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Title: Impact of stereochemistry on rheology and nanostructure of PLA–PEO–PLA triblocks: stiff gels at intermediate l/d -lactide ratios

Abstract

Hydrogels of PLA–PEO–PLA display a striking enhancement of the stiffness at intermediate l/d ratio, demonstrating the impact of block stereochemistry on the rheology.

Authors:
 [1];  [1];  [1];  [1];  [1]; ORCiD logo [2]; ORCiD logo [1]; ORCiD logo [1]
  1. Department of Chemistry, Stony Brook University, Stony Brook, USA
  2. Department of Chemistry, Stony Brook University, Stony Brook, USA, Department of Chemistry
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1466066
Grant/Contract Number:  
SC0012704
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Soft Matter
Additional Journal Information:
Journal Name: Soft Matter Journal Volume: 14 Journal Issue: 35; Journal ID: ISSN 1744-683X
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Yin, Xuechen, Hewitt, David R. O., Quah, Suan P., Zheng, Bingqian, Mattei, Gerard S., Khalifah, Peter G., Grubbs, Robert B., and Bhatia, Surita R. Impact of stereochemistry on rheology and nanostructure of PLA–PEO–PLA triblocks: stiff gels at intermediate l/d -lactide ratios. United Kingdom: N. p., 2018. Web. doi:10.1039/C8SM01559G.
Yin, Xuechen, Hewitt, David R. O., Quah, Suan P., Zheng, Bingqian, Mattei, Gerard S., Khalifah, Peter G., Grubbs, Robert B., & Bhatia, Surita R. Impact of stereochemistry on rheology and nanostructure of PLA–PEO–PLA triblocks: stiff gels at intermediate l/d -lactide ratios. United Kingdom. doi:10.1039/C8SM01559G.
Yin, Xuechen, Hewitt, David R. O., Quah, Suan P., Zheng, Bingqian, Mattei, Gerard S., Khalifah, Peter G., Grubbs, Robert B., and Bhatia, Surita R. Mon . "Impact of stereochemistry on rheology and nanostructure of PLA–PEO–PLA triblocks: stiff gels at intermediate l/d -lactide ratios". United Kingdom. doi:10.1039/C8SM01559G.
@article{osti_1466066,
title = {Impact of stereochemistry on rheology and nanostructure of PLA–PEO–PLA triblocks: stiff gels at intermediate l/d -lactide ratios},
author = {Yin, Xuechen and Hewitt, David R. O. and Quah, Suan P. and Zheng, Bingqian and Mattei, Gerard S. and Khalifah, Peter G. and Grubbs, Robert B. and Bhatia, Surita R.},
abstractNote = {Hydrogels of PLA–PEO–PLA display a striking enhancement of the stiffness at intermediate l/d ratio, demonstrating the impact of block stereochemistry on the rheology.},
doi = {10.1039/C8SM01559G},
journal = {Soft Matter},
number = 35,
volume = 14,
place = {United Kingdom},
year = {2018},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1039/C8SM01559G

Citation Metrics:
Cited by: 1 work
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Works referenced in this record:

Novel drug release profiles from micellar solutions of PLA–PEO–PLA triblock copolymers
journal, May 2006

  • Agrawal, Sarvesh K.; Sanabria-DeLong, Naomi; Coburn, Jeannine M.
  • Journal of Controlled Release, Vol. 112, Issue 1
  • DOI: 10.1016/j.jconrel.2005.12.024

Viscoelastic properties of physically crosslinked networks. 1. Transient network theory
journal, September 1992


A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA-g-OLA)s
journal, May 2000


The impact of monomer sequence and stereochemistry on the swelling and erosion of biodegradable poly(lactic-co-glycolic acid) matrices
journal, February 2017


Guanidine and Amidine Organocatalysts for Ring-Opening Polymerization of Cyclic Esters
journal, December 2006

  • Lohmeijer, Bas G. G.; Pratt, Russell C.; Leibfarth, Frank
  • Macromolecules, Vol. 39, Issue 25
  • DOI: 10.1021/ma0619381

Sequence-Controlled Copolymers Prepared via Entropy-Driven Ring-Opening Metathesis Polymerization
journal, September 2015


Polylactide copolymers: Effect of copolymer ratio and end capping on their properties
journal, January 2005

  • Bigg, D. M.
  • Advances in Polymer Technology, Vol. 24, Issue 2
  • DOI: 10.1002/adv.20032

