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Title: Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells

Abstract

Miniaturized multidimensional peptide separations can greatly increase the coverage in proteome profiling for trace samples.

Authors:
ORCiD logo [1]; ORCiD logo [1];  [1];  [1];  [2];  [1];  [1];  [1];  [1];  [2];  [2]; ORCiD logo [1]; ORCiD logo [1]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  2. Univ. of Florida, Gainesville, FL (United States)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1461650
Report Number(s):
PNNL-SA-133217
Journal ID: ISSN 2041-6520
Grant/Contract Number:  
DP3DK110844; UC4DK104167; R33CA225248; R21EB020976; AC05-76RL01830
Resource Type:
Accepted Manuscript
Journal Name:
Chemical Science
Additional Journal Information:
Journal Volume: 9; Journal Issue: 34; Journal ID: ISSN 2041-6520
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Dou, Maowei, Zhu, Ying, Liyu, Andrey, Liang, Yiran, Chen, Jing, Piehowski, Paul D., Xu, Kerui, Zhao, Rui, Moore, Ronald J., Atkinson, Mark A., Mathews, Clayton E., Qian, Wei -Jun, and Kelly, Ryan T. Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells. United States: N. p., 2018. Web. doi:10.1039/C8SC02680G.
Dou, Maowei, Zhu, Ying, Liyu, Andrey, Liang, Yiran, Chen, Jing, Piehowski, Paul D., Xu, Kerui, Zhao, Rui, Moore, Ronald J., Atkinson, Mark A., Mathews, Clayton E., Qian, Wei -Jun, & Kelly, Ryan T. Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells. United States. doi:10.1039/C8SC02680G.
Dou, Maowei, Zhu, Ying, Liyu, Andrey, Liang, Yiran, Chen, Jing, Piehowski, Paul D., Xu, Kerui, Zhao, Rui, Moore, Ronald J., Atkinson, Mark A., Mathews, Clayton E., Qian, Wei -Jun, and Kelly, Ryan T. Wed . "Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells". United States. doi:10.1039/C8SC02680G. https://www.osti.gov/servlets/purl/1461650.
@article{osti_1461650,
title = {Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells},
author = {Dou, Maowei and Zhu, Ying and Liyu, Andrey and Liang, Yiran and Chen, Jing and Piehowski, Paul D. and Xu, Kerui and Zhao, Rui and Moore, Ronald J. and Atkinson, Mark A. and Mathews, Clayton E. and Qian, Wei -Jun and Kelly, Ryan T.},
abstractNote = {Miniaturized multidimensional peptide separations can greatly increase the coverage in proteome profiling for trace samples.},
doi = {10.1039/C8SC02680G},
journal = {Chemical Science},
number = 34,
volume = 9,
place = {United States},
year = {2018},
month = {7}
}

Journal Article:
Free Publicly Available Full Text
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