Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis

doi:10.1016/j.tube.2018.07.005

Title: Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis

Article Details
Other Related Research

Authors:

Kedia, Komal ; Wendler, Jason P. ; ; Burnum-Johnson, Kristin E. ; ; Stratton, Kelly G. ; ; ; Gritsenko, Marina A. ; Lewinsohn, David M. ; Sigal, George B. ; Weiner, Marc H. ; Smith, Richard D. ; Jacobs, Jon M. ;

Publication Date:: 2018-09-01

Grant/Contract Number:: AC05-76RLO 1830

Type:: Published Article

Journal Name:: Tuberculosis

Additional Journal Information:: Journal Name: Tuberculosis Journal Volume: 112 Journal Issue: C; Journal ID: ISSN 1472-9792

Publisher:: Elsevier

Sponsoring Org:: USDOE

Country of Publication:: Netherlands

Language:: English

OSTI Identifier:: 1461904


                    Kedia, Komal, Wendler, Jason P., Baker, Erin S., Burnum-Johnson, Kristin E., Jarsberg, Leah G., Stratton, Kelly G., Wright, Aaron T., Piehowski, Paul D., Gritsenko, Marina A., Lewinsohn, David M., Sigal, George B., Weiner, Marc H., Smith, Richard D., Jacobs, Jon M., and Nahid, Payam. Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis.  Netherlands: N. p.,  
        Web.  doi:10.1016/j.tube.2018.07.005.

Copy to clipboard


                    Kedia, Komal, Wendler, Jason P., Baker, Erin S., Burnum-Johnson, Kristin E., Jarsberg, Leah G., Stratton, Kelly G., Wright, Aaron T., Piehowski, Paul D., Gritsenko, Marina A., Lewinsohn, David M., Sigal, George B., Weiner, Marc H., Smith, Richard D., Jacobs, Jon M., & Nahid, Payam. Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis.  Netherlands.  doi:10.1016/j.tube.2018.07.005.

Copy to clipboard


                    Kedia, Komal, Wendler, Jason P., Baker, Erin S., Burnum-Johnson, Kristin E., Jarsberg, Leah G., Stratton, Kelly G., Wright, Aaron T., Piehowski, Paul D., Gritsenko, Marina A., Lewinsohn, David M., Sigal, George B., Weiner, Marc H., Smith, Richard D., Jacobs, Jon M., and Nahid, Payam. 2018.  
        "Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis".  Netherlands.  
        doi:10.1016/j.tube.2018.07.005.

Copy to clipboard


                    
@article{osti_1461904,

  title        = {Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis},

  author       = {Kedia, Komal and Wendler, Jason P. and Baker, Erin S. and Burnum-Johnson, Kristin E. and Jarsberg, Leah G. and Stratton, Kelly G. and Wright, Aaron T. and Piehowski, Paul D. and Gritsenko, Marina A. and Lewinsohn, David M. and Sigal, George B. and Weiner, Marc H. and Smith, Richard D. and Jacobs, Jon M. and Nahid, Payam},

  abstractNote = {},

  doi          = {10.1016/j.tube.2018.07.005},

  journal      = {Tuberculosis},

  number       = C,

  volume       = 112,

  place        = {Netherlands},

  year         = {2018},

  month        = {9}

}

Copy to clipboard

Free Publicly Accessible Full Text
Publisher's Version of Record at 10.1016/j.tube.2018.07.005

Similar Records

Similar records in DOE PAGES and OSTI.GOV collections:

Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis

Journal Article Kedia, Komal ; Wendler, Jason ; Baker, Erin S. ; ... July 2018 - Tuberculosis

Here, the monitoring of TB treatments in clinical practice and clinical trials relies on traditional sputum-based culture status indicators at specific time points. Accurate, predictive, blood-based protein markers would provide a simpler and more informative view of patient health and response to treatment. We utilized sensitive, high throughput multiplexed ion mobility-mass spectrometry (IM-MS) to characterize the serum proteome of TB patients at the start of and at 8 weeks of rifamycin-based treatment. We sought to identify treatment specific signatures within patients as well as correlate the proteome signatures to various clinical markers of treatment efficacy. Serum samples were collected frommore »« less
Full Text Available
Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry

Journal Article - in OSTI.gov collection Baker, Erin Shammel ; Burnum-Johnson, Kristin E. ; Jacobs, Jon M. ; ... April 2014 - Molecular and Cellular Proteomics, 13(4):1119-1127

Rapid diagnosis of disease states using less invasive, safer, and more clinically acceptable approaches than presently employed is an imperative goal for the field of medicine. While mass spectrometry (MS)-based proteomics approaches have attempted to meet these objectives, challenges such as the enormous dynamic range of protein concentrations in clinically relevant biofluid samples coupled with the need to address human biodiversity have slowed their employment. Herein, we report on the use of a new platform that addresses these challenges by coupling technical advances in rapid gas phase multiplexed ion mobility spectrometry (IMS) separations [1, 2] with liquid chromatography (LC) andmore »« less
Full Text Available
Native mass spectrometry and ion mobility characterize the orange carotenoid protein functional domains

Journal Article Zhang, Hao ; Liu, Haijun ; Lu, Yue ; ... June 2016 - Biochimica et Biophysica Acta - Bioenergetics

Cited by 9Full Text Available
Native mass spectrometry and ion mobility characterize the orange carotenoid protein functional domains

Journal Article Zhang, Hao ; Liu, Haijun ; Lu, Yue ; ... June 2016 - Biochimica et Biophysica Acta - Bioenergetics

Cited by 9Full Text Available
Mobility-Resolved Ion Selection in Uniform Drift Field Ion Mobility Spectrometry/Mass Spectrometry: Dynamic Switching in Structures for Lossless Ion Manipulations

Journal Article Webb, Ian K. ; Garimella, Sandilya V. B. ; Tolmachev, Aleksey V. ; ... September 2014 - Analytical Chemistry

A Structures for Lossless Ion Manipulations (SLIM) module that allows ion mobility separations and the switching of ions between alternative drift paths is described. The SLIM switch component has a “Tee” configuration and allows switching of ions between a linear path and a 90-degree bend. By controlling switching times, ions can be deflected to an alternative channel as a function of their mobilities. In the initial evaluation the switch is used in a static mode and shown compatible with high performance ion mobility separations at 4 torr. In the “dynamic mode” we show that mobility-selected ions can be switched intomore »« less
Cited by 26Full Text Available

Access journal articles and accepted manuscripts resulting from DOE research funding

Title: Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis

Access journal articles and accepted manuscripts
resulting from DOE research funding