Multivalent, multiflavored droplets by design
Abstract
Nature self-assembles functional materials by programming flexible linear arrangements of molecules and then folding them to make 2D and 3D objects. To understand and emulate this process, we have made emulsion droplets with specific recognition and controlled valence. Uniquely monovalent droplets form dimers: divalent lead to polymer-like chains, trivalent allow for branching, and programmed mixtures of different valences enable a variety of designed architectures and the ability to subsequently close and open structures. Our functional building blocks are a hybrid of micrometer-scale emulsion droplets and nanoscale DNA origami technologies. Functional DNA origami rafts are first added to droplets and then herded into a patch using specifically designated “shepherding” rafts. Additional patches with the same or different specificities can be formed on the same droplet, programming multiflavored, multivalence droplets. The mobile patch can bind to a patch on another droplet containing complementary functional rafts, leading to primary structure formation. Further binding of nonneighbor droplets can produce secondary structures, a third step in hierarchical self-assembly. As a result, the use of mobile patches rather than uniform DNA coverage has the advantage of valence control at the expense of slow kinetics. Droplets with controlled flavors and valences enable a host of different materialmore »
- Authors:
- Publication Date:
- Research Org.:
- New York Univ. (NYU), NY (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1466882
- Alternate Identifier(s):
- OSTI ID: 1540272
- Grant/Contract Number:
- SC0007991
- Resource Type:
- Published Article
- Journal Name:
- Proceedings of the National Academy of Sciences of the United States of America
- Additional Journal Information:
- Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Volume: 115 Journal Issue: 37; Journal ID: ISSN 0027-8424
- Publisher:
- National Academy of Sciences, Washington, DC (United States)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; Science & Technology; Other Topics; patchy particle; self-assembly; DNA origami
Citation Formats
Zhang, Yin, He, Xiaojin, Zhuo, Rebecca, Sha, Ruojie, Brujic, Jasna, Seeman, Nadrian C., and Chaikin, Paul M. Multivalent, multiflavored droplets by design. United States: N. p., 2018.
Web. doi:10.1073/pnas.1718511115.
Zhang, Yin, He, Xiaojin, Zhuo, Rebecca, Sha, Ruojie, Brujic, Jasna, Seeman, Nadrian C., & Chaikin, Paul M. Multivalent, multiflavored droplets by design. United States. https://doi.org/10.1073/pnas.1718511115
Zhang, Yin, He, Xiaojin, Zhuo, Rebecca, Sha, Ruojie, Brujic, Jasna, Seeman, Nadrian C., and Chaikin, Paul M. Mon .
"Multivalent, multiflavored droplets by design". United States. https://doi.org/10.1073/pnas.1718511115.
@article{osti_1466882,
title = {Multivalent, multiflavored droplets by design},
author = {Zhang, Yin and He, Xiaojin and Zhuo, Rebecca and Sha, Ruojie and Brujic, Jasna and Seeman, Nadrian C. and Chaikin, Paul M.},
abstractNote = {Nature self-assembles functional materials by programming flexible linear arrangements of molecules and then folding them to make 2D and 3D objects. To understand and emulate this process, we have made emulsion droplets with specific recognition and controlled valence. Uniquely monovalent droplets form dimers: divalent lead to polymer-like chains, trivalent allow for branching, and programmed mixtures of different valences enable a variety of designed architectures and the ability to subsequently close and open structures. Our functional building blocks are a hybrid of micrometer-scale emulsion droplets and nanoscale DNA origami technologies. Functional DNA origami rafts are first added to droplets and then herded into a patch using specifically designated “shepherding” rafts. Additional patches with the same or different specificities can be formed on the same droplet, programming multiflavored, multivalence droplets. The mobile patch can bind to a patch on another droplet containing complementary functional rafts, leading to primary structure formation. Further binding of nonneighbor droplets can produce secondary structures, a third step in hierarchical self-assembly. As a result, the use of mobile patches rather than uniform DNA coverage has the advantage of valence control at the expense of slow kinetics. Droplets with controlled flavors and valences enable a host of different material and device architectures.},
doi = {10.1073/pnas.1718511115},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 37,
volume = 115,
place = {United States},
year = {Mon Aug 27 00:00:00 EDT 2018},
month = {Mon Aug 27 00:00:00 EDT 2018}
}
https://doi.org/10.1073/pnas.1718511115
Web of Science
Figures / Tables:
Works referenced in this record:
Enzyme-Free Nucleic Acid Logic Circuits
journal, December 2006
- Seelig, G.; Soloveichik, D.; Zhang, D. Y.
