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Title: Surface-Mediated Hyperpolarization of Liquid Water from Parahydrogen

This paper reports the discovery of surface-mediated parahydrogen-induced alignment of the proton magnetic moments in liquid water as well as methanol and ethanol. In this SWAMP (surface waters are magnetized by parahydrogen) effect, the spin polarization of the solvent protons is enhanced simply by the bubbling of parahydrogen through a suspension of Pt 3Sn intermetallic nanoparticles (iNPs) encapsulated within a protectective mesoporous silica shell (Pt 3Sn@mSiO 2). The conversion of singlet spin order into magnetization is mediated by symmetry-breaking interactions on the surface of the iNPs. Stimulated emission NMR signals of the exchangeable hydroxy protons are observed. Non-exchangeable methyl or methylene protons are also hyperpolarized, an observation that provides insight into the molecular mechanism. Finally, SWAMP has a myriad of potential applications, ranging from low-field MRI to drug discovery.
Authors:
 [1] ;  [2] ;  [1] ;  [1] ;  [3] ;  [4] ;  [4] ;  [2] ; ORCiD logo [5] ;  [1]
  1. Univ. of Florida, Gainesville, FL (United States). Dept. of Chemistry
  2. Iowa State Univ., Ames, IA (United States). Dept. of Chemistry
  3. McKnight Brain Inst., Gainesville, FL (United States)
  4. Ames Lab., Ames, IA (United States)
  5. Iowa State Univ., Ames, IA (United States). Dept. of Chemistry; Ames Lab., Ames, IA (United States)
Publication Date:
Report Number(s):
IS-J-9724
Journal ID: ISSN 2451-9294; PII: S2451929418301177
Grant/Contract Number:
CHE-1507230; AC02-07CH11358
Type:
Accepted Manuscript
Journal Name:
Chem
Additional Journal Information:
Journal Volume: 4; Journal Issue: 6; Journal ID: ISSN 2451-9294
Publisher:
Cell Press, Elsevier
Research Org:
Ames Laboratory (AMES), Ames, IA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Pt3Sn; parahydrogen; PHIP; NMR; SWAMP; hyperpolarization; low-field MRI; hyperpolarized water; PASADENA effect; intermetallic nanoparticles
OSTI Identifier:
1464477

Zhao, Evan Wenbo, Maligal-Ganesh, Raghu, Du, Yong, Zhao, Tommy Yunpu, Collins, James, Ma, Tao, Zhou, Lin, Goh, Tian-Wei, Huang, Wenyu, and Bowers, Clifford R. Surface-Mediated Hyperpolarization of Liquid Water from Parahydrogen. United States: N. p., Web. doi:10.1016/j.chempr.2018.03.004.
Zhao, Evan Wenbo, Maligal-Ganesh, Raghu, Du, Yong, Zhao, Tommy Yunpu, Collins, James, Ma, Tao, Zhou, Lin, Goh, Tian-Wei, Huang, Wenyu, & Bowers, Clifford R. Surface-Mediated Hyperpolarization of Liquid Water from Parahydrogen. United States. doi:10.1016/j.chempr.2018.03.004.
Zhao, Evan Wenbo, Maligal-Ganesh, Raghu, Du, Yong, Zhao, Tommy Yunpu, Collins, James, Ma, Tao, Zhou, Lin, Goh, Tian-Wei, Huang, Wenyu, and Bowers, Clifford R. 2018. "Surface-Mediated Hyperpolarization of Liquid Water from Parahydrogen". United States. doi:10.1016/j.chempr.2018.03.004. https://www.osti.gov/servlets/purl/1464477.
@article{osti_1464477,
title = {Surface-Mediated Hyperpolarization of Liquid Water from Parahydrogen},
author = {Zhao, Evan Wenbo and Maligal-Ganesh, Raghu and Du, Yong and Zhao, Tommy Yunpu and Collins, James and Ma, Tao and Zhou, Lin and Goh, Tian-Wei and Huang, Wenyu and Bowers, Clifford R.},
abstractNote = {This paper reports the discovery of surface-mediated parahydrogen-induced alignment of the proton magnetic moments in liquid water as well as methanol and ethanol. In this SWAMP (surface waters are magnetized by parahydrogen) effect, the spin polarization of the solvent protons is enhanced simply by the bubbling of parahydrogen through a suspension of Pt3Sn intermetallic nanoparticles (iNPs) encapsulated within a protectective mesoporous silica shell (Pt3Sn@mSiO2). The conversion of singlet spin order into magnetization is mediated by symmetry-breaking interactions on the surface of the iNPs. Stimulated emission NMR signals of the exchangeable hydroxy protons are observed. Non-exchangeable methyl or methylene protons are also hyperpolarized, an observation that provides insight into the molecular mechanism. Finally, SWAMP has a myriad of potential applications, ranging from low-field MRI to drug discovery.},
doi = {10.1016/j.chempr.2018.03.004},
journal = {Chem},
number = 6,
volume = 4,
place = {United States},
year = {2018},
month = {4}
}