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This content will become publicly available on June 8, 2019

Title: Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials

We present that the widespread use of engineered nanomaterials or nanotechnology makes the characterization of biological responses to nanomaterials an important area of research. The application of omics approaches, such as mass spectrometry-based proteomics, has revealed new insights into the cellular responses of exposure to nanomaterials, including how nanomaterials interact and alter cellular pathways. In addition, exposure to engineered nanomaterials often leads to the generation of reactive oxygen species and cellular oxidative stress, which implicates a redox-dependent regulation of cellular responses under such conditions. Here, in this review, we discuss quantitative proteomics-based approaches, with an emphasis on redox proteomics, as a tool for system-level characterization of the biological responses induced by engineered nanomaterials.
Authors:
 [1] ;  [1] ;  [1] ; ORCiD logo [1]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division
Publication Date:
Report Number(s):
PNNL-SA-133275
Journal ID: ISSN 1618-2642; PII: 1168
Grant/Contract Number:
AC05-76RL01830; P41GM103493; U01ES027292
Type:
Accepted Manuscript
Journal Name:
Analytical and Bioanalytical Chemistry
Additional Journal Information:
Journal Name: Analytical and Bioanalytical Chemistry; Journal ID: ISSN 1618-2642
Publisher:
Springer
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 36 MATERIALS SCIENCE; 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY; Engineered nanomaterials; Proteomics; Post-translational modifications; Redox proteomics; Thiol; Oxidative stress
OSTI Identifier:
1457755