- Science, Vol. 314, Issue 5805
Quasicrystalline order in self-assembled binary nanoparticle superlattices
journal, October 2009
- Talapin, Dmitri V.; Shevchenko, Elena V.; Bodnarchuk, Maryna I.
- Nature, Vol. 461, Issue 7266
Specificity, flexibility and valence of DNA bonds guide emulsion architecture
journal, January 2013
- Feng, Lang; Pontani, Lea-Laetitia; Dreyfus, Rémi
- Soft Matter, Vol. 9, Issue 41
Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures
journal, November 2012
- Langecker, M.; Arnaut, V.; Martin, T. G.
- Science, Vol. 338, Issue 6109
Diamond family of nanoparticle superlattices
journal, February 2016
- Liu, W.; Tagawa, M.; Xin, H. L.
- Science, Vol. 351, Issue 6273, p. 582-586
Ionic colloidal crystals of oppositely charged particles
journal, September 2005
- Leunissen, Mirjam E.; Christova, Christina G.; Hynninen, Antti-Pekka
- Nature, Vol. 437, Issue 7056
Self-assembly of size-controlled liposomes on DNA nanotemplates
journal, March 2016
- Yang, Yang; Wang, Jing; Shigematsu, Hideki
- Nature Chemistry, Vol. 8, Issue 5
Guest-Mediated Access to a Single DNA Nanostructure from a Library of Multiple Assemblies
journal, August 2007
- Aldaye, Faisal A.; Sleiman, Hanadi F.
- Journal of the American Chemical Society, Vol. 129, Issue 33
Kinetics of DNA-coated sticky particles
journal, August 2013
- Wu, Kun-Ta; Feng, Lang; Sha, Ruojie
- Physical Review E, Vol. 88, Issue 2
Programming colloidal phase transitions with DNA strand displacement
journal, February 2015
- Rogers, W. Benjamin; Manoharan, Vinothan N.
- Science, Vol. 347, Issue 6222
Hierarchical assembly of metal nanoparticles, quantum dots and organic dyes using DNA origami scaffolds
journal, December 2013
- Schreiber, Robert; Do, Jaekwon; Roller, Eva-Maria
- Nature Nanotechnology, Vol. 9, Issue 1
Colloids with valence and specific directional bonding
journal, October 2012
- Wang, Yufeng; Wang, Yu; Breed, Dana R.
- Nature, Vol. 491, Issue 7422
Nanoparticle Superlattice Engineering with DNA
journal, October 2011
- Macfarlane, R. J.; Lee, B.; Jones, M. R.
- Science, Vol. 334, Issue 6053, p. 204-208
Dense Packing and Symmetry in Small Clusters of Microspheres
journal, July 2003
- Manoharan, Vinothan N.; Elsesser, Mark T.; Pine, David J.
- Science, Vol. 301, Issue 5632, p. 483-487
Neural network computation with DNA strand displacement cascades
journal, July 2011
- Qian, Lulu; Winfree, Erik; Bruck, Jehoshua
- Nature, Vol. 475, Issue 7356
Complex shapes self-assembled from single-stranded DNA tiles
journal, May 2012
- Wei, Bryan; Dai, Mingjie; Yin, Peng
- Nature, Vol. 485, Issue 7400
Membrane-Assisted Growth of DNA Origami Nanostructure Arrays
journal, February 2015
- Kocabey, Samet; Kempter, Susanne; List, Jonathan
- ACS Nano, Vol. 9, Issue 4
A general strategy for the DNA-mediated self-assembly of functional nanoparticles into heterogeneous systems
journal, October 2013
- Zhang, Yugang; Lu, Fang; Yager, Kevin G.
- Nature Nanotechnology, Vol. 8, Issue 11
Lipid-bilayer-assisted two-dimensional self-assembly of DNA origami nanostructures
journal, August 2015
- Suzuki, Yuki; Endo, Masayuki; Sugiyama, Hiroshi
- Nature Communications, Vol. 6, Issue 1
Sequential self-assembly of DNA functionalized droplets
journal, June 2017
- Zhang, Yin; McMullen, Angus; Pontani, Lea-Laetitia
- Nature Communications, Vol. 8, Issue 1
Folding DNA to create nanoscale shapes and patterns
journal, March 2006
- Rothemund, Paul W. K.
