Serum biomarkers for diagnosis and prediction of type 1 diabetes
Abstract
Here, Type 1 diabetes (T1D) culminates in the autoimmune destruction of the pancreatic β-cells, leading to insufficient production of insulin and development of hyperglycemia. Serum biomarkers including a combination of glucose, glycated molecules, c-peptide, and autoantibodies have been well established for the diagnosis of T1D. However, these molecules often mark a late stage of the disease when ~90% of the pancreatic insulin-producing β-cells have already been lost. With the prevalence of T1D increasing worldwide and because of the physical and psychological burden induced by this disease, there is a great need for prognostic biomarkers to predict T1D development or progression. This would allow us to identify individuals at high risk for early prevention and intervention. Therefore, considerable efforts have been dedicated to the understanding of disease etiology and the discovery of novel biomarkers in the last few decades. The advent of high-throughput and sensitive ‘-omics’ technologies for the study of proteins, nucleic acids, and metabolites have allowed large scale profiling of protein expression and gene changes in T1D patients relative to disease-free controls. In this review, we briefly discuss the classical diagnostic biomarkers of T1D but mainly focus on the novel biomarkers that are identified as markers of β-cell destructionmore »
- Authors:
-
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1464493
- Report Number(s):
- PNNL-SA-134879
Journal ID: ISSN 1931-5244; PII: S1931524418301105
- Grant/Contract Number:
- DP3 DK110844; UC4 DK104167; AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Translational Research
- Additional Journal Information:
- Journal Volume: 201; Journal ID: ISSN 1931-5244
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Yi, Lian, Swensen, Adam C., and Qian, Wei -Jun. Serum biomarkers for diagnosis and prediction of type 1 diabetes. United States: N. p., 2018.
Web. doi:10.1016/j.trsl.2018.07.009.
Yi, Lian, Swensen, Adam C., & Qian, Wei -Jun. Serum biomarkers for diagnosis and prediction of type 1 diabetes. United States. https://doi.org/10.1016/j.trsl.2018.07.009
Yi, Lian, Swensen, Adam C., and Qian, Wei -Jun. Wed .
"Serum biomarkers for diagnosis and prediction of type 1 diabetes". United States. https://doi.org/10.1016/j.trsl.2018.07.009. https://www.osti.gov/servlets/purl/1464493.
@article{osti_1464493,
title = {Serum biomarkers for diagnosis and prediction of type 1 diabetes},
author = {Yi, Lian and Swensen, Adam C. and Qian, Wei -Jun},
abstractNote = {Here, Type 1 diabetes (T1D) culminates in the autoimmune destruction of the pancreatic β-cells, leading to insufficient production of insulin and development of hyperglycemia. Serum biomarkers including a combination of glucose, glycated molecules, c-peptide, and autoantibodies have been well established for the diagnosis of T1D. However, these molecules often mark a late stage of the disease when ~90% of the pancreatic insulin-producing β-cells have already been lost. With the prevalence of T1D increasing worldwide and because of the physical and psychological burden induced by this disease, there is a great need for prognostic biomarkers to predict T1D development or progression. This would allow us to identify individuals at high risk for early prevention and intervention. Therefore, considerable efforts have been dedicated to the understanding of disease etiology and the discovery of novel biomarkers in the last few decades. The advent of high-throughput and sensitive ‘-omics’ technologies for the study of proteins, nucleic acids, and metabolites have allowed large scale profiling of protein expression and gene changes in T1D patients relative to disease-free controls. In this review, we briefly discuss the classical diagnostic biomarkers of T1D but mainly focus on the novel biomarkers that are identified as markers of β-cell destruction and screened with the use of state-of-the-art ‘-omics’ technologies.},
doi = {10.1016/j.trsl.2018.07.009},
journal = {Translational Research},
number = ,
volume = 201,
place = {United States},
year = {Wed Aug 01 00:00:00 EDT 2018},
month = {Wed Aug 01 00:00:00 EDT 2018}
}
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Works referenced in this record:
Type I Diabetes Mellitus
journal, May 1986
- Flier, Jeffrey S.; Underhill, Lisa H.; Eisenbarth, George S.
- New England Journal of Medicine, Vol. 314, Issue 21
Targeted immune interventions for type 1 diabetes: not as easy as it looks!
journal, January 2014
- Rigby, Mark R.; Ehlers, Mario R.
