Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia: Targeted Proteomics in Alzheimer's Dementia

doi:10.1002/ana.25266

Title: Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia: Targeted Proteomics in Alzheimer's Dementia

Authors:

Yu, Lei ^[1]; Petyuk, Vladislav A. ^[2]; Gaiteri, Chris ^[1]; Mostafavi, Sara ^[3]; Young-Pearse, Tracy ^[4]; Shah, Raj C. ^[5]; Buchman, Aron S. ^[1]; Schneider, Julie A. ^[6]; Piehowski, Paul D. ^[2]; Sontag, Ryan L. ^[2]; Fillmore, Thomas L. ^[2]; Shi, Tujin ^[2]; Smith, Richard D. ^[2]; De Jager, Philip L. ^[7]; Bennett, David A. ^[1]

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, Department of Neurological Sciences, Rush University Medical Center, Chicago IL
Pacific Northwest National Laboratory, Richland WA
University of British Columbia, Vancouver British Columbia Canada
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston MA, Harvard Medical School, Boston MA
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, Department of Family Medicine, Rush University Medical Center, Chicago IL
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, Department of Neurological Sciences, Rush University Medical Center, Chicago IL, Department of Pathology, Rush University Medical Center, Chicago IL
Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York NY, Cell Circuits Program, Broad Institute, Cambridge MA

Publication Date:: 2018-07-03

Sponsoring Org.:: USDOE

OSTI Identifier:: 1458778

Grant/Contract Number:: AC05-76RL0 1830

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Annals of Neurology

Additional Journal Information:: Journal Name: Annals of Neurology Journal Volume: 84 Journal Issue: 1; Journal ID: ISSN 0364-5134

Publisher:: Wiley Blackwell (John Wiley & Sons)

Country of Publication:: United States

Language:: English

Citation Formats


                    Yu, Lei, Petyuk, Vladislav A., Gaiteri, Chris, Mostafavi, Sara, Young-Pearse, Tracy, Shah, Raj C., Buchman, Aron S., Schneider, Julie A., Piehowski, Paul D., Sontag, Ryan L., Fillmore, Thomas L., Shi, Tujin, Smith, Richard D., De Jager, Philip L., and Bennett, David A. Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia: Targeted Proteomics in Alzheimer's Dementia.  United States: N. p., 2018. 
        Web.  doi:10.1002/ana.25266.

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                    Yu, Lei, Petyuk, Vladislav A., Gaiteri, Chris, Mostafavi, Sara, Young-Pearse, Tracy, Shah, Raj C., Buchman, Aron S., Schneider, Julie A., Piehowski, Paul D., Sontag, Ryan L., Fillmore, Thomas L., Shi, Tujin, Smith, Richard D., De Jager, Philip L., & Bennett, David A. Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia: Targeted Proteomics in Alzheimer's Dementia.  United States.  doi:https://doi.org/10.1002/ana.25266

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                    Yu, Lei, Petyuk, Vladislav A., Gaiteri, Chris, Mostafavi, Sara, Young-Pearse, Tracy, Shah, Raj C., Buchman, Aron S., Schneider, Julie A., Piehowski, Paul D., Sontag, Ryan L., Fillmore, Thomas L., Shi, Tujin, Smith, Richard D., De Jager, Philip L., and Bennett, David A. Tue .  
        "Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia: Targeted Proteomics in Alzheimer's Dementia".  United States.  doi:https://doi.org/10.1002/ana.25266.

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@article{osti_1458778,

  title        = {Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia: Targeted Proteomics in Alzheimer's Dementia},

  author       = {Yu, Lei and Petyuk, Vladislav A. and Gaiteri, Chris and Mostafavi, Sara and Young-Pearse, Tracy and Shah, Raj C. and Buchman, Aron S. and Schneider, Julie A. and Piehowski, Paul D. and Sontag, Ryan L. and Fillmore, Thomas L. and Shi, Tujin and Smith, Richard D. and De Jager, Philip L. and Bennett, David A.},

  abstractNote = {},

  doi          = {10.1002/ana.25266},

  journal      = {Annals of Neurology},

  number       = 1,

  volume       = 84,

  place        = {United States},

  year         = {2018},

  month        = {7}

}

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DOI: https://doi.org/10.1002/ana.25266

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Works referenced in this record:

Microinfarct Pathology, Dementia, and Cognitive Systems
journal, March 2011

Arvanitakis, Zoe; Leurgans, Sue E.; Barnes, Lisa L.
Stroke, Vol. 42, Issue 3
DOI: 10.1161/STROKEAHA.110.595082

