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Title: Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials

Abstract

We present that the widespread use of engineered nanomaterials or nanotechnology makes the characterization of biological responses to nanomaterials an important area of research. The application of omics approaches, such as mass spectrometry-based proteomics, has revealed new insights into the cellular responses of exposure to nanomaterials, including how nanomaterials interact and alter cellular pathways. In addition, exposure to engineered nanomaterials often leads to the generation of reactive oxygen species and cellular oxidative stress, which implicates a redox-dependent regulation of cellular responses under such conditions. Here, in this review, we discuss quantitative proteomics-based approaches, with an emphasis on redox proteomics, as a tool for system-level characterization of the biological responses induced by engineered nanomaterials.

Authors:
 [1];  [1];  [1]; ORCiD logo [1]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1457755
Report Number(s):
PNNL-SA-133275
Journal ID: ISSN 1618-2642; PII: 1168
Grant/Contract Number:  
AC05-76RL01830; P41GM103493; U01ES027292
Resource Type:
Accepted Manuscript
Journal Name:
Analytical and Bioanalytical Chemistry
Additional Journal Information:
Journal Volume: 410; Journal Issue: 24; Journal ID: ISSN 1618-2642
Publisher:
Springer
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 36 MATERIALS SCIENCE; 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY; Engineered nanomaterials; Proteomics; Post-translational modifications; Redox proteomics; Thiol; Oxidative stress

Citation Formats

Zhang, Tong, Gaffrey, Matthew J., Thrall, Brian D., and Qian, Wei-Jun. Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials. United States: N. p., 2018. Web. doi:10.1007/S00216-018-1168-6.
Zhang, Tong, Gaffrey, Matthew J., Thrall, Brian D., & Qian, Wei-Jun. Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials. United States. doi:10.1007/S00216-018-1168-6.
Zhang, Tong, Gaffrey, Matthew J., Thrall, Brian D., and Qian, Wei-Jun. Fri . "Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials". United States. doi:10.1007/S00216-018-1168-6. https://www.osti.gov/servlets/purl/1457755.
@article{osti_1457755,
title = {Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials},
author = {Zhang, Tong and Gaffrey, Matthew J. and Thrall, Brian D. and Qian, Wei-Jun},
abstractNote = {We present that the widespread use of engineered nanomaterials or nanotechnology makes the characterization of biological responses to nanomaterials an important area of research. The application of omics approaches, such as mass spectrometry-based proteomics, has revealed new insights into the cellular responses of exposure to nanomaterials, including how nanomaterials interact and alter cellular pathways. In addition, exposure to engineered nanomaterials often leads to the generation of reactive oxygen species and cellular oxidative stress, which implicates a redox-dependent regulation of cellular responses under such conditions. Here, in this review, we discuss quantitative proteomics-based approaches, with an emphasis on redox proteomics, as a tool for system-level characterization of the biological responses induced by engineered nanomaterials.},
doi = {10.1007/S00216-018-1168-6},
journal = {Analytical and Bioanalytical Chemistry},
number = 24,
volume = 410,
place = {United States},
year = {2018},
month = {6}
}

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