- Current Opinion in Endocrinology & Diabetes and Obesity, Vol. 21, Issue 4
Epidemiology of Type 1 Diabetes
journal, September 2010
- Maahs, David M.; West, Nancy A.; Lawrence, Jean M.
- Endocrinology and Metabolism Clinics of North America, Vol. 39, Issue 3
Type 1 diabetes mellitus
journal, March 2017
- Katsarou, Anastasia; Gudbjörnsdottir, Soffia; Rawshani, Araz
- Nature Reviews Disease Primers, Vol. 3, Issue 1
Factors affecting the level of burden of caregivers of children with type 1 diabetes
journal, May 2015
- Kobos, Ewa; Imiela, Jacek
- Applied Nursing Research, Vol. 28, Issue 2
Perceived family burden and emotional distress: similarities and differences between mothers and fathers of children with type 1 diabetes in a population-based study
journal, February 2011
- Haugstvedt, Anne; Wentzel-Larsen, Tore; Rokne, Berit
- Pediatric Diabetes, Vol. 12, Issue 2
Proteomic Technologies for the Discovery of Type 1 Diabetes Biomarkers
journal, July 2010
- Zhi, Wenbo; Purohit, Sharad; Carey, Colleen
- Journal of Diabetes Science and Technology, Vol. 4, Issue 4
-Cell Mass and Turnover in Humans: Effects of obesity and aging
journal, August 2012
- Saisho, Y.; Butler, A. E.; Manesso, E.
- Diabetes Care, Vol. 36, Issue 1
Current Concepts on the Pathogenesis of Type 1 Diabetes—Considerations for Attempts to Prevent and Reverse the Disease
journal, May 2015
- Atkinson, Mark A.; von Herrath, Matthias; Powers, Alvin C.
- Diabetes Care, Vol. 38, Issue 6
Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2
journal, March 2008
- Törn, C.; Mueller, P. W.; Schlosser, M.
- Diabetologia, Vol. 51, Issue 5
Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies
journal, September 2010
- Schlosser, M.; Mueller, P. W.; Törn, C.
- Diabetologia, Vol. 53, Issue 12
Diabetes Antibody Standardization Program: Table 1: First evaluation of assays for autoantibodies to IA-2β
journal, September 2011
- Schlosser, Michael; Mueller, Patricia W.; Achenbach, Peter
- Diabetes Care, Vol. 34, Issue 11
Diabetes Antibody Standardization Program: First Proficiency Evaluation of Assays for Autoantibodies to Zinc Transporter 8
journal, December 2011
- Lampasona, Vito; Schlosser, Michael; Mueller, Patricia W.
- Clinical Chemistry, Vol. 57, Issue 12
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
journal, March 2002
- Sacks, David B.; Bruns, David E.; Goldstein, David E.
- Clinical Chemistry, Vol. 48, Issue 3
Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children
journal, June 2013
- Ziegler, Anette G.; Rewers, Marian; Simell, Olli
- JAMA, Vol. 309, Issue 23
Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes
journal, May 2004
- Scholin, A.; Torn, C.; Nystrom, L.
- Diabetic Medicine, Vol. 21, Issue 5
A Practical Review of C-Peptide Testing in Diabetes
journal, May 2017
- Leighton, Emma; Sainsbury, Christopher AR; Jones, Gregory C.
- Diabetes Therapy, Vol. 8, Issue 3
Preserved C-peptide levels in overweight or obese compared with underweight children upon diagnosis of type 1 diabetes mellitus
journal, January 2015
- Yu, Hyeoh Won; Lee, Yun Jeong; Cho, Won Im
- Annals of Pediatric Endocrinology & Metabolism, Vol. 20, Issue 2
C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve -Cell Function: Report of an ADA Workshop, 21-22 October 2001
journal, December 2003
- Palmer, J. P.; Fleming, G. A.; Greenbaum, C. J.
- Diabetes, Vol. 53, Issue 1
Disease-associated Autoimmunity and Prevention of Insulin-dependent Diabetes Mellitus
journal, January 1997
- Knip, Mikael
- Annals of Medicine, Vol. 29, Issue 5
Prediction of Type 1 Diabetes in the General Population
journal, May 2010
- Knip, M.; Korhonen, S.; Kulmala, P.
