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Title: Quantification of mixing in vesicle suspensions using numerical simulations in two dimensions

Journal Article · · Physics of Fluids
DOI: https://doi.org/10.1063/1.4975154 · OSTI ID:1466739
ORCiD logo [1];  [2];  [3]
  1. Univ. of Texas, Austin, TX (United States). Department of Mechanical Engineering
  2. Florida State Univ., Tallahassee, FL (United States). Department of Scientific Computing
  3. Univ. of Texas, Austin, TX (United States). Department of Mechanical Engineering and Institute for Computational Engineering and Sciences

Here, we study mixing in Stokesian vesicle suspensions in two dimensions on a cylindrical Couette apparatus using numerical simulations. The vesicle flow simulation is done using a boundary integral method, and the advection-diffusion equation for the mixing of the solute is solved using a pseudo-spectral scheme. We study the effect of the area fraction, the viscosity contrast between the inside (the vesicles) and the outside (the bulk) fluid, the initial condition of the solute, and the mixing metric. We compare mixing in the suspension with mixing in the Couette apparatus without vesicles. On the one hand, the presence of vesicles in most cases slightly suppresses mixing. This is because the solute can be only diffused across the vesicle interface and not advected. On the other hand, there exist spatial distributions of the solute for which the unperturbed Couette flow completely fails to mix whereas the presence of vesicles enables mixing. Finally, we derive a simple condition that relates the velocity and solute and can be used to characterize the cases in which the presence of vesicles promotes mixing.

Research Organization:
Univ. of Texas, Austin, TX (United States). Department of Mechanical Engineering
Sponsoring Organization:
USDOE Office of Science (SC), Advanced Scientific Computing Research (ASCR); USDOE
Grant/Contract Number:
SC0010518; SC0009286
OSTI ID:
1466739
Alternate ID(s):
OSTI ID: 1349338
Journal Information:
Physics of Fluids, Vol. 29, Issue 2; ISSN 1070-6631
Publisher:
American Institute of Physics (AIP)Copyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 11 works
Citation information provided by
Web of Science

References (61)

Effect of red blood cell shape on oxygen transport in capillaries journal July 1993
Analysis of chaotic mixing in two model systems journal November 1986
Self-Similar Spatiotemporal Structure of Intermaterial Boundaries in Chaotic Flows journal October 1998
Mixing, Chaotic Advection, and Turbulence journal January 1990
Optimal mixing in two-dimensional plane Poiseuille flow at finite Péclet number journal April 2014
Hemodynamics journal January 1975
Pollution release tied to invariant manifolds: A case study for the coast of Florida journal October 2005
Optimal stirring strategies for passive scalar mixing journal March 2011
Introduction: mixing in microfluidics
  • Ottino, Julio M.; Wiggins, Stephen
  • Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, Vol. 362, Issue 1818 https://doi.org/10.1098/rsta.2003.1355
journal May 2004
Optimal control of mixing in Stokes fluid flows journal May 2007
The behaviors of ferromagnetic nano-particles in and around blood vessels under applied magnetic fields journal March 2011
Mixing in the shear superposition micromixer: three-dimensional analysis
  • Bottausci, Frederic; Mezić, Igor; Meinhart, Carl D.
  • Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, Vol. 362, Issue 1818 https://doi.org/10.1098/rsta.2003.1359
journal May 2004
A blinking rotlet model for chaotic advection journal December 1996
Dynamic simulation of locally inextensible vesicles suspended in an arbitrary two-dimensional domain, a boundary integral method journal September 2010
Finite Difference Methods for Ordinary and Partial Differential Equations book January 2007
Vacillating Breathing and Tumbling of Vesicles under Shear Flow journal January 2006
On the Construction and Comparison of Difference Schemes journal September 1968
Convergence Analysis for a Class of High-Order Semi-Lagrangian Advection Schemes journal June 1998
Persistent patterns in transient chaotic fluid mixing journal October 1999
A Semi-Lagrangian High-Order Method for Navier–Stokes Equations journal September 2001
Microcirculation and Hemorheology journal January 2005
A high order time splitting method based on integral deferred correction for semi-Lagrangian Vlasov simulations journal June 2014
Adaptive time stepping for vesicle suspensions journal February 2016
Micromixers—a review on passive and active mixing principles journal April 2005
Active control in combustion systems journal December 1995
Shape transitions of fluid vesicles and red blood cells in capillary flows journal September 2005
Fluid Vesicles in Shear Flow journal October 1996
On smoothing of the Crank–Nicolson scheme and higher order schemes for pricing barrier options journal July 2007
Using multiscale norms to quantify mixing and transport journal January 2012
Mixing measures for a two-dimensional chaotic Stokes flow journal February 2004
Multiscale mixing efficiencies for steady sources journal August 2006
Diffusion and Spatial Correlations in Suspensions of Swimming Particles journal June 2008
A spectral boundary integral method for flowing blood cells journal May 2010
A multiscale measure for mixing journal November 2005
A stable numerical integration scheme for the primitive meteorological equations journal March 1981
Enhanced diffusion due to motile bacteria journal August 2004
Stirring by squirmers journal February 2011
A viscosity-enhanced mechanism for biogenic ocean mixing journal July 2009
High-volume fraction simulations of two-dimensional vesicle suspensions journal October 2014
Spectral Methods in MATLAB book January 2000
Chaotic advection in a Stokes flow journal January 1986
The statistics of stretching and stirring in chaotic flows journal May 1991
A boundary integral method for simulating the dynamics of inextensible vesicles suspended in a viscous fluid in 2D journal April 2009
Control of mixing in fluid flow: a maximum entropy approach journal January 1999
A bound on mixing efficiency for the advection–diffusion equation journal January 1999
Motion of a tank-treading ellipsoidal particle in a shear flow journal July 1982
PDE methods for pricing barrier options journal October 2000
High-volume fraction simulations of two-dimensional vesicle suspensions text January 2013
Adaptive Time Stepping for Vesicle Suspensions preprint January 2014
A Semi-Lagrangian High-Order Method for Navier–Stokes Equations journal September 2001
A boundary integral method for simulating the dynamics of inextensible vesicles suspended in a viscous fluid in 2D journal April 2009
Dynamic simulation of locally inextensible vesicles suspended in an arbitrary two-dimensional domain, a boundary integral method journal September 2010
A multiscale measure for mixing journal November 2005
Acceleration of one-dimensional mixing by discontinuous mappings journal July 2002
Optimal mixing in two-dimensional plane Poiseuille flow at finite Péclet number journal April 2014
Chaotic advection in a Stokes flow journal January 1986
Mixing in the shear superposition micromixer: three-dimensional analysis
  • Bottausci, Frederic; Mezić, Igor; Meinhart, Carl D.
  • Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, Vol. 362, Issue 1818 https://doi.org/10.1098/rsta.2003.1359
journal May 2004
Analytic expression for the short-time rate of growth of the intermaterial contact perimeter in two-dimensional chaotic flows and Hamiltonian systems journal July 1998
Active control in combustion systems journal December 1995
Using multiscale norms to quantify mixing and transport text January 2011
Adaptive Time Stepping for Vesicle Suspensions preprint January 2014

Cited By (7)