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Title: Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

 [1];  [1]; ORCiD logo [1]
  1. Department of Chemistry and CESAM Centre for Environmental and Marine Studies University of Aveiro Aveiro Portugal
Publication Date:
Sponsoring Org.:
USDOE Office of Nuclear Energy (NE), Fuel Cycle Technologies (NE-5)
OSTI Identifier:
Grant/Contract Number:  
SFRH/BD/88572/2012; UID/AMB/50017/2013
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Reviews in Aquaculture
Additional Journal Information:
Journal Name: Reviews in Aquaculture Journal Volume: 11 Journal Issue: 4; Journal ID: ISSN 1753-5123
Country of Publication:
Country unknown/Code not available

Citation Formats

Leal, Joana F., Santos, Eduarda B. H., and Esteves, Valdemar I. Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance. Country unknown/Code not available: N. p., 2018. Web. doi:10.1111/raq.12286.
Leal, Joana F., Santos, Eduarda B. H., & Esteves, Valdemar I. Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance. Country unknown/Code not available. doi:10.1111/raq.12286.
Leal, Joana F., Santos, Eduarda B. H., and Esteves, Valdemar I. Thu . "Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance". Country unknown/Code not available. doi:10.1111/raq.12286.
title = {Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance},
author = {Leal, Joana F. and Santos, Eduarda B. H. and Esteves, Valdemar I.},
abstractNote = {},
doi = {10.1111/raq.12286},
journal = {Reviews in Aquaculture},
number = 4,
volume = 11,
place = {Country unknown/Code not available},
year = {2018},
month = {8}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1111/raq.12286

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Cited by: 1 work
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Works referenced in this record:

Fish drug analysis—Phish-pharm: A searchable database of pharmacokinetics data in fish
journal, June 2005

  • Reimschuessel, Renate; Stewart, Leslie; Squibb, Elizabeth
  • The AAPS Journal, Vol. 7, Issue 2
  • DOI: 10.1208/aapsj070230

Effects of Inorganic Anions and Humic Acid on the Photocatalytic and Ozone Oxidation of Oxytetracycline in Aqueous Solution
journal, January 2009

  • Yalap, Keziban Seven; Balcioglu, Isil Akmehmet
  • Journal of Advanced Oxidation Technologies, Vol. 12, Issue 1
  • DOI: 10.1515/jaots-2009-0117

Chemical use in salmon aquaculture: A review of current practices and possible environmental effects
journal, August 2010

A novel approach to modeling the reaction kinetics of tetracycline antibiotics with aqueous ozone
journal, January 2014

Antibiotics in the aquatic environment – A review – Part I
journal, April 2009

Effect of Halide Ions and Carbonates on Organic Contaminant Degradation by Hydroxyl Radical-Based Advanced Oxidation Processes in Saline Waters
journal, September 2010

  • Grebel, Janel E.; Pignatello, Joseph J.; Mitch, William A.
  • Environmental Science & Technology, Vol. 44, Issue 17
  • DOI: 10.1021/es1010225

Genotoxic responses of juvenile tilapia (Oreochromis niloticus) exposed to florfenicol and oxytetracycline
journal, August 2015

Bioavailability of oxytetracycline from medicated feed administered to Atlantic salmon (Salmo salar L.) in seawater
journal, July 1996

Environmental Risk Assessment of antimicrobials applied in veterinary medicine—A field study and laboratory approach
journal, January 2013

  • Slana, Marko; Dolenc, Marija Sollner
  • Environmental Toxicology and Pharmacology, Vol. 35, Issue 1
  • DOI: 10.1016/j.etap.2012.11.017

Aquatic toxicity of four veterinary drugs commonly applied in fish farming and animal husbandry
journal, August 2013

Complexes of tetracyclines with divalent metal cations investigated by stationary and femtosecond-pulsed techniques
journal, January 2012

  • Carlotti, Benedetta; Cesaretti, Alessio; Elisei, Fausto
  • Phys. Chem. Chem. Phys., Vol. 14, Issue 2
  • DOI: 10.1039/C1CP22703C

