A carbon nanotube reporter of microRNA hybridization events in vivo
Abstract
MicroRNAs and other small oligonucleotides in biofluids are promising disease biomarkers, yet conventional assays require complex processing steps that are unsuitable for point-of-care testing or for implantable or wearable sensors. Single-walled carbon nanotubes are an ideal material for implantable sensors, owing to their emission in the near-infrared spectral region, photostability and exquisite sensitivity. Here, we report an engineered carbon-nanotube-based sensor capable of real-time optical quantification of hybridization events of microRNA and other oligonucleotides. The mechanism of the sensor arises from competitive effects between displacement of both oligonucleotide charge groups and water from the nanotube surface, which result in a solvatochromism-like response. The sensor, which allows for detection via single-molecule sensor elements and for multiplexing by using multiple nanotube chiralities, can monitor toehold-based strand-displacement events, which reverse the sensor response and regenerate the sensor complex. We also show that the sensor functions in whole urine and serum, and can non-invasively measure DNA and microRNA after implantation in live mice.
- Authors:
-
- Memorial Sloan Kettering Cancer Center, New York City, NY (United States). Molecular Pharmacology Program; Weill Cornell Medical College, New York City, NY (United States). Dept. of Pharmacology
- Memorial Sloan Kettering Cancer Center, New York City, NY (United States). Molecular Pharmacology Program
- Lehigh Univ., Bethlehem, PA (United States). Dept. of Chemical and Biomolecular Engineering
- Univ. of Rhode Island, Kingston, RI (United States). Dept. of Chemical Engineering
- Publication Date:
- Research Org.:
- Lehigh Univ., Bethlehem, PA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Materials Sciences & Engineering Division; National Institutes of Health (NIH); National Science Foundation (NSF); Ovarian Cancer Research Fund Alliance (OCRFA); American Cancer Society (ACS)
- Contributing Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)
- OSTI Identifier:
- 1462350
- Alternate Identifier(s):
- OSTI ID: 1490254
- Grant/Contract Number:
- SC0013979; DP2-HD075698; P30-CA008748; TG-MCB-120014; AC02-05CH11231; 2T32CA062948-21; T32GM007739; 370463
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Biomedical Engineering (Online)
- Additional Journal Information:
- Journal Name: Nature Biomedical Engineering (Online); Journal Volume: 1; Journal Issue: 4; Journal ID: ISSN 2157-846X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY
Citation Formats
Harvey, Jackson D., Jena, Prakrit V., Baker, Hanan A., Zerze, Gül H., Williams, Ryan M., Galassi, Thomas V., Roxbury, Daniel, Mittal, Jeetain, and Heller, Daniel A. A carbon nanotube reporter of microRNA hybridization events in vivo. United States: N. p., 2017.
Web. doi:10.1038/s41551-017-0041.
Harvey, Jackson D., Jena, Prakrit V., Baker, Hanan A., Zerze, Gül H., Williams, Ryan M., Galassi, Thomas V., Roxbury, Daniel, Mittal, Jeetain, & Heller, Daniel A. A carbon nanotube reporter of microRNA hybridization events in vivo. United States. https://doi.org/10.1038/s41551-017-0041
Harvey, Jackson D., Jena, Prakrit V., Baker, Hanan A., Zerze, Gül H., Williams, Ryan M., Galassi, Thomas V., Roxbury, Daniel, Mittal, Jeetain, and Heller, Daniel A. Mon .
"A carbon nanotube reporter of microRNA hybridization events in vivo". United States. https://doi.org/10.1038/s41551-017-0041. https://www.osti.gov/servlets/purl/1462350.
@article{osti_1462350,
title = {A carbon nanotube reporter of microRNA hybridization events in vivo},
author = {Harvey, Jackson D. and Jena, Prakrit V. and Baker, Hanan A. and Zerze, Gül H. and Williams, Ryan M. and Galassi, Thomas V. and Roxbury, Daniel and Mittal, Jeetain and Heller, Daniel A.},
abstractNote = {MicroRNAs and other small oligonucleotides in biofluids are promising disease biomarkers, yet conventional assays require complex processing steps that are unsuitable for point-of-care testing or for implantable or wearable sensors. Single-walled carbon nanotubes are an ideal material for implantable sensors, owing to their emission in the near-infrared spectral region, photostability and exquisite sensitivity. Here, we report an engineered carbon-nanotube-based sensor capable of real-time optical quantification of hybridization events of microRNA and other oligonucleotides. The mechanism of the sensor arises from competitive effects between displacement of both oligonucleotide charge groups and water from the nanotube surface, which result in a solvatochromism-like response. The sensor, which allows for detection via single-molecule sensor elements and for multiplexing by using multiple nanotube chiralities, can monitor toehold-based strand-displacement events, which reverse the sensor response and regenerate the sensor complex. We also show that the sensor functions in whole urine and serum, and can non-invasively measure DNA and microRNA after implantation in live mice.},
doi = {10.1038/s41551-017-0041},
journal = {Nature Biomedical Engineering (Online)},
number = 4,
volume = 1,
place = {United States},
year = {Mon Mar 13 00:00:00 EDT 2017},
month = {Mon Mar 13 00:00:00 EDT 2017}
}
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