skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Visualization of 3-Dimensional Vectors in a Dynamic Embryonic System—WormGUIDES

Abstract

WormGUIDES is an open-source dynamic embryonic system designed to facilitate global understanding of cellular decisions in the developing nervous system of the nematode C. elegans. WormGUIDES was designed to allow investigation and exploration of the observational results of the C. elegans life cycle from laboratory experiments. In the process of a mechanistic C. elegans model development, some functionalities of WormGUIDES needed to be enhanced to support model validation and verification. Here in this study, a new way to visualize 3-dimentional vectors within WormGUIDES was investigated and presented. Then, the practical values of this method were demonstrated by visualizing two biologically significant directions (i.e., division orientation and cell polarity) of individual embryonic cells in C. elegans. Lastly, a mathematic approach was designed to illustrate the differences between these two sets of vectors and provide easy indications of the location of these individual cells that have large data discrepancies within the C. elegans embryonic system.

Authors:
ORCiD logo [1];  [2];  [3];  [4];  [2]
  1. Univ. of Tennessee, Knoxville, TN (United States). Dept. of Electric Engineering and Computer Science; Farragut High School, Knoxville, TN (United States). Coding Club
  2. Memorial Sloan Kettering Cancer Center, New York, NY (United States). Developmental Biology Program
  3. Univ. of Tennessee, Knoxville, TN (United States). Dept. of Electric Engineering and Computer Science
  4. Univ. of Tennessee, Knoxville, TN (United States). Dept. of Electric Engineering and Computer Science; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Environmental Science Division
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1463977
Grant/Contract Number:  
[AC05-00OR22725; R01GM097576; 2R01GM097576; P30CA008748]
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Computer and Communications
Additional Journal Information:
[ Journal Volume: 5; Journal Issue: 12]; Journal ID: ISSN 2327-5219
Publisher:
Scientific Research Publishing, Inc.
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 97 MATHEMATICS AND COMPUTING; Embryonic Data Visualization; WormGUIDES; Workflow; Software Architecture; Division Orientation; Cell Polarity; C. elegans

Citation Formats

Wang, Eric, Santella, Anthony, Wang, Zi, Wang, Dali, and Bao, Zhirong. Visualization of 3-Dimensional Vectors in a Dynamic Embryonic System—WormGUIDES. United States: N. p., 2017. Web. doi:10.4236/jcc.2017.512008.
Wang, Eric, Santella, Anthony, Wang, Zi, Wang, Dali, & Bao, Zhirong. Visualization of 3-Dimensional Vectors in a Dynamic Embryonic System—WormGUIDES. United States. doi:10.4236/jcc.2017.512008.
Wang, Eric, Santella, Anthony, Wang, Zi, Wang, Dali, and Bao, Zhirong. Mon . "Visualization of 3-Dimensional Vectors in a Dynamic Embryonic System—WormGUIDES". United States. doi:10.4236/jcc.2017.512008. https://www.osti.gov/servlets/purl/1463977.
@article{osti_1463977,
title = {Visualization of 3-Dimensional Vectors in a Dynamic Embryonic System—WormGUIDES},
author = {Wang, Eric and Santella, Anthony and Wang, Zi and Wang, Dali and Bao, Zhirong},
abstractNote = {WormGUIDES is an open-source dynamic embryonic system designed to facilitate global understanding of cellular decisions in the developing nervous system of the nematode C. elegans. WormGUIDES was designed to allow investigation and exploration of the observational results of the C. elegans life cycle from laboratory experiments. In the process of a mechanistic C. elegans model development, some functionalities of WormGUIDES needed to be enhanced to support model validation and verification. Here in this study, a new way to visualize 3-dimentional vectors within WormGUIDES was investigated and presented. Then, the practical values of this method were demonstrated by visualizing two biologically significant directions (i.e., division orientation and cell polarity) of individual embryonic cells in C. elegans. Lastly, a mathematic approach was designed to illustrate the differences between these two sets of vectors and provide easy indications of the location of these individual cells that have large data discrepancies within the C. elegans embryonic system.},
doi = {10.4236/jcc.2017.512008},
journal = {Journal of Computer and Communications},
number = [12],
volume = [5],
place = {United States},
year = {2017},
month = {10}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Save / Share: