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Title: High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair: High γH2AX Associates with Replication in iPSCs

Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [3] ;  [1] ;  [4] ;  [3] ; ORCiD logo [1]
  1. Division of Cellular and Gene Therapy, Office of Tissue and Advanced Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring Maryland USA
  2. Division of Biotechnology Review and Research II, Office of Pharmaceutical Quality, Center for Drugs Evaluation and Research, U.S. Food and Drug Administration, Silver Spring Maryland USA
  3. Laboratory of Cardiovascular Regenerative Medicine, National Heart, Lung and Blood Institute, Bethesda Maryland USA
  4. Stem Cell Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda Maryland USA
Publication Date:
Type:
Publisher's Accepted Manuscript
Journal Name:
STEM CELLS
Additional Journal Information:
Journal Name: STEM CELLS Journal Volume: 36 Journal Issue: 10; Journal ID: ISSN 1066-5099
Publisher:
Wiley Blackwell (John Wiley & Sons)
Sponsoring Org:
USDOE
Country of Publication:
Country unknown/Code not available
Language:
English
OSTI Identifier:
1462114

Vallabhaneni, Haritha, Lynch, Patrick J., Chen, Guibin, Park, Kyeyoon, Liu, Yangtengyu, Goehe, Rachel, Mallon, Barbara S., Boehm, Manfred, and Hursh, Deborah A.. High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair: High γH2AX Associates with Replication in iPSCs. Country unknown/Code not available: N. p., Web. doi:10.1002/stem.2861.
Vallabhaneni, Haritha, Lynch, Patrick J., Chen, Guibin, Park, Kyeyoon, Liu, Yangtengyu, Goehe, Rachel, Mallon, Barbara S., Boehm, Manfred, & Hursh, Deborah A.. High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair: High γH2AX Associates with Replication in iPSCs. Country unknown/Code not available. doi:10.1002/stem.2861.
Vallabhaneni, Haritha, Lynch, Patrick J., Chen, Guibin, Park, Kyeyoon, Liu, Yangtengyu, Goehe, Rachel, Mallon, Barbara S., Boehm, Manfred, and Hursh, Deborah A.. 2018. "High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair: High γH2AX Associates with Replication in iPSCs". Country unknown/Code not available. doi:10.1002/stem.2861.
@article{osti_1462114,
title = {High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair: High γH2AX Associates with Replication in iPSCs},
author = {Vallabhaneni, Haritha and Lynch, Patrick J. and Chen, Guibin and Park, Kyeyoon and Liu, Yangtengyu and Goehe, Rachel and Mallon, Barbara S. and Boehm, Manfred and Hursh, Deborah A.},
abstractNote = {},
doi = {10.1002/stem.2861},
journal = {STEM CELLS},
number = 10,
volume = 36,
place = {Country unknown/Code not available},
year = {2018},
month = {7}
}

Works referenced in this record:

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
journal, March 1998
  • Rogakou, Emmy P.; Pilch, Duane R.; Orr, Ann H.
  • Journal of Biological Chemistry, Vol. 273, Issue 10, p. 5858-5868
  • DOI: 10.1074/jbc.273.10.5858