skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells

; ; ; ; ; ; ; ORCiD logo
Publication Date:
Sponsoring Org.:
USDOE Office of Electricity Delivery and Energy Reliability (OE), Power Systems Engineering Research and Development (R&D) (OE-10)
OSTI Identifier:
Grant/Contract Number:  
Resource Type:
Published Article
Journal Name:
Development (Cambridge)
Additional Journal Information:
[Journal Name: Development (Cambridge) Journal Volume: 145 Journal Issue: 16]; Journal ID: ISSN 0950-1991
The Company of Biologists
Country of Publication:
United Kingdom

Citation Formats

Nakajima, Taiki, Shibata, Mitsuaki, Nishio, Megumi, Nagata, Sanae, Alev, Cantas, Sakurai, Hidetoshi, Toguchida, Junya, and Ikeya, Makoto. Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells. United Kingdom: N. p., 2018. Web. doi:10.1242/dev.165431.
Nakajima, Taiki, Shibata, Mitsuaki, Nishio, Megumi, Nagata, Sanae, Alev, Cantas, Sakurai, Hidetoshi, Toguchida, Junya, & Ikeya, Makoto. Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells. United Kingdom. doi:10.1242/dev.165431.
Nakajima, Taiki, Shibata, Mitsuaki, Nishio, Megumi, Nagata, Sanae, Alev, Cantas, Sakurai, Hidetoshi, Toguchida, Junya, and Ikeya, Makoto. Thu . "Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells". United Kingdom. doi:10.1242/dev.165431.
title = {Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells},
author = {Nakajima, Taiki and Shibata, Mitsuaki and Nishio, Megumi and Nagata, Sanae and Alev, Cantas and Sakurai, Hidetoshi and Toguchida, Junya and Ikeya, Makoto},
abstractNote = {},
doi = {10.1242/dev.165431},
journal = {Development (Cambridge)},
number = [16],
volume = [145],
place = {United Kingdom},
year = {2018},
month = {8}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1242/dev.165431

Citation Metrics:
Cited by: 6 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Signalling dynamics in vertebrate segmentation
journal, October 2014

  • Hubaud, Alexis; Pourquié, Olivier
  • Nature Reviews Molecular Cell Biology, Vol. 15, Issue 11
  • DOI: 10.1038/nrm3891

Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro
journal, April 2013

Retinoic acid synthesis and functions in early embryonic development
journal, January 2012

  • Kam, Richard Kin Ting; Deng, Yi; Chen, Yonglong
  • Cell & Bioscience, Vol. 2, Issue 1
  • DOI: 10.1186/2045-3701-2-11

The developmental basis of mesenchymal stem/stromal cells (MSCs)
journal, November 2015

Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells
journal, June 2012

  • Umeda, Katsutsugu; Zhao, Jiangang; Simmons, Paul
  • Scientific Reports, Vol. 2, Issue 1
  • DOI: 10.1038/srep00455

A proliferative role for Wnt-3a in chick somites
journal, May 2004

A Somitic Compartment of Tendon Progenitors
journal, April 2003

Generation of articular chondrocytes from human pluripotent stem cells
journal, May 2015

  • Craft, April M.; Rockel, Jason S.; Nartiss, Yulia
  • Nature Biotechnology, Vol. 33, Issue 6
  • DOI: 10.1038/nbt.3210

Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy
journal, August 2015

  • Chal, Jérome; Oginuma, Masayuki; Al Tanoury, Ziad
  • Nature Biotechnology, Vol. 33, Issue 9
  • DOI: 10.1038/nbt.3297

A more efficient method to generate integration-free human iPS cells
journal, April 2011

  • Okita, Keisuke; Matsumura, Yasuko; Sato, Yoshiko
  • Nature Methods, Vol. 8, Issue 5
  • DOI: 10.1038/nmeth.1591

Establishment of the epaxial–hypaxial boundary in the avian myotome
journal, January 2006

  • Ahmed, Mohi U.; Cheng, Louise; Dietrich, Susanne
  • Developmental Dynamics, Vol. 235, Issue 7
  • DOI: 10.1002/dvdy.20832

Formation and Segmentation of the Vertebrate Body Axis
journal, October 2013

Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
journal, July 2017

  • Hino, Kyosuke; Horigome, Kazuhiko; Nishio, Megumi
  • Journal of Clinical Investigation, Vol. 127, Issue 9
  • DOI: 10.1172/JCI93521

Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis
journal, July 2016

  • Suzuki, Hidetsugu; Ito, Yoshiaki; Shinohara, Masahiro
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 28
  • DOI: 10.1073/pnas.1522054113

FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression
journal, January 2011

  • Hardy, Katharine M.; Yatskievych, Tatiana A.; Konieczka, Jh
  • BMC Developmental Biology, Vol. 11, Issue 1
  • DOI: 10.1186/1471-213X-11-20

GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen
journal, January 2007

  • Moriyama, Akemi; Kii, Isao; Sunabori, Takehiko
  • genesis, Vol. 45, Issue 2
  • DOI: 10.1002/dvg.20268

In Vitro Modeling of Paraxial Mesodermal Progenitors Derived from Induced Pluripotent Stem Cells
journal, October 2012

BMP4 and noggin control embryonic blood vessel formation by antagonistic regulation of VEGFR-2 (Quek1) expression
journal, April 2005

  • Nimmagadda, Suresh; Geetha Loganathan, Poongodi; Huang, Ruijin
  • Developmental Biology, Vol. 280, Issue 1
  • DOI: 10.1016/j.ydbio.2005.01.005

Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo
journal, January 2010

Notch signalling and the synchronization of the somite segmentation clock
journal, November 2000

  • Jiang, Yun-Jin; Aerne, Birgit L.; Smithers, Lucy
  • Nature, Vol. 408, Issue 6811
  • DOI: 10.1038/35044091

Recruitment and maintenance of tendon progenitors by TGF  signaling are essential for tendon formation
journal, March 2009

  • Pryce, B. A.; Watson, S. S.; Murchison, N. D.
  • Development, Vol. 136, Issue 8
  • DOI: 10.1242/dev.027342

Evidence That Absence ofWnt-3aSignaling Promotes Neuralization Instead of Paraxial Mesoderm Development in the Mouse
journal, March 1997

  • Yoshikawa, Yoshiaki; Fujimori, Toshihiko; McMahon, Andrew P.
  • Developmental Biology, Vol. 183, Issue 2
  • DOI: 10.1006/dbio.1997.8502

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
journal, November 2007

Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types
journal, July 2016

New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva: In Vitro Modeling of FOP
journal, May 2015

  • Matsumoto, Yoshihisa; Ikeya, Makoto; Hino, Kyosuke
  • STEM CELLS, Vol. 33, Issue 6
  • DOI: 10.1002/stem.1981

BMP-12 Treatment of Adult Mesenchymal Stem Cells In Vitro Augments Tendon-Like Tissue Formation and Defect Repair In Vivo
journal, March 2011

Signaling Gradients during Paraxial Mesoderm Development
journal, July 2009

A Gene Regulatory Network Balances Neural and Mesoderm Specification during Vertebrate Trunk Development
journal, May 2017

Directed differentiation of human embryonic stem cells toward chondrocytes
journal, October 2010

  • Oldershaw, Rachel A.; Baxter, Melissa A.; Lowe, Emma T.
  • Nature Biotechnology, Vol. 28, Issue 11
  • DOI: 10.1038/nbt.1683

Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro
journal, September 2016

  • Chal, Jérome; Al Tanoury, Ziad; Hestin, Marie
  • Nature Protocols, Vol. 11, Issue 10
  • DOI: 10.1038/nprot.2016.110

Enhanced differentiation of human embryonic stem cells to mesenchymal progenitors by inhibition of TGF-β/activin/nodal signaling using SB-431542
journal, January 2010

  • Mahmood, Amer; Harkness, Linda; Schrøder, Henrik Daa
  • Journal of Bone and Mineral Research, Vol. 25, Issue 6
  • DOI: 10.1002/jbmr.34

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells
journal, March 2015

  • Iyer, D.; Gambardella, L.; Bernard, W. G.
  • Development, Vol. 142, Issue 8
  • DOI: 10.1242/dev.119271

Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation
journal, January 2013

  • Matsumoto, Yoshihisa; Hayashi, Yohei; Schlieve, Christopher R.
  • Orphanet Journal of Rare Diseases, Vol. 8, Issue 1
  • DOI: 10.1186/1750-1172-8-190

Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity
journal, April 1999

Expression analysis of chick Wnt and frizzled genes and selected inhibitors in early chick patterning
journal, January 2004

  • Chapman, Susan C.; Brown, Ryan; Lees, Lydia
  • Developmental Dynamics, Vol. 229, Issue 3
  • DOI: 10.1002/dvdy.10491

Developmental regulation of somite derivatives: muscle, cartilage and tendon
journal, October 2002

