Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension

Shaffi, Saeed; Galas, David; Etheridge, Alton; Argyropoulos, Christos

doi:10.3390/ijms19061797

Title: Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension

Journal Article · 17 June 2018 · International Journal of Molecular Sciences (Online)

DOI: https://doi.org/10.3390/ijms19061797 · OSTI ID:1463343

Shaffi, Saeed ^[1]; Galas, David ^[2]; Etheridge, Alton ^[2]; Argyropoulos, Christos ^[1]

Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Internal Medicine. Division of Nephrology
Pacific Northwest Research Inst., Seattle, WA (United States)

Since their discovery in 1993, numerous microRNAs (miRNAs) have been identified in humans and other eukaryotic organisms, and their role as key regulators of gene expression is still being elucidated. It is now known that miRNAs not only play a central role in the processes that ensure normal development and physiology, but they are often dysregulated in various diseases. In this review, we present an overview of the role of miRNAs in normal renal development and physiology, in maladaptive renal repair after injury, and in the pathogenesis of renal parenchymal diseases. In addition, we describe methods used for their detection and their potential as therapeutic targets. Continued research on renal miRNAs will undoubtedly improve our understanding of diseases affecting the kidneys and may also lead to new therapeutic agents.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Pacific Northwest Research Inst., Seattle, WA (United States); Univ. of New Mexico, Albuquerque, NM (United States)

Sponsoring Organization:: Dialysis Clinic Inc. (DCI) (United States); National Inst. of Health (NIH) (United States); USDOE

OSTI ID:: 1463343

Journal Information:: International Journal of Molecular Sciences (Online), Journal Name: International Journal of Molecular Sciences (Online) Journal Issue: 6 Vol. 19; ISSN 1422-0067

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

References (211)

