Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation

Sweet, Tara B.; Hurley, Sean D.; Wu, Michael D.; Olschowka, John A.; Williams, Jacqueline P.; O'Banion, M. Kerry

doi:10.1667/RR14530.1

Title: Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation

Abstract

Understanding the dose-toxicity profile of radiation is critical when evaluating potential health risks associated with natural and man-made sources in our environment. This study was done to evaluate the effects of low-dose whole-body high-energy charged (HZE) iron (Fe) ions and low-energy gamma exposure on proliferation and differentiation of adult-born neurons within the dentate gyrus of the hippocampus, cells deemed to play a critical role in memory regulation. To determine the dose-response characteristics of the brain to whole-body Fe-ion vs. gamma-radiation exposure, C57BL/6J mice were irradiated with 1 GeV/n Fe ions or a static ¹³⁷Cs source (0.662 MeV) at doses ranging from 0 to 300 cGy. The neurogenesis was analyzed at 48 h and one month postirradiation. These experiments revealed that whole-body exposure to either Fe ions or gamma radiation leads to: 1. An acute decrease in cell division within the dentate gyrus of the hippocampus, detected at doses as low as 30 and 100 cGy for Fe ions and gamma radiation, respectively; and 2. A reduction in newly differentiated neurons (DCX immunoreactivity) at one month postirradiation, with significant decreases detected at doses as low as 100 cGy for both Fe ions and gamma rays. The data presented here contribute tomore »« less

Authors:

Sweet, Tara B. ^[1]; Hurley, Sean D. ^[1]; Wu, Michael D. ^[1]; Olschowka, John A. ^[1]; Williams, Jacqueline P. ^[2]; O'Banion, M. Kerry ^[3]

Univ. of Rochester, NY (United States). School of Medicine and Dentistry and Dept. of Neuroscience
Univ. of Rochester, NY (United States). School of Medicine and Dentistry, Dept. of Radiation Oncology and Dept. of Environmental Medicine
Univ. of Rochester, NY (United States). School of Medicine and Dentistry and Dept. of Neuroscience and Neurology

Publication Date:: Thu Dec 01 00:00:00 EST 2016

Research Org.:: Univ. of Rochester, NY (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; National Aeronautics and Space Administration (NASA); National Institutes of Health (NIH)

Contributing Org.:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

OSTI Identifier:: 1463107

Grant/Contract Number:: FG02-07ER64338; 5U19 AI091036

Resource Type:: Accepted Manuscript

Journal Name:: Radiation Research

Additional Journal Information:: Journal Volume: 186; Journal Issue: 6; Journal ID: ISSN 0033-7587

Publisher:: Radiation Research Society

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 61 RADIATION PROTECTION AND DOSIMETRY

Citation Formats


                    Sweet, Tara B., Hurley, Sean D., Wu, Michael D., Olschowka, John A., Williams, Jacqueline P., and O'Banion, M. Kerry. Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation.  United States: N. p., 2016. 
Web.  doi:10.1667/RR14530.1.

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                    Sweet, Tara B., Hurley, Sean D., Wu, Michael D., Olschowka, John A., Williams, Jacqueline P., & O'Banion, M. Kerry. Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation.  United States.  https://doi.org/10.1667/RR14530.1

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                    Sweet, Tara B., Hurley, Sean D., Wu, Michael D., Olschowka, John A., Williams, Jacqueline P., and O'Banion, M. Kerry. Thu .  
"Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation".  United States.  https://doi.org/10.1667/RR14530.1.  https://www.osti.gov/servlets/purl/1463107.

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@article{osti_1463107,

  title        = {Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation},

  author       = {Sweet, Tara B. and Hurley, Sean D. and Wu, Michael D. and Olschowka, John A. and Williams, Jacqueline P. and O'Banion, M. Kerry},

  abstractNote = {Understanding the dose-toxicity profile of radiation is critical when evaluating potential health risks associated with natural and man-made sources in our environment. This study was done to evaluate the effects of low-dose whole-body high-energy charged (HZE) iron (Fe) ions and low-energy gamma exposure on proliferation and differentiation of adult-born neurons within the dentate gyrus of the hippocampus, cells deemed to play a critical role in memory regulation. To determine the dose-response characteristics of the brain to whole-body Fe-ion vs. gamma-radiation exposure, C57BL/6J mice were irradiated with 1 GeV/n Fe ions or a static 137Cs source (0.662 MeV) at doses ranging from 0 to 300 cGy. The neurogenesis was analyzed at 48 h and one month postirradiation. These experiments revealed that whole-body exposure to either Fe ions or gamma radiation leads to: 1. An acute decrease in cell division within the dentate gyrus of the hippocampus, detected at doses as low as 30 and 100 cGy for Fe ions and gamma radiation, respectively; and 2. A reduction in newly differentiated neurons (DCX immunoreactivity) at one month postirradiation, with significant decreases detected at doses as low as 100 cGy for both Fe ions and gamma rays. The data presented here contribute to our understanding of brain responses to whole-body Fe ions and gamma rays and may help inform health-risk evaluations related to systemic exposure during a medical or radiologic/nuclear event or as a result of prolonged space travel.},

  doi          = {10.1667/RR14530.1},

  journal      = {Radiation Research},

  number       = 6,

  volume       = 186,

  place        = {United States},

  year         = {Thu Dec 01 00:00:00 EST 2016},

  month        = {Thu Dec 01 00:00:00 EST 2016}

}

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Works referencing / citing this record:

Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer’s-like transgenic mice
journal, August 2019

Liu, Bin; Hinshaw, Robert G.; Le, Kevin X.
Scientific Reports, Vol. 9, Issue 1
DOI: 10.1038/s41598-019-48615-1

Central Nervous System Responses to Simulated Galactic Cosmic Rays
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Cekanaviciute, Egle; Rosi, Susanna; Costes, Sylvain
International Journal of Molecular Sciences, Vol. 19, Issue 11
DOI: 10.3390/ijms19113669

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Citation Formats

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