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Title: Response to Mortazavi et al. on Detecting Bone-seeking Radionuclides in Brain Tissue

Abstract

WE DISAGREE with most of the issues raised by Mortazavi et al. (2018), both scientifically and inferentially. Cranial deposition of radium (or any other bone seeker) is not relevant to our evaluation of alpha particle exposure to brain tissue (Ellis et al. 2018). Radiochemical analysis of tissues has demonstrated that radium is deposited in the brain and results in alpha particle exposure to brain tissue (Schlenker et al. 1982). Radiochemical analyses also have confirmed brain depositions for other bone seekers including plutonium (James et al. 2003, 2007), americium (McInroy et al. 1985), and uranium (Avtandilashvili et al. 2015 ; Kathren and Tolmachev 2015), as well as for the more nearly uniformly distributed alpha emitter polonium (Nathwani et al. 2016).

Authors:
 [1]; ORCiD logo [2];  [3];  [4];  [5];  [6];  [6]
  1. National Council on Radiation Protection and Measurements, Bethesda, MD (United States); Vanderbilt Univ., Nashville, TN (United States). Dept. of Medicine, Division of Epidemiology
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Environmental Sciences Division
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  4. Washington State Univ., Richland, WA (United States). US Transuranium and Uranium Registries
  5. Northwestern Univ., Evanston, IL (United States). Dept. of Radiation Oncology Radiology, and Cell and Molecular Biology
  6. Oak Ridge Associated Univ., Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1468010
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 115; Journal Issue: 3; Journal ID: ISSN 0017-9078
Publisher:
Health Physics Society
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Boice, John D., Leggett, Richard Wayne, Eckerman, Keith F., Tolmachev, Sergei, Woloschak, Gayle, Golden, Ashley, and Ellis, Elizabeth. Response to Mortazavi et al. on Detecting Bone-seeking Radionuclides in Brain Tissue. United States: N. p., 2018. Web. doi:10.1097/HP.0000000000000922.
Boice, John D., Leggett, Richard Wayne, Eckerman, Keith F., Tolmachev, Sergei, Woloschak, Gayle, Golden, Ashley, & Ellis, Elizabeth. Response to Mortazavi et al. on Detecting Bone-seeking Radionuclides in Brain Tissue. United States. doi:10.1097/HP.0000000000000922.
Boice, John D., Leggett, Richard Wayne, Eckerman, Keith F., Tolmachev, Sergei, Woloschak, Gayle, Golden, Ashley, and Ellis, Elizabeth. Sat . "Response to Mortazavi et al. on Detecting Bone-seeking Radionuclides in Brain Tissue". United States. doi:10.1097/HP.0000000000000922. https://www.osti.gov/servlets/purl/1468010.
@article{osti_1468010,
title = {Response to Mortazavi et al. on Detecting Bone-seeking Radionuclides in Brain Tissue},
author = {Boice, John D. and Leggett, Richard Wayne and Eckerman, Keith F. and Tolmachev, Sergei and Woloschak, Gayle and Golden, Ashley and Ellis, Elizabeth},
abstractNote = {WE DISAGREE with most of the issues raised by Mortazavi et al. (2018), both scientifically and inferentially. Cranial deposition of radium (or any other bone seeker) is not relevant to our evaluation of alpha particle exposure to brain tissue (Ellis et al. 2018). Radiochemical analysis of tissues has demonstrated that radium is deposited in the brain and results in alpha particle exposure to brain tissue (Schlenker et al. 1982). Radiochemical analyses also have confirmed brain depositions for other bone seekers including plutonium (James et al. 2003, 2007), americium (McInroy et al. 1985), and uranium (Avtandilashvili et al. 2015 ; Kathren and Tolmachev 2015), as well as for the more nearly uniformly distributed alpha emitter polonium (Nathwani et al. 2016).},
doi = {10.1097/HP.0000000000000922},
journal = {Health Physics},
number = 3,
volume = 115,
place = {United States},
year = {2018},
month = {9}
}

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