- Diabetes Care, Vol. 33, Issue 6
Predicting Type 1 Diabetes Using Biomarkers
journal, May 2015
- Bonifacio, Ezio
- Diabetes Care, Vol. 38, Issue 6
Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity: ILONEN et al.
journal, June 2017
- Ilonen, Jorma; Lempainen, Johanna; Hammais, Anna
- Pediatric Diabetes, Vol. 19, Issue 2
A novel approach for the analysis of longitudinal profiles reveals delayed progression to type 1 diabetes in a subgroup of multiple-islet-autoantibody-positive children
journal, July 2016
- Endesfelder, David; Hagen, Michael; Winkler, Christiane
- Diabetologia, Vol. 59, Issue 10
Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study
journal, June 2016
- Vehik, Kendra; Lynch, Kristian F.; Schatz, Desmond A.
- Diabetes Care, Vol. 39, Issue 9
Islet Autoantibodies and Type 1 Diabetes: Does the Evidence Support Screening?
journal, March 2014
- Calderon, Boris; Sacks, David B.
- Clinical Chemistry, Vol. 60, Issue 3
Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
journal, August 2004
- Achenbach, Peter; Koczwara, Kerstin; Knopff, Annette
- Journal of Clinical Investigation, Vol. 114, Issue 4
Clinical Applications of Diabetes Antibody Testing
journal, January 2010
- Bingley, Polly J.
- The Journal of Clinical Endocrinology & Metabolism, Vol. 95, Issue 1
Autoimmune Markers in Diabetes
journal, February 2011
- Winter, William E.; Schatz, Desmond A.
- Clinical Chemistry, Vol. 57, Issue 2
Novel Biomarkers in Type 1 Diabetes
journal, January 2012
- Jin, Yulan; She, Jin-Xiong
- The Review of Diabetic Studies, Vol. 9, Issue 4
Prediction and Pathogenesis in Type 1 Diabetes
journal, April 2010
- Ziegler, Anette-G.; Nepom, Gerald T.
- Immunity, Vol. 32, Issue 4
Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity
journal, November 2016
- Cianciaruso, Chiara; Phelps, Edward A.; Pasquier, Miriella
- Diabetes, Vol. 66, Issue 2
High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation
journal, February 2016
- Robitaille, Karine; Rourke, Jillian L.; McBane, Joanne E.
- Journal of Biological Chemistry, Vol. 291, Issue 9
Identification of proliferative and mature β-cells in the islets of Langerhans
journal, July 2016
- Bader, Erik; Migliorini, Adriana; Gegg, Moritz
- Nature, Vol. 535, Issue 7612
Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes
journal, September 2014
- Rondas, Dieter; Crèvecoeur, Inne; D’Hertog, Wannes
- Diabetes, Vol. 64, Issue 2
Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics
journal, June 2015
- El Ouaamari, Abdelfattah; Zhou, Jian-Ying; Liew, Chong Wee
- Journal of Proteome Research, Vol. 14, Issue 8
Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes
journal, August 2015
- Burch, Tanya C.; Morris, Margaret A.; Campbell-Thompson, Martha
- PLOS ONE, Vol. 10, Issue 8
Proteomic profiling of human islets collected from frozen pancreata using laser capture microdissection
journal, January 2017
- Zhang, Lina; Lanzoni, Giacomo; Battarra, Matteo
- Journal of Proteomics, Vol. 150
Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes
journal, September 2017
- Nyalwidhe, Julius O.; Grzesik, Wojciech J.; Burch, Tanya C.
- PLOS ONE, Vol. 12, Issue 9
Nanodroplet processing platform for deep and quantitative proteome profiling of 10–100 mammalian cells
journal, February 2018
- Zhu, Ying; Piehowski, Paul D.; Zhao, Rui
- Nature Communications, Vol. 9, Issue 1
MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic Islets
journal, January 2013
- Klein, Dagmar; Misawa, Ryosuke; Bravo-Egana, Valia
- PLoS ONE, Vol. 8, Issue 1
Enhanced Detection of Low Abundance Human Plasma Proteins Using a Tandem IgY12-SuperMix Immunoaffinity Separation Strategy
journal, July 2008
- Qian, Wei-Jun; Kaleta, David T.; Petritis, Brianne O.