Mapping protein abundance patterns in the brain using voxelation combined with liquid chromatography and mass spectrometry
journal, February 2010

Petyuk, Vladislav A.; Qian, Wei-Jun; Smith, Richard D.
Methods, Vol. 50, Issue 2
DOI: 10.1016/j.ymeth.2009.07.009

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
journal, July 1984

McKhann, G.; Drachman, D.; Folstein, M.
Neurology, Vol. 34, Issue 7
DOI: 10.1212/WNL.34.7.939

Heat shock proteins: Cellular and molecular mechanisms in the central nervous system
journal, October 2010

Stetler, R. Anne; Gan, Yu; Zhang, Wenting
Progress in Neurobiology, Vol. 92, Issue 2
DOI: 10.1016/j.pneurobio.2010.05.002

Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies
journal, October 2012

Schneider, J. A.; Arvanitakis, Z.; Yu, L.
Brain, Vol. 135, Issue 10
DOI: 10.1093/brain/aws234

Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease: HS and TDP-43 in Aging and AD
journal, April 2015

Nag, Sukriti; Yu, Lei; Capuano, Ana W.
Annals of Neurology, Vol. 77, Issue 6
DOI: 10.1002/ana.24388

A draft map of the human proteome
journal, May 2014

Kim, Min-Sik; Pinto, Sneha M.; Getnet, Derese
Nature, Vol. 509, Issue 7502
DOI: 10.1038/nature13302

The Pathway for the Production of Inositol Hexakisphosphate in Human Cells
journal, November 2004

Verbsky, John W.; Chang, Shao-Chun; Wilson, Monita P.
Journal of Biological Chemistry, Vol. 280, Issue 3
DOI: 10.1074/jbc.M411528200

Decision Rules Guiding the Clinical Diagnosis of Alzheimer’s Disease in Two Community-Based Cohort Studies Compared to Standard Practice in a Clinic-Based Cohort Study
journal, January 2006

Bennett, David A.; Schneider, Julie A.; Aggarwal, Neelum T.
Neuroepidemiology, Vol. 27, Issue 3
DOI: 10.1159/000096129

Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery
journal, March 2017

Bennett, David A.
PLOS Medicine, Vol. 14, Issue 3
DOI: 10.1371/journal.pmed.1002256

The Apolipoprotein E ε4 Allele Increases the Odds of Chronic Cerebral Infarction Detected at Autopsy in Older Persons
journal, May 2005

Schneider, J. A.; Bienias, J. L.; Wilson, R. S.
Stroke, Vol. 36, Issue 5
DOI: 10.1161/01.STR.0000160747.27470.2a

Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells
journal, December 2002

Marshman, E.
Journal of Cell Science, Vol. 116, Issue 4
DOI: 10.1242/jcs.00263

APOE and cerebral amyloid angiopathy in community-dwelling older persons
journal, November 2015

Yu, Lei; Boyle, Patricia A.; Nag, Sukriti
Neurobiology of Aging, Vol. 36, Issue 11
DOI: 10.1016/j.neurobiolaging.2015.08.008

Heat shock proteins in neurodegenerative disorders and aging
journal, September 2014

Leak, Rehana K.
Journal of Cell Communication and Signaling, Vol. 8, Issue 4
DOI: 10.1007/s12079-014-0243-9

Overview and Findings from the Religious Orders Study
journal, June 2012

A. Bennett, David; A. Schneider, Julie; Arvanitakis, Zoe
Current Alzheimer Research, Vol. 9, Issue 6
DOI: 10.2174/156720512801322573

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
journal, February 2010

MacLean, Brendan; Tomazela, Daniela M.; Shulman, Nicholas
Bioinformatics, Vol. 26, Issue 7
DOI: 10.1093/bioinformatics/btq054

Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
journal, March 2013

Wilson, R. S.; Nag, S.; Boyle, P. A.
Neurology, Vol. 80, Issue 13
DOI: 10.1212/WNL.0b013e3182897103

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
journal, April 2013

Zhang, Bin; Gaiteri, Chris; Bodea, Liviu-Gabriel
Cell, Vol. 153, Issue 3
DOI: 10.1016/j.cell.2013.03.030

Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse
journal, June 2006

Ito, Yuri; Oinuma, Izumi; Katoh, Hironori
EMBO reports, Vol. 7, Issue 7
DOI: 10.1038/sj.embor.7400737

