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Title: Modular DNA strand-displacement controllers for directing material expansion

Abstract

Soft materials that swell or change shape in response to external stimuli show extensive promise in regenerative medicine, targeted therapeutics, and soft robotics. Generally, a stimulus for shape change must interact directly with the material, limiting the types of stimuli that may be used and necessitating high stimulus concentrations. Here, we show how DNA strand-displacement controllers within hydrogels can mediate size change by interpreting, amplifying, and integrating stimuli and releasing signals that direct the response. These controllers tune the time scale and degree of DNA-crosslinked hydrogel swelling and can actuate dramatic material size change in response to <100 nM of a specific biomolecular input. Controllers can also direct swelling in response to small molecules or perform logic. The integration of these stimuli-responsive materials with biomolecular circuits is a major step towards autonomous soft robotic systems in which sensing and actuation are implemented by biomolecular reaction networks.

Authors:
ORCiD logo; ORCiD logo
Publication Date:
Research Org.:
Johns Hopkins Univ., Baltimore, MD (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1469248
Alternate Identifier(s):
OSTI ID: 1624113
Grant/Contract Number:  
SC0015906; SC0010687
Resource Type:
Published Article
Journal Name:
Nature Communications
Additional Journal Information:
Journal Name: Nature Communications Journal Volume: 9 Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United Kingdom
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Science & Technology - Other Topics

Citation Formats

Fern, Joshua, and Schulman, Rebecca. Modular DNA strand-displacement controllers for directing material expansion. United Kingdom: N. p., 2018. Web. doi:10.1038/s41467-018-06218-w.
Fern, Joshua, & Schulman, Rebecca. Modular DNA strand-displacement controllers for directing material expansion. United Kingdom. doi:10.1038/s41467-018-06218-w.
Fern, Joshua, and Schulman, Rebecca. Fri . "Modular DNA strand-displacement controllers for directing material expansion". United Kingdom. doi:10.1038/s41467-018-06218-w.
@article{osti_1469248,
title = {Modular DNA strand-displacement controllers for directing material expansion},
author = {Fern, Joshua and Schulman, Rebecca},
abstractNote = {Soft materials that swell or change shape in response to external stimuli show extensive promise in regenerative medicine, targeted therapeutics, and soft robotics. Generally, a stimulus for shape change must interact directly with the material, limiting the types of stimuli that may be used and necessitating high stimulus concentrations. Here, we show how DNA strand-displacement controllers within hydrogels can mediate size change by interpreting, amplifying, and integrating stimuli and releasing signals that direct the response. These controllers tune the time scale and degree of DNA-crosslinked hydrogel swelling and can actuate dramatic material size change in response to <100 nM of a specific biomolecular input. Controllers can also direct swelling in response to small molecules or perform logic. The integration of these stimuli-responsive materials with biomolecular circuits is a major step towards autonomous soft robotic systems in which sensing and actuation are implemented by biomolecular reaction networks.},
doi = {10.1038/s41467-018-06218-w},
journal = {Nature Communications},
number = 1,
volume = 9,
place = {United Kingdom},
year = {2018},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1038/s41467-018-06218-w

Citation Metrics:
Cited by: 9 works
Citation information provided by
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    Works referencing / citing this record:

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