- Molecular & Cellular Proteomics, Vol. 7, Issue 10
Depletion of Abundant Plasma Proteins and Limitations of Plasma Proteomics
journal, October 2010
- Tu, Chengjian; Rudnick, Paul A.; Martinez, Misti Y.
- Journal of Proteome Research, Vol. 9, Issue 10
Human Plasma Proteome Analysis by Multidimensional Chromatography Prefractionation and Linear Ion Trap Mass Spectrometry Identification
journal, April 2005
- Jin, Wen-Hai; Dai, Jie; Li, Su-Jun
- Journal of Proteome Research, Vol. 4, Issue 2
Discovery and Validation of Serum Protein Changes in Type 1 Diabetes Patients Using High Throughput Two Dimensional Liquid Chromatography-Mass Spectrometry and Immunoassays
journal, September 2011
- Zhi, Wenbo; Sharma, Ashok; Purohit, Sharad
- Molecular & Cellular Proteomics, Vol. 10, Issue 11
Peptide serum markers in islet autoantibody-positive children
journal, November 2016
- von Toerne, Christine; Laimighofer, Michael; Achenbach, Peter
- Diabetologia, Vol. 60, Issue 2
Application of Proteomics in the Discovery of Candidate Protein Biomarkers in a Diabetes Autoantibody Standardization Program Sample Subset
journal, February 2008
- Metz, Thomas O.; Qian, Wei-Jun; Jacobs, Jon M.
- Journal of Proteome Research, Vol. 7, Issue 2
Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes
journal, December 2012
- Zhang, Qibin; Fillmore, Thomas L.; Schepmoes, Athena A.
- The Journal of Experimental Medicine, Vol. 210, Issue 1
Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort With HLA-Conferred Susceptibility
journal, January 2015
- Moulder, Robert; Bhosale, Santosh D.; Erkkilä, Timo
- Diabetes, Vol. 64, Issue 6
Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression
journal, February 2018
- Liu, Chih-Wei; Bramer, Lisa; Webb-Robertson, Bobbie-Jo
- Journal of Proteomics, Vol. 172
Protein labeling by iTRAQ: A new tool for quantitative mass spectrometry in proteome research
journal, February 2007
- Wiese, Sebastian; Reidegeld, Kai A.; Meyer, Helmut E.
- PROTEOMICS, Vol. 7, Issue 3
Tandem Mass Tags: A Novel Quantification Strategy for Comparative Analysis of Complex Protein Mixtures by MS/MS
journal, April 2003
- Thompson, Andrew; Schäfer, Jürgen; Kuhn, Karsten
- Analytical Chemistry, Vol. 75, Issue 8
Revisiting biomarker discovery by plasma proteomics
journal, September 2017
- Geyer, Philipp E.; Holdt, Lesca M.; Teupser, Daniel
- Molecular Systems Biology, Vol. 13, Issue 9
ER Stress in Pancreatic Cells: The Thin Red Line Between Adaptation and Failure
journal, February 2010
- Eizirik, D. L.; Cnop, M.
- Science Signaling, Vol. 3, Issue 110
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
journal, March 2010
- Hotamisligil, Gökhan S.
- Cell, Vol. 140, Issue 6
Serological Proteome Analysis (SERPA) as a tool for the identification of new candidate autoantigens in type 1 diabetes
journal, April 2013
- Massa, Ornella; Alessio, Massimo; Russo, Lucia
- Journal of Proteomics, Vol. 82
Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes
journal, April 2014
- McGinty, J. W.; Chow, I. -T.; Greenbaum, C.
- Diabetes, Vol. 63, Issue 9
Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes
journal, October 2013
- van Lummel, M.; Duinkerken, G.; van Veelen, P. A.
- Diabetes, Vol. 63, Issue 1
HLA-dependent autoantibodies against post-translationally modified collagen type II in type 1 diabetes mellitus
journal, November 2012
- Strollo, R.; Rizzo, P.; Spoletini, M.