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study
journal, August 2016

Arvanitakis, Zoe; Capuano, Ana W.; Leurgans, Sue E.
The Lancet Neurology, Vol. 15, Issue 9
DOI: 10.1016/S1474-4422(16)30029-1

Postmortem MRI: a novel window into the neurobiology of late life cognitive decline
journal, September 2016

Dawe, Robert J.; Yu, Lei; Leurgans, Sue E.
Neurobiology of Aging, Vol. 45
DOI: 10.1016/j.neurobiolaging.2016.05.023

The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
journal, May 2006

Bennett, David A.; Schneider, Julie A.; Tang, Yuxiao
The Lancet Neurology, Vol. 5, Issue 5
DOI: 10.1016/S1474-4422(06)70417-3

Neurodevelopmental effects of insulin-like growth factor signaling
journal, August 2012

O’Kusky, John; Ye, Ping
Frontiers in Neuroendocrinology, Vol. 33, Issue 3
DOI: 10.1016/j.yfrne.2012.06.002

Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase
journal, June 2009

Liu, Rujuan; Ström, Anna-Lena; Zhai, Jianjun
The International Journal of Biochemistry & Cell Biology, Vol. 41, Issue 6
DOI: 10.1016/j.biocel.2008.12.002

Cognitive reserve, presynaptic proteins and dementia in the elderly
journal, May 2012

Honer, W. G.; Barr, A. M.; Sawada, K.
Translational Psychiatry, Vol. 2, Issue 5
DOI: 10.1038/tp.2012.38

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease
journal, May 2018

Mostafavi, Sara; Gaiteri, Chris; Sullivan, Sarah E.
Nature Neuroscience, Vol. 21, Issue 6
DOI: 10.1038/s41593-018-0154-9

Supervising the fold: functional principles of molecular chaperones.
journal, January 1996

Buchner, J.
The FASEB Journal, Vol. 10, Issue 1
DOI: 10.1096/fasebj.10.1.8566529

Conscientiousness, dementia related pathology, and trajectories of cognitive aging.
journal, March 2015

Wilson, Robert S.; Boyle, Patricia A.; Yu, Lei
Psychology and Aging, Vol. 30, Issue 1
DOI: 10.1037/pag0000013

Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4
journal, January 2010

Panayiotou, Christakis; Solaroli, Nicola; Johansson, Magnus
The International Journal of Biochemistry & Cell Biology, Vol. 42, Issue 1
DOI: 10.1016/j.biocel.2009.09.007

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
journal, July 2013

Nelson, Peter T.; Smith, Charles D.; Abner, Erin L.
Acta Neuropathologica, Vol. 126, Issue 2
DOI: 10.1007/s00401-013-1154-1

Person-specific contribution of neuropathologies to cognitive loss in old age: Neuropathologies and Cognition
journal, January 2018

Boyle, Patricia A.; Yu, Lei; Wilson, Robert S.
Annals of Neurology, Vol. 83, Issue 1
DOI: 10.1002/ana.25123

Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains
journal, May 2012

Andreev, Victor P.; Petyuk, Vladislav A.; Brewer, Heather M.
Journal of Proteome Research, Vol. 11, Issue 6
DOI: 10.1021/pr3001546

Residual decline in cognition after adjustment for common neuropathologic conditions.
journal, January 2015

Yu, Lei; Boyle, Patricia A.; Segawa, Eisuke
Neuropsychology, Vol. 29, Issue 3
DOI: 10.1037/neu0000159

Pathological correlates of dementia in a longitudinal, population-based sample of aging
journal, August 2007

Sonnen, Joshua A.; Larson, Eric B.; Crane, Paul K.
Annals of Neurology, Vol. 62, Issue 4
DOI: 10.1002/ana.21208

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data
journal, April 2017

White, Charles C.; Yang, Hyun-Sik; Yu, Lei
PLOS Medicine, Vol. 14, Issue 4
DOI: 10.1371/journal.pmed.1002287

Mixed brain pathologies account for most dementia cases in community-dwelling older persons
journal, June 2007

Schneider, J. A.; Arvanitakis, Z.; Bang, W.
Neurology, Vol. 69, Issue 24
DOI: 10.1212/01.wnl.0000271090.28148.24

AD brain pathology: Vascular origins?
journal, October 2008

Launer, Lenore J.; Petrovitch, Helen; Ross, G. Webster
Neurobiology of Aging, Vol. 29, Issue 10
DOI: 10.1016/j.neurobiolaging.2007.03.008

Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy
journal, May 2015

Simon, Christian M.; Rauskolb, Stefanie; Gunnersen, Jennifer M.
Acta Neuropathologica, Vol. 130, Issue 3
DOI: 10.1007/s00401-015-1446-8

Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains
journal, April 2006

Wilhelmus, M. M. M.; Otte-Holler, I.; Wesseling, P.
Neuropathology and Applied Neurobiology, Vol. 32, Issue 2
DOI: 10.1111/j.1365-2990.2006.00689.x

Much of late life cognitive decline is not due to common neurodegenerative pathologies: Cognitive Decline
journal, July 2013

Boyle, Patricia A.; Wilson, Robert S.; Yu, Lei
Annals of Neurology, Vol. 74, Issue 3
DOI: 10.1002/ana.23964

Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects
journal, January 2010

Majerus, Philip W.; Wilson, David B.; Zhang, Chunfen
Advances in Enzyme Regulation, Vol. 50, Issue 1
DOI: 10.1016/j.advenzreg.2009.10.017

The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-Ras
journal, August 2004

Oinuma, I.
Science, Vol. 305, Issue 5685
DOI: 10.1126/science.1097545

The TMEM106B locus and TDP-43 pathology in older persons without FTLD
journal, February 2015

Yu, L.; De Jager, P. L.; Yang, J.
Neurology, Vol. 84, Issue 9
DOI: 10.1212/WNL.0000000000001313

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders: Beyond modules and hubs
journal, December 2013

Gaiteri, C.; Ding, Y.; French, B.
Genes, Brain and Behavior, Vol. 13, Issue 1
DOI: 10.1111/gbb.12106

The neuropathology of probable Alzheimer disease and mild cognitive impairment
journal, August 2009

Schneider, Julie A.; Arvanitakis, Zoe; Leurgans, Sue E.
Annals of Neurology, Vol. 66, Issue 2
DOI: 10.1002/ana.21706

Higher brain BDNF gene expression is associated with slower cognitive decline in older adults
journal, January 2016

Buchman, Aron S.; Yu, Lei; Boyle, Patricia A.
Neurology, Vol. 86, Issue 8
DOI: 10.1212/WNL.0000000000002387

Overview and Findings from the Rush Memory and Aging Project
journal, June 2012

A. Bennett, David; A. Schneider, Julie; S. Buchman, Aron
Current Alzheimer Research, Vol. 9, Issue 6
DOI: 10.2174/156720512801322663

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Similar Records

Title: Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia: Targeted Proteomics in Alzheimer's Dementia

Citation Formats

Microinfarct Pathology, Dementia, and Cognitive Systems journal, March 2011

Mapping protein abundance patterns in the brain using voxelation combined with liquid chromatography and mass spectrometry journal, February 2010

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease journal, July 1984

Heat shock proteins: Cellular and molecular mechanisms in the central nervous system journal, October 2010

Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies journal, October 2012

Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease: HS and TDP-43 in Aging and AD journal, April 2015

A draft map of the human proteome journal, May 2014

The Pathway for the Production of Inositol Hexakisphosphate in Human Cells journal, November 2004

Decision Rules Guiding the Clinical Diagnosis of Alzheimer’s Disease in Two Community-Based Cohort Studies Compared to Standard Practice in a Clinic-Based Cohort Study journal, January 2006

Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery journal, March 2017

The Apolipoprotein E ε4 Allele Increases the Odds of Chronic Cerebral Infarction Detected at Autopsy in Older Persons journal, May 2005

Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells journal, December 2002

APOE and cerebral amyloid angiopathy in community-dwelling older persons journal, November 2015

Heat shock proteins in neurodegenerative disorders and aging journal, September 2014

Overview and Findings from the Religious Orders Study journal, June 2012

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments journal, February 2010

Neural reserve, neuronal density in the locus ceruleus, and cognitive decline journal, March 2013

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease journal, April 2013

Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse journal, June 2006

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study journal, August 2016

Postmortem MRI: a novel window into the neurobiology of late life cognitive decline journal, September 2016

The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study journal, May 2006

Neurodevelopmental effects of insulin-like growth factor signaling journal, August 2012

Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase journal, June 2009

Cognitive reserve, presynaptic proteins and dementia in the elderly journal, May 2012

