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Title: A Six-Coordinate Peroxynitrite Low-Spin Iron(III) Porphyrinate Complex—The Product of the Reaction of