skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH

Abstract

Double-hydrophilic diblock copolymers can assemble into pH-switchable containers for the encapsulation and release of cargo across biologically-relevant pH ranges.

Authors:
 [1];  [1];  [2];  [3];  [1];  [4]; ORCiD logo [1]
  1. Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, USA
  2. Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, USA, Omphalos Bioscience LLC
  3. Nano and Micro Sensors, Sandia National Laboratories, Albuquerque, USA
  4. Office of Research and Economic Development, University of Nebraska – Lincoln, Lincoln, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1461902
Grant/Contract Number:  
NA-0003525
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Chemical Communications
Additional Journal Information:
Journal Name: Chemical Communications Journal Volume: 54 Journal Issue: 65; Journal ID: ISSN 1359-7345
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Shin, Sun Hae Ra, McAninch, Patrick T., Henderson, Ian M., Gomez, Andrew, Greene, Adrienne C., Carnes, Eric C., and Paxton, Walter F. Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH. United Kingdom: N. p., 2018. Web. doi:10.1039/C8CC05155K.
Shin, Sun Hae Ra, McAninch, Patrick T., Henderson, Ian M., Gomez, Andrew, Greene, Adrienne C., Carnes, Eric C., & Paxton, Walter F. Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH. United Kingdom. doi:10.1039/C8CC05155K.
Shin, Sun Hae Ra, McAninch, Patrick T., Henderson, Ian M., Gomez, Andrew, Greene, Adrienne C., Carnes, Eric C., and Paxton, Walter F. Mon . "Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH". United Kingdom. doi:10.1039/C8CC05155K.
@article{osti_1461902,
title = {Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH},
author = {Shin, Sun Hae Ra and McAninch, Patrick T. and Henderson, Ian M. and Gomez, Andrew and Greene, Adrienne C. and Carnes, Eric C. and Paxton, Walter F.},
abstractNote = {Double-hydrophilic diblock copolymers can assemble into pH-switchable containers for the encapsulation and release of cargo across biologically-relevant pH ranges.},
doi = {10.1039/C8CC05155K},
journal = {Chemical Communications},
number = 65,
volume = 54,
place = {United Kingdom},
year = {2018},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1039/C8CC05155K

Save / Share:

Works referenced in this record:

Templated formation of giant polymer vesicles with controlled size distributions
journal, May 2009

  • Howse, Jonathan R.; Jones, Richard A. L.; Battaglia, Giuseppe
  • Nature Materials, Vol. 8, Issue 6
  • DOI: 10.1038/nmat2446

A Polymersome Nanoreactor with Controllable Permeability Induced by Stimuli-Responsive Block Copolymers
journal, March 2009

  • Kim, Kyoung Taek; Cornelissen, Jeroen J. L. M.; Nolte, Roeland J. M.
  • Advanced Materials, Vol. 21, Issue 27
  • DOI: 10.1002/adma.200900300

Self-association of double-hydrophilic copolymers of acrylic acid and poly(ethylene oxide) macromonomer
journal, November 2004


Self-Assembly of Poly(ethylene oxide)- block -poly(acrylic acid) Induced by CaCl 2 : Mechanistic Study
journal, August 2008

  • Sondjaja, H. Ronny; Hatton, T. Alan; Tam, K. C.
  • Langmuir, Vol. 24, Issue 16
  • DOI: 10.1021/la800727e

pH Effects in the Complex Formation and Blending of Poly(acrylic acid) with Poly(ethylene oxide)
journal, April 2004

  • Khutoryanskiy, Vitaliy V.; Dubolazov, Artem V.; Nurkeeva, Zauresh S.
  • Langmuir, Vol. 20, Issue 9
  • DOI: 10.1021/la049807l

Association Reactions for Poly(alkylene Oxides) and Polymeric Poly(carboxylic Acids)
journal, November 1959

  • Smith, K. L.; Winslow, A. E.; Petersen, D. E.
  • Industrial & Engineering Chemistry, Vol. 51, Issue 11
  • DOI: 10.1021/ie50599a029

One-Step Preparation of Block Copolymer Vesicles with Preferentially Segregated Acidic and Basic Corona Chains
journal, March 2002


Bioinspired polymer vesicles and membranes for biological and medical applications
journal, January 2016

