DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH

Journal Article · · Chemical Communications
DOI: https://doi.org/10.1039/C8CC05155K · OSTI ID:1461902
 [1];  [1];  [2];  [3];  [1];  [4]; ORCiD logo [1]
  1. Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, USA
  2. Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, USA, Omphalos Bioscience LLC
  3. Nano and Micro Sensors, Sandia National Laboratories, Albuquerque, USA
  4. Office of Research and Economic Development, University of Nebraska – Lincoln, Lincoln, USA

Double-hydrophilic diblock copolymers can assemble into pH-switchable containers for the encapsulation and release of cargo across biologically-relevant pH ranges.

Sponsoring Organization:
USDOE
Grant/Contract Number:
NA-0003525
OSTI ID:
1461902
Journal Information:
Chemical Communications, Journal Name: Chemical Communications Vol. 54 Journal Issue: 65; ISSN 1359-7345
Publisher:
Royal Society of Chemistry (RSC)Copyright Statement
Country of Publication:
United Kingdom
Language:
English

References (30)

Templated formation of giant polymer vesicles with controlled size distributions journal May 2009
A Polymersome Nanoreactor with Controllable Permeability Induced by Stimuli-Responsive Block Copolymers journal March 2009
Self-association of double-hydrophilic copolymers of acrylic acid and poly(ethylene oxide) macromonomer journal November 2004
Self-Assembly of Poly(ethylene oxide)- block -poly(acrylic acid) Induced by CaCl 2 : Mechanistic Study journal August 2008
pH Effects in the Complex Formation and Blending of Poly(acrylic acid) with Poly(ethylene oxide) journal April 2004
Association Reactions for Poly(alkylene Oxides) and Polymeric Poly(carboxylic Acids) journal November 1959
One-Step Preparation of Block Copolymer Vesicles with Preferentially Segregated Acidic and Basic Corona Chains journal March 2002
Bioinspired polymer vesicles and membranes for biological and medical applications journal January 2016
PH response behavior of giant vesicles comprised of amphiphilic poly(methacrylic acid)-block-poly(methyl methacrylate-random-mathacrylic acid) journal December 2014
pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates journal August 2012
Polymersomes: nature inspired nanometer sized compartments journal January 2009
Microencapsulation of probiotics for gastrointestinal delivery journal August 2012
Polymersomes: Tough Vesicles Made from Diblock Copolymers journal May 1999
Self-assembly of block copolymers journal January 2012
Reversible Inside−Out Micellization of pH-responsive and Water-Soluble Vesicles Based on Polypeptide Diblock Copolymers journal February 2005
α-Cyclodextrin-Induced Self-Assembly of a Double-Hydrophilic Block Copolymer in Aqueous Solution journal April 2007
Synthesis and characterization of PNIPAM‐ b ‐(PEA‐ g ‐PDEA) double hydrophilic graft copolymer journal August 2008
Hydroxide ion flux and pH-gradient driven ester hydrolysis in polymer vesicle reactors journal January 2013
Polymer Vesicles journal August 2002
Stimuli-Responsive Polymersomes for Biomedical Applications journal February 2017
pH-Responsive polymers journal January 2017
Interchain Hydrogen-Bonding-Induced Association of Poly(acrylic acid)- graft -poly(ethylene oxide) in Water journal February 2010
Polymer-polymer complexation in dilute aqueous solutions: poly(acrylic acid)-poly(ethylene oxide) and poly(acrylic acid)-poly(vinylpyrrolidone) journal October 1991
pH-Sensitive Vesicles Based on a Biocompatible Zwitterionic Diblock Copolymer journal December 2005
The Role of Membrane Fluidization in the Gel-Assisted Formation of Giant Polymersomes journal July 2016
Polymeric vesicles in biomedical applications journal January 2011
Polymersome-based drug-delivery strategies for cancer therapeutics journal April 2015
Cellulose Abetted Assembly and Temporally Decoupled Loading of Cargo into Vesicles Synthesized from Functionally Diverse Lamellar Phase Forming Amphiphiles journal January 2018
Fluorometric study of the equilibrium and kinetics of poly(acrylic acid) association with polyoxyethylene or poly(vinyl pyrrolidone) journal January 1983
Synthesis of double hydrophilic block copolymers and induced assembly with oligochitosan for the preparation of polyion complex micelles journal January 2011