Regulation of primary microRNA processing Creugny, Antoine; Fender, Aurélie; Pfeffer, Sébastien FEBS Letters, Vol. 592, Issue 12 https://doi.org/10.1002/1873-3468.13067	journal	May 2018
MicroRNA-29, a key regulator of collagen expression in systemic sclerosis Maurer, Britta; Stanczyk, Joanna; Jüngel, Astrid Arthritis & Rheumatism, Vol. 62, Issue 6 https://doi.org/10.1002/art.27443	journal	March 2010
Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192 Sun, Lin; Zhang, Dongshan; Liu, Fuyou The Journal of Pathology, Vol. 225, Issue 3 https://doi.org/10.1002/path.2961	journal	August 2011
BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization: BDNF repairs podocyte damage Li, Min; Armelloni, Silvia; Zennaro, Cristina The Journal of Pathology, Vol. 235, Issue 5 https://doi.org/10.1002/path.4484	journal	January 2015
Recent progress toward the use of circulating microRNAs as clinical biomarkers Ghai, Vikas; Wang, Kai Archives of Toxicology, Vol. 90, Issue 12 https://doi.org/10.1007/s00204-016-1828-2	journal	September 2016
Diversity of Microbial Functional Genes Should Be Considered During the Interpretation of the qPCR Melting Curves Almendras, Katerin; Iannuzzi, Stefania; Carú, Margarita Microbial Ecology, Vol. 84, Issue 3 https://doi.org/10.1007/s00248-021-01883-9	journal	October 2021
MicroRNA Expression Abnormalities in Limited Cutaneous Scleroderma and Diffuse Cutaneous Scleroderma Zhu, Honglin; Li, Yisha; Qu, Shunlin Journal of Clinical Immunology, Vol. 32, Issue 3 https://doi.org/10.1007/s10875-011-9647-y	journal	February 2012
MicroRNA-21 in Scleroderma Fibrosis and its Function in TGF-β- Regulated Fibrosis-Related Genes Expression Zhu, Honglin; Luo, Hui; Li, Yisha Journal of Clinical Immunology, Vol. 33, Issue 6 https://doi.org/10.1007/s10875-013-9896-z	journal	May 2013
Essential Role of TGF-β Signaling in Glucose-Induced Cell Hypertrophy Wu, Liyu; Derynck, Rik Developmental Cell, Vol. 17, Issue 1 https://doi.org/10.1016/j.devcel.2009.05.010	journal	July 2009
MicroRNA biomarkers in clinical renal disease: from diabetic nephropathy renal transplantation and beyond Nassirpour, Rounak; Raj, Dominic; Townsend, Raymond Food and Chemical Toxicology, Vol. 98 https://doi.org/10.1016/j.fct.2016.02.018	journal	December 2016
MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development O'Connell, Ryan M.; Kahn, Daniel; Gibson, William S. J. Immunity, Vol. 33, Issue 4 https://doi.org/10.1016/j.immuni.2010.09.009	journal	October 2010
Hematopoietic-specific microRNA expression in human cells Ramkissoon, Shakti H.; Mainwaring, Lori A.; Ogasawara, Yoji Leukemia Research, Vol. 30, Issue 5 https://doi.org/10.1016/j.leukres.2005.09.001	journal	May 2006
Is IgA nephropathy induced by abnormalities of CD4+CD25+Treg cells in the tonsils? Huang, Hongdong; Peng, Youming; Liu, Fuyou Medical Hypotheses, Vol. 69, Issue 2 https://doi.org/10.1016/j.mehy.2006.11.050	journal	January 2007
TGF-β in Renal Injury and Disease Böttinger, Erwin P. Seminars in Nephrology, Vol. 27, Issue 3 https://doi.org/10.1016/j.semnephrol.2007.02.009	journal	May 2007
Recent advances involving the renin–angiotensin system Crowley, Steven D.; Coffman, Thomas M. Experimental Cell Research, Vol. 318, Issue 9 https://doi.org/10.1016/j.yexcr.2012.02.023	journal	May 2012
Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin–angiotensin system Kemp, Jacqueline R.; Unal, Hamiyet; Desnoyer, Russell Journal of Molecular and Cellular Cardiology, Vol. 75 https://doi.org/10.1016/j.yjmcc.2014.06.008	journal	October 2014
Intrarenal Expression of miRNAs in Patients With Hypertensive Nephrosclerosis Wang, G.; Kwan, B. C. -H.; Lai, F. M. -M. American Journal of Hypertension, Vol. 23, Issue 1 https://doi.org/10.1038/ajh.2009.208	journal	January 2010
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease Mogilyansky, E.; Rigoutsos, I. Cell Death & Differentiation, Vol. 20, Issue 12 https://doi.org/10.1038/cdd.2013.125	journal	November 2013
Claudin-14 regulates renal Ca ⁺⁺ transport in response to CaSR signalling via a novel microRNA pathway : Claudin-14 function and regulation Gong, Yongfeng; Renigunta, Vijayaram; Himmerkus, Nina The EMBO Journal, Vol. 31, Issue 8 https://doi.org/10.1038/emboj.2012.49	journal	February 2012
Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney Nagalakshmi, Vidya K.; Ren, Qun; Pugh, Margaret M. Kidney International, Vol. 79, Issue 3 https://doi.org/10.1038/ki.2010.385	journal	February 2011
The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy Zhdanova, Olga; Srivastava, Shekhar; Di, Lie Kidney International, Vol. 80, Issue 7 https://doi.org/10.1038/ki.2011.122	journal	October 2011
A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells Kato, Mitsuo; Arce, Laura; Wang, Mei Kidney International, Vol. 80, Issue 4 https://doi.org/10.1038/ki.2011.43	journal	August 2011
Origin and function of myofibroblasts in kidney fibrosis LeBleu, Valerie S.; Taduri, Gangadhar; O'Connell, Joyce Nature Medicine, Vol. 19, Issue 8 https://doi.org/10.1038/nm.3218	journal	June 2013
Limitations and possibilities of small RNA digital gene expression profiling Linsen, Sam E. V.; de Wit, Elzo; Janssens, Georges Nature Methods, Vol. 6, Issue 7 https://doi.org/10.1038/nmeth0709-474	journal	July 2009
Regulation of microRNA biogenesis Ha, Minju; Kim, V. Narry Nature Reviews Molecular Cell Biology, Vol. 15, Issue 8 https://doi.org/10.1038/nrm3838	journal	July 2014
MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells Cerna, Katerina; Oppelt, Jan; Chochola, Vaclav Leukemia, Vol. 33, Issue 2 https://doi.org/10.1038/s41375-018-0230-x	journal	August 2018
Hypertension and the heart Schmieder, Re; Messerli, Fh Journal of Human Hypertension, Vol. 14, Issue 10-11 https://doi.org/10.1038/sj.jhh.1001044	journal	October 2000
Plasma MicroRNA-186 and Proteinuria in Focal Segmental Glomerulosclerosis Zhang, Changming; Zhang, Wanfen; Chen, Hui-Mei American Journal of Kidney Diseases, Vol. 65, Issue 2 https://doi.org/10.1053/j.ajkd.2014.07.013	journal	February 2015
Role of Transforming Growth Factor β in Human Disease Blobe, Gerard C.; Schiemann, William P.; Lodish, Harvey F. New England Journal of Medicine, Vol. 342, Issue 18 https://doi.org/10.1056/nejm200005043421807	journal	May 2000
MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors Kato, M.; Zhang, J.; Wang, M. Proceedings of the National Academy of Sciences, Vol. 104, Issue 9 https://doi.org/10.1073/pnas.0611192104	journal	February 2007
Post-transcriptional Up-regulation of Tsc-22 by Ybx1, a Target of miR-216a, Mediates TGF-β-induced Collagen Expression in Kidney Cells Kato, Mitsuo; Wang, Lin; Putta, Sumanth Journal of Biological Chemistry, Vol. 285, Issue 44 https://doi.org/10.1074/jbc.m110.165027	journal	August 2010
MicroRNA-29c Is a Signature MicroRNA under High Glucose Conditions That Targets Sprouty Homolog 1, and Its in Vivo Knockdown Prevents Progression of Diabetic Nephropathy Long, Jianyin; Wang, Yin; Wang, Wenjian Journal of Biological Chemistry, Vol. 286, Issue 13 https://doi.org/10.1074/jbc.m110.194969	journal	February 2011
Logic and Extent of miRNA-Mediated Control of Autoimmune Gene Expression Vinuesa, Carola G.; Rigby, Robert J.; Yu, Di International Reviews of Immunology, Vol. 28, Issue 3-4 https://doi.org/10.1080/08830180902934909	journal	January 2009
Nephrotoxic Nephritis and Glomerulonephritis: Animal Model Versus Human Disease Muhammad, S. British Journal of Biomedical Science, Vol. 71, Issue 4 https://doi.org/10.1080/09674845.2014.11669982	journal	January 2014
Experimental Glomerulonephritis Unanue, Emil R.; Dixon, Frank J. Journal of Experimental Medicine, Vol. 121, Issue 5 https://doi.org/10.1084/jem.121.5.715	journal	May 1965
Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors Herrera-Carrillo, Elena; Liu, Ying Poi; Berkhout, Ben Human Gene Therapy Methods, Vol. 28, Issue 4 https://doi.org/10.1089/hgtb.2017.036	journal	August 2017