- Diabetologia, Vol. 56, Issue 3
Antibodies to post-translationally modified insulin as a novel biomarker for prediction of type 1 diabetes in children
journal, May 2017
- Strollo, Rocky; Vinci, Chiara; Napoli, Nicola
- Diabetologia, Vol. 60, Issue 8
Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus
journal, May 2016
- Doran, Todd M.; Morimoto, Jumpei; Simanski, Scott
- Cell Chemical Biology, Vol. 23, Issue 5
The insulin A-chain epitope recognized by human T cells is posttranslationally modified
journal, October 2005
- Mannering, Stuart I.; Harrison, Leonard C.; Williamson, Nicholas A.
- The Journal of Experimental Medicine, Vol. 202, Issue 9
eIF2α phosphorylation is pathognomonic for immunogenic cell death
journal, January 2018
- Bezu, Lucillia; Sauvat, Allan; Humeau, Juliette
- Cell Death & Differentiation, Vol. 25, Issue 8
Pharmacological Inhibition of Protein Lipidation
journal, August 2015
- Ganesan, Lakshmi; Levental, Ilya
- The Journal of Membrane Biology, Vol. 248, Issue 6
Glycated albumin: a potential biomarker in diabetes
journal, June 2017
- Freitas, Priscila Aparecida Correa; Ehlert, Lethicia Rozales; Camargo, Joíza Lins
- Archives of Endocrinology and Metabolism, Vol. 61, Issue 3
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
journal, February 2016
- Delong, T.; Wiles, T. A.; Baker, R. L.
- Science, Vol. 351, Issue 6274
The role of inflammation in insulitis and β-cell loss in type 1 diabetes
journal, April 2009
- Eizirik, Décio L.; Colli, Maikel L.; Ortis, Fernanda
- Nature Reviews Endocrinology, Vol. 5, Issue 4
High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes
journal, January 2007
- Stechova, Katerina; Bohmova, Kristyna; Vrabelova, Zuzana
- Diabetes/Metabolism Research and Reviews, Vol. 23, Issue 6
Children With Islet Autoimmunity and Enterovirus Infection Demonstrate a Distinct Cytokine Profile
journal, April 2012
- Yeung, W. -C. G.; Al-Shabeeb, A.; Pang, C. N. I.
- Diabetes, Vol. 61, Issue 6
Serum CXCL1 concentrations are elevated in type 1 diabetes mellitus, possibly reflecting activity of anti-islet autoimmune activity
journal, November 2011
- Takahashi, Kazuma; Ohara, Mio; Sasai, Takayoshi
- Diabetes/Metabolism Research and Reviews, Vol. 27, Issue 8
Large-Scale Discovery and Validation Studies Demonstrate Significant Reductions in Circulating Levels of IL8, IL-1Ra, MCP-1, and MIP-1β in Patients With Type 1 Diabetes
journal, September 2015
- Purohit, Sharad; Sharma, Ashok; Hopkins, Diane
- The Journal of Clinical Endocrinology & Metabolism, Vol. 100, Issue 9
Serum cytokines as biomarkers of disease and clues to pathogenesis
journal, January 2007
- Mack, Cara L.
- Hepatology, Vol. 46, Issue 1
The Role of Biomarkers in the Diagnosis and Risk Stratification of Acute Graft-versus-Host Disease: A Systematic Review
journal, September 2016
- Ali, Alaa M.; DiPersio, John F.; Schroeder, Mark A.
- Biology of Blood and Marrow Transplantation, Vol. 22, Issue 9
Dual and opposing roles of the unfolded protein response regulated by IRE1 and XBP1 in proinsulin processing and insulin secretion
journal, May 2011
- Lee, A. -H.; Heidtman, K.; Hotamisligil, G. S.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 21
Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes
journal, July 2016
- Sims, Emily K.; Chaudhry, Zunaira; Watkins, Renecia
- Diabetes Care, Vol. 39, Issue 9
Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes
journal, October 2005
- Truyen, I.; De Pauw, P.; Jørgensen, P. N.
- Diabetologia, Vol. 48, Issue 11
Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes
journal, March 2016
- McLaughlin, Kerry A.; Richardson, Carolyn C.; Ravishankar, Aarthi
- Diabetes, Vol. 65, Issue 6
Islet Cell Surface Antibodies from Insulin-dependent Diabetics Bind Specifically to Pancreatic B Cells
journal, July 1982
- Van De Winkel, M.; Smets, G.; Gepts, W.
- Journal of Clinical Investigation, Vol. 70, Issue 1
Circulating Reg1α Proteins and Autoantibodies to Reg1α Proteins as Biomarkers of β-Cell Regeneration and Damage in Type 1 Diabetes
journal, October 2010
- Astorri, E.; Guglielmi, C.; Bombardieri, M.
- Hormone and Metabolic Research, Vol. 42, Issue 13
Pancreatic duodenal homeobox 1 protein is a novel β-cell-specific autoantigen for type I diabetes
journal, November 2009
- Li, Shi-Wu; Koya, Vijay; Li, Yi
- Laboratory Investigation, Vol. 90, Issue 1
Selective Autoantibody Production against CCL3 Is Associated with Human Type 1 Diabetes Mellitus and Serves As a Novel Biomarker for Its Diagnosis
journal, June 2009
- Shehadeh, Naim; Pollack, Shirly; Wildbaum, Gizi
- The Journal of Immunology, Vol. 182, Issue 12
Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes
journal, May 2010
- Fierabracci, Alessandra; Saura, Francesca
- Diabetes Research and Clinical Practice, Vol. 88, Issue 2
Amylase -2A Autoantibodies: Novel Marker of Autoimmune Pancreatitis and Fulminant Type 1 Diabetes
journal, November 2008
- Endo, T.; Takizawa, S.; Tanaka, S.
- Diabetes, Vol. 58, Issue 3
Autoantibodies to calcium channels in type 1 diabetes mediate autonomic dysfunction by different mechanisms in colon and bladder and are neutralized by antiidiotypic antibodies
journal, August 2008
- Wan, En-Chi; Gordon, Tom P.; Jackson, Michael W.
- Journal of Autoimmunity, Vol. 31, Issue 1
A novel impedance-based cellular assay for the detection of anti-calcium channel autoantibodies in type 1 diabetes
journal, September 2010
- Jackson, Michael W.; Gordon, Tom P.
- Journal of Immunological Methods, Vol. 361, Issue 1-2
Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus
journal, January 2010
- Park, Sang Gyu; Park, Ho Seon; Jeong, In-Kyong
- Biomarkers, Vol. 15, Issue 4
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.
journal, January 1992
- Kaufman, D. L.; Erlander, M. G.; Clare-Salzler, M.
- Journal of Clinical Investigation, Vol. 89, Issue 1
Molecular Cloning of Phogrin, a Protein-tyrosine Phosphatase Homologue Localized to Insulin Secretory Granule Membranes
journal, July 1996
- Wasmeier, Christina; Hutton, John C.
- Journal of Biological Chemistry, Vol. 271, Issue 30
Utilization of an intron located polyadenlyation site resulted in four novel glutamate decarboxylase transcripts
journal, August 2008
- Liu, Haixiong; Wang, Zhiqiang; Li, Shifeng
- Molecular Biology Reports, Vol. 36, Issue 6
Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen
journal, April 2001
- Diez, J.; Park, Y.; Zeller, M.
- Diabetes, Vol. 50, Issue 4
Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene With Diabetes
journal, February 2007
- Marchand, L.; Polychronakos, C.
- Diabetes, Vol. 56, Issue 3
Novel fusion proteins in the analysis of diabetes-associated autoantibodies to GAD65 and IA-2
journal, December 2000
- Zavialov, Anton; Ankelo, Matti; Westerlund-Karlsson, Annette
- Journal of Immunological Methods, Vol. 246, Issue 1-2
Novel Diabetes Autoantibodies and Prediction of Type 1 Diabetes
journal, July 2013
- Wenzlau, Janet M.; Hutton, John C.
- Current Diabetes Reports, Vol. 13, Issue 5
The Origin of Circulating Free DNA
journal, December 2007
- van der Vaart, Maniesh; Pretorius, Piet J.
