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Title: Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers

The use of nanoparticles as a potential building block for photosensitizers has recently become a focus of interest in the field of photocatalysis and photodynamic therapy. Porphyrins and their derivatives are effective photosensitizers due to extended π-conjugated electronic structure, high molar absorption from visible to near-infrared spectrum, and high singlet oxygen quantum yields as well as chemical versatility. In this work, we report a synthesis of self-assembled porphyrin nanoparticle photosensitizers using zinc meso-tetra(4-pyridyl)porphyrin (ZnTPyP) through a confined noncovalent self-assembly process. Scanning electron microscopy reveals formation of monodisperse cubic nanoparticles. UV–vis characterizations reveal that optical absorption of the nanoparticles exhibits a red shift due to noncovalent self-assembly of porphyrins, which not only effectively increase intensity of light absorption but also extend light absorption broadly covering visible light for enhanced photodynamic therapy. Electron spin-resonance spectroscopy (ESR) studies show the resultant porphyrin nanoparticles release a high yield of singlet oxygen. Nitric oxide (NO) coordinates to central metal Zn ions to form stabilized ZnTPyP@NO nanoparticles. We show that under light irradiation ZnTPyP@NO nanoparticles release highly reactive peroxynitrite molecules that exhibit enhanced antibacterial photodynamic therapy (APDT) activity. Finally, the ease of the synthesis of self-assembled porphyrin nanoparticles and light-triggered release of highly reactive moieties representmore » a completely different photosensitizer system for APDT application.« less
Authors:
 [1] ;  [1] ;  [2] ;  [2] ;  [1] ; ORCiD logo [1] ;  [1] ; ORCiD logo [2] ; ORCiD logo [3]
  1. Henan Univ., Kaifeng (China). Key Lab. for Special Functional Materials of the Ministry of Education. Collaborative Innovation Center of Nano Functional Materials and Applications
  2. National Center for Nanoscience and Technology (NCNST), Beijing (China). CAS Key Lab. for Biological Effects of Nanomaterials and Nanosafety
  3. Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Chemical and Biological Engineering; Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Report Number(s):
SAND-2018-9735J
Journal ID: ISSN 1936-0851; 667620
Grant/Contract Number:
NA0003525; 21422102; 21771055; U1604139; 21171049; 174200510019; PCS IRT_15R18
Type:
Accepted Manuscript
Journal Name:
ACS Nano
Additional Journal Information:
Journal Volume: 12; Journal Issue: 4; Journal ID: ISSN 1936-0851
Publisher:
American Chemical Society (ACS)
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Henan Univ., Kaifeng (China); National Center for Nanoscience and Technology (NCNST), Beijing (China)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); USDOE National Nuclear Security Administration (NNSA); National Natural Science Foundation of China (NNSFC); Plan for Scientific Innovation Talent of Henan Province (China); Program for Changjiang Scholars and Innovative Research Team in University (China)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; antibacterial photodynamic therapy; APDT; photosensitizers; porphyrin nanoparticles; self-assembly
OSTI Identifier:
1469627

Wang, Dong, Niu, Lijuan, Qiao, Zeng-Ying, Cheng, Dong-Bing, Wang, Jiefei, Zhong, Yong, Bai, Feng, Wang, Hao, and Fan, Hongyou. Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers. United States: N. p., Web. doi:10.1021/acsnano.8b01010.
Wang, Dong, Niu, Lijuan, Qiao, Zeng-Ying, Cheng, Dong-Bing, Wang, Jiefei, Zhong, Yong, Bai, Feng, Wang, Hao, & Fan, Hongyou. Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers. United States. doi:10.1021/acsnano.8b01010.
Wang, Dong, Niu, Lijuan, Qiao, Zeng-Ying, Cheng, Dong-Bing, Wang, Jiefei, Zhong, Yong, Bai, Feng, Wang, Hao, and Fan, Hongyou. 2018. "Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers". United States. doi:10.1021/acsnano.8b01010. https://www.osti.gov/servlets/purl/1469627.
@article{osti_1469627,
title = {Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers},
author = {Wang, Dong and Niu, Lijuan and Qiao, Zeng-Ying and Cheng, Dong-Bing and Wang, Jiefei and Zhong, Yong and Bai, Feng and Wang, Hao and Fan, Hongyou},
abstractNote = {The use of nanoparticles as a potential building block for photosensitizers has recently become a focus of interest in the field of photocatalysis and photodynamic therapy. Porphyrins and their derivatives are effective photosensitizers due to extended π-conjugated electronic structure, high molar absorption from visible to near-infrared spectrum, and high singlet oxygen quantum yields as well as chemical versatility. In this work, we report a synthesis of self-assembled porphyrin nanoparticle photosensitizers using zinc meso-tetra(4-pyridyl)porphyrin (ZnTPyP) through a confined noncovalent self-assembly process. Scanning electron microscopy reveals formation of monodisperse cubic nanoparticles. UV–vis characterizations reveal that optical absorption of the nanoparticles exhibits a red shift due to noncovalent self-assembly of porphyrins, which not only effectively increase intensity of light absorption but also extend light absorption broadly covering visible light for enhanced photodynamic therapy. Electron spin-resonance spectroscopy (ESR) studies show the resultant porphyrin nanoparticles release a high yield of singlet oxygen. Nitric oxide (NO) coordinates to central metal Zn ions to form stabilized ZnTPyP@NO nanoparticles. We show that under light irradiation ZnTPyP@NO nanoparticles release highly reactive peroxynitrite molecules that exhibit enhanced antibacterial photodynamic therapy (APDT) activity. Finally, the ease of the synthesis of self-assembled porphyrin nanoparticles and light-triggered release of highly reactive moieties represent a completely different photosensitizer system for APDT application.},
doi = {10.1021/acsnano.8b01010},
journal = {ACS Nano},
number = 4,
volume = 12,
place = {United States},
year = {2018},
month = {4}
}