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Title: Antimicrobial Properties of 2D MnO 2 and MoS 2 Nanomaterials Vertically Aligned on Graphene Materials and Ti 3C 2 MXene

Abstract

Two-dimensional (2D) nanomaterials have attracted considerable attention in biomedical and environmental applications due to their antimicrobial activity. In the interest of investigating the primary antimicrobial mode-of-action of 2D nanomaterials, we studied the antimicrobial properties of MnO 2 and MoS 2, toward Gram-positive and Gram-negative bacteria. Bacillus subtilis and Escherichia coli bacteria were treated individually with 100 μg/mL of randomly oriented and vertically aligned nanomaterials for ~3 h in the dark. The vertically aligned 2D MnO 2 and MoS 2 were grown on 2D sheets of graphene oxide, reduced graphene oxide, and Ti 3C 2 MXene. Measurements to determine the viability of bacteria in the presence of the 2D nanomaterials performed by using two complementary techniques, flow cytometry, and fluorescence imaging showed that, while MnO 2 and MoS 2 nanosheets show different antibacterial activities, in both cases, Gram-positive bacteria show a higher loss in membrane integrity. Scanning electron microscopy images suggest that the 2D nanomaterials, which have a detrimental effect on bacteria viability, compromise the cell wall, leading to significant morphological changes. Here, we propose that the peptidoglycan mesh (PM) in the bacterial wall is likely the primary target of the 2D nanomaterials. Vertically aligned 2D MnO 2 nanosheets showed themore » highest antimicrobial activity, suggesting that the edges of the nanosheets were likely compromising the cell walls upon contact.« less

Authors:
ORCiD logo [1];  [2]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [3]; ORCiD logo [3]; ORCiD logo [1]
  1. Temple Univ., Philadelphia, PA (United States). Dept. of Chemistry, and Center for Computational Design of Functional Layered Materials (CCDM)
  2. Temple Univ., Philadelphia, PA (United States). Dept. of Chemistry
  3. Drexel Univ., Philadelphia, PA (United States). Dept. of Materials Science and Engineering, and A.J. Drexel Nanomaterials Inst.
Publication Date:
Research Org.:
Energy Frontier Research Centers (EFRC) (United States). Center for the Computational Design of Functional Layered Materials (CCDM)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1470630
Grant/Contract Number:  
[SC0012575]
Resource Type:
Accepted Manuscript
Journal Name:
Langmuir
Additional Journal Information:
[ Journal Volume: 34; Journal Issue: 24; Related Information: CCDM partners with Temple University (lead); Brookhaven National Laboratory; Drexel University; Duke University; North Carolina State University; Northeastern University; Princeton University; Rice University; University of Pennsylvania]; Journal ID: ISSN 0743-7463
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 59 BASIC BIOLOGICAL SCIENCES; catalysis (heterogeneous); solar (photovoltaic); energy storage (including batteries and capacitors); hydrogen and fuel cells; defects; mechanical behavior; materials and chemistry by design; synthesis (novel materials); 2D nanomaterials; antimicrobial; birnessite; mode-of-action; nano-knife; cell wall; peptidoglycan mesh

Citation Formats

Alimohammadi, Farbod, Sharifian Gh., Mohammad, Attanayake, Nuwan H., Thenuwara, Akila C., Gogotsi, Yury, Anasori, Babak, and Strongin, Daniel R. Antimicrobial Properties of 2D MnO2 and MoS2 Nanomaterials Vertically Aligned on Graphene Materials and Ti3C2 MXene. United States: N. p., 2018. Web. doi:10.1021/acs.langmuir.8b00262.
Alimohammadi, Farbod, Sharifian Gh., Mohammad, Attanayake, Nuwan H., Thenuwara, Akila C., Gogotsi, Yury, Anasori, Babak, & Strongin, Daniel R. Antimicrobial Properties of 2D MnO2 and MoS2 Nanomaterials Vertically Aligned on Graphene Materials and Ti3C2 MXene. United States. doi:10.1021/acs.langmuir.8b00262.
Alimohammadi, Farbod, Sharifian Gh., Mohammad, Attanayake, Nuwan H., Thenuwara, Akila C., Gogotsi, Yury, Anasori, Babak, and Strongin, Daniel R. Mon . "Antimicrobial Properties of 2D MnO2 and MoS2 Nanomaterials Vertically Aligned on Graphene Materials and Ti3C2 MXene". United States. doi:10.1021/acs.langmuir.8b00262. https://www.osti.gov/servlets/purl/1470630.
@article{osti_1470630,
title = {Antimicrobial Properties of 2D MnO2 and MoS2 Nanomaterials Vertically Aligned on Graphene Materials and Ti3C2 MXene},
author = {Alimohammadi, Farbod and Sharifian Gh., Mohammad and Attanayake, Nuwan H. and Thenuwara, Akila C. and Gogotsi, Yury and Anasori, Babak and Strongin, Daniel R.},
abstractNote = {Two-dimensional (2D) nanomaterials have attracted considerable attention in biomedical and environmental applications due to their antimicrobial activity. In the interest of investigating the primary antimicrobial mode-of-action of 2D nanomaterials, we studied the antimicrobial properties of MnO2 and MoS2, toward Gram-positive and Gram-negative bacteria. Bacillus subtilis and Escherichia coli bacteria were treated individually with 100 μg/mL of randomly oriented and vertically aligned nanomaterials for ~3 h in the dark. The vertically aligned 2D MnO2 and MoS2 were grown on 2D sheets of graphene oxide, reduced graphene oxide, and Ti3C2 MXene. Measurements to determine the viability of bacteria in the presence of the 2D nanomaterials performed by using two complementary techniques, flow cytometry, and fluorescence imaging showed that, while MnO2 and MoS2 nanosheets show different antibacterial activities, in both cases, Gram-positive bacteria show a higher loss in membrane integrity. Scanning electron microscopy images suggest that the 2D nanomaterials, which have a detrimental effect on bacteria viability, compromise the cell wall, leading to significant morphological changes. Here, we propose that the peptidoglycan mesh (PM) in the bacterial wall is likely the primary target of the 2D nanomaterials. Vertically aligned 2D MnO2 nanosheets showed the highest antimicrobial activity, suggesting that the edges of the nanosheets were likely compromising the cell walls upon contact.},
doi = {10.1021/acs.langmuir.8b00262},
journal = {Langmuir},
number = [24],
volume = [34],
place = {United States},
year = {2018},
month = {5}
}

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