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Title: An automated synthesizer for electrochemical 18F-fluorination of organic compounds

Electrochemical 18F-fluorination of organic compounds provides a means to synthesize Positron-Emission-Tomography (PET) tracers difficult to obtain otherwise. The first automated synthesizer that enables radiolabeling through carrier-added electrochemical 18F-fluorination is described. The system provides capabilities for all necessary operations such as drying of cyclotron derived [ 18F]fluoride, electrochemical incorporation of the radioisotope into a precursor molecule, subsequent reactions such as protecting group removals, HPLC-purification and formulation of the final tracer. Demonstrated is the aliphatic electrochemical 18F-fluorination of methyl 2-(phenylthio)acetate.
Authors:
 [1] ;  [1] ;  [1] ;  [1]
  1. Univ. of California, Los Angeles, CA (United States). David Geffen School of Medicine and Dept. of Molecular and Medical Pharmacology
Publication Date:
Grant/Contract Number:
SC0012353; CA186842; CA086306; R25TCA098010
Type:
Accepted Manuscript
Journal Name:
Applied Radiation and Isotopes
Additional Journal Information:
Journal Volume: 127; Journal Issue: C; Journal ID: ISSN 0969-8043
Publisher:
Elsevier
Research Org:
Univ. of California, Los Angeles, CA (United States)
Sponsoring Org:
USDOE; National Institutes of Health (NIH)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; Electrochemistry; [18F]fluoride; Radiosynthesizer; Late-stage fluorination; PET
OSTI Identifier:
1463082