A Morphological Study of a Semicrystalline Poly( l -lactic acid- b -ethylene oxide- b - l -lactic acid) Triblock Copolymer
journal, January 2005

  • Shin, Dongseok; Shin, Kyusoon; Aamer, Khaled A.
  • Macromolecules, Vol. 38, Issue 1
  • DOI: 10.1021/ma0481712

Preparation of Curcumin Loaded Poly(Vinyl Alcohol)-Poly(Ethylene Oxide)-Carboxymethyl Cellulose Membranes for Wound Care Application
journal, June 2013

  • Agarwal, Roopali; Alam, M. Sarwar; Gupta, Bhuvanesh
  • Journal of Biomaterials and Tissue Engineering, Vol. 3, Issue 3
  • DOI: 10.1166/jbt.2013.1092

Viscoelastic and SAXS investigation of fractal structure near the gel point in alginate aqueous systems
journal, September 1992

  • Matsumoto, Takayoshi; Kawai, Masahiro; Masuda, Toshiro
  • Macromolecules, Vol. 25, Issue 20
  • DOI: 10.1021/ma00046a047

Structural Studies of Polyethers, (-(CH 2 )m-O-) n . X. Crystal Structure of Poly(ethylene oxide)
journal, September 1973

  • Takahashi, Yasuhiro; Tadokoro, Hiroyuki
  • Macromolecules, Vol. 6, Issue 5
  • DOI: 10.1021/ma60035a005

A Statistical Kinetic Model for the Bulk Degradation of PLA- b -PEG- b -PLA Hydrogel Networks:  Incorporating Network Non-Idealities
journal, August 2001

  • Metters, Andrew T.; Anseth, Kristi S.; Bowman, Christopher N.
  • The Journal of Physical Chemistry B, Vol. 105, Issue 34
  • DOI: 10.1021/jp004083h

Associating polymers: Equilibrium and linear viscoelasticity
journal, July 1995

  • Semenov, A. N.; Joanny, J. -F.; Khokhlov, A. R.
  • Macromolecules, Vol. 28, Issue 4
  • DOI: 10.1021/ma00108a038

Thermoresponsive phase transitions of PLA-block-PEO-block-PLA triblock stereo-copolymers in aqueous solution
journal, December 2002

  • Lee, Hyung Tak; Lee, Doo Sung
  • Macromolecular Research, Vol. 10, Issue 6
  • DOI: 10.1007/BF03218330

Organic Catalysis for Ring-Opening Polymerization
journal, November 2012


The rheology of solutions of associating polymers: Comparison of experimental behavior with transient network theory
journal, July 1993

  • Annable, Tom; Buscall, Richard; Ettelaie, Rammile
  • Journal of Rheology, Vol. 37, Issue 4
  • DOI: 10.1122/1.550391

Synthesis and Stereocomplex Formation of Star-Shaped Stereoblock Polylactides Consisting of Poly( l -lactide) and Poly( d -lactide) Arms
journal, October 2013

  • Isono, Takuya; Kondo, Yohei; Otsuka, Issei
  • Macromolecules, Vol. 46, Issue 21
  • DOI: 10.1021/ma401375x

Rheological characterization of biocompatible associative polymer hydrogels with crystalline and amorphous endblocks
journal, August 2006

  • Agrawal, Sarvesh K.; Sanabria-DeLong, Naomi; Tew, Gregory N.
  • Journal of Materials Research, Vol. 21, Issue 8
  • DOI: 10.1557/jmr.2006.0261

Crystallization and Melting Behavior of Polylactides
journal, June 1998

  • Sarasua, Jose-Ramon; Prud'homme, Robert E.; Wisniewski, Muriel
  • Macromolecules, Vol. 31, Issue 12
  • DOI: 10.1021/ma971545p

In situ forming degradable networks and their application in tissue engineering and drug delivery
journal, January 2002

  • Anseth, Kristi S.; Metters, Andrew T.; Bryant, Stephanie J.
  • Journal of Controlled Release, Vol. 78, Issue 1-3, p. 199-209
  • DOI: 10.1016/S0168-3659(01)00500-4

Bridging by End-Adsorbed Triblock Copolymers
journal, January 1996

  • Nguyen-Misra, Mai; Misra, Sanjay; Mattice, Wayne L.
  • Macromolecules, Vol. 29, Issue 5
  • DOI: 10.1021/ma950802s

Protein release from physically crosslinked hydrogels of the PLA/PEO/PLA triblock copolymer-type
journal, February 2001