- Nature, Vol. 440, Issue 7082, p. 297-302
Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components
journal, March 2015
- Gerling, T.; Wagenbauer, K. F.; Neuner, A. M.
- Science, Vol. 347, Issue 6229
Biomimetic emulsions reveal the effect of mechanical forces on cell-cell adhesion
journal, June 2012
- Pontani, L. -L.; Jorjadze, I.; Viasnoff, V.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 25
Directed self-assembly of a colloidal kagome lattice
journal, January 2011
- Chen, Qian; Bae, Sung Chul; Granick, Steve
- Nature, Vol. 469, Issue 7330
Lock and key colloids
journal, March 2010
- Sacanna, S.; Irvine, W. T. M.; Chaikin, P. M.
- Nature, Vol. 464, Issue 7288
DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
journal, March 2012
- Kuzyk, Anton; Schreiber, Robert; Fan, Zhiyuan
- Nature, Vol. 483, Issue 7389
Surface roughness directed self-assembly of patchy particles into colloidal micelles
journal, June 2012
- Kraft, D. J.; Ni, R.; Smallenburg, F.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 27
Anisotropy of building blocks and their assembly into complex structures
journal, August 2007
- Glotzer, Sharon C.; Solomon, Michael J.
- Nature Materials, Vol. 6, Issue 8, p. 557-562
DNA Gridiron Nanostructures Based on Four-Arm Junctions
journal, March 2013
- Han, D.; Pal, S.; Yang, Y.
- Science, Vol. 339, Issue 6126
Beyond molecules: Self-assembly of mesoscopic and macroscopic components
journal, April 2002
- Whitesides, G. M.; Boncheva, M.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 8, p. 4769-4774
Self-Assembly at All Scales
journal, March 2002
- Whitesides, George M.; Grzybowski, Bartosz
- Science, Vol. 295, Issue 5564, p. 2418-2421
COLLOIDAL SYSTEMS: Playing Tricks with Designer "Atoms"
journal, April 2002
- Frenkel, D.
- Science, Vol. 296, Issue 5565
From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal
journal, September 2009
- Zheng, Jianping; Birktoft, Jens J.; Chen, Yi
- Nature, Vol. 461, Issue 7260
Kinetic control of the coverage of oil droplets by DNA-functionalized colloids
journal, August 2016
- Joshi, Darshana; Bargteil, Dylan; Caciagli, Alessio
- Science Advances, Vol. 2, Issue 8
Colloidal joints with designed motion range and tunable joint flexibility
journal, January 2017
- Chakraborty, Indrani; Meester, Vera; van der Wel, Casper
- Nanoscale, Vol. 9, Issue 23
A DNA-based method for rationally assembling nanoparticles into macroscopic materials
journal, August 1996
- Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.
- Nature, Vol. 382, Issue 6592, p. 607-609
Crystalline Two-Dimensional DNA-Origami Arrays
journal, November 2010
- Liu, Wenyan; Zhong, Hong; Wang, Risheng
- Angewandte Chemie International Edition, Vol. 50, Issue 1
Ligand−Receptor Interactions in Chains of Colloids: When Reactions Are Limited by Rotational Diffusion †
journal, February 2008
- Lee, Nam-Kyung; Johner, Albert; Thalmann, Fabrice
- Langmuir, Vol. 24, Issue 4
Acceleration of the recognition rate between grafted ligands and receptors with magnetic forces
journal, October 2006
- Baudry, J.; Rouzeau, C.; Goubault, C.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 44
A DNA-fuelled molecular machine made of DNA
journal, August 2000
- Yurke, Bernard; Turberfield, Andrew J.; Mills, Allen P.
- Nature, Vol. 406, Issue 6796
Three-Dimensional Structures Self-Assembled from DNA Bricks
journal, November 2012
- Ke, Y.; Ong, L. L.; Shih, W. M.
- Science, Vol. 338, Issue 6111
Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra
journal, March 2008
- He, Yu; Ye, Tao; Su, Min
- Nature, Vol. 452, Issue 7184
Self-assembly of DNA into nanoscale three-dimensional shapes
journal, May 2009
- Douglas, Shawn M.; Dietz, Hendrik; Liedl, Tim
- Nature, Vol. 459, Issue 7245
Figures / Tables found in this record: