The dynamics of simian immunodeficiency virus after depletion of CD8+ cells

Cardozo, Erwing Fabian; Apetrei, Cristian; Pandrea, Ivona; Ribeiro, Ruy M.

doi:10.1111/imr.12691

Title: The dynamics of simian immunodeficiency virus after depletion of CD8+ cells

Journal Article · 11 August 2018 · Immunological Reviews

DOI: https://doi.org/10.1111/imr.12691 · OSTI ID:1467347

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Fred Hutchinson Cancer Research Center, Seattle, WA (United States). Vaccine and Infectious Disease Division
Univ. of Pittsburgh, PA (United States). Center for Vaccine Research
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of Lisbon (Portugal). Medical School. Biomathematics Lab.

Human immunodeficiency virus infection is still one of the most important causes of morbidity and mortality in the world, with a disproportionate human and economic burden especially in poorer countries. Despite many years of intense research, an aspect that still is not well understood is what (immune) mechanisms control the viral load during the prolonged asymptomatic stage of infection. Because CD8+ T cells have been implicated in this control by multiple lines of evidence, there has been a focus on understanding the potential mechanisms of action of this immune effector population. One type of experiment used to this end has been depleting these cells with monoclonal antibodies in the simian immunodeficiency virus-macaque model and then studying the effect of that depletion on the viral dynamics. In this paper, we review what these experiments have told us. Finally, we emphasize modeling studies to interpret the changes in viral load observed in these experiments, including discussion of alternative models, assumptions and interpretations, as well as potential future experiments.

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Research Organization:: Los Alamos National Laboratory (LANL)

Sponsoring Organization:: USDOE; National Inst. of Health (NIH) (United States)

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1467347

Report Number(s):: LA-UR-18-26039

Journal Information:: Immunological Reviews, Journal Name: Immunological Reviews Journal Issue: 1 Vol. 285; ISSN 0105-2896

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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24 hours in the life of HIV-1 in a T cell line Mohammadi, Pejman; Desfarges, Sébastien; Bartha, István Public Library of Science (PLoS) https://doi.org/10.5167/uzh-81662	text	January 2013
Implications of CTL-Mediated Killing of HIV-Infected Cells during the Non-Productive Stage of Infection Althaus, Christian L.; De Boer, Rob J.; Dieli, Francesco Public Library of Science https://doi.org/10.7892/boris.73401	text	January 2011

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Introduction to modeling viral infections and immunity Perelson, Alan S.; Ribeiro, Ruy M. Immunological Reviews, Vol. 285, Issue 1 https://doi.org/10.1111/imr.12700	journal	August 2018

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