Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
Abstract
We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements. The UCNPs maintain photoluminescent properties even when embedded with the MNPs into the polymer bead. Moreover, the light emitted by the magnetic and upconverting nanobeads (MUCNBs) under NIR excitation (λexc = 980 nm) was clearly observed through different thicknesses of agarose gel or through a mouse skin layer. The comparison with magnetic and luminescent nanobeads based on red-emitting quantum dots (QDs) demonstrated that while the QD-based beads show significant autofluorescence background from the skin, the signal obtained by the MUCNBs allows a decrease in this background. In summary, these results indicate that MUCNBs are good magnetic and optical probes for in vivo multimodal imaging sensors.
- Authors:
-
- Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
- Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy, BIONAND, Andalusian Centre for Nanomedicine and Biotechnology (Junta de Andalucía-Universidad de Málaga), 29590 Málaga, Spain
- BIONAND, Andalusian Centre for Nanomedicine and Biotechnology (Junta de Andalucía-Universidad de Málaga), 29590 Málaga, Spain
- The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1464277
- Alternate Identifier(s):
- OSTI ID: 1507995; OSTI ID: 1630602
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Published Article
- Journal Name:
- Bioconjugate Chemistry
- Additional Journal Information:
- Journal Name: Bioconjugate Chemistry Journal Volume: 28 Journal Issue: 11; Journal ID: ISSN 1043-1802
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., and Pellegrino, Teresa. Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools. United States: N. p., 2017.
Web. doi:10.1021/acs.bioconjchem.7b00432.
Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., & Pellegrino, Teresa. Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools. United States. https://doi.org/10.1021/acs.bioconjchem.7b00432
Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., and Pellegrino, Teresa. Mon .
"Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools". United States. https://doi.org/10.1021/acs.bioconjchem.7b00432.
@article{osti_1464277,
title = {Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools},
author = {Materia, Maria Elena and Pernia Leal, Manuel and Scotto, Marco and Balakrishnan, Preethi Bala and Kumar Avugadda, Sahitya and García-Martín, María L. and Cohen, Bruce E. and Chan, Emory M. and Pellegrino, Teresa},
abstractNote = {We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements. The UCNPs maintain photoluminescent properties even when embedded with the MNPs into the polymer bead. Moreover, the light emitted by the magnetic and upconverting nanobeads (MUCNBs) under NIR excitation (λexc = 980 nm) was clearly observed through different thicknesses of agarose gel or through a mouse skin layer. The comparison with magnetic and luminescent nanobeads based on red-emitting quantum dots (QDs) demonstrated that while the QD-based beads show significant autofluorescence background from the skin, the signal obtained by the MUCNBs allows a decrease in this background. In summary, these results indicate that MUCNBs are good magnetic and optical probes for in vivo multimodal imaging sensors.},
doi = {10.1021/acs.bioconjchem.7b00432},
journal = {Bioconjugate Chemistry},
number = 11,
volume = 28,
place = {United States},
year = {Mon Sep 25 00:00:00 EDT 2017},
month = {Mon Sep 25 00:00:00 EDT 2017}
}
https://doi.org/10.1021/acs.bioconjchem.7b00432
Web of Science
Figures / Tables:
Works referencing / citing this record:
A water-soluble, upconverting Sr 2 Yb 0.3 Gd 0.7 F 7 :Er 3+ /Tm 3+ @PSI oAm bio-probe for in vivo trimodality imaging
journal, January 2018
- Xiang, Li-Jun; Zhu, Xiao-Jiao; Zhang, Hui-Hui
- Nanoscale, Vol. 10, Issue 30
Figures / Tables found in this record: