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Title: Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering

In nature, specific biomolecules interacting with mineral precursors are responsible for the precise production of nanostructured inorganic materials that exhibit complex morphologies and superior performance. Despite advances in developing biomimetic approaches, the design rules for creating sequence-defined molecules that lead to the synthesis of inorganic nanomaterials with predictable complex morphologies are unknown. Herein we report the design of sequence-defined peptoids for controlled synthesis of highly branched plasmonic gold particles. By engineering peptoid sequences and investigating the resulting particle formation mechanisms, we develop a rule of thumb for designing peptoids that predictively enabled the morphological evolution from spherical to coral-shaped nanoparticles. Through a combination of hyperspectral UV-Vis extinction microscopy and three-photon photoemission electron microscopy, we demonstrate that the individual coral-shaped gold nanoparticles exhibit a plasmonic enhancement as high as 10 5-fold. This research significantly advances our ultimate vision of predictive bio-inspired materials synthesis using sequence-defined synthetic molecules that mimic proteins and peptides.
Authors:
 [1] ; ORCiD logo [2] ; ORCiD logo [3] ; ORCiD logo [4] ; ORCiD logo [4] ;  [5] ; ORCiD logo [5] ;  [6] ; ORCiD logo [5] ; ORCiD logo [4] ; ORCiD logo [4]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Physical Sciences Division; Linyi Univ. (China). College of Chemistry & Chemical Engineering
  2. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Physical Sciences Division; Texas Tech Univ., Lubbock, TX (United States). Dept. of Mechanical Engineering
  3. Deakin Univ., Geelong, VIC (Australia). Inst. for Frontier Materials
  4. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Physical Sciences Division
  5. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab.
  6. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Physical Sciences Division; Univ. of Washington, Seattle, WA (United States). Depts. of Materials Science and Engineering and of Chemistry
Publication Date:
Report Number(s):
PNNL-SA-118537
Journal ID: ISSN 2041-1723; PII: 4789
Grant/Contract Number:
AC05-76RL01830
Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 9; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); PNNL Laboratory Directed Research and Development (LDRD) Program
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; bioinspired materials; biomimetic synthesis; biomineralization; nanophotonics and plasmonics
OSTI Identifier:
1457772