Epstein–Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway Gatto, Graziana; Rossi, Annalisa; Rossi, Daniela Nucleic Acids Research, Vol. 36, Issue 20 https://doi.org/10.1093/nar/gkn666	journal	October 2008
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo Minakuchi, Y. Nucleic Acids Research, Vol. 32, Issue 13 https://doi.org/10.1093/nar/gnh093	journal	July 2004
Role of let-7b in the regulation of N -acetylgalactosaminyltransferase 2 in IgA nephropathy Serino, Grazia; Sallustio, Fabio; Curci, Claudia Nephrology Dialysis Transplantation, Vol. 30, Issue 7 https://doi.org/10.1093/ndt/gfv032	journal	March 2015
MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy Wang, Qiang; Wang, Youli; Minto, Andrew W. The FASEB Journal, Vol. 22, Issue 12 https://doi.org/10.1096/fj.08-112326	journal	December 2008
Blood Pressure as a Cardiovascular Risk Factor Kannel, W. B. Survey of Anesthesiology, Vol. XLI, Issue 3 https://doi.org/10.1097/00132586-199706000-00058	journal	June 1997
Blood pressure levels and brain volume reduction: a systematic review and meta-analysis Beauchet, Olivier; Celle, Sébastien; Roche, Frédéric Journal of Hypertension, Vol. 31, Issue 8 https://doi.org/10.1097/hjh.0b013e32836184b5	journal	January 2013
High-Throughput Selection of Effective RNAi Probes for Gene Silencing Kumar, R. Genome Research, Vol. 13, Issue 10 https://doi.org/10.1101/gr.1575003	journal	October 2003
Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies Law, M. R.; Morris, J. K.; Wald, N. J. BMJ, Vol. 338, Issue may19 1 https://doi.org/10.1136/bmj.b1665	journal	May 2009
Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13 ^BN congenic strains Moreno, Carol; Williams, Jan M.; Lu, Limin American Journal of Physiology-Heart and Circulatory Physiology, Vol. 300, Issue 4 https://doi.org/10.1152/ajpheart.01026.2010	journal	April 2011
Elevated Levels of miR-146a and miR-155 in Kidney Biopsy and Urine from Patients with IgA Nephropathy Wang, Gang; Kwan, Bonnie Ching-Ha; Lai, Fernand Mac-Moune Disease Markers, Vol. 30, Issue 4 https://doi.org/10.1155/2011/304852	journal	January 2011
Protection of Human Umbilical Vein Endothelial Cells against Oxidative Stress by MicroRNA-210 Li, Tianyi; Song, Xianjing; Zhang, Jichang Oxidative Medicine and Cellular Longevity, Vol. 2017 https://doi.org/10.1155/2017/3565613	journal	January 2017
A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics Takei, Yoshifumi; Kadomatsu, Kenji; Yuzawa, Yukio Cancer Research, Vol. 64, Issue 10 https://doi.org/10.1158/0008-5472.can-03-2682	journal	May 2004
Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma Hu-Lieskovan, Siwen; Heidel, Jeremy D.; Bartlett, Derek W. Cancer Research, Vol. 65, Issue 19 https://doi.org/10.1158/0008-5472.can-05-0565	journal	October 2005
Signaling-Mediated Regulation of MicroRNA Processing Shen, J.; Hung, M. -C. Cancer Research, Vol. 75, Issue 5 https://doi.org/10.1158/0008-5472.can-14-2568	journal	February 2015
Molecular and Cell Biology of TGF-β Roberts, Anita B. Mineral and Electrolyte Metabolism, Vol. 24, Issue 2-3 https://doi.org/10.1159/000057358	journal	January 1998
Nitric Oxide and Its Putative Role in Hypertension Dominiczak, Anna F.; Bohr, David F. Hypertension, Vol. 25, Issue 6 https://doi.org/10.1161/01.hyp.25.6.1202	journal	June 1995
Renal Medullary MicroRNAs in Dahl Salt-Sensitive Rats: miR-29b Regulates Several Collagens and Related Genes Liu, Yong; Taylor, Norman E.; Lu, Limin Hypertension, Vol. 55, Issue 4 https://doi.org/10.1161/hypertensionaha.109.144428	journal	April 2010
Gene Expression Profiling Reveals Renin mRNA Overexpression in Human Hypertensive Kidneys and a Role for MicroRNAs Marques, Francine Z.; Campain, Anna E.; Tomaszewski, Maciej Hypertension, Vol. 58, Issue 6 https://doi.org/10.1161/hypertensionaha.111.180729	journal	December 2011
One miR Level of Control Shi, Lei; Fleming, Ingrid Hypertension, Vol. 60, Issue 6 https://doi.org/10.1161/hypertensionaha.112.203497	journal	December 2012
A Novel Interaction Between Sympathetic Overactivity and Aberrant Regulation of Renin by miR-181a in BPH/2J Genetically Hypertensive Mice Jackson, Kristy L.; Marques, Francine Z.; Watson, Anna M. D. Hypertension, Vol. 62, Issue 4 https://doi.org/10.1161/hypertensionaha.113.01701	journal	October 2013
Nonviral delivery of synthetic siRNAs in vivo Akhtar, Saghir; Benter, Ibrahim F. Journal of Clinical Investigation, Vol. 117, Issue 12 https://doi.org/10.1172/jci33494	journal	December 2007
MicroRNA-modulated targeting of vascular smooth muscle cells Parmacek, Michael S. Journal of Clinical Investigation, Vol. 119, Issue 9 https://doi.org/10.1172/jci40503	journal	September 2009
Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways Gomez, Ivan G.; MacKenna, Deidre A.; Johnson, Bryce G. Journal of Clinical Investigation, Vol. 125, Issue 1 https://doi.org/10.1172/jci75852	journal	November 2014
MicroRNA-155 inhibits angiotensin II-induced vascular smooth muscle cell proliferation Yang, Li-xia; Liu, Gao; Zhu, Guo-fu Journal of the Renin-Angiotensin-Aldosterone System, Vol. 15, Issue 2 https://doi.org/10.1177/1470320313503693	journal	March 2014
Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease Pandey, Priyanka; Brors, Benedikt; Srivastava, Prashant K. BMC Genomics, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2164-9-624	journal	January 2008
Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease Pandey, Priyanka; Qin, Shan; Ho, Jacqueline BMC Systems Biology, Vol. 5, Issue 1 https://doi.org/10.1186/1752-0509-5-56	journal	January 2011
Reducing ligation bias of small RNAs in libraries for next generation sequencing Sorefan, Karim; Pais, Helio; Hall, Adam E. Silence, Vol. 3, Issue 1 https://doi.org/10.1186/1758-907x-3-4	journal	January 2012
High-efficiency RNA cloning enables accurate quantification of miRNA expression by deep sequencing Zhang, Zhaojie; Lee, Jerome E.; Riemondy, Kent Genome Biology, Vol. 14, Issue 10 https://doi.org/10.1186/gb-2013-14-10-r109	journal	January 2013
Systematic comparison of small RNA library preparation protocols for next-generation sequencing Dard-Dascot, Cloelia; Naquin, Delphine; d’Aubenton-Carafa, Yves BMC Genomics, Vol. 19, Issue 1 https://doi.org/10.1186/s12864-018-4491-6	journal	February 2018
Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression Git, A.; Dvinge, H.; Salmon-Divon, M. RNA, Vol. 16, Issue 5 https://doi.org/10.1261/rna.1947110	journal	April 2010
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries Hafner, M.; Renwick, N.; Brown, M. RNA, Vol. 17, Issue 9 https://doi.org/10.1261/rna.2799511	journal	July 2011
Statistical Properties and Robustness of Biological Controller-Target Networks Feala, Jacob D.; Cortes, Jorge; Duxbury, Phillip M. PLoS ONE, Vol. 7, Issue 1 https://doi.org/10.1371/journal.pone.0029374	journal	January 2012
Trastuzumab Produces Therapeutic Actions by Upregulating miR-26a and miR-30b in Breast Cancer Cells Ichikawa, Takehiro; Sato, Fumiaki; Terasawa, Kazuya PLoS ONE, Vol. 7, Issue 2 https://doi.org/10.1371/journal.pone.0031422	journal	February 2012
Podocyte-Selective Deletion of Dicer Induces Proteinuria and Glomerulosclerosis Shi, Shaolin; Yu, Liping; Chiu, Celine Journal of the American Society of Nephrology, Vol. 19, Issue 11 https://doi.org/10.1681/asn.2008030312	journal	September 2008
Loss of MicroRNA-192 Promotes Fibrogenesis in Diabetic Nephropathy Krupa, Aleksandra; Jenkins, Robert; Luo, Dong Dong Journal of the American Society of Nephrology, Vol. 21, Issue 3 https://doi.org/10.1681/asn.2009050530	journal	January 2010
The MicroRNA-Processing Enzyme Dicer Maintains Juxtaglomerular Cells Sequeira-Lopez, Maria Luisa S.; Weatherford, Eric T.; Borges, Giulianna R. Journal of the American Society of Nephrology, Vol. 21, Issue 3 https://doi.org/10.1681/asn.2009090964	journal	January 2010
Regulation of WNK1 Expression by miR-192 and Aldosterone Elvira-Matelot, Emilie; Zhou, Xiao-ou; Farman, Nicolette Journal of the American Society of Nephrology, Vol. 21, Issue 10 https://doi.org/10.1681/asn.2009111186	journal	September 2010
