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Title: An automated synthesizer for electrochemical 18F-fluorination of organic compounds

Abstract

Electrochemical 18F-fluorination of organic compounds provides a means to synthesize Positron-Emission-Tomography (PET) tracers difficult to obtain otherwise. The first automated synthesizer that enables radiolabeling through carrier-added electrochemical 18F-fluorination is described. The system provides capabilities for all necessary operations such as drying of cyclotron derived [18F]fluoride, electrochemical incorporation of the radioisotope into a precursor molecule, subsequent reactions such as protecting group removals, HPLC-purification and formulation of the final tracer. Demonstrated is the aliphatic electrochemical 18F-fluorination of methyl 2-(phenylthio)acetate.

Authors:
 [1];  [1];  [1];  [1]
  1. Univ. of California, Los Angeles, CA (United States). David Geffen School of Medicine and Dept. of Molecular and Medical Pharmacology
Publication Date:
Research Org.:
Univ. of California, Los Angeles, CA (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1463082
Alternate Identifier(s):
OSTI ID: 1550184
Grant/Contract Number:  
SC0012353; CA186842; CA086306; R25TCA098010
Resource Type:
Accepted Manuscript
Journal Name:
Applied Radiation and Isotopes
Additional Journal Information:
Journal Volume: 127; Journal Issue: C; Journal ID: ISSN 0969-8043
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; Electrochemistry; [18F]fluoride; Radiosynthesizer; Late-stage fluorination; PET

Citation Formats

Waldmann, Christopher M., Lebedev, Artem, Allison, Nathaniel, and Sadeghi, Saman. An automated synthesizer for electrochemical 18F-fluorination of organic compounds. United States: N. p., 2017. Web. doi:10.1016/j.apradiso.2017.06.028.
Waldmann, Christopher M., Lebedev, Artem, Allison, Nathaniel, & Sadeghi, Saman. An automated synthesizer for electrochemical 18F-fluorination of organic compounds. United States. doi:10.1016/j.apradiso.2017.06.028.
Waldmann, Christopher M., Lebedev, Artem, Allison, Nathaniel, and Sadeghi, Saman. Wed . "An automated synthesizer for electrochemical 18F-fluorination of organic compounds". United States. doi:10.1016/j.apradiso.2017.06.028. https://www.osti.gov/servlets/purl/1463082.
@article{osti_1463082,
title = {An automated synthesizer for electrochemical 18F-fluorination of organic compounds},
author = {Waldmann, Christopher M. and Lebedev, Artem and Allison, Nathaniel and Sadeghi, Saman},
abstractNote = {Electrochemical 18F-fluorination of organic compounds provides a means to synthesize Positron-Emission-Tomography (PET) tracers difficult to obtain otherwise. The first automated synthesizer that enables radiolabeling through carrier-added electrochemical 18F-fluorination is described. The system provides capabilities for all necessary operations such as drying of cyclotron derived [18F]fluoride, electrochemical incorporation of the radioisotope into a precursor molecule, subsequent reactions such as protecting group removals, HPLC-purification and formulation of the final tracer. Demonstrated is the aliphatic electrochemical 18F-fluorination of methyl 2-(phenylthio)acetate.},
doi = {10.1016/j.apradiso.2017.06.028},
journal = {Applied Radiation and Isotopes},
number = C,
volume = 127,
place = {United States},
year = {2017},
month = {6}
}

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Cited by: 4 works
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Works referencing / citing this record:

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules
journal, March 2018

  • Trobe, Melanie; Burke, Martin D.
  • Angewandte Chemie International Edition, Vol. 57, Issue 16
  • DOI: 10.1002/anie.201710482