Pharmacokinetics and tissue distribution of oxytetracycline in sea bass, Dicentrarchus labrax, at two water temperatures
journal, July 2002

Effect of Two Broad-Spectrum Antibiotics on Activity and Stability of Continuous Nitrifying System
journal, January 2001

  • Campos, J. Luis; Garrido, Juan M.; Méndez, Ramón
  • Applied Biochemistry and Biotechnology, Vol. 95, Issue 1
  • DOI: 10.1385/ABAB:95:1:01

The toxic effect of oxytetracycline and trimethoprim in the aquatic environment
journal, November 2014

Antibacterial activity of oxytetracycline photoproducts in marine aquaculture's water
journal, January 2017

Photodegradation of tetracyclines in aqueous solution by using UV and UV/H2O2 oxidation processes
journal, September 2010

  • López-Peñalver, Jesús J.; Sánchez-Polo, Manuel; Gómez-Pacheco, Carla V.
  • Journal of Chemical Technology & Biotechnology, Vol. 85, Issue 10
  • DOI: 10.1002/jctb.2435

Tissue distribution and elimination of oxytetracycline in seawater chinook and coho salmon following medicated-feed treatment
journal, September 1996

Superparamagnetic MnFe2O4 dispersed over graphitic carbon sand composite and bentonite as magnetically recoverable photocatalyst for antibiotic mineralization
journal, January 2017

Pharmacokinetics and bioavailability of oxytetracycline in gilthead sea bream (Sparus aurata) after a single dose
journal, May 2003

Tetracycline degradation in aqueous phase by ultraviolet radiation
journal, April 2012

  • Gómez-Pacheco, C. V.; Sánchez-Polo, M.; Rivera-Utrilla, J.
  • Chemical Engineering Journal, Vol. 187
  • DOI: 10.1016/j.cej.2012.01.096

Hydrolysis and photolysis of oxytetracycline in aqueous solution
journal, December 2009

  • Xuan, Richeng; Arisi, Lestley; Wang, Qiquan
  • Journal of Environmental Science and Health, Part B, Vol. 45, Issue 1
  • DOI: 10.1080/03601230903404556

Circular Dichroism Measurements of the Tetracyclines IV. 5-Hydroxylated Derivatives
journal, August 1972

  • Mitscher, L. A.; Slater-Eng, B.; Sokoloski, T. D.
  • Antimicrobial Agents and Chemotherapy, Vol. 2, Issue 2
  • DOI: 10.1128/AAC.2.2.66

Poor bioavailability of oxytetracycline in sharpsnout sea bream Diplodus puntazzo
journal, June 2004

The chemistry of ozone in the treatment of water
journal, January 1976

Occurrence of antibiotics in water from 13 fish hatcheries, 2001-2003
journal, December 2005

  • Dietze, Julie.; Scribner, Elisabeth; Meyer, M. T.
  • International Journal of Environmental Analytical Chemistry, Vol. 85, Issue 15
  • DOI: 10.1080/03067310500273682

Chemistry of tetracyclines
journal, January 1968

Tetracycline antibiotics in the environment: a review
journal, March 2013

Tetracycline degradation by ozonation in the aqueous phase: Proposed degradation intermediates and pathway
journal, September 2010

The Kinetics of Oxytetracycline Degradation in Deionized Water under Varying Temperature, pH, Light, Substrate, and Organic Matter
journal, September 2000

Toxicity of Tetracyclines and Tetracycline Degradation Products to Environmentally Relevant Bacteria, Including Selected Tetracycline-Resistant Bacteria
journal, March 2002

  • Halling-Sørensen, G. Sengel, B.
  • Archives of Environmental Contamination and Toxicology, Vol. 42, Issue 3
  • DOI: 10.1007/s00244-001-0017-2