The Pro-Apoptotic Protein Bim Is a MicroRNA Target in Kidney Progenitors Ho, Jacqueline; Pandey, Priyanka; Schatton, Tobias Journal of the American Society of Nephrology, Vol. 22, Issue 6 https://doi.org/10.1681/asn.2010080841	journal	May 2011
MicroRNA 802 Stimulates ROMK Channels by Suppressing Caveolin-1 Lin, Dao-Hong; Yue, Peng; Pan, Chunyang Journal of the American Society of Nephrology, Vol. 22, Issue 6 https://doi.org/10.1681/asn.2010090927	journal	May 2011
Abnormal miR-148b Expression Promotes Aberrant Glycosylation of IgA1 in IgA Nephropathy Serino, Grazia; Sallustio, Fabio; Cox, Sharon N. Journal of the American Society of Nephrology, Vol. 23, Issue 5 https://doi.org/10.1681/asn.2011060567	journal	February 2012
MicroRNAs Regulate Renal Tubule Maturation through Modulation of Pkd1 Patel, Vishal; Hajarnis, Sachin; Williams, Darren Journal of the American Society of Nephrology, Vol. 23, Issue 12 https://doi.org/10.1681/asn.2012030321	journal	November 2012
MicroRNA-17~92 Is Required for Nephrogenesis and Renal Function Marrone, April K.; Stolz, Donna B.; Bastacky, Sheldon I. Journal of the American Society of Nephrology, Vol. 25, Issue 7 https://doi.org/10.1681/asn.2013040390	journal	February 2014
MicroRNA-155 a New Therapeutic Target in Crescentic GN Holdsworth, Stephen R.; Summers, Shaun A. Journal of the American Society of Nephrology, Vol. 24, Issue 12 https://doi.org/10.1681/asn.2013090924	journal	December 2013
A comparison of miRNA isolation and RT-qPCR technologies and their effects on quantification accuracy and repeatability Redshaw, Nicholas; Wilkes, Timothy; Whale, Alexandra BioTechniques, Vol. 54, Issue 3 https://doi.org/10.2144/000114002	journal	March 2013
Circulating Permeability Factors in Idiopathic Nephrotic Syndrome and Focal Segmental Glomerulosclerosis McCarthy, Ellen T.; Sharma, Mukut; Savin, Virginia J. Clinical Journal of the American Society of Nephrology, Vol. 5, Issue 11 https://doi.org/10.2215/cjn.03800609	journal	October 2010
Can Biomarkers of Disease Activity Guide Treatment in FSGS? Campbell, Kirk N.; He, John C. Clinical Journal of the American Society of Nephrology, Vol. 9, Issue 9 https://doi.org/10.2215/cjn.07170714	journal	September 2014
Targeting of RhoA/ROCK Signaling Ameliorates Progression of Diabetic Nephropathy Independent of Glucose Control Kolavennu, Vasantha; Zeng, Lixia; Peng, Hui Diabetes, Vol. 57, Issue 3 https://doi.org/10.2337/db07-1241	journal	December 2007
E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor- Wang, B.; Herman-Edelstein, M.; Koh, P. Diabetes, Vol. 59, Issue 7 https://doi.org/10.2337/db09-1736	journal	April 2010
Addressing Bias in Small RNA Library Preparation for Sequencing: A New Protocol Recovers MicroRNAs that Evade Capture by Current Methods Baran-Gale, Jeanette; Kurtz, C. Lisa; Erdos, Michael R. Frontiers in Genetics, Vol. 6 https://doi.org/10.3389/fgene.2015.00352	journal	December 2015
Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells Kohlhaas, Susan; Garden, Oliver A.; Scudamore, Cheryl The Journal of Immunology, Vol. 182, Issue 5 https://doi.org/10.4049/jimmunol.0803162	journal	February 2009
A combination of transcriptional and microRNA regulation improves the stability of the relative concentrations of target genes Riba, Andrea; Bosia, Carla; Baroudi, Mariama El arXiv https://doi.org/10.48550/arxiv.1307.3358	text	January 2013
Blood Pressure as a Cardiovascular Risk Factor: Prevention and Treatment Kannel, William B. JAMA, Vol. 275, Issue 20 https://doi.org/10.1001/jama.1996.03530440051036	journal	May 1996
Regulation of primary microRNA processing Creugny, Antoine; Fender, Aurélie; Pfeffer, Sébastien FEBS Letters, Vol. 592, Issue 12 https://doi.org/10.1002/1873-3468.13067	journal	May 2018
MicroRNA-29, a key regulator of collagen expression in systemic sclerosis Maurer, Britta; Stanczyk, Joanna; Jüngel, Astrid Arthritis & Rheumatism, Vol. 62, Issue 6 https://doi.org/10.1002/art.27443	journal	March 2010
The Role of MicroRNAs and Human Epidermal Growth Factor Receptor 2 in Proliferative Lupus Nephritis: MicroRNAs AND HER-2 IN PROLIFERATIVE LN Costa-Reis, Patrícia; Russo, Pierre A.; Zhang, Zhe Arthritis & Rheumatology, Vol. 67, Issue 9 https://doi.org/10.1002/art.39219	journal	August 2015
Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192 Sun, Lin; Zhang, Dongshan; Liu, Fuyou The Journal of Pathology, Vol. 225, Issue 3 https://doi.org/10.1002/path.2961	journal	August 2011
BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization: BDNF repairs podocyte damage Li, Min; Armelloni, Silvia; Zennaro, Cristina The Journal of Pathology, Vol. 235, Issue 5 https://doi.org/10.1002/path.4484	journal	January 2015
Recent progress toward the use of circulating microRNAs as clinical biomarkers Ghai, Vikas; Wang, Kai Archives of Toxicology, Vol. 90, Issue 12 https://doi.org/10.1007/s00204-016-1828-2	journal	September 2016
MicroRNA Expression Abnormalities in Limited Cutaneous Scleroderma and Diffuse Cutaneous Scleroderma Zhu, Honglin; Li, Yisha; Qu, Shunlin Journal of Clinical Immunology, Vol. 32, Issue 3 https://doi.org/10.1007/s10875-011-9647-y	journal	February 2012
MicroRNA-21 in Scleroderma Fibrosis and its Function in TGF-β- Regulated Fibrosis-Related Genes Expression Zhu, Honglin; Luo, Hui; Li, Yisha Journal of Clinical Immunology, Vol. 33, Issue 6 https://doi.org/10.1007/s10875-013-9896-z	journal	May 2013
Urinary sediment miRNA levels in adult nephrotic syndrome Wang, Gang; Kwan, Bonnie Ching-Ha; Lai, Fernand Mac-Moune Clinica Chimica Acta, Vol. 418 https://doi.org/10.1016/j.cca.2012.12.011	journal	March 2013
Bacterially Derived 400 nm Particles for Encapsulation and Cancer Cell Targeting of Chemotherapeutics MacDiarmid, Jennifer A.; Mugridge, Nancy B.; Weiss, Jocelyn C. Cancer Cell, Vol. 11, Issue 5 https://doi.org/10.1016/j.ccr.2007.03.012	journal	May 2007
Integrated Analyses Identify a Master MicroRNA Regulatory Network for the Mesenchymal Subtype in Serous Ovarian Cancer Yang, Da; Sun, Yan; Hu, Limei Cancer Cell, Vol. 23, Issue 2 https://doi.org/10.1016/j.ccr.2012.12.020	journal	February 2013
Essential Role of TGF-β Signaling in Glucose-Induced Cell Hypertrophy Wu, Liyu; Derynck, Rik Developmental Cell, Vol. 17, Issue 1 https://doi.org/10.1016/j.devcel.2009.05.010	journal	July 2009
MicroRNA biomarkers in clinical renal disease: from diabetic nephropathy renal transplantation and beyond Nassirpour, Rounak; Raj, Dominic; Townsend, Raymond Food and Chemical Toxicology, Vol. 98 https://doi.org/10.1016/j.fct.2016.02.018	journal	December 2016
MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development O'Connell, Ryan M.; Kahn, Daniel; Gibson, William S. J. Immunity, Vol. 33, Issue 4 https://doi.org/10.1016/j.immuni.2010.09.009	journal	October 2010
High loading efficiency and tunable release of plasmid DNA encapsulated in submicron particles fabricated from PLGA conjugated with poly-L-lysine Blum, Jeremy S.; Saltzman, W. Mark Journal of Controlled Release, Vol. 129, Issue 1 https://doi.org/10.1016/j.jconrel.2008.04.002	journal	July 2008
Hematopoietic-specific microRNA expression in human cells Ramkissoon, Shakti H.; Mainwaring, Lori A.; Ogasawara, Yoji Leukemia Research, Vol. 30, Issue 5 https://doi.org/10.1016/j.leukres.2005.09.001	journal	May 2006
Investigating the microRNA signature of ANCA associated vasculitis Brown, N.; Harris, S.; Venning, M. La Presse Médicale, Vol. 42, Issue 4 https://doi.org/10.1016/j.lpm.2013.02.247	journal	April 2013
Is IgA nephropathy induced by abnormalities of CD4+CD25+Treg cells in the tonsils? Huang, Hongdong; Peng, Youming; Liu, Fuyou Medical Hypotheses, Vol. 69, Issue 2 https://doi.org/10.1016/j.mehy.2006.11.050	journal	January 2007
NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses Jiang, Fan; Liu, Guei-Sheung; Dusting, Gregory J. Redox Biology, Vol. 2 https://doi.org/10.1016/j.redox.2014.01.012	journal	January 2014
