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Title: Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies

The multimodality theranostic system, which can integrate two or more different therapeutic modalities and multimodal imaging agents into a nanoentity, shows great promising prospects for the cancer treatment. For this, we developed an efficient and novel strategy to synthesize hybrid anisotropic nanoparticles (HANs) with intrinsic multimodal theranostic capability [chemotherapy, photothermal therapy, magnetic resonance imaging (MRI), and photoacoustic imaging (PAI)]. For the first time, under the guidance of MRI and PAI, the chemotherapy and thermotherapy induced by administration of multifunctional hybrid nanoprobes were applied simultaneously to the treatment of colon cancer-bearing mice in vivo.
Authors:
 [1] ;  [2] ;  [3] ;  [2] ;  [2] ;  [2] ;  [2] ;  [2] ;  [3] ;  [4] ; ORCiD logo [2]
  1. Shanxi Medical Univ. (China). Dept. of Radiology of the First Hospital of Shanxi Medical Univ. and Molecular Imaging Precision Medical Collaborative Innovation Center; Stanford Univ., CA (United States). School of Medicine, Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection and Dept. of Radiology and Bio-X Program
  2. Stanford Univ., CA (United States). School of Medicine, Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection and Dept. of Radiology and Bio-X Program
  3. Stanford Univ., CA (United States). Dept. of Chemistry
  4. Zhejiang Univ., Hangzhou (China). The Second Hospital of Zhejiang Univ. School of Medicine, PET Center and Dept. of Nuclear Medicine
Publication Date:
Grant/Contract Number:
SC0008397; CCNE-TR U54 CA119367; CA151459; P50 CA114747; 81571747; 81371628; 2015CB931800; 2015081035; 2015035; 2015057; 2011CB935801
Type:
Accepted Manuscript
Journal Name:
Biomaterials
Additional Journal Information:
Journal Volume: 103; Journal Issue: C; Journal ID: ISSN 0142-9612
Publisher:
Elsevier
Research Org:
Stanford Univ., CA (United States)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); National Institutes of Health (NIH); National Nature Science Foundation of China (NSFC); National Key Basic Research Program of China
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 77 NANOSCIENCE AND NANOTECHNOLOGY; Hybrid anisotropic NanoStructures; Photoacoustic imaging; Magnetic resonance imaging; Photothermal therapy; Chemotherapy
OSTI Identifier:
1463085
Alternate Identifier(s):
OSTI ID: 1397090