Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension

Shaffi, Saeed; Galas, David; Etheridge, Alton; Argyropoulos, Christos

doi:10.3390/ijms19061797

Title: Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension

Journal Article · 17 June 2018 · International Journal of Molecular Sciences (Online)

DOI: https://doi.org/10.3390/ijms19061797 · OSTI ID:1463343

Shaffi, Saeed ^[1]; Galas, David ^[2]; Etheridge, Alton ^[2]; Argyropoulos, Christos ^[1]

Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Internal Medicine. Division of Nephrology
Pacific Northwest Research Inst., Seattle, WA (United States)

Since their discovery in 1993, numerous microRNAs (miRNAs) have been identified in humans and other eukaryotic organisms, and their role as key regulators of gene expression is still being elucidated. It is now known that miRNAs not only play a central role in the processes that ensure normal development and physiology, but they are often dysregulated in various diseases. In this review, we present an overview of the role of miRNAs in normal renal development and physiology, in maladaptive renal repair after injury, and in the pathogenesis of renal parenchymal diseases. In addition, we describe methods used for their detection and their potential as therapeutic targets. Continued research on renal miRNAs will undoubtedly improve our understanding of diseases affecting the kidneys and may also lead to new therapeutic agents.

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Research Organization:: Univ. of New Mexico, Albuquerque, NM (United States); Pacific Northwest Research Inst., Seattle, WA (United States)

Sponsoring Organization:: USDOE; National Inst. of Health (NIH) (United States); Dialysis Clinic Inc. (DCI) (United States)

Grant/Contract Number:: U01HL126496; U54DA036134; UL1TR001449; DCI #C-3765; DCI RF#C-3861.201

OSTI ID:: 1463343

Journal Information:: International Journal of Molecular Sciences (Online), Vol. 19, Issue 6; ISSN 1422-0067

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 18 works

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