TGF-β in Renal Injury and Disease Böttinger, Erwin P. Seminars in Nephrology, Vol. 27, Issue 3 https://doi.org/10.1016/j.semnephrol.2007.02.009	journal	May 2007
miRNA Biogenesis: A Dynamic Pathway Achkar, Natalia P.; Cambiagno, Damián A.; Manavella, Pablo A. Trends in Plant Science, Vol. 21, Issue 12 https://doi.org/10.1016/j.tplants.2016.09.003	journal	December 2016
Recent advances involving the renin–angiotensin system Crowley, Steven D.; Coffman, Thomas M. Experimental Cell Research, Vol. 318, Issue 9 https://doi.org/10.1016/j.yexcr.2012.02.023	journal	May 2012
Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin–angiotensin system Kemp, Jacqueline R.; Unal, Hamiyet; Desnoyer, Russell Journal of Molecular and Cellular Cardiology, Vol. 75 https://doi.org/10.1016/j.yjmcc.2014.06.008	journal	October 2014
Intrarenal Expression of miRNAs in Patients With Hypertensive Nephrosclerosis Wang, G.; Kwan, B. C. -H.; Lai, F. M. -M. American Journal of Hypertension, Vol. 23, Issue 1 https://doi.org/10.1038/ajh.2009.208	journal	January 2010
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease Mogilyansky, E.; Rigoutsos, I. Cell Death & Differentiation, Vol. 20, Issue 12 https://doi.org/10.1038/cdd.2013.125	journal	November 2013
Claudin-14 regulates renal Ca ⁺⁺ transport in response to CaSR signalling via a novel microRNA pathway : Claudin-14 function and regulation Gong, Yongfeng; Renigunta, Vijayaram; Himmerkus, Nina The EMBO Journal, Vol. 31, Issue 8 https://doi.org/10.1038/emboj.2012.49	journal	February 2012
Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney Nagalakshmi, Vidya K.; Ren, Qun; Pugh, Margaret M. Kidney International, Vol. 79, Issue 3 https://doi.org/10.1038/ki.2010.385	journal	February 2011
The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy Zhdanova, Olga; Srivastava, Shekhar; Di, Lie Kidney International, Vol. 80, Issue 7 https://doi.org/10.1038/ki.2011.122	journal	October 2011
Altered expression of microRNA miR-146a correlates with the development of chronic renal inflammation Ichii, Osamu; Otsuka, Saori; Sasaki, Nobuya Kidney International, Vol. 81, Issue 3 https://doi.org/10.1038/ki.2011.345	journal	February 2012
A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells Kato, Mitsuo; Arce, Laura; Wang, Mei Kidney International, Vol. 80, Issue 4 https://doi.org/10.1038/ki.2011.43	journal	August 2011
Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice Trang, Phong; Wiggins, Jason F.; Daige, Christopher L. Molecular Therapy, Vol. 19, Issue 6 https://doi.org/10.1038/mt.2011.48	journal	June 2011
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells Zheng, Ye; Josefowicz, Steven Z.; Kas, Arnold Nature, Vol. 445, Issue 7130 https://doi.org/10.1038/nature05563	journal	January 2007
Origin and function of myofibroblasts in kidney fibrosis LeBleu, Valerie S.; Taduri, Gangadhar; O'Connell, Joyce Nature Medicine, Vol. 19, Issue 8 https://doi.org/10.1038/nm.3218	journal	June 2013
Limitations and possibilities of small RNA digital gene expression profiling Linsen, Sam E. V.; de Wit, Elzo; Janssens, Georges Nature Methods, Vol. 6, Issue 7 https://doi.org/10.1038/nmeth0709-474	journal	July 2009
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases Rupaimoole, Rajesha; Slack, Frank J. Nature Reviews Drug Discovery, Vol. 16, Issue 3 https://doi.org/10.1038/nrd.2016.246	journal	February 2017
Regulation of microRNA biogenesis Ha, Minju; Kim, V. Narry Nature Reviews Molecular Cell Biology, Vol. 15, Issue 8 https://doi.org/10.1038/nrm3838	journal	July 2014
Droplet Digital PCR versus qPCR for gene expression analysis with low abundant targets: from variable nonsense to publication quality data Taylor, Sean C.; Laperriere, Genevieve; Germain, Hugo Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-02217-x	journal	May 2017
Hypertension and the heart Schmieder, Re; Messerli, Fh Journal of Human Hypertension, Vol. 14, Issue 10-11 https://doi.org/10.1038/sj.jhh.1001044	journal	October 2000
Plasma MicroRNA-186 and Proteinuria in Focal Segmental Glomerulosclerosis Zhang, Changming; Zhang, Wanfen; Chen, Hui-Mei American Journal of Kidney Diseases, Vol. 65, Issue 2 https://doi.org/10.1053/j.ajkd.2014.07.013	journal	February 2015
US Renal Data System 2016 Annual Data Report: Epidemiology of Kidney Disease in the United States Saran, Rajiv; Robinson, Bruce; Abbott, Kevin C. American Journal of Kidney Diseases, Vol. 69, Issue 3 https://doi.org/10.1053/j.ajkd.2016.12.004	journal	March 2017
Circulating Factor Associated with Increased Glomerular Permeability to Albumin in Recurrent Focal Segmental Glomerulosclerosis Savin, Virginia J.; Sharma, Ram; Sharma, Mukut New England Journal of Medicine, Vol. 334, Issue 14 https://doi.org/10.1056/NEJM199604043341402	journal	April 1996
Role of Transforming Growth Factor β in Human Disease Blobe, Gerard C.; Schiemann, William P.; Lodish, Harvey F. New England Journal of Medicine, Vol. 342, Issue 18 https://doi.org/10.1056/NEJM200005043421807	journal	May 2000
MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors Kato, M.; Zhang, J.; Wang, M. Proceedings of the National Academy of Sciences, Vol. 104, Issue 9 https://doi.org/10.1073/pnas.0611192104	journal	February 2007
Post-transcriptional Up-regulation of Tsc-22 by Ybx1, a Target of miR-216a, Mediates TGF-β-induced Collagen Expression in Kidney Cells Kato, Mitsuo; Wang, Lin; Putta, Sumanth Journal of Biological Chemistry, Vol. 285, Issue 44 https://doi.org/10.1074/jbc.M110.165027	journal	August 2010
MicroRNA-29c Is a Signature MicroRNA under High Glucose Conditions That Targets Sprouty Homolog 1, and Its in Vivo Knockdown Prevents Progression of Diabetic Nephropathy Long, Jianyin; Wang, Yin; Wang, Wenjian Journal of Biological Chemistry, Vol. 286, Issue 13 https://doi.org/10.1074/jbc.M110.194969	journal	February 2011
MicroRNA-21 Orchestrates High Glucose-induced Signals to TOR Complex 1, Resulting in Renal Cell Pathology in Diabetes Dey, Nirmalya; Das, Falguni; Mariappan, Meenalakshmi M. Journal of Biological Chemistry, Vol. 286, Issue 29 https://doi.org/10.1074/jbc.M110.208066	journal	May 2011
Logic and Extent of miRNA-Mediated Control of Autoimmune Gene Expression Vinuesa, Carola G.; Rigby, Robert J.; Yu, Di International Reviews of Immunology, Vol. 28, Issue 3-4 https://doi.org/10.1080/08830180902934909	journal	January 2009
Nephrotoxic Nephritis and Glomerulonephritis: Animal Model Versus Human Disease Muhammad, S. British Journal of Biomedical Science, Vol. 71, Issue 4 https://doi.org/10.1080/09674845.2014.11669982	journal	January 2014
Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity Hollins, Andrew J.; Omidi, Yadollah; Benter, Ibrahim F. Journal of Drug Targeting, Vol. 15, Issue 1 https://doi.org/10.1080/10611860601151860	journal	January 2007
Experimental Glomerulonephritis: iv. Participation of Complement in Nephrotoxic Nephritis Unanue, E. Journal of Experimental Medicine, Vol. 119, Issue 6 https://doi.org/10.1084/jem.119.6.965	journal	June 1964
Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors Herrera-Carrillo, Elena; Liu, Ying Poi; Berkhout, Ben Human Gene Therapy Methods, Vol. 28, Issue 4 https://doi.org/10.1089/hgtb.2017.036	journal	August 2017
Epstein–Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway Gatto, Graziana; Rossi, Annalisa; Rossi, Daniela Nucleic Acids Research, Vol. 36, Issue 20 https://doi.org/10.1093/nar/gkn666	journal	October 2008
Identification and remediation of biases in the activity of RNA ligases in small-RNA deep sequencing Jayaprakash, Anitha D.; Jabado, Omar; Brown, Brian D. Nucleic Acids Research, Vol. 39, Issue 21 https://doi.org/10.1093/nar/gkr693	journal	September 2011
MicroRNAs contribute to the maintenance of cell-type-specific physiological characteristics: miR-192 targets Na+/K+-ATPase β1 Mladinov, Domagoj; Liu, Yong; Mattson, David L. Nucleic Acids Research, Vol. 41, Issue 2 https://doi.org/10.1093/nar/gks1228	journal	December 2012
