Suggested reference values for regional blood volumes in children and adolescents
Abstract
Estimates of regional blood volumes (BVs) in humans are needed in dosimetric models of radionuclides and radiopharmaceuticals that decay in the circulation to a significant extent. These values are also needed to refine models of tissue elemental composition in computational human phantoms of both patients and exposed members of the general public. The International Commission on Radiological Protection (ICRP) in its Publication 89 provides reference values for total blood content in the full series of their reference individuals, to include the male and female newborn, 1 year-old, 5 year-old, 10 year-old, 15 year-old, and adult. Furthermore, Publication 89 provides reference values for the percentage distribution of total blood volume in 27 different blood-filled organs and tissues of the reference adult male and adult female. However, no similar distribution values are provided for non-adults. The goal of the present paper is to present a volumetric scaling methodology to derive these values for the same organs and tissues at ages younger than the reference adult. Finally, literature data on organ-specific vascular growth in the brain, kidneys, and skeletal tissues are also considered.
- Authors:
-
- Univ. of Florida, Gainesville, FL (United States). J. Crayton Pruitt Family Dept. of Biomedical Engineering
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Radiation Protection Knowledge
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Radiation Protection Knowledge; Francis Marion Univ., Florence, SC (United States). Dept. of Physics and Engineering
- National Cancer Inst., Bethesda, MD (United States). Radiation Epidemiology Branch
- Publication Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Florida, Gainesville, FL (United States); National Cancer Inst., Bethesda, MD (United States)
- Sponsoring Org.:
- USDOE; National Inst. of Health (NIH) (United States)
- OSTI Identifier:
- 1468169
- Grant/Contract Number:
- AC05-00OR22725; R01 CA116743; R01 EB013558
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Physics in Medicine and Biology (Online)
- Additional Journal Information:
- Journal Name: Physics in Medicine and Biology (Online); Journal Volume: 63; Journal Issue: 15; Journal ID: ISSN 1361-6560
- Publisher:
- IOP Publishing
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 61 RADIATION PROTECTION AND DOSIMETRY
Citation Formats
Wayson, Michael B., Leggett, Richard W., Jokisch, Derek W., Lee, Choonsik, Schwarz, Bryan C., Godwin, William J., and Bolch, Wesley E. Suggested reference values for regional blood volumes in children and adolescents. United States: N. p., 2018.
Web. doi:10.1088/1361-6560/aad313.
Wayson, Michael B., Leggett, Richard W., Jokisch, Derek W., Lee, Choonsik, Schwarz, Bryan C., Godwin, William J., & Bolch, Wesley E. Suggested reference values for regional blood volumes in children and adolescents. United States. https://doi.org/10.1088/1361-6560/aad313
Wayson, Michael B., Leggett, Richard W., Jokisch, Derek W., Lee, Choonsik, Schwarz, Bryan C., Godwin, William J., and Bolch, Wesley E. Thu .
"Suggested reference values for regional blood volumes in children and adolescents". United States. https://doi.org/10.1088/1361-6560/aad313. https://www.osti.gov/servlets/purl/1468169.
@article{osti_1468169,
title = {Suggested reference values for regional blood volumes in children and adolescents},
author = {Wayson, Michael B. and Leggett, Richard W. and Jokisch, Derek W. and Lee, Choonsik and Schwarz, Bryan C. and Godwin, William J. and Bolch, Wesley E.},
abstractNote = {Estimates of regional blood volumes (BVs) in humans are needed in dosimetric models of radionuclides and radiopharmaceuticals that decay in the circulation to a significant extent. These values are also needed to refine models of tissue elemental composition in computational human phantoms of both patients and exposed members of the general public. The International Commission on Radiological Protection (ICRP) in its Publication 89 provides reference values for total blood content in the full series of their reference individuals, to include the male and female newborn, 1 year-old, 5 year-old, 10 year-old, 15 year-old, and adult. Furthermore, Publication 89 provides reference values for the percentage distribution of total blood volume in 27 different blood-filled organs and tissues of the reference adult male and adult female. However, no similar distribution values are provided for non-adults. The goal of the present paper is to present a volumetric scaling methodology to derive these values for the same organs and tissues at ages younger than the reference adult. Finally, literature data on organ-specific vascular growth in the brain, kidneys, and skeletal tissues are also considered.},
doi = {10.1088/1361-6560/aad313},
journal = {Physics in Medicine and Biology (Online)},
number = 15,
volume = 63,
place = {United States},
year = {Thu Jul 12 00:00:00 EDT 2018},
month = {Thu Jul 12 00:00:00 EDT 2018}
}
Web of Science
Works referenced in this record:
A Proposed Blood Circulation Model for Reference Man
journal, January 1995
- Leggett, R. W.; Williams, L. R.
- Health Physics, Vol. 69, Issue 2
Cortical and Cancellous Bone: Age-Related Changes in Morphologic Features, Fluid Spaces, and Calcium Homeostasis in Dogs
journal, February 1988
- Simonet, William T.; Bronk, James T.; Pinto, Manuel R.
- Mayo Clinic Proceedings, Vol. 63, Issue 2
ICRP Publication 133: The ICRP computational framework for internal dose assessment for reference adults: specific absorbed fractions
journal, November 2016
- Bolch, W. E.; Jokisch, D.; Zankl, M.
- Annals of the ICRP, Vol. 45, Issue 2
Reference values for resting blood flow to organs of man
journal, August 1989
- Williams, L. R.; Leggett, R. W.
- Clinical Physics and Physiological Measurement, Vol. 10, Issue 3
Maturation of Renal Function in Childhood: Clearance Studies12
journal, September 1949
- Rubin, Mitchell I.; Bruck, Erika; Rapoport, Milton
- Journal of Clinical Investigation, Vol. 28, Issue 5 Pt 2
Computational lymphatic node models in pediatric and adult hybrid phantoms for radiation dosimetry
journal, February 2013
- Lee, Choonsik; Lamart, Stephanie; Moroz, Brian E.
- Physics in Medicine and Biology, Vol. 58, Issue 5
MIRD Pamphlet No. 21: A Generalized Schema for Radiopharmaceutical Dosimetry--Standardization of Nomenclature
journal, February 2009
- Bolch, W. E.; Eckerman, K. F.; Sgouros, G.
- Journal of Nuclear Medicine, Vol. 50, Issue 3
Suggested Reference Values for Regional Blood Volumes in Humans
journal, January 1991
- Leggett, R. W.; Williams, L. R.
- Health Physics, Vol. 60, Issue 2
A Method for Calculating Regional Cerebral Blood Flow from Emission Computed Tomography of Inert Gas Concentrations
journal, January 1981
- Celsis, P.; Goldman, T.; Henriksen, L.
- Journal of Computer Assisted Tomography, Vol. 5, Issue 5
The UF family of reference hybrid phantoms for computational radiation dosimetry
journal, December 2009
- Lee, Choonsik; Lodwick, Daniel; Hurtado, Jorge
- Physics in Medicine and Biology, Vol. 55, Issue 2
Basic anatomical and physiological data for use in radiological protection: reference values: ICRP Publication 89: Approved by the Commission in September 2001
journal, September 2002
- Valentin, J.
- Annals of the ICRP, Vol. 32, Issue 3-4