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Title: Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools

Abstract

We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements. The UCNPs maintain photoluminescent properties even when embedded with the MNPs into the polymer bead. Moreover, the light emitted by the magnetic and upconverting nanobeads (MUCNBs) under NIR excitation (λexc = 980 nm) was clearly observed through different thicknesses of agarose gel or through a mouse skin layer. The comparison with magnetic and luminescent nanobeads based on red-emitting quantum dots (QDs) demonstrated that while the QD-based beads show significant autofluorescence background from the skin, the signal obtained by the MUCNBs allows a decrease in this background. In summary, these results indicate that MUCNBs are good magnetic and optical probes for in vivo multimodal imaging sensors.

Authors:
 [1];  [2];  [1];  [1];  [1];  [3]; ORCiD logo [4];  [4]; ORCiD logo [1]
  1. Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
  2. Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy, BIONAND, Andalusian Centre for Nanomedicine and Biotechnology (Junta de Andalucía-Universidad de Málaga), 29590 Málaga, Spain
  3. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology (Junta de Andalucía-Universidad de Málaga), 29590 Málaga, Spain
  4. The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1464277
Alternate Identifier(s):
OSTI ID: 1507995
Grant/Contract Number:  
[AC02-05CH11231]
Resource Type:
Published Article
Journal Name:
Bioconjugate Chemistry
Additional Journal Information:
[Journal Name: Bioconjugate Chemistry Journal Volume: 28 Journal Issue: 11]; Journal ID: ISSN 1043-1802
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., and Pellegrino, Teresa. Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools. United States: N. p., 2017. Web. doi:10.1021/acs.bioconjchem.7b00432.
Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., & Pellegrino, Teresa. Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools. United States. doi:10.1021/acs.bioconjchem.7b00432.
Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., and Pellegrino, Teresa. Mon . "Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools". United States. doi:10.1021/acs.bioconjchem.7b00432.
@article{osti_1464277,
title = {Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools},
author = {Materia, Maria Elena and Pernia Leal, Manuel and Scotto, Marco and Balakrishnan, Preethi Bala and Kumar Avugadda, Sahitya and García-Martín, María L. and Cohen, Bruce E. and Chan, Emory M. and Pellegrino, Teresa},
abstractNote = {We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements. The UCNPs maintain photoluminescent properties even when embedded with the MNPs into the polymer bead. Moreover, the light emitted by the magnetic and upconverting nanobeads (MUCNBs) under NIR excitation (λexc = 980 nm) was clearly observed through different thicknesses of agarose gel or through a mouse skin layer. The comparison with magnetic and luminescent nanobeads based on red-emitting quantum dots (QDs) demonstrated that while the QD-based beads show significant autofluorescence background from the skin, the signal obtained by the MUCNBs allows a decrease in this background. In summary, these results indicate that MUCNBs are good magnetic and optical probes for in vivo multimodal imaging sensors.},
doi = {10.1021/acs.bioconjchem.7b00432},
journal = {Bioconjugate Chemistry},
number = [11],
volume = [28],
place = {United States},
year = {2017},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1021/acs.bioconjchem.7b00432

Citation Metrics:
Cited by: 4 works
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Figures / Tables:

Figure 1 Figure 1: Scheme for synthesis of MUCNBs (A); TEM images of 23 nm UCNPs (B), 15 nm IONPs (C), 6 nm UCNPs (D), and MUCNBs with 15 nm IONPs and 23 nm UCNPs (E) or 6 nm UCNPs (F).

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Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.