Modeling bias and variation in the stochastic processes of small RNA sequencing Argyropoulos, Christos; Etheridge, Alton; Sakhanenko, Nikita Nucleic Acids Research, Vol. 45, Issue 11 https://doi.org/10.1093/nar/gkx199	journal	March 2017
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo Minakuchi, Y. Nucleic Acids Research, Vol. 32, Issue 13 https://doi.org/10.1093/nar/gnh093	journal	July 2004
Role of let-7b in the regulation of N -acetylgalactosaminyltransferase 2 in IgA nephropathy Serino, Grazia; Sallustio, Fabio; Curci, Claudia Nephrology Dialysis Transplantation, Vol. 30, Issue 7 https://doi.org/10.1093/ndt/gfv032	journal	March 2015
MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy Wang, Qiang; Wang, Youli; Minto, Andrew W. The FASEB Journal, Vol. 22, Issue 12 https://doi.org/10.1096/fj.08-112326	journal	December 2008
Blood pressure levels and brain volume reduction: a systematic review and meta-analysis Beauchet, Olivier; Celle, Sébastien; Roche, Frédéric Journal of Hypertension, Vol. 31, Issue 8 https://doi.org/10.1097/HJH.0b013e32836184b5	journal	January 2013
High-Throughput Selection of Effective RNAi Probes for Gene Silencing Kumar, R. Genome Research, Vol. 13, Issue 10 https://doi.org/10.1101/gr.1575003	journal	October 2003
PCR inhibitors - occurrence, properties and removal Schrader, C.; Schielke, A.; Ellerbroek, L. Journal of Applied Microbiology, Vol. 113, Issue 5 https://doi.org/10.1111/j.1365-2672.2012.05384.x	journal	July 2012
Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis: miRNA in lupus nephritis Lu, Jianxin; Kwan, Bonnie Ching-Ha; Lai, Fernand Mac-Moune Nephrology, Vol. 17, Issue 4 https://doi.org/10.1111/j.1440-1797.2012.01573.x	journal	April 2012
Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes: Angiotensin II regulation of microRNA expression Jeppesen, Pia Lindgren; Christensen, Gitte Lund; Schneider, Mikael British Journal of Pharmacology, Vol. 164, Issue 2 https://doi.org/10.1111/j.1476-5381.2011.01375.x	journal	August 2011
Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies Law, M. R.; Morris, J. K.; Wald, N. J. BMJ, Vol. 338, Issue may19 1 https://doi.org/10.1136/bmj.b1665	journal	May 2009
Genome-wide analysis of microRNAs expression profiling in patients with primary IgA nephropathy Tan, Kuibi; Chen, Jing; Li, Wuxian Genome, Vol. 56, Issue 3 https://doi.org/10.1139/gen-2012-0159	journal	March 2013
Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13 ^BN congenic strains Moreno, Carol; Williams, Jan M.; Lu, Limin American Journal of Physiology-Heart and Circulatory Physiology, Vol. 300, Issue 4 https://doi.org/10.1152/ajpheart.01026.2010	journal	April 2011
Elevated Levels of miR-146a and miR-155 in Kidney Biopsy and Urine from Patients with IgA Nephropathy Wang, Gang; Kwan, Bonnie Ching-Ha; Lai, Fernand Mac-Moune Disease Markers, Vol. 30, Issue 4 https://doi.org/10.1155/2011/304852	journal	January 2011
Protection of Human Umbilical Vein Endothelial Cells against Oxidative Stress by MicroRNA-210 Li, Tianyi; Song, Xianjing; Zhang, Jichang Oxidative Medicine and Cellular Longevity, Vol. 2017 https://doi.org/10.1155/2017/3565613	journal	January 2017
Delivery Systems for the Direct Application of siRNAs to Induce RNA Interference (RNAi) In Vivo Aigner, Achim Journal of Biomedicine and Biotechnology, Vol. 2006 https://doi.org/10.1155/JBB/2006/71659	journal	January 2006
A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics Takei, Yoshifumi; Kadomatsu, Kenji; Yuzawa, Yukio Cancer Research, Vol. 64, Issue 10 https://doi.org/10.1158/0008-5472.CAN-03-2682	journal	May 2004
Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma Hu-Lieskovan, Siwen; Heidel, Jeremy D.; Bartlett, Derek W. Cancer Research, Vol. 65, Issue 19 https://doi.org/10.1158/0008-5472.CAN-05-0565	journal	October 2005
Signaling-Mediated Regulation of MicroRNA Processing Shen, J.; Hung, M. -C. Cancer Research, Vol. 75, Issue 5 https://doi.org/10.1158/0008-5472.CAN-14-2568	journal	February 2015
Molecular and Cell Biology of TGF-β Roberts, Anita B. Mineral and Electrolyte Metabolism, Vol. 24, Issue 2-3 https://doi.org/10.1159/000057358	journal	January 1998
Nitric Oxide and Its Putative Role in Hypertension Dominiczak, Anna F.; Bohr, David F. Hypertension, Vol. 25, Issue 6 https://doi.org/10.1161/01.HYP.25.6.1202	journal	June 1995
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association Mozaffarian, Dariush; Benjamin, Emelia J.; Go, Alan S. Circulation, Vol. 131, Issue 4 https://doi.org/10.1161/CIR.0000000000000152	journal	January 2015
Renal Medullary MicroRNAs in Dahl Salt-Sensitive Rats: miR-29b Regulates Several Collagens and Related Genes Liu, Yong; Taylor, Norman E.; Lu, Limin Hypertension, Vol. 55, Issue 4 https://doi.org/10.1161/HYPERTENSIONAHA.109.144428	journal	April 2010
Gene Expression Profiling Reveals Renin mRNA Overexpression in Human Hypertensive Kidneys and a Role for MicroRNAs Marques, Francine Z.; Campain, Anna E.; Tomaszewski, Maciej Hypertension, Vol. 58, Issue 6 https://doi.org/10.1161/HYPERTENSIONAHA.111.180729	journal	December 2011
Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase Sun, Hai-Xiang; Zeng, De-Yi; Li, Ruo-Tian Hypertension, Vol. 60, Issue 6 https://doi.org/10.1161/HYPERTENSIONAHA.112.197301	journal	December 2012
A Novel Interaction Between Sympathetic Overactivity and Aberrant Regulation of Renin by miR-181a in BPH/2J Genetically Hypertensive Mice Jackson, Kristy L.; Marques, Francine Z.; Watson, Anna M. D. Hypertension, Vol. 62, Issue 4 https://doi.org/10.1161/HYPERTENSIONAHA.113.01701	journal	October 2013
Nonviral delivery of synthetic siRNAs in vivo Akhtar, Saghir; Benter, Ibrahim F. Journal of Clinical Investigation, Vol. 117, Issue 12 https://doi.org/10.1172/JCI33494	journal	December 2007
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster Boettger, Thomas; Beetz, Nadine; Kostin, Sawa Journal of Clinical Investigation, Vol. 119, Issue 9 https://doi.org/10.1172/JCI38864	journal	September 2009
Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways Gomez, Ivan G.; MacKenna, Deidre A.; Johnson, Bryce G. Journal of Clinical Investigation, Vol. 125, Issue 1 https://doi.org/10.1172/JCI75852	journal	November 2014
MicroRNA-155 inhibits angiotensin II-induced vascular smooth muscle cell proliferation Yang, Li-xia; Liu, Gao; Zhu, Guo-fu Journal of the Renin-Angiotensin-Aldosterone System, Vol. 15, Issue 2 https://doi.org/10.1177/1470320313503693	journal	March 2014
Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease Pandey, Priyanka; Brors, Benedikt; Srivastava, Prashant K. BMC Genomics, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2164-9-624	journal	January 2008
"Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression" Muth, Michaela; Theophile, Katharina; Hussein, Kais Journal of Translational Medicine, Vol. 8, Issue 1 https://doi.org/10.1186/1479-5876-8-33	journal	January 2010
Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease Pandey, Priyanka; Qin, Shan; Ho, Jacqueline BMC Systems Biology, Vol. 5, Issue 1 https://doi.org/10.1186/1752-0509-5-56	journal	January 2011
Reducing ligation bias of small RNAs in libraries for next generation sequencing Sorefan, Karim; Pais, Helio; Hall, Adam E. Silence, Vol. 3, Issue 1 https://doi.org/10.1186/1758-907X-3-4	journal	January 2012
High-efficiency RNA cloning enables accurate quantification of miRNA expression by deep sequencing Zhang, Zhaojie; Lee, Jerome E.; Riemondy, Kent Genome Biology, Vol. 14, Issue 10 https://doi.org/10.1186/gb-2013-14-10-r109	journal	January 2013
Systematic comparison of small RNA library preparation protocols for next-generation sequencing Dard-Dascot, Cloelia; Naquin, Delphine; d’Aubenton-Carafa, Yves BMC Genomics, Vol. 19, Issue 1 https://doi.org/10.1186/s12864-018-4491-6	journal	February 2018
Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression Git, A.; Dvinge, H.; Salmon-Divon, M. RNA, Vol. 16, Issue 5 https://doi.org/10.1261/rna.1947110	journal	April 2010