Photochemical Fate of Sulfa Drugs in the Aquatic Environment:  Sulfa Drugs Containing Five-Membered Heterocyclic Groups
journal, July 2004

  • Boreen, Anne L.; Arnold, William A.; McNeill, Kristopher
  • Environmental Science & Technology, Vol. 38, Issue 14
  • DOI: 10.1021/es0353053

Ozonation performance of WWTP secondary effluent of antibiotic manufacturing wastewater
journal, November 2010

Drinking-water treatment with ozone
journal, March 1987

  • Glaze, William H.
  • Environmental Science & Technology, Vol. 21, Issue 3
  • DOI: 10.1021/es00157a001

Marine fungi isolated from Chilean fjord sediments can degrade oxytetracycline
journal, July 2016

  • Ahumada-Rudolph, R.; Novoa, V.; Sáez, K.
  • Environmental Monitoring and Assessment, Vol. 188, Issue 8
  • DOI: 10.1007/s10661-016-5475-0

Oxidation of Antibacterial Compounds by Ozone and Hydroxyl Radical: Elimination of Biological Activity during Aqueous Ozonation Processes
journal, April 2009

  • Dodd, Michael C.; Kohler, Hans-Peter E.; von Gunten, Urs
  • Environmental Science & Technology, Vol. 43, Issue 7
  • DOI: 10.1021/es8025424

Ozonation of oxytetracycline and toxicological assessment of its oxidation by-products
journal, June 2008

Photodegradation and toxicity changes of antibiotics in UV and UV/H2O2 process
journal, January 2011

Toxicity of Oxytetracycline and Calcein to Juvenile Striped Bass
journal, January 1996

Aqueous oxytetracycline degradation and the toxicity change of degradation compounds in photoirradiation process
journal, January 2008

Acute and chronic toxicity of veterinary antibiotics to Daphnia magna
journal, April 2000

The Complexation of Tetracycline and Anhydrotetracycline with Mg 2+ and Ca 2+ :  A Spectroscopic Study
journal, November 1998

  • Wessels, J. M.; Ford, W. E.; Szymczak, W.
  • The Journal of Physical Chemistry B, Vol. 102, Issue 46
  • DOI: 10.1021/jp9824050

Fluoroquinolones and Tetracycline Antibiotics in a Portuguese Aquaculture System and Aquatic Surroundings: Occurrence and Environmental Impact
journal, August 2015

  • Pereira, André M. P. T.; Silva, Liliana J. G.; Meisel, Leonor M.
  • Journal of Toxicology and Environmental Health, Part A, Vol. 78, Issue 15
  • DOI: 10.1080/15287394.2015.1036185

Effects of Ionic Strength, Temperature, and pH on Degradation of Selected Antibiotics
journal, January 2008

  • Loftin, Keith A.; Adams, Craig D.; Meyer, Michael T.
  • Journal of Environment Quality, Vol. 37, Issue 2
  • DOI: 10.2134/jeq2007.0230

Do antibiotics have environmental side-effects? Impact of synthetic antibiotics on biogeochemical processes
journal, July 2015

  • Roose-Amsaleg, Céline; Laverman, Anniet M.
  • Environmental Science and Pollution Research, Vol. 23, Issue 5
  • DOI: 10.1007/s11356-015-4943-3

The Interaction Between Oxytetracycline and Divalent Metal Ions in Aqueous and Mixed Solvent Systems
journal, January 1999

  • Tongaree, Sauwaluxana; Flanagan, Douglas R.; Poust, Rolland I.
  • Pharmaceutical Development and Technology, Vol. 4, Issue 4
  • DOI: 10.1081/PDT-100101397

Photocatalytic mineralization and degradation kinetics of ampicillin and oxytetracycline antibiotics using graphene sand composite and chitosan supported BiOCl
journal, November 2016

Occurrence of Tetracycline Resistance Genes in Aquaculture Facilities with Varying Use of Oxytetracycline
journal, March 2010

Spectroscopic investigation of complexation between various tetracyclines and Mg2+ or Ca2+
journal, January 2000

