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Title: Suggested reference values for regional blood volumes in children and adolescents

Abstract

Estimates of regional blood volumes (BVs) in humans are needed in dosimetric models of radionuclides and radiopharmaceuticals that decay in the circulation to a significant extent. These values are also needed to refine models of tissue elemental composition in computational human phantoms of both patients and exposed members of the general public. The International Commission on Radiological Protection (ICRP) in its Publication 89 provides reference values for total blood content in the full series of their reference individuals, to include the male and female newborn, 1 year-old, 5 year-old, 10 year-old, 15 year-old, and adult. Furthermore, Publication 89 provides reference values for the percentage distribution of total blood volume in 27 different blood-filled organs and tissues of the reference adult male and adult female. However, no similar distribution values are provided for non-adults. The goal of the present paper is to present a volumetric scaling methodology to derive these values for the same organs and tissues at ages younger than the reference adult. Finally, literature data on organ-specific vascular growth in the brain, kidneys, and skeletal tissues are also considered.

Authors:
 [1];  [2]; ORCiD logo [3];  [4];  [1];  [1]; ORCiD logo [1]
  1. Univ. of Florida, Gainesville, FL (United States). J. Crayton Pruitt Family Dept. of Biomedical Engineering
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Radiation Protection Knowledge
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Radiation Protection Knowledge; Francis Marion Univ., Florence, SC (United States). Dept. of Physics and Engineering
  4. National Cancer Inst., Bethesda, MD (United States). Radiation Epidemiology Branch
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Florida, Gainesville, FL (United States); National Cancer Inst., Bethesda, MD (United States)
Sponsoring Org.:
USDOE; National Inst. of Health (NIH) (United States)
OSTI Identifier:
1468169
Grant/Contract Number:  
AC05-00OR22725; R01 CA116743; R01 EB013558
Resource Type:
Accepted Manuscript
Journal Name:
Physics in Medicine and Biology (Online)
Additional Journal Information:
Journal Name: Physics in Medicine and Biology (Online); Journal Volume: 63; Journal Issue: 15; Journal ID: ISSN 1361-6560
Publisher:
IOP Publishing
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 61 RADIATION PROTECTION AND DOSIMETRY

Citation Formats

Wayson, Michael B., Leggett, Richard W., Jokisch, Derek W., Lee, Choonsik, Schwarz, Bryan C., Godwin, William J., and Bolch, Wesley E. Suggested reference values for regional blood volumes in children and adolescents. United States: N. p., 2018. Web. doi:10.1088/1361-6560/aad313.
Wayson, Michael B., Leggett, Richard W., Jokisch, Derek W., Lee, Choonsik, Schwarz, Bryan C., Godwin, William J., & Bolch, Wesley E. Suggested reference values for regional blood volumes in children and adolescents. United States. doi:10.1088/1361-6560/aad313.
Wayson, Michael B., Leggett, Richard W., Jokisch, Derek W., Lee, Choonsik, Schwarz, Bryan C., Godwin, William J., and Bolch, Wesley E. Thu . "Suggested reference values for regional blood volumes in children and adolescents". United States. doi:10.1088/1361-6560/aad313. https://www.osti.gov/servlets/purl/1468169.
@article{osti_1468169,
title = {Suggested reference values for regional blood volumes in children and adolescents},
author = {Wayson, Michael B. and Leggett, Richard W. and Jokisch, Derek W. and Lee, Choonsik and Schwarz, Bryan C. and Godwin, William J. and Bolch, Wesley E.},
abstractNote = {Estimates of regional blood volumes (BVs) in humans are needed in dosimetric models of radionuclides and radiopharmaceuticals that decay in the circulation to a significant extent. These values are also needed to refine models of tissue elemental composition in computational human phantoms of both patients and exposed members of the general public. The International Commission on Radiological Protection (ICRP) in its Publication 89 provides reference values for total blood content in the full series of their reference individuals, to include the male and female newborn, 1 year-old, 5 year-old, 10 year-old, 15 year-old, and adult. Furthermore, Publication 89 provides reference values for the percentage distribution of total blood volume in 27 different blood-filled organs and tissues of the reference adult male and adult female. However, no similar distribution values are provided for non-adults. The goal of the present paper is to present a volumetric scaling methodology to derive these values for the same organs and tissues at ages younger than the reference adult. Finally, literature data on organ-specific vascular growth in the brain, kidneys, and skeletal tissues are also considered.},
doi = {10.1088/1361-6560/aad313},
journal = {Physics in Medicine and Biology (Online)},
number = 15,
volume = 63,
place = {United States},
year = {2018},
month = {7}
}

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