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Title: Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension

Abstract

Since their discovery in 1993, numerous microRNAs (miRNAs) have been identified in humans and other eukaryotic organisms, and their role as key regulators of gene expression is still being elucidated. It is now known that miRNAs not only play a central role in the processes that ensure normal development and physiology, but they are often dysregulated in various diseases. In this review, we present an overview of the role of miRNAs in normal renal development and physiology, in maladaptive renal repair after injury, and in the pathogenesis of renal parenchymal diseases. In addition, we describe methods used for their detection and their potential as therapeutic targets. Continued research on renal miRNAs will undoubtedly improve our understanding of diseases affecting the kidneys and may also lead to new therapeutic agents.

Authors:
 [1];  [2];  [2];  [1]
  1. Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Internal Medicine. Division of Nephrology
  2. Pacific Northwest Research Inst., Seattle, WA (United States)
Publication Date:
Research Org.:
Univ. of New Mexico, Albuquerque, NM (United States); Pacific Northwest Research Inst., Seattle, WA (United States)
Sponsoring Org.:
USDOE; National Inst. of Health (NIH) (United States); Dialysis Clinic Inc. (DCI) (United States)
OSTI Identifier:
1463343
Grant/Contract Number:  
U01HL126496; U54DA036134; UL1TR001449; DCI #C-3765; DCI RF#C-3861.201
Resource Type:
Accepted Manuscript
Journal Name:
International Journal of Molecular Sciences (Online)
Additional Journal Information:
Journal Name: International Journal of Molecular Sciences (Online); Journal Volume: 19; Journal Issue: 6; Journal ID: ISSN 1422-0067
Publisher:
MDPI
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; miRNA; micro RNA; renal parenchymal diseases; miRNA in renal parenchymal diseases; miRNA detection; miRNA-based therapeutics

Citation Formats

Shaffi, Saeed, Galas, David, Etheridge, Alton, and Argyropoulos, Christos. Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension. United States: N. p., 2018. Web. doi:10.3390/ijms19061797.
Shaffi, Saeed, Galas, David, Etheridge, Alton, & Argyropoulos, Christos. Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension. United States. doi:10.3390/ijms19061797.
Shaffi, Saeed, Galas, David, Etheridge, Alton, and Argyropoulos, Christos. Sun . "Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension". United States. doi:10.3390/ijms19061797. https://www.osti.gov/servlets/purl/1463343.
@article{osti_1463343,
title = {Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension},
author = {Shaffi, Saeed and Galas, David and Etheridge, Alton and Argyropoulos, Christos},
abstractNote = {Since their discovery in 1993, numerous microRNAs (miRNAs) have been identified in humans and other eukaryotic organisms, and their role as key regulators of gene expression is still being elucidated. It is now known that miRNAs not only play a central role in the processes that ensure normal development and physiology, but they are often dysregulated in various diseases. In this review, we present an overview of the role of miRNAs in normal renal development and physiology, in maladaptive renal repair after injury, and in the pathogenesis of renal parenchymal diseases. In addition, we describe methods used for their detection and their potential as therapeutic targets. Continued research on renal miRNAs will undoubtedly improve our understanding of diseases affecting the kidneys and may also lead to new therapeutic agents.},
doi = {10.3390/ijms19061797},
journal = {International Journal of Molecular Sciences (Online)},
number = 6,
volume = 19,
place = {United States},
year = {2018},
month = {6}
}

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