- Clinical Chemistry, Vol. 53, Issue 12
Characterization of the release and biological significance of cell-free DNA from breast cancer cell lines
journal, May 2017
- Wang, Wei; Kong, Peng; Ma, Ge
- Oncotarget, Vol. 8, Issue 26
Nucleic acid biomarkers of β cell stress and death in type 1 diabetes
journal, January 2016
- Syed, Farooq; Evans-Molina, Carmella
- Current Opinion in Endocrinology & Diabetes and Obesity, Vol. 23, Issue 4
β Cell death and dysfunction during type 1 diabetes development in at-risk individuals
journal, February 2015
- Herold, Kevan C.; Usmani-Brown, Sahar; Ghazi, Tara
- Journal of Clinical Investigation, Vol. 125, Issue 3
Detection of cell death in diabetes using differentially methylated circulating DNA
journal, November 2011
- Akirav, E. M.; Lebastchi, J.; Galvan, E. M.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 47
Identification of tissue-specific cell death using methylation patterns of circulating DNA
journal, March 2016
- Lehmann-Werman, Roni; Neiman, Daniel; Zemmour, Hai
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 13
Analysis of β-Cell Death in Type 1 Diabetes by Droplet Digital PCR
journal, September 2014
- Usmani-Brown, Sahar; Lebastchi, Jasmin; Steck, Andrea K.
- Endocrinology, Vol. 155, Issue 9
Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes
journal, July 2015
- Fisher, Marisa M.; Watkins, Renecia A.; Blum, Janice
- Diabetes, Vol. 64, Issue 11
Immune Therapy and -Cell Death in Type 1 Diabetes
journal, February 2013
- Lebastchi, J.; Deng, S.; Lebastchi, A. H.
- Diabetes, Vol. 62, Issue 5
Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes
journal, April 2016
- Olsen, John A.; Kenna, Lauren A.; Spelios, Michael G.
- PLOS ONE, Vol. 11, Issue 4
Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility
journal, February 2014
- Kallionpaa, H.; Elo, L. L.; Laajala, E.
- Diabetes, Vol. 63, Issue 7
Risk of Type 1 Diabetes Progression in Islet Autoantibody-Positive Children Can Be Further Stratified Using Expression Patterns of Multiple Genes Implicated in Peripheral Blood Lymphocyte Activation and Function
journal, March 2014
- Jin, Y.; Sharma, A.; Bai, S.
- Diabetes, Vol. 63, Issue 7
A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
journal, February 2014
- Ferreira, R. C.; Guo, H.; Coulson, R. M. R.
- Diabetes, Vol. 63, Issue 7
Peripheral Blood Monocyte Gene Expression Profile Clinically Stratifies Patients With Recent-Onset Type 1 Diabetes
journal, March 2012
- Irvine, Katharine M.; Gallego, Patricia; An, Xiaoyu
- Diabetes, Vol. 61, Issue 5
MicroRNA expression profiles and type 1 diabetes mellitus: systematic review and bioinformatic analysis
journal, November 2017
- Assmann, Taís S.; Recamonde-Mendoza, Mariana; De Souza, Bianca M.
- Endocrine Connections, Vol. 6, Issue 8
Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study
journal, August 2016
- Seyhan, Attila A.; Nunez Lopez, Yury O.; Xie, Hui
- Scientific Reports, Vol. 6, Issue 1
Circulating miRNA Profiles in Patients with Metabolic Syndrome
journal, December 2012
- Karolina, Dwi Setyowati; Tavintharan, Subramaniam; Armugam, Arunmozhiarasi
- The Journal of Clinical Endocrinology & Metabolism, Vol. 97, Issue 12
miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development
journal, May 2015
- Latreille, Mathieu; Herrmanns, Karolin; Renwick, Neil
- Journal of Molecular Medicine, Vol. 93, Issue 10
miRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes
journal, January 2016
- Marchand, Lucien; Jalabert, Audrey; Meugnier, Emmanuelle
- Journal of Diabetes Research, Vol. 2016
Profiling of circulating microRNAs in children with recent onset of type 1 diabetes
journal, February 2017
- Erener, Suheda; Marwaha, Ashish; Tan, Rusung
- JCI Insight, Vol. 2, Issue 4
Diabetes-Associated MicroRNAs in Pediatric Patients With Type 1 Diabetes Mellitus: A Cross-Sectional Cohort Study
journal, September 2014
- Osipova, Julia; Fischer, Dagmar-Christiane; Dangwal, Seema
- The Journal of Clinical Endocrinology & Metabolism, Vol. 99, Issue 9
Circulating miR-375 as a Biomarker of β-Cell Death and Diabetes in Mice
journal, January 2013
- Erener, Suheda; Mojibian, Majid; Fox, Jessica K.
