Polyketide synthases as a platform for chemical product design

Zargar, Amin; Barajas, Jesus F.; Lal, Ravi; Keasling, Jay D.

doi:10.1002/aic.16351

Title: Polyketide synthases as a platform for chemical product design

Journal Article · 16 July 2018 · AIChE Journal

DOI: https://doi.org/10.1002/aic.16351 · OSTI ID:1460495

Zargar, Amin ^[1]; Barajas, Jesus F. ^[2]; Lal, Ravi ^[3];

^[4]

Lawrence Berkeley National Laboratory Joint BioEnergy Institute Emeryville CA 94608, Physical Biosciences Div. Lawrence Berkeley National Laboratory Berkeley CA 94720
Physical Biosciences Div. Lawrence Berkeley National Laboratory Berkeley CA 94720, Dept. of Energy Agile BioFoundry Emeryville CA 94608
Lawrence Berkeley National Laboratory Joint BioEnergy Institute Emeryville CA 94608
Lawrence Berkeley National Laboratory Joint BioEnergy Institute Emeryville CA 94608, Physical Biosciences Div. Lawrence Berkeley National Laboratory Berkeley CA 94720, QB3 Institute, University of California‐Berkeley Emeryville CA 94608, Dept. of Chemical and Biomolecular Engineering University of California Berkeley CA 94720, Dept. of Bioengineering University of California Berkeley CA 94720

To reduce the effects of greenhouse gas emissions on climate change, scientific efforts have sought to develop biofuels and bio‐based commodity chemicals as petrochemical replacements primarily for their environmental benefits. As the biological design space is far greater than chemical synthesis, there has been a drive to leverage this ability to create and replace fine and specialty chemicals. While polyketide synthases have traditionally been studied for their biosynthesis of pharmaceutical chemicals, the unique advantages of engineering polyketide synthases for the production of biofuels, commodity chemicals, and both pharmaceutical and nonpharmaceutical fine and specialty chemicals are discussed. With our increased understanding of polyketide biosynthetic logic, new computational tools for prospective polyketide synthesis pathways for the creation of existing and novel biochemicals are also outlined. © 2018 American Institute of Chemical Engineers AIChE J , 64: 4201–4207, 2018

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Sponsoring Organization:: USDOE

Grant/Contract Number:: NONE; AC02-05CH11231

OSTI ID:: 1460495

Journal Information:: AIChE Journal, Journal Name: AIChE Journal Journal Issue: 12 Vol. 64; ISSN 0001-1541

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

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