Wnt-3a regulates somite and tailbud formation in the mouse embryo.
journal, January 1994

  • Takada, S.; Stark, K. L.; Shea, M. J.
  • Genes & Development, Vol. 8, Issue 2
  • DOI: 10.1101/gad.8.2.174

Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells
journal, February 2011

  • Takemoto, Tatsuya; Uchikawa, Masanori; Yoshida, Megumi
  • Nature, Vol. 470, Issue 7334
  • DOI: 10.1038/nature09729

Dual mode of paraxial mesoderm formation during chick gastrulation
journal, February 2007

  • Iimura, T.; Yang, X.; Weijer, C. J.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 8
  • DOI: 10.1073/pnas.0610997104

Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells
journal, November 2013

  • Koyanagi-Aoi, M.; Ohnuki, M.; Takahashi, K.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 51
  • DOI: 10.1073/pnas.1319061110

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification
journal, November 2016

BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages
journal, August 2011

Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells
journal, April 2010

Characterization of mechanical and biochemical properties of developing embryonic tendon
journal, April 2013

  • Marturano, J. E.; Arena, J. D.; Schiller, Z. A.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 16
  • DOI: 10.1073/pnas.1300135110

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
journal, March 2009

  • Chambers, Stuart M.; Fasano, Christopher A.; Papapetrou, Eirini P.
  • Nature Biotechnology, Vol. 27, Issue 3
  • DOI: 10.1038/nbt.1529

Analysis of Spatial and Temporal Gene Expression Patterns in Blastula and Gastrula Stage Chick Embryos
journal, May 2002

  • Chapman, Susan C.; Schubert, Frank R.; Schoenwolf, Gary C.
  • Developmental Biology, Vol. 245, Issue 1
  • DOI: 10.1006/dbio.2002.0641

Cells of all somitic compartments are determined with respect to segmental identity
journal, January 2005

  • Fomenou, Marlyse Dieuguie; Scaal, Martin; Stockdale, Frank E.
  • Developmental Dynamics, Vol. 233, Issue 4
  • DOI: 10.1002/dvdy.20464

In Vivo Human Somitogenesis Guides Somite Development from hPSCs
journal, February 2017

Redefining the Progression of Lineage Segregations during Mammalian Embryogenesis by Clonal Analysis
journal, September 2009

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells
journal, January 2014

  • Nakagawa, Masato; Taniguchi, Yukimasa; Senda, Sho
  • Scientific Reports, Vol. 4, Issue 1
  • DOI: 10.1038/srep03594

Acceleration of early chick embryo morphogenesis by insulin is associated with altered expression of embryonic genes
journal, January 2004

  • Patwardhan, Vidya; Gokhale, Madhavi; Ghaskadbi, Surendra
  • The International Journal of Developmental Biology, Vol. 48, Issue 4
  • DOI: 10.1387/ijdb.041844vp

Embryonic Stem Cell Lines Derived from Human Blastocysts
journal, November 1998

Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro
journal, March 2018

  • Chal, Jérome; Al Tanoury, Ziad; Oginuma, Masayuki
  • Development, Vol. 145, Issue 6
  • DOI: 10.1242/dev.157339

Bone Morphogenetic Protein 7 (BMP-7) Influences Tendon-Bone Integration In Vitro
journal, February 2015

Mapping Wnt/ -catenin signaling during mouse development and in colorectal tumors
journal, March 2003

  • Maretto, S.; Cordenonsi, M.; Dupont, S.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 6
  • DOI: 10.1073/pnas.0434590100

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
journal, April 2014

  • Chong, James J. H.; Yang, Xiulan; Don, Creighton W.
  • Nature, Vol. 510, Issue 7504
  • DOI: 10.1038/nature13233

Bidirectional induction toward paraxial mesodermal derivatives from mouse ES cells in chemically defined medium
journal, September 2009

Proliferation and collagen production of human patellar tendon fibroblasts in response to cyclic uniaxial stretching in serum-free conditions
journal, October 2004

Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells
journal, December 2012

Endogenous Patterns of BMP Signaling during Early Chick Development
journal, April 2002

  • Faure, Sandrine; de Santa Barbara, Pascal; Roberts, Drucilla J.
  • Developmental Biology, Vol. 244, Issue 1
  • DOI: 10.1006/dbio.2002.0579

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva
journal, November 2015

  • Hino, Kyosuke; Ikeya, Makoto; Horigome, Kazuhiko
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 50
  • DOI: 10.1073/pnas.1510540112

Retinoic acid signalling during development
journal, February 2012