- Endocrinology, Vol. 154, Issue 2
The Association Between Circulating Levels of miRNA-181a and Pancreatic Beta Cells Dysfunction via SMAD7 in Type 1 Diabetic Children and Adolescents: miRNA-181a and Pancreatic Beta Cells Dysfunction
journal, February 2016
- Nabih, Enas Samir; Andrawes, Nevine Gamal
- Journal of Clinical Laboratory Analysis, Vol. 30, Issue 5
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
journal, May 2007
- Valadi, Hadi; Ekström, Karin; Bossios, Apostolos
- Nature Cell Biology, Vol. 9, Issue 6
Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes
journal, February 2018
- Lakhter, Alexander J.; Pratt, Rachel E.; Moore, Rachel E.
- Diabetologia, Vol. 61, Issue 5
Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes
journal, July 2017
- Garcia-Contreras, Marta; Shah, Sanket H.; Tamayo, Alejandro
- Scientific Reports, Vol. 7, Issue 1
Age- and Islet Autoimmunity–Associated Differences in Amino Acid and Lipid Metabolites in Children at Risk for Type 1 Diabetes
journal, October 2011
- Pflueger, Maren; Seppänen-Laakso, Tuulikki; Suortti, Tapani
- Diabetes, Vol. 60, Issue 11
Metabolic profiling of type 1 diabetes mellitus in children and adolescents: a case–control study
journal, June 2017
- Bervoets, Liene; Massa, Guy; Guedens, Wanda
- Diabetology & Metabolic Syndrome, Vol. 9, Issue 1
Metabolomics Makes a Mark: Early Changes Associated With Autoimmune Diabetes
journal, October 2011
- Leslie, R. David; Beyan, Huriya
- Diabetes, Vol. 60, Issue 11
Circulating sphingolipid biomarkers in models of type 1 diabetes
journal, March 2011
- Fox, Todd E.; Bewley, Maria C.; Unrath, Kellee A.
- Journal of Lipid Research, Vol. 52, Issue 3
Decreased Cord-Blood Phospholipids in Young Age-at-Onset Type 1 Diabetes
journal, August 2013
- La Torre, D.; Seppanen-Laakso, T.; Larsson, H. E.
- Diabetes, Vol. 62, Issue 11
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
journal, December 2008
- Orešič, Matej; Simell, Satu; Sysi-Aho, Marko
- Journal of Experimental Medicine, Vol. 205, Issue 13
Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes
journal, April 2013
- Orešič, Matej; Gopalacharyulu, Peddinti; Mykkänen, Juha
- Diabetes, Vol. 62, Issue 9
Advances in targeted proteomics and applications to biomedical research
journal, August 2016
- Shi, Tujin; Song, Ehwang; Nie, Song
- PROTEOMICS, Vol. 16, Issue 15-16
Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome
journal, August 2017
- Saeedi Borujeni, Mohammad Javad; Esfandiary, Ebrahim; Taheripak, Gholamreza
- Journal of Cellular Biochemistry, Vol. 119, Issue 2
Circulating Endothelial Microparticles in Diabetes Mellitus
journal, January 2010
- Tramontano, A. F.; Lyubarova, R.; Tsiakos, J.
- Mediators of Inflammation, Vol. 2010
Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles
journal, March 2018
- Lietz, Christopher B.; Toneff, Thomas; Mosier, Charles
- Journal of The American Society for Mass Spectrometry, Vol. 29, Issue 5
Impaired immune phenotype of circulating endothelial-derived microparticles in patients with metabolic syndrome and diabetes mellitus
journal, April 2015
- Berezin, A. E.; Kremzer, A. A.; Samura, T. A.
- Journal of Endocrinological Investigation, Vol. 38, Issue 8
Works referencing / citing this record:
Fetal malnutrition-induced catch up failure is caused by elevated levels of miR-322 in rats
journal, January 2020
- Nemoto, Takahiro; Kakinuma, Yoshihiko
- Scientific Reports, Vol. 10, Issue 1
The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes
journal, June 2019
- Nakayasu, Ernesto S.; Qian, Wei-Jun; Evans-Molina, Carmella
- Expert Review of Proteomics, Vol. 16, Issue 7
Fetal malnutrition-induced catch up failure is caused by elevated levels of miR-322 in rats
journal, January 2020
- Nemoto, Takahiro; Kakinuma, Yoshihiko
- Scientific Reports, Vol. 10, Issue 1