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Title: pH-Dependent Assembly of Porphyrin–Silica Nanocomposites and Their Application in Targeted Photodynamic Therapy

Abstract

Structurally controlled nanoparticles, such as core–shell nanocomposite particles by combining two or more compositions, possess enhanced or new functionalities that benefited from the synergistic coupling of the two components. In this paper, we report new nanocomposite particles with self-assembled porphyrin arrays as the core surrounded by amorphous silica as the shell. The synthesis of such nanocomposite nanoparticles was conducted through a combined surfactant micelle confined self-assembly and silicate sol–gel process using optically active porphyrin as a functional building block. Depending on kinetic conditions, these particles exhibit structure and function at multiple length scales and locations. At the molecular scale, the porphyrins as the building blocks provide well-defined macromolecular structures for noncovalent self-assembly and unique chemistry for high-yield generation of singlet oxygen for photodynamic therapy (PDT). On the nanoscale, controlled noncovalent interactions of the porphyrin building block result in an extensive self-assembled porphyrin network that enables efficient energy transfer and impressive fluorescence for cell labeling, evidenced by absorption and photoluminescence spectra. The thin silicate shell on the nanoparticle surface allows easy functionalization, and the resultant targeting porphyrin-silica nanocomposites can selectively destroy tumor cells upon receiving light irradiation.

Authors:
 [1];  [1];  [1];  [2];  [3]; ORCiD logo [2];  [4];  [4]; ORCiD logo [5]
  1. Henan Univ., Kaifeng (China). Key Lab. for Special Functional Materials of the Ministry of Education
  2. Tongji Univ. School of Medicine, Shanghai (China). Inst. of Photomedicine. Shanghai Skin Disease Hospital. The Inst. for Biomedical Engineering & Nano Science
  3. Henan Univ., Kaifeng (China). Key Lab. for Special Functional Materials of the Ministry of Education. Collaborative Innovation Center of Nano Functional Materials and Applications
  4. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  5. Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Chemical and Biological Engineering; Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Henan Univ., Kaifeng (China); Tongji Univ. School of Medicine, Shanghai (China)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); USDOE National Nuclear Security Administration (NNSA); National Natural Science Foundation of China (NNSFC); Plan For Scientific Innovation Talent of Henan Province (China); Program for Changjiang Scholars and Innovative Research Team in University (China)
OSTI Identifier:
1469629
Report Number(s):
[SAND-2018-9734J]
[Journal ID: ISSN 1530-6984; 667619]
Grant/Contract Number:  
[NA0003525; 21422102; 21771055; U1604139; 21171049; 81371618; 174200510019; PCS IRT_15R18]
Resource Type:
Accepted Manuscript
Journal Name:
Nano Letters
Additional Journal Information:
[ Journal Volume: 17; Journal Issue: 11]; Journal ID: ISSN 1530-6984
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; photodynamic therapy; photosensitizer; porphyrins; self-assembly; singlet oxygen

Citation Formats

Wang, Jiefei, Zhong, Yong, Wang, Xiao, Yang, Weitao, Bai, Feng, Zhang, Bingbo, Alarid, Leanne, Bian, Kaifu, and Fan, Hongyou. pH-Dependent Assembly of Porphyrin–Silica Nanocomposites and Their Application in Targeted Photodynamic Therapy. United States: N. p., 2017. Web. doi:10.1021/acs.nanolett.7b03310.
Wang, Jiefei, Zhong, Yong, Wang, Xiao, Yang, Weitao, Bai, Feng, Zhang, Bingbo, Alarid, Leanne, Bian, Kaifu, & Fan, Hongyou. pH-Dependent Assembly of Porphyrin–Silica Nanocomposites and Their Application in Targeted Photodynamic Therapy. United States. doi:10.1021/acs.nanolett.7b03310.
Wang, Jiefei, Zhong, Yong, Wang, Xiao, Yang, Weitao, Bai, Feng, Zhang, Bingbo, Alarid, Leanne, Bian, Kaifu, and Fan, Hongyou. Wed . "pH-Dependent Assembly of Porphyrin–Silica Nanocomposites and Their Application in Targeted Photodynamic Therapy". United States. doi:10.1021/acs.nanolett.7b03310. https://www.osti.gov/servlets/purl/1469629.
@article{osti_1469629,
title = {pH-Dependent Assembly of Porphyrin–Silica Nanocomposites and Their Application in Targeted Photodynamic Therapy},
author = {Wang, Jiefei and Zhong, Yong and Wang, Xiao and Yang, Weitao and Bai, Feng and Zhang, Bingbo and Alarid, Leanne and Bian, Kaifu and Fan, Hongyou},
abstractNote = {Structurally controlled nanoparticles, such as core–shell nanocomposite particles by combining two or more compositions, possess enhanced or new functionalities that benefited from the synergistic coupling of the two components. In this paper, we report new nanocomposite particles with self-assembled porphyrin arrays as the core surrounded by amorphous silica as the shell. The synthesis of such nanocomposite nanoparticles was conducted through a combined surfactant micelle confined self-assembly and silicate sol–gel process using optically active porphyrin as a functional building block. Depending on kinetic conditions, these particles exhibit structure and function at multiple length scales and locations. At the molecular scale, the porphyrins as the building blocks provide well-defined macromolecular structures for noncovalent self-assembly and unique chemistry for high-yield generation of singlet oxygen for photodynamic therapy (PDT). On the nanoscale, controlled noncovalent interactions of the porphyrin building block result in an extensive self-assembled porphyrin network that enables efficient energy transfer and impressive fluorescence for cell labeling, evidenced by absorption and photoluminescence spectra. The thin silicate shell on the nanoparticle surface allows easy functionalization, and the resultant targeting porphyrin-silica nanocomposites can selectively destroy tumor cells upon receiving light irradiation.},
doi = {10.1021/acs.nanolett.7b03310},
journal = {Nano Letters},
number = [11],
volume = [17],
place = {United States},
year = {2017},
month = {10}
}

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