Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry

Zhang, Fei; Simmons, Chad R.; Gates, Jade; Liu, Yan; Yan, Hao

doi:10.1002/anie.201807223

Title: Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry

Abstract

Abstract Programming self‐assembled designer DNA crystals with various lattices and functions is one of the most important goals for nanofabrication using nucleic acids. The resulting porous materials possess atomic precision for several potential applications that rely on crystalline lattices and cavities. Herein, we present a rationally designed and self‐assembled 3D DNA crystal lattice with hexagonal symmetry. In our design, two 21‐base oligonucleotides are used to form a duplex motif that further assembles into a 3D array. The interactions between the strands are programmed using Watson–Crick base‐pairing. The six‐fold symmetry, as well as the chirality, is directed by the Holliday junctions formed between the duplex motifs. The rationally designed DNA crystal provides a new avenue that could create self‐assembled macromolecular 3D crystalline lattices with atomic precision. In addition, the structure contains a highly organized array of well‐defined cavities that are suitable for future applications with immobilized guests.

Authors:

^[1];

^[1]; Gates, Jade ^[1];

^[1];

^[1]

School of Molecular Sciences and Biodesign Institution Arizona State University 1001 S McAllister Ave Tempe AZ 85281 USA

Publication Date:: Mon Aug 27 00:00:00 EDT 2018

Sponsoring Org.:: USDOE

OSTI Identifier:: 1467535

Grant/Contract Number:: KP1605010

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Angewandte Chemie (International Edition)

Additional Journal Information:: Journal Name: Angewandte Chemie (International Edition) Journal Volume: 57 Journal Issue: 38; Journal ID: ISSN 1433-7851

Publisher:: Wiley Blackwell (John Wiley & Sons)

Country of Publication:: Germany

Language:: English

Citation Formats


                    Zhang, Fei, Simmons, Chad R., Gates, Jade, Liu, Yan, and Yan, Hao. Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry.  Germany: N. p., 2018. 
Web.  doi:10.1002/anie.201807223.

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                    Zhang, Fei, Simmons, Chad R., Gates, Jade, Liu, Yan, & Yan, Hao. Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry.  Germany.  https://doi.org/10.1002/anie.201807223

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                    Zhang, Fei, Simmons, Chad R., Gates, Jade, Liu, Yan, and Yan, Hao. Mon .  
"Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry".  Germany.  https://doi.org/10.1002/anie.201807223.

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@article{osti_1467535,

  title        = {Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry},

  author       = {Zhang, Fei and Simmons, Chad R. and Gates, Jade and Liu, Yan and Yan, Hao},

  abstractNote = {Abstract Programming self‐assembled designer DNA crystals with various lattices and functions is one of the most important goals for nanofabrication using nucleic acids. The resulting porous materials possess atomic precision for several potential applications that rely on crystalline lattices and cavities. Herein, we present a rationally designed and self‐assembled 3D DNA crystal lattice with hexagonal symmetry. In our design, two 21‐base oligonucleotides are used to form a duplex motif that further assembles into a 3D array. The interactions between the strands are programmed using Watson–Crick base‐pairing. The six‐fold symmetry, as well as the chirality, is directed by the Holliday junctions formed between the duplex motifs. The rationally designed DNA crystal provides a new avenue that could create self‐assembled macromolecular 3D crystalline lattices with atomic precision. In addition, the structure contains a highly organized array of well‐defined cavities that are suitable for future applications with immobilized guests.},

  doi          = {10.1002/anie.201807223},

  journal      = {Angewandte Chemie (International Edition)},

  number       = 38,

  volume       = 57,

  place        = {Germany},

  year         = {Mon Aug 27 00:00:00 EDT 2018},

  month        = {Mon Aug 27 00:00:00 EDT 2018}

}

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Title: Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry

Abstract

Citation Formats

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Self-assembly of DNA into nanoscale three-dimensional shapes journal, May 2009

Encapsulation of a Nerve Agent Detoxifying Enzyme by a Mesoporous Zirconium Metal–Organic Framework Engenders Thermal and Long-Term Stability
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Assembly of Borromean rings from DNA
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Applications of metal–organic frameworks in heterogeneous supramolecular catalysis
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Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication
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Complex shapes self-assembled from single-stranded DNA tiles
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Rhodopsin-Phospholipid Reconstitution from Octyl Glucoside-solubilized Samples
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Assembling Materials with DNA as the Guide
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Three-Dimensional Structures Self-Assembled from DNA Bricks
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