  • Palivan, Cornelia G.; Goers, Roland; Najer, Adrian
  • Chemical Society Reviews, Vol. 45, Issue 2
  • DOI: 10.1039/C5CS00569H

pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates
journal, August 2012

  • Felber, Arnaud E.; Dufresne, Marie-Hélène; Leroux, Jean-Christophe
  • Advanced Drug Delivery Reviews, Vol. 64, Issue 11
  • DOI: 10.1016/j.addr.2011.09.006

Polymersomes: nature inspired nanometer sized compartments
journal, January 2009

  • LoPresti, Caterina; Lomas, Hannah; Massignani, Marzia
  • Journal of Materials Chemistry, Vol. 19, Issue 22
  • DOI: 10.1039/b818869f

Microencapsulation of probiotics for gastrointestinal delivery
journal, August 2012

  • Cook, Michael T.; Tzortzis, George; Charalampopoulos, Dimitris
  • Journal of Controlled Release, Vol. 162, Issue 1
  • DOI: 10.1016/j.jconrel.2012.06.003

Polymersomes: Tough Vesicles Made from Diblock Copolymers
journal, May 1999


Self-assembly of block copolymers
journal, January 2012

  • Mai, Yiyong; Eisenberg, Adi
  • Chemical Society Reviews, Vol. 41, Issue 18
  • DOI: 10.1039/c2cs35115c

Reversible Inside−Out Micellization of pH-responsive and Water-Soluble Vesicles Based on Polypeptide Diblock Copolymers
journal, February 2005

  • Rodríguez-Hernández, Juan; Lecommandoux, Sébastien
  • Journal of the American Chemical Society, Vol. 127, Issue 7
  • DOI: 10.1021/ja043920g

α-Cyclodextrin-Induced Self-Assembly of a Double-Hydrophilic Block Copolymer in Aqueous Solution
journal, April 2007

  • Liu, Jianhong; Sondjaja, Herriyanto R.; Tam, Kam C.
  • Langmuir, Vol. 23, Issue 9
  • DOI: 10.1021/la063365r

Synthesis and characterization of PNIPAM‐ b ‐(PEA‐ g ‐PDEA) double hydrophilic graft copolymer
journal, August 2008

  • Feng, Chun; Shen, Zhong; Gu, Lina
  • Journal of Polymer Science Part A: Polymer Chemistry, Vol. 46, Issue 16
  • DOI: 10.1002/pola.22885

Hydroxide ion flux and pH-gradient driven ester hydrolysis in polymer vesicle reactors
journal, January 2013

  • Paxton, Walter F.; Price, Delisia; Richardson, Nicholas J.
  • Soft Matter, Vol. 9, Issue 47
  • DOI: 10.1039/c3sm51575c

Polymer Vesicles
journal, August 2002


Stimuli-Responsive Polymersomes for Biomedical Applications
journal, February 2017


pH-Responsive polymers
journal, January 2017

  • Kocak, G.; Tuncer, C.; Bütün, V.
  • Polymer Chemistry, Vol. 8, Issue 1
  • DOI: 10.1039/C6PY01872F

Interchain Hydrogen-Bonding-Induced Association of Poly(acrylic acid)- graft -poly(ethylene oxide) in Water
journal, February 2010

  • Hao, Jinkun; Yuan, Guangcui; He, Weidong
  • Macromolecules, Vol. 43, Issue 4
  • DOI: 10.1021/ma9025515

pH-Sensitive Vesicles Based on a Biocompatible Zwitterionic Diblock Copolymer
journal, December 2005

  • Du, Jianzhong; Tang, Yiqing; Lewis, Andrew L.
  • Journal of the American Chemical Society, Vol. 127, Issue 51
  • DOI: 10.1021/ja056514l

The Role of Membrane Fluidization in the Gel-Assisted Formation of Giant Polymersomes
journal, July 2016


Polymeric vesicles in biomedical applications
journal, January 2011

  • Brinkhuis, René P.; Rutjes, Floris P. J. T.; van Hest, Jan C. M.
  • Polymer Chemistry, Vol. 2, Issue 7
  • DOI: 10.1039/c1py00061f

Polymersome-based drug-delivery strategies for cancer therapeutics
journal, April 2015

  • Anajafi, Tayebeh; Mallik, Sanku
  • Therapeutic Delivery, Vol. 6, Issue 4
  • DOI: 10.4155/tde.14.125