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries Hafner, M.; Renwick, N.; Brown, M. RNA, Vol. 17, Issue 9 https://doi.org/10.1261/rna.2799511	journal	July 2011
A Combination of Transcriptional and MicroRNA Regulation Improves the Stability of the Relative Concentrations of Target Genes Riba, Andrea; Bosia, Carla; El Baroudi, Mariama PLoS Computational Biology, Vol. 10, Issue 2 https://doi.org/10.1371/journal.pcbi.1003490	journal	February 2014
Intra-Platform Repeatability and Inter-Platform Comparability of MicroRNA Microarray Technology Sato, Fumiaki; Tsuchiya, Soken; Terasawa, Kazuya PLoS ONE, Vol. 4, Issue 5 https://doi.org/10.1371/journal.pone.0005540	journal	May 2009
Post-Transcriptional Regulation of Transforming Growth Factor Beta-1 by MicroRNA-744 Martin, John; Jenkins, Robert H.; Bennagi, Rasha PLoS ONE, Vol. 6, Issue 10 https://doi.org/10.1371/journal.pone.0025044	journal	October 2011
Statistical Properties and Robustness of Biological Controller-Target Networks Feala, Jacob D.; Cortes, Jorge; Duxbury, Phillip M. PLoS ONE, Vol. 7, Issue 1 https://doi.org/10.1371/journal.pone.0029374	journal	January 2012
Trastuzumab Produces Therapeutic Actions by Upregulating miR-26a and miR-30b in Breast Cancer Cells Ichikawa, Takehiro; Sato, Fumiaki; Terasawa, Kazuya PLoS ONE, Vol. 7, Issue 2 https://doi.org/10.1371/journal.pone.0031422	journal	February 2012
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments Bustin, S. A.; Benes, V.; Garson, J. A. Clinical Chemistry, Vol. 55, Issue 4 https://doi.org/10.1373/clinchem.2008.112797	journal	February 2009
Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease Harvey, Scott J.; Jarad, George; Cunningham, Jeanette Journal of the American Society of Nephrology, Vol. 19, Issue 11 https://doi.org/10.1681/ASN.2008020233	journal	September 2008
Podocyte-Selective Deletion of Dicer Induces Proteinuria and Glomerulosclerosis Shi, Shaolin; Yu, Liping; Chiu, Celine Journal of the American Society of Nephrology, Vol. 19, Issue 11 https://doi.org/10.1681/ASN.2008030312	journal	September 2008
Loss of MicroRNA-192 Promotes Fibrogenesis in Diabetic Nephropathy Krupa, Aleksandra; Jenkins, Robert; Luo, Dong Dong Journal of the American Society of Nephrology, Vol. 21, Issue 3 https://doi.org/10.1681/ASN.2009050530	journal	January 2010
The MicroRNA-Processing Enzyme Dicer Maintains Juxtaglomerular Cells Sequeira-Lopez, Maria Luisa S.; Weatherford, Eric T.; Borges, Giulianna R. Journal of the American Society of Nephrology, Vol. 21, Issue 3 https://doi.org/10.1681/ASN.2009090964	journal	January 2010
Regulation of WNK1 Expression by miR-192 and Aldosterone Elvira-Matelot, Emilie; Zhou, Xiao-ou; Farman, Nicolette Journal of the American Society of Nephrology, Vol. 21, Issue 10 https://doi.org/10.1681/ASN.2009111186	journal	September 2010
miR-192 Mediates TGF-β/Smad3-Driven Renal Fibrosis Chung, Arthur C. K.; Huang, Xiao R.; Meng, Xiaoming Journal of the American Society of Nephrology, Vol. 21, Issue 8 https://doi.org/10.1681/ASN.2010020134	journal	May 2010
Angiotensin II as a Morphogenic Cytokine Stimulating Renal Fibrogenesis Rüster, Christiane; Wolf, Gunter Journal of the American Society of Nephrology, Vol. 22, Issue 7 https://doi.org/10.1681/ASN.2010040384	journal	June 2011
The Pro-Apoptotic Protein Bim Is a MicroRNA Target in Kidney Progenitors Ho, Jacqueline; Pandey, Priyanka; Schatton, Tobias Journal of the American Society of Nephrology, Vol. 22, Issue 6 https://doi.org/10.1681/ASN.2010080841	journal	May 2011
MicroRNA 802 Stimulates ROMK Channels by Suppressing Caveolin-1 Lin, Dao-Hong; Yue, Peng; Pan, Chunyang Journal of the American Society of Nephrology, Vol. 22, Issue 6 https://doi.org/10.1681/ASN.2010090927	journal	May 2011
Abnormal miR-148b Expression Promotes Aberrant Glycosylation of IgA1 in IgA Nephropathy Serino, Grazia; Sallustio, Fabio; Cox, Sharon N. Journal of the American Society of Nephrology, Vol. 23, Issue 5 https://doi.org/10.1681/ASN.2011060567	journal	February 2012
MicroRNA-324-3p Promotes Renal Fibrosis and Is a Target of ACE Inhibition Macconi, Daniela; Tomasoni, Susanna; Romagnani, Paola Journal of the American Society of Nephrology, Vol. 23, Issue 9 https://doi.org/10.1681/ASN.2011121144	journal	July 2012
MicroRNAs Regulate Renal Tubule Maturation through Modulation of Pkd1 Patel, Vishal; Hajarnis, Sachin; Williams, Darren Journal of the American Society of Nephrology, Vol. 23, Issue 12 https://doi.org/10.1681/ASN.2012030321	journal	November 2012
Downregulation of MicroRNA-30 Facilitates Podocyte Injury and Is Prevented by Glucocorticoids Wu, Junnan; Zheng, Chunxia; Fan, Yun Journal of the American Society of Nephrology, Vol. 25, Issue 1 https://doi.org/10.1681/ASN.2012111101	journal	September 2013
MicroRNA-155 Drives T _H 17 Immune Response and Tissue Injury in Experimental Crescentic GN Krebs, Christian F.; Kapffer, Sonja; Paust, Hans-Joachim Journal of the American Society of Nephrology, Vol. 24, Issue 12 https://doi.org/10.1681/ASN.2013020130	journal	August 2013
MicroRNA-17~92 Is Required for Nephrogenesis and Renal Function Marrone, April K.; Stolz, Donna B.; Bastacky, Sheldon I. Journal of the American Society of Nephrology, Vol. 25, Issue 7 https://doi.org/10.1681/ASN.2013040390	journal	February 2014
A comparison of miRNA isolation and RT-qPCR technologies and their effects on quantification accuracy and repeatability Redshaw, Nicholas; Wilkes, Timothy; Whale, Alexandra BioTechniques, Vol. 54, Issue 3 https://doi.org/10.2144/000114002	journal	March 2013
Circulating Permeability Factors in Idiopathic Nephrotic Syndrome and Focal Segmental Glomerulosclerosis McCarthy, Ellen T.; Sharma, Mukut; Savin, Virginia J. Clinical Journal of the American Society of Nephrology, Vol. 5, Issue 11 https://doi.org/10.2215/CJN.03800609	journal	October 2010
Evaluation of MicroRNAs miR-196a, miR-30a-5P, and miR-490 as Biomarkers of Disease Activity among Patients with FSGS Zhang, Wanfen; Zhang, Changming; Chen, Huimei Clinical Journal of the American Society of Nephrology, Vol. 9, Issue 9 https://doi.org/10.2215/CJN.11561113	journal	August 2014
Targeting of RhoA/ROCK Signaling Ameliorates Progression of Diabetic Nephropathy Independent of Glucose Control Kolavennu, Vasantha; Zeng, Lixia; Peng, Hui Diabetes, Vol. 57, Issue 3 https://doi.org/10.2337/db07-1241	journal	December 2007
E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor- Wang, B.; Herman-Edelstein, M.; Koh, P. Diabetes, Vol. 59, Issue 7 https://doi.org/10.2337/db09-1736	journal	April 2010
miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression Wang, Bo; Koh, Philip; Winbanks, Catherine Diabetes, Vol. 60, Issue 1 https://doi.org/10.2337/db10-0892	journal	October 2010
Addressing Bias in Small RNA Library Preparation for Sequencing: A New Protocol Recovers MicroRNAs that Evade Capture by Current Methods Baran-Gale, Jeanette; Kurtz, C. Lisa; Erdos, Michael R. Frontiers in Genetics, Vol. 6 https://doi.org/10.3389/fgene.2015.00352	journal	December 2015
Urinary MicroRNA Profiling Predicts the Development of Microalbuminuria in Patients with Type 1 Diabetes Argyropoulos, Christos; Wang, Kai; Bernardo, Jose Journal of Clinical Medicine, Vol. 4, Issue 7 https://doi.org/10.3390/jcm4071498	journal	July 2015
Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells Kohlhaas, Susan; Garden, Oliver A.; Scudamore, Cheryl The Journal of Immunology, Vol. 182, Issue 5 https://doi.org/10.4049/jimmunol.0803162	journal	February 2009
EBV and Systemic Lupus Erythematosus: A New Perspective Gross, Andrew J.; Hochberg, Donna; Rand, William M. The Journal of Immunology, Vol. 174, Issue 11 https://doi.org/10.4049/jimmunol.174.11.6599	journal	May 2005
Systematic comparison of small RNA library preparation protocols for next-generation sequencing Dard-Dascot, Cloelia; Naquin, Delphine; d’Aubenton-Carafa, Yves figshare https://doi.org/10.6084/m9.figshare.c.3996939.v1	collection	January 2018

