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Title: A coupled chlorinase–fluorinase system with a high efficiency of trans -halogenation and a shared substrate tolerance

SAM-dependent chlorinases exhibited tolerance to the modification at the C-2 position of the adenosine substrate and acted cooperatively with fluorinase for rapid trans -halogenation.
Authors:
ORCiD logo [1] ; ORCiD logo [1] ; ORCiD logo [1]
  1. Metabolic Engineering Research Laboratory (MERL), Institute of Chemical & Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), Singapore 138669, Singapore
Publication Date:
Grant/Contract Number:
SC0018420
Type:
Publisher's Accepted Manuscript
Journal Name:
Chemical Communications
Additional Journal Information:
Journal Name: Chemical Communications Journal Volume: 54 Journal Issue: 68; Journal ID: ISSN 1359-7345
Publisher:
Royal Society of Chemistry (RSC)
Sponsoring Org:
USDOE
Country of Publication:
United Kingdom
Language:
English
OSTI Identifier:
1463186

Sun, H., Zhao, H., and Ang, E. L.. A coupled chlorinase–fluorinase system with a high efficiency of trans -halogenation and a shared substrate tolerance. United Kingdom: N. p., Web. doi:10.1039/C8CC04436H.
Sun, H., Zhao, H., & Ang, E. L.. A coupled chlorinase–fluorinase system with a high efficiency of trans -halogenation and a shared substrate tolerance. United Kingdom. doi:10.1039/C8CC04436H.
Sun, H., Zhao, H., and Ang, E. L.. 2018. "A coupled chlorinase–fluorinase system with a high efficiency of trans -halogenation and a shared substrate tolerance". United Kingdom. doi:10.1039/C8CC04436H.
@article{osti_1463186,
title = {A coupled chlorinase–fluorinase system with a high efficiency of trans -halogenation and a shared substrate tolerance},
author = {Sun, H. and Zhao, H. and Ang, E. L.},
abstractNote = {SAM-dependent chlorinases exhibited tolerance to the modification at the C-2 position of the adenosine substrate and acted cooperatively with fluorinase for rapid trans -halogenation.},
doi = {10.1039/C8CC04436H},
journal = {Chemical Communications},
number = 68,
volume = 54,
place = {United Kingdom},
year = {2018},
month = {1}
}