Recent advances in stereocomplexation of enantiomeric PLA-based copolymers and applications
journal, November 2016


PEG–PLLA and PEG–PDLA multiblock copolymers: Synthesis and in situ hydrogel formation by stereocomplexation
journal, November 2006


Physical gelation of a bacterial thermoplastic elastomer
journal, April 1992

  • Richtering, H. W.; Gagnon, K. D.; Lenz, R. W.
  • Macromolecules, Vol. 25, Issue 9
  • DOI: 10.1021/ma00035a021

Synthesis, Characterization, and Hydrolytic Degradation of PLA/PEO/PLA Triblock Copolymers with Long Poly( l -lactic acid) Blocks
journal, January 1996

  • Li, S. M.; Rashkov, I.; Espartero, J. L.
  • Macromolecules, Vol. 29, Issue 1
  • DOI: 10.1021/ma950531l

Simple Approach to Stabilized Micelles Employing Miktoarm Terpolymers and Stereocomplexes with Application in Paclitaxel Delivery
journal, June 2009

  • Nederberg, Fredrik; Appel, Eric; Tan, Jeremy P. K.
  • Biomacromolecules, Vol. 10, Issue 6
  • DOI: 10.1021/bm900056g

A Mini Review on the Functional Biomaterials Based on Poly(lactic acid) Stereocomplex
journal, January 2016


Structural Characterization of PLA−PEO−PLA Solutions and Hydrogels:  Crystalline vs Amorphous PLA Domains
journal, March 2008

  • Agrawal, Sarvesh K.; Sanabria-DeLong, Naomi; Tew, Gregory N.
  • Macromolecules, Vol. 41, Issue 5
  • DOI: 10.1021/ma070634r

Enantiomeric PLA–PEG block copolymers and their stereocomplex micelles used as rifampin delivery
journal, July 2006


Thermal degradation of poly(l-lactide): Accelerating effect of residual DBU-based organic catalysts
journal, May 2011


Analysis of Linear Viscoelasticity of a Crosslinking Polymer at the Gel Point
journal, April 1986

  • Winter, H. Henning; Chambon, Francois
  • Journal of Rheology, Vol. 30, Issue 2
  • DOI: 10.1122/1.549853

Micro- to Nanoscale Structure of Biocompatible PLA−PEO−PLA Hydrogels
journal, April 2007

  • Agrawal, Sarvesh K.; Sanabria-DeLong, Naomi; Jemian, Pete R.
  • Langmuir, Vol. 23, Issue 9
  • DOI: 10.1021/la063390x

Elastically Effective Chains in Transient Gels with Multiple Junctions
journal, January 1996

  • Tanaka, Fumihiko; Ishida, Masahiko
  • Macromolecules, Vol. 29, Issue 23
  • DOI: 10.1021/ma960604g

Rheological studies of PLLA–PEO–PLLA triblock copolymer hydrogels
journal, March 2004


50th Anniversary Perspective : There Is a Great Future in Sustainable Polymers
journal, May 2017


Determining Sequence Fidelity in Repeating Sequence Poly(lactic- co -glycolic acid)s
journal, January 2017


Controlling Hydrogel Properties by Crystallization of Hydrophobic Domains
journal, February 2006

  • Sanabria-DeLong, Naomi; Agrawal, Sarvesh K.; Bhatia, Surita R.
  • Macromolecules, Vol. 39, Issue 4
  • DOI: 10.1021/ma052243n

Amidine-Mediated Zwitterionic Polymerization of Lactide
journal, August 2012

  • Brown, Hayley A.; De Crisci, Antonio G.; Hedrick, James L.
  • ACS Macro Letters, Vol. 1, Issue 9
  • DOI: 10.1021/mz300276u

Evolution of phase behavior and orientation in uniaxially deformed polylactic acid films
journal, August 2002

  • Kokturk, G.; Piskin, E.; Serhatkulu, T. F.
  • Polymer Engineering & Science, Vol. 42, Issue 8
  • DOI: 10.1002/pen.11057

Crosslinked biopolymers: Experimental evidence for scalar percolation theory
journal, March 1990


New properties from PLA–PEO–PLA hydrogels
journal, January 2005

  • Tew, Gregory N.; Sanabria-DeLong, Naomi; Agrawal, Sarvesh K.
  • Soft Matter, Vol. 1, Issue 4
  • DOI: 10.1039/b509800a

Synthesis and Rheological Properties of Polylactide/Poly(ethylene glycol) Multiblock Copolymers
journal, November 2005