Cited By (4)

Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values Dhama, Kuldeep; Latheef, Shyma K.; Dadar, Maryam Frontiers in Molecular Biosciences, Vol. 6 https://doi.org/10.3389/fmolb.2019.00091	journal	October 2019
Non-coding RNAs in kidney injury and repair Liu, Zhiwen; Wang, Ying; Shu, Shaoqun American Journal of Physiology-Cell Physiology, Vol. 317, Issue 2 https://doi.org/10.1152/ajpcell.00048.2019	journal	August 2019
Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values Dhama, Kuldeep; Latheef, Shyma K.; Dadar, Maryam Frontiers in Molecular Biosciences, Vol. 6 https://doi.org/10.3389/fmolb.2019.00091	journal	October 2019
MicroRNAs Involved in Carcinogenesis, Prognosis, Therapeutic Resistance, and Applications in Human Triple-Negative Breast Cancer Ding, Lei; Gu, Huan; Xiong, Xianhui Cells, Vol. 8, Issue 12 https://doi.org/10.3390/cells8121492	journal	November 2019

Similar Records

MicroRNA-10b downregulation mediates acute rejection of renal allografts by derepressing BCL2L11

Journal Article · 2015 · Experimental Cell Research · OSTI ID:22462277

Liu, Xiaoyou; Dong, Changgui; Jiang, Zhengyao; +6 more

MicroRNAs and their target gene networks in renal cell carcinoma

Journal Article · 2011 · Biochemical and Biophysical Research Communications · OSTI ID:22204788

Redova, Martina; Svoboda, Marek; Slaby, Ondrej

Nephron segment specific microRNA biomarkers of pre-clinical drug-induced renal toxicity: Opportunities and challenges

Journal Article · 2016 · Toxicology and Applied Pharmacology · OSTI ID:22690861

Nassirpour, Rounak; Ramaiah, Shashi K.; Whiteley, Laurence O.

Related Subjects

60 APPLIED LIFE SCIENCES
miRNA
miRNA detection
miRNA in renal parenchymal diseases
miRNA-based therapeutics
micro RNA
renal parenchymal diseases

Title: Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension

Citation Formats

References (211)

Cited By (4)

Similar Records

Related Subjects