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Title: Tuning antimicrobial properties of biomimetic nanopatterned surfaces

Abstract

Here, nature has amassed an impressive array of structures that afford protection from microbial colonization/infection when displayed on the exterior surfaces of organisms. Here, controlled variation of the features of mimetics derived from etched silicon allows for tuning of their antimicrobial efficacy. Materials with nanopillars up to 7 μm in length are extremely effective against a wide range of microbial species and exceed the performance of natural surfaces; in contrast, materials with shorter/blunter nanopillars (<2 μm) selectively killed specific species. Using a combination of microscopies, the mechanisms by which bacteria are killed are demonstrated, emphasizing the dependence upon pillar density and tip geometry. Additionally, real-time imaging reveals how cells are immobilized and killed rapidly. Generic or selective protection from microbial colonization could be conferred to surfaces [for, e.g., internal medicine, implants (joint, dental, and cosmetic), food preparation, and the agricultural industry] patterned with these materials as coatings.

Authors:
ORCiD logo [1];  [1];  [1];  [2]; ORCiD logo [1];  [1]; ORCiD logo [1]
  1. Argonne National Lab. (ANL), Argonne, IL (United States)
  2. Argonne National Lab. (ANL), Argonne, IL (United States); Pennsylvania State Univ., University Park, PA (United States)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1460974
Alternate Identifier(s):
OSTI ID: 1434121
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Accepted Manuscript
Journal Name:
Nanoscale
Additional Journal Information:
Journal Volume: 10; Journal Issue: 14; Journal ID: ISSN 2040-3364
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; bactericidal; biomimetic surface; bioselectivity; black silicon; nanofabrication; nanotopography

Citation Formats

Michalska, Martyna, Gambacorta, Francesca, Divan, Ralu, Aranson, Igor S., Sokolov, Andrey, Noirot, Philippe, and Laible, Philip D. Tuning antimicrobial properties of biomimetic nanopatterned surfaces. United States: N. p., 2018. Web. doi:10.1039/c8nr00439k.
Michalska, Martyna, Gambacorta, Francesca, Divan, Ralu, Aranson, Igor S., Sokolov, Andrey, Noirot, Philippe, & Laible, Philip D. Tuning antimicrobial properties of biomimetic nanopatterned surfaces. United States. doi:10.1039/c8nr00439k.
Michalska, Martyna, Gambacorta, Francesca, Divan, Ralu, Aranson, Igor S., Sokolov, Andrey, Noirot, Philippe, and Laible, Philip D. Tue . "Tuning antimicrobial properties of biomimetic nanopatterned surfaces". United States. doi:10.1039/c8nr00439k. https://www.osti.gov/servlets/purl/1460974.
@article{osti_1460974,
title = {Tuning antimicrobial properties of biomimetic nanopatterned surfaces},
author = {Michalska, Martyna and Gambacorta, Francesca and Divan, Ralu and Aranson, Igor S. and Sokolov, Andrey and Noirot, Philippe and Laible, Philip D.},
abstractNote = {Here, nature has amassed an impressive array of structures that afford protection from microbial colonization/infection when displayed on the exterior surfaces of organisms. Here, controlled variation of the features of mimetics derived from etched silicon allows for tuning of their antimicrobial efficacy. Materials with nanopillars up to 7 μm in length are extremely effective against a wide range of microbial species and exceed the performance of natural surfaces; in contrast, materials with shorter/blunter nanopillars (<2 μm) selectively killed specific species. Using a combination of microscopies, the mechanisms by which bacteria are killed are demonstrated, emphasizing the dependence upon pillar density and tip geometry. Additionally, real-time imaging reveals how cells are immobilized and killed rapidly. Generic or selective protection from microbial colonization could be conferred to surfaces [for, e.g., internal medicine, implants (joint, dental, and cosmetic), food preparation, and the agricultural industry] patterned with these materials as coatings.},
doi = {10.1039/c8nr00439k},
journal = {Nanoscale},
number = 14,
volume = 10,
place = {United States},
year = {2018},
month = {3}
}

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Works referenced in this record:

Black silicon method: X. A review on high speed and selective plasma etching of silicon with profile control: an in-depth comparison between Bosch and cryostat DRIE processes as a roadmap to next generation equipment
journal, February 2009

  • Jansen, H. V.; de Boer, M. J.; Unnikrishnan, S.
  • Journal of Micromechanics and Microengineering, Vol. 19, Issue 3, Article No. 033001
  • DOI: 10.1088/0960-1317/19/3/033001