (United States). Department of Animal Science
  2. Univ. of Tennessee, Knoxville, TN (United States). Department of Chemistry
  3. Univ. of Tennessee, Knoxville, TN (United States). Graduate School of Genome Science and Technology
  4. Univ. of Tennessee, Knoxville, TN (United States). Graduate School of Genome Science and Technology and Chemical Sciences Division
  5. Univ. of Georgia, Athens, GA (United States). Department of Poultry Science
  6. Univ. of Tennessee, Knoxville, TN (United States). Department of Animal Science and Graduate School of Genome Science and Technology
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1470893
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 7; Journal Issue: 1; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Beckford, Ronique C., Howard, Sarah J., Das, Suchita, Farmer, Abigail T., Campagna, Shawn R., Yu, Jiali, Hettich, Robert L., Wilson, Jeanna L., and Voy, Brynn H. Maternal consumption of fish oil programs reduced adiposity in broiler chicks. United States: N. p., 2017. Web. doi:10.1038/s41598-017-13519-5.
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Beckford, Ronique C., Howard, Sarah J., Das, Suchita, Farmer, Abigail T., Campagna, Shawn R., Yu, Jiali, Hettich, Robert L., Wilson, Jeanna L., & Voy, Brynn H. Maternal consumption of fish oil programs reduced adiposity in broiler chicks. United States. https://doi.org/10.1038/s41598-017-13519-5
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Beckford, Ronique C., Howard, Sarah J., Das, Suchita, Farmer, Abigail T., Campagna, Shawn R., Yu, Jiali, Hettich, Robert L., Wilson, Jeanna L., and Voy, Brynn H. Fri . "Maternal consumption of fish oil programs reduced adiposity in broiler chicks". United States. https://doi.org/10.1038/s41598-017-13519-5. https://www.osti.gov/servlets/purl/1470893.
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@article{osti_1470893,
title = {Maternal consumption of fish oil programs reduced adiposity in broiler chicks},
author = {Beckford, Ronique C. and Howard, Sarah J. and Das, Suchita and Farmer, Abigail T. and Campagna, Shawn R. and Yu, Jiali and Hettich, Robert L. and Wilson, Jeanna L. and Voy, Brynn H.},
abstractNote = {We report that maternal intake of eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (22:6 n-3) has been associated with reduced adiposity in children, suggesting the possibility to program adipose development through dietary fatty acids before birth. This study determined if enriching the maternal diet in fish oil, the primary source of EPA and DHA, affected adipose development in offspring. Broiler chickens were used because they are obesity-prone, and because fatty acids provided to the embryo can be manipulated through the hen diet. Hens were fed diets supplemented (2.8% wt:wt) with corn oil (CO; n-6) or fish oil (FO; n-3) for 28 d. Chicks from both maternal diet groups were fed the same diet after hatch. Maternal FO consumption enriched chick adipose tissue in EPA and DHA and reduced adiposity by promoting more, but smaller, adipocytes. This adipocyte profile was paralleled by lower expression of the adipogenic regulator PPARG and its co-activator PPARGC1B, and elevated expression of LPL. Proteomics identified 95 differentially abundant proteins between FO and CO adipose tissue, including components of glucose metabolism, lipid droplet trafficking, and cytoskeletal organization. Lastly, these results demonstrate that the maternal dietary fatty acid profile programs offspring adipose development.},
doi = {10.1038/s41598-017-13519-5},
journal = {Scientific Reports},
number = 1,
volume = 7,
place = {United States},
year = {Fri Oct 13 00:00:00 EDT 2017},
month = {Fri Oct 13 00:00:00 EDT 2017}
}
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https://doi.org/10.1038/s41598-017-13519-5
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MyriMatch:  Highly Accurate Tandem Mass Spectral Peptide Identification by Multivariate Hypergeometric Analysis
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Characterization of major elements of insulin signaling cascade in chicken adipose tissue: Apparent insulin refractoriness
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Nutritional manipulations in the perinatal period program adipose tissue in offspring
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Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort
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Regulation of Hepatic De Novo Lipogenesis in Humans
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Weight Gain in Infancy and Overweight or Obesity in Childhood across the Gestational Spectrum: a Prospective Birth Cohort Study
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Relationship of Childhood Obesity to Coronary Heart Disease Risk Factors in Adulthood: The Bogalusa Heart Study
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Effect of prenatal DHA supplementation on the infant epigenome: results from a randomized controlled trial
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Perilipin Overexpression in White Adipose Tissue Induces a Brown Fat-Like Phenotype
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Tracking of body mass index in children in relation to overweight in adulthood
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Eicosapentaenoic acid and arachidonic acid differentially regulate adipogenesis, acquisition of a brite phenotype and mitochondrial function in primary human adipocytes
journal, June 2016

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APOBEC2 mRNA and protein is predominantly expressed in skeletal and cardiac muscles of chickens
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A Rapid Method of Total Lipid Extraction and Purification
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Uncovering the novel characteristics of Asian honey bee, Apis cerana, by whole genome sequencing
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In Vivo Lipogenesis in the Domestic Chicken
journal, June 1968

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  • DOI: 10.3181/00379727-128-33022

Fat Utilization and Lipogenesis in the Young Pig
journal, October 1971

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Mapping of leptin and its syntenic genes to chicken chromosome 1p
journal, August 2017

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