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Title: The network of epithelial–mesenchymal transition: potential new targets for tumor resistance

In multiple cell metazoans, the ability of polarized epithelial cells to convert to motile mesenchymal cells in order to relocate to another location is governed by a unique process termed epithelial-mesenchymal transition (EMT). While being an essential process of cellular plasticity for normal tissue and organ developments, EMT is found to be involved in an array of malignant phenotypes of tumor cells including proliferation and invasion, angiogenesis, stemness of cancer cells and resistance to chemo-radiotherapy. Although EMT is being extensively studied and demonstrated to play a key role in tumor metastasis and in sustaining tumor hallmarks, there is a lack of clear picture of the overall EMT signaling network, wavering the potential clinical trials targeting EMT.
Authors:
 [1] ;  [2] ;  [3]
  1. Chulabhorn Hospital, Bangkok (Thailand). Radiation Oncology Unit
  2. Univ. of California, Davis, CA (United States). Dept. of Radiation Oncology
  3. Univ. of California Davis School of Medicine, Sacramento CA (United States). Dept. of Radiation Oncology and NCI-Designated Comprehensive Cancer Center
Publication Date:
Grant/Contract Number:
SC0001271
Type:
Accepted Manuscript
Journal Name:
Journal of Cancer Research and Clinical Oncology
Additional Journal Information:
Journal Volume: 141; Journal Issue: 10; Journal ID: ISSN 0171-5216
Research Org:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; epithelial-mesenchymal transition; metastasis; cancer stem cell; tumor aggressiveness; therapeutic resistance
OSTI Identifier:
1467464

Nantajit, Danupon, Lin, Dong, and Li, Jian Jian. The network of epithelial–mesenchymal transition: potential new targets for tumor resistance. United States: N. p., Web. doi:10.1007/s00432-014-1840-y.
Nantajit, Danupon, Lin, Dong, & Li, Jian Jian. The network of epithelial–mesenchymal transition: potential new targets for tumor resistance. United States. doi:10.1007/s00432-014-1840-y.
Nantajit, Danupon, Lin, Dong, and Li, Jian Jian. 2014. "The network of epithelial–mesenchymal transition: potential new targets for tumor resistance". United States. doi:10.1007/s00432-014-1840-y. https://www.osti.gov/servlets/purl/1467464.
@article{osti_1467464,
title = {The network of epithelial–mesenchymal transition: potential new targets for tumor resistance},
author = {Nantajit, Danupon and Lin, Dong and Li, Jian Jian},
abstractNote = {In multiple cell metazoans, the ability of polarized epithelial cells to convert to motile mesenchymal cells in order to relocate to another location is governed by a unique process termed epithelial-mesenchymal transition (EMT). While being an essential process of cellular plasticity for normal tissue and organ developments, EMT is found to be involved in an array of malignant phenotypes of tumor cells including proliferation and invasion, angiogenesis, stemness of cancer cells and resistance to chemo-radiotherapy. Although EMT is being extensively studied and demonstrated to play a key role in tumor metastasis and in sustaining tumor hallmarks, there is a lack of clear picture of the overall EMT signaling network, wavering the potential clinical trials targeting EMT.},
doi = {10.1007/s00432-014-1840-y},
journal = {Journal of Cancer Research and Clinical Oncology},
number = 10,
volume = 141,
place = {United States},
year = {2014},
month = {10}
}