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Title: Perspectives on the basic and applied aspects of crassulacean acid metabolism (CAM) research

Abstract

Here, due to public concerns about the decreasing supply of blue water and increasing heat and drought stress on plant growth caused by urbanization, increasing human population and climate change, interest in crassulacean acid metabolism (CAM), a specialized type of photosynthesis enhancing water-use efficiency (WUE) and drought tolerance, has increased markedly. Significant progress has been achieved in both basic and applied research in CAM plants since the beginning of this century. Here we provide a brief overview of the current status of CAM research, and discuss future needs and opportunities in a wide range of areas including systems biology, synthetic biology, and utilization of CAM crops for human benefit, with a focus on the following aspects: application of genome-editing technology and high-throughput phenotyping to functional genomics research in model CAM species and genetic improvement of CAM crops, challenges for multi-scale metabolic modeling of CAM systems, opportunities and new strategies for CAM pathway engineering to enhance WUE and drought tolerance in C3 (and C4) photosynthesis crops, potential of CAM species as resources for food, feed, natural products, pharmaceuticals and biofuels, and development of CAM crops for ecological and aesthetic benefits.

Authors:
ORCiD logo [1];  [2]; ORCiD logo [1];  [2];  [3];  [4]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1];  [5];  [6]; ORCiD logo [1]; ORCiD logo [2]
+ Show Author Affiliations
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
  3. Univ. of Tennessee, Knoxville, TN (United States)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Southwest Univ. of Science and Technology, Sichuan (China)
  5. Univ. of Nevada, Reno, NV (United States)
  6. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Newcastle Univ., Newcastle upon Tyne (United Kingdom)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI Identifier:
1464013
Alternate Identifier(s):
OSTI ID: 1582986
Grant/Contract Number:  
AC05-00OR22725; SC0008834
Resource Type:
Accepted Manuscript
Journal Name:
Plant Science
Additional Journal Information:
Journal Volume: 274; Journal Issue: C; Journal ID: ISSN 0168-9452
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Crassulacean acid metabolism; Genome editing; Metabolic modeling; Synthetic biology; Water-use efficiency; Natural products

Citation Formats

Liu, Degao, Palla, Kaitlin J., Hu, Rongbin, Moseley, Robert C., Mendoza, Christopher, Chen, Mei, Abraham, Paul E., Labbe, Jessy L., Kalluri, Udaya C., Tschaplinski, Timothy J., Cushman, John C., Borland, Anne M., Tuskan, Gerald A., and Yang, Xiaohan. Perspectives on the basic and applied aspects of crassulacean acid metabolism (CAM) research. United States: N. p., 2018. Web. doi:10.1016/j.plantsci.2018.06.012.
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Liu, Degao, Palla, Kaitlin J., Hu, Rongbin, Moseley, Robert C., Mendoza, Christopher, Chen, Mei, Abraham, Paul E., Labbe, Jessy L., Kalluri, Udaya C., Tschaplinski, Timothy J., Cushman, John C., Borland, Anne M., Tuskan, Gerald A., & Yang, Xiaohan. Perspectives on the basic and applied aspects of crassulacean acid metabolism (CAM) research. United States. doi:10.1016/j.plantsci.2018.06.012.
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Liu, Degao, Palla, Kaitlin J., Hu, Rongbin, Moseley, Robert C., Mendoza, Christopher, Chen, Mei, Abraham, Paul E., Labbe, Jessy L., Kalluri, Udaya C., Tschaplinski, Timothy J., Cushman, John C., Borland, Anne M., Tuskan, Gerald A., and Yang, Xiaohan. Tue . "Perspectives on the basic and applied aspects of crassulacean acid metabolism (CAM) research". United States. doi:10.1016/j.plantsci.2018.06.012. https://www.osti.gov/servlets/purl/1464013.
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@article{osti_1464013,
title = {Perspectives on the basic and applied aspects of crassulacean acid metabolism (CAM) research},
author = {Liu, Degao and Palla, Kaitlin J. and Hu, Rongbin and Moseley, Robert C. and Mendoza, Christopher and Chen, Mei and Abraham, Paul E. and Labbe, Jessy L. and Kalluri, Udaya C. and Tschaplinski, Timothy J. and Cushman, John C. and Borland, Anne M. and Tuskan, Gerald A. and Yang, Xiaohan},
abstractNote = {Here, due to public concerns about the decreasing supply of blue water and increasing heat and drought stress on plant growth caused by urbanization, increasing human population and climate change, interest in crassulacean acid metabolism (CAM), a specialized type of photosynthesis enhancing water-use efficiency (WUE) and drought tolerance, has increased markedly. Significant progress has been achieved in both basic and applied research in CAM plants since the beginning of this century. Here we provide a brief overview of the current status of CAM research, and discuss future needs and opportunities in a wide range of areas including systems biology, synthetic biology, and utilization of CAM crops for human benefit, with a focus on the following aspects: application of genome-editing technology and high-throughput phenotyping to functional genomics research in model CAM species and genetic improvement of CAM crops, challenges for multi-scale metabolic modeling of CAM systems, opportunities and new strategies for CAM pathway engineering to enhance WUE and drought tolerance in C3 (and C4) photosynthesis crops, potential of CAM species as resources for food, feed, natural products, pharmaceuticals and biofuels, and development of CAM crops for ecological and aesthetic benefits.},
doi = {10.1016/j.plantsci.2018.06.012},
journal = {Plant Science},
number = C,
volume = 274,
place = {United States},
year = {2018},
month = {6}
}
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Journal Article:
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Publisher's Version of Record
DOI:  10.1016/j.plantsci.2018.06.012
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Cited by: 3 works
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Figures / Tables:

Table 1 Table 1: Natural products from economically representative CAM crops and their applications.
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Works referencing / citing this record:

CRISPR/Cas9-mediated targeted mutagenesis for functional genomics research of crassulacean acid metabolism plants
journal, September 2019

  • Liu, Degao; Chen, Mei; Mendoza, Brian
  • Journal of Experimental Botany, Vol. 70, Issue 22
  • DOI: 10.1093/jxb/erz415

CRISPR/Cas9-mediated targeted mutagenesis for functional genomics research of crassulacean acid metabolism plants
journal, September 2019

  • Liu, Degao; Chen, Mei; Mendoza, Brian
  • Journal of Experimental Botany, Vol. 70, Issue 22
  • DOI: 10.1093/jxb/erz415

Undervalued potential of crassulacean acid metabolism for current and future agricultural production
journal, June 2019

  • Davis, Sarah C.; Simpson, June; Gil-Vega, Katia del Carmen
  • Journal of Experimental Botany, Vol. 70, Issue 22
  • DOI: 10.1093/jxb/erz223

Comparative genomics can provide new insights into the evolutionary mechanisms and gene function in CAM plants
journal, September 2019

  • Yang, Xiaohan; Liu, Degao; Tschaplinski, Timothy J.
  • Journal of Experimental Botany, Vol. 70, Issue 22
  • DOI: 10.1093/jxb/erz408

CAM plasticity in epiphytic tropical orchid species responding to environmental stress
journal, May 2019

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