  • O. Schmitt, Matthias; Schneider, Siegfried
  • PhysChemComm, Vol. 3, Issue 9
  • DOI: 10.1039/b005722n

Photocatalytic degradation of oxytetracycline using TiO2 under natural and simulated solar radiation
journal, November 2011

Ozonation and UV irradiation—an introduction and examples of current applications
journal, June 2003

Use, fate and ecological risks of antibiotics applied in tilapia cage farming in Thailand
journal, August 2014

A critical approach on pharmacokinetics, pharmacodynamics, dose optimisation and withdrawal times of oxytetracycline in aquaculture
journal, December 2013

  • Rigos, George; Smith, Peter
  • Reviews in Aquaculture, Vol. 7, Issue 2
  • DOI: 10.1111/raq.12055

Effects of oxytetracycline on nitrification in a model aquatic system
journal, June 1994

Photostability of eight antibacterial agents in seawater
journal, July 1995

A kinetic study of ozone decay and bromine formation in saltwater ozonation: Effect of O3 dose, salinity, pH, and temperature
journal, March 2017

Bromate Formation during Ozonization of Bromide-Containing Waters: Interaction of Ozone and Hydroxyl Radical Reactions
journal, July 1994

  • von Gunten, Urs.; Hoigne, Juerg.
  • Environmental Science & Technology, Vol. 28, Issue 7
  • DOI: 10.1021/es00056a009

Photodegradation of tetracycline antibiotics in aqueous solution by UV/ZnO
journal, October 2015

Use of sunlight to degrade oxytetracycline in marine aquaculture's waters
journal, June 2016

Magnetically retrievable Bi 2 WO 6 /Fe 3 O 4 immobilized on graphene sand composite for investigation of photocatalytic mineralization of oxytetracycline and ampicillin
journal, February 2017

  • Raizada, Pankaj; Kumari, Jyoti; Shandilya, Pooja
  • Process Safety and Environmental Protection, Vol. 106
  • DOI: 10.1016/j.psep.2016.12.012

Removal of typical antibiotics in the advanced treatment process of productive drinking water
journal, May 2015

Insights into solar TiO2-assisted photocatalytic oxidation of two antibiotics employed in aquatic animal production, oxolinic acid and oxytetracycline
journal, October 2013

Photoproducts of tetracycline and oxytetracycline involving self-sensitized oxidation in aqueous solutions: Effects of Ca2+ and Mg2+
journal, October 2011

Ozone Application in Recirculating Aquaculture System: An Overview
journal, September 2011

Comparative pharmacokinetics of oxytetracycline in tilapia (Oreochromis spp.) maintained at three different salinities
journal, October 2018

Degradation and removal methods of antibiotics from aqueous matrices – A review
journal, October 2011

Reduction in the antibacterial effect of oxy-tetracycline in sea water by complex formation with magnesium and calcium
journal, January 1990

  • Lunestad, Bt; Goksøyr, J.
  • Diseases of Aquatic Organisms, Vol. 9
  • DOI: 10.3354/dao009067

Circular Dichroism Spectra of Tetracycline Complexes with Mg+2 and Ca+2
journal, December 1976

  • Newman, E. C.; Frank, C. W.
  • Journal of Pharmaceutical Sciences, Vol. 65, Issue 12
  • DOI: 10.1002/jps.2600651209

Use of formalin in intensive aquaculture: properties, application and effects on fish and water quality
journal, June 2016

  • Leal, Joana F.; Neves, Maria Graça P. M. S.; Santos, Eduarda B. H.
  • Reviews in Aquaculture, Vol. 10, Issue 2
  • DOI: 10.1111/raq.12160

Outer membrane permeability and antibiotic resistance
journal, May 2009

Potential drug (oxytetracycline and oxolinic acid) pollution from Mediterranean sparid fish farms
journal, August 2004

Photocatalytic degradation of tetracycline by Ti-MCM-41 prepared at room temperature and biotoxicity of degradation products
journal, September 2017