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease journal, May 2018

Supervising the fold: functional principles of molecular chaperones. journal, January 1996

Conscientiousness, dementia related pathology, and trajectories of cognitive aging. journal, March 2015

Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4 journal, January 2010

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease journal, July 2013

Person-specific contribution of neuropathologies to cognitive loss in old age: Neuropathologies and Cognition journal, January 2018

Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains journal, May 2012

Residual decline in cognition after adjustment for common neuropathologic conditions. journal, January 2015

Pathological correlates of dementia in a longitudinal, population-based sample of aging journal, August 2007

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data journal, April 2017

Mixed brain pathologies account for most dementia cases in community-dwelling older persons journal, June 2007

AD brain pathology: Vascular origins? journal, October 2008

Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy journal, May 2015

Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains journal, April 2006

Much of late life cognitive decline is not due to common neurodegenerative pathologies: Cognitive Decline journal, July 2013

Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects journal, January 2010

The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-Ras journal, August 2004

The TMEM106B locus and TDP-43 pathology in older persons without FTLD journal, February 2015

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders: Beyond modules and hubs journal, December 2013

The neuropathology of probable Alzheimer disease and mild cognitive impairment journal, August 2009

Higher brain BDNF gene expression is associated with slower cognitive decline in older adults journal, January 2016

Overview and Findings from the Rush Memory and Aging Project journal, June 2012

Microinfarct Pathology, Dementia, and Cognitive Systems
journal, March 2011

Mapping protein abundance patterns in the brain using voxelation combined with liquid chromatography and mass spectrometry
journal, February 2010

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
journal, July 1984

Heat shock proteins: Cellular and molecular mechanisms in the central nervous system
journal, October 2010

Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies
journal, October 2012

Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease: HS and TDP-43 in Aging and AD
journal, April 2015

A draft map of the human proteome
journal, May 2014

The Pathway for the Production of Inositol Hexakisphosphate in Human Cells
journal, November 2004

Decision Rules Guiding the Clinical Diagnosis of Alzheimer’s Disease in Two Community-Based Cohort Studies Compared to Standard Practice in a Clinic-Based Cohort Study
journal, January 2006

Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery
journal, March 2017

The Apolipoprotein E ε4 Allele Increases the Odds of Chronic Cerebral Infarction Detected at Autopsy in Older Persons
journal, May 2005

Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells
journal, December 2002

APOE and cerebral amyloid angiopathy in community-dwelling older persons
journal, November 2015

Heat shock proteins in neurodegenerative disorders and aging
journal, September 2014

Overview and Findings from the Religious Orders Study
journal, June 2012

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
journal, February 2010

Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
journal, March 2013

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
journal, April 2013

Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse
journal, June 2006

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study
journal, August 2016

Postmortem MRI: a novel window into the neurobiology of late life cognitive decline
journal, September 2016

The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
journal, May 2006

Neurodevelopmental effects of insulin-like growth factor signaling
journal, August 2012

Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase
journal, June 2009

Cognitive reserve, presynaptic proteins and dementia in the elderly
journal, May 2012

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease
journal, May 2018

Supervising the fold: functional principles of molecular chaperones.
journal, January 1996

Conscientiousness, dementia related pathology, and trajectories of cognitive aging.
journal, March 2015

Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4
journal, January 2010

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
journal, July 2013

Person-specific contribution of neuropathologies to cognitive loss in old age: Neuropathologies and Cognition
journal, January 2018

Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains
journal, May 2012

Residual decline in cognition after adjustment for common neuropathologic conditions.
journal, January 2015

Pathological correlates of dementia in a longitudinal, population-based sample of aging
journal, August 2007

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data
journal, April 2017

Mixed brain pathologies account for most dementia cases in community-dwelling older persons
journal, June 2007

AD brain pathology: Vascular origins?
journal, October 2008

Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy
journal, May 2015

Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains
journal, April 2006

Much of late life cognitive decline is not due to common neurodegenerative pathologies: Cognitive Decline
journal, July 2013

Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects
journal, January 2010

The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-Ras
journal, August 2004

The TMEM106B locus and TDP-43 pathology in older persons without FTLD
journal, February 2015

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders: Beyond modules and hubs
journal, December 2013

The neuropathology of probable Alzheimer disease and mild cognitive impairment
journal, August 2009

Higher brain BDNF gene expression is associated with slower cognitive decline in older adults
journal, January 2016

Overview and Findings from the Rush Memory and Aging Project
journal, June 2012