Mathematical modeling of within-host Zika virus dynamics
Abstract
Recent Zika virus outbreaks have been associated with severe outcomes, especially during pregnancy. A great deal of effort has been put toward understanding this virus, particularly the immune mechanisms responsible for rapid viral control in the majority of infections. Identifying and understanding the key mechanisms of immune control will provide the foundation for the development of effective vaccines and antiviral therapy. In this paper, we outline a mathematical modeling approach for analyzing the within-host dynamics of Zika virus, and we describe how these models can be used to understand key aspects of the viral life cycle and to predict antiviral efficacy.
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE; National Inst. of Health (NIH) (United States)
- OSTI Identifier:
- 1467343
- Report Number(s):
- LA-UR-18-24074
Journal ID: ISSN 0105-2896
- Grant/Contract Number:
- AC52-06NA25396; R01-AI078881; R01-OD0110955; R01-AI028433
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Immunological Reviews
- Additional Journal Information:
- Journal Volume: 285; Journal Issue: 1; Journal ID: ISSN 0105-2896
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 97 MATHEMATICS AND COMPUTING; Biological Science
Citation Formats
Best, Katharine, and Perelson, Alan S. Mathematical modeling of within-host Zika virus dynamics. United States: N. p., 2018.
Web. doi:10.1111/imr.12687.
Best, Katharine, & Perelson, Alan S. Mathematical modeling of within-host Zika virus dynamics. United States. https://doi.org/10.1111/imr.12687
Best, Katharine, and Perelson, Alan S. Sat .
"Mathematical modeling of within-host Zika virus dynamics". United States. https://doi.org/10.1111/imr.12687. https://www.osti.gov/servlets/purl/1467343.
@article{osti_1467343,
title = {Mathematical modeling of within-host Zika virus dynamics},
author = {Best, Katharine and Perelson, Alan S.},
abstractNote = {Recent Zika virus outbreaks have been associated with severe outcomes, especially during pregnancy. A great deal of effort has been put toward understanding this virus, particularly the immune mechanisms responsible for rapid viral control in the majority of infections. Identifying and understanding the key mechanisms of immune control will provide the foundation for the development of effective vaccines and antiviral therapy. In this paper, we outline a mathematical modeling approach for analyzing the within-host dynamics of Zika virus, and we describe how these models can be used to understand key aspects of the viral life cycle and to predict antiviral efficacy.},
doi = {10.1111/imr.12687},
journal = {Immunological Reviews},
number = 1,
volume = 285,
place = {United States},
year = {Sat Aug 11 00:00:00 EDT 2018},
month = {Sat Aug 11 00:00:00 EDT 2018}
}
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