Adsorptional photocatalytic mineralization of oxytetracycline and ampicillin antibiotics using Bi2O3/BiOCl supported on graphene sand composite and chitosan
journal, October 2016

Characterization of microbial degradation of oxytetracycline in river water and sediment using reversed phase high performance liquid chromatography [English]
journal, January 2015

  • Kugara, J.; Dzomba, P.; Zaranyika, M. F.
  • African Journal of Biotechnology, Vol. 14, Issue 1
  • DOI: 10.5897/AJB2014.14091

Inhibition of Aerobic Growth and Nitrification of Bacteria in Sewage Sludge by Antibacterial Agents
journal, April 2001

  • Halling-Sørensen, B.
  • Archives of Environmental Contamination and Toxicology, Vol. 40, Issue 4
  • DOI: 10.1007/s002440010197

Tetracycline: production, waste treatment and environmental impact assessment
journal, March 2014

Pharmacokinetics and residue elimination of oxytetracycline in grass carp, Ctenopharyngodon idellus
journal, November 2007

Does light-screening by humic substances completely explain their retardation effect on contaminants photo-degradation?
journal, December 2015

  • Leal, J. F.; Esteves, V. I.; Santos, E. B. H.
  • Journal of Environmental Chemical Engineering, Vol. 3, Issue 4
  • DOI: 10.1016/j.jece.2014.12.025

Investigating the Molecular Interactions of Oxytetracycline in Clay and Organic Matter:  Insights on Factors Affecting Its Mobility in Soil
journal, August 2004

  • Kulshrestha, Pankaj; Giese,, Rossman F.; Aga, Diana S.
  • Environmental Science & Technology, Vol. 38, Issue 15
  • DOI: 10.1021/es034856q

Monitoring the degradation of tetracycline by ozone in aqueous medium via atmospheric pressure ionization mass spectrometry
journal, April 2007

  • Dalmázio, Ilza; Almeida, Mariana O.; Augusti, Rodinei
  • Journal of the American Society for Mass Spectrometry, Vol. 18, Issue 4
  • DOI: 10.1016/j.jasms.2006.12.001

Primary biodegradation of veterinary antibiotics in aerobic and anaerobic surface water simulation systems
journal, August 2001

Effect of temperature and diet composition on residue depletion of oxytetracycline in cultured channel catfish
journal, January 1994

  • Luzzana, Umberto; Serrini, Giovanni; Moretti, Vittorio Maria
  • The Analyst, Vol. 119, Issue 12
  • DOI: 10.1039/AN9941902757

Ozonation of bromide-containing waters: kinetics of formation of hypobromous acid and bromate
journal, May 1983

  • Haag, Werner R.; Hoigne, Juerg.
  • Environmental Science & Technology, Vol. 17, Issue 5
  • DOI: 10.1021/es00111a004

Impact of metal coordination on the antibiotic and non-antibiotic activities of tetracycline-based drugs
journal, November 2016

  • Guerra, Wendell; Silva-Caldeira, Priscila P.; Terenzi, Hernán
  • Coordination Chemistry Reviews, Vol. 327-328
  • DOI: 10.1016/j.ccr.2016.04.009

Aquaculture practices and potential human health risks: Current knowledge and future priorities
journal, November 2008

Toxicological Effects of the Antibiotic Oxytetracycline to an Indian Major Carp Labeo rohita
journal, November 2012

  • Ambili, T. R.; Saravanan, M.; Ramesh, M.
  • Archives of Environmental Contamination and Toxicology, Vol. 64, Issue 3
  • DOI: 10.1007/s00244-012-9836-6

Binding constants of oxytetracycline to animal feed divalent cations
journal, January 2007

Temperature-related absorption and excretion of oxytetracycline in rainbow trout (Salmo gairdneri R.)
journal, February 1990

Biodegradation of oxytetracycline by Pleurotus ostreatus mycelium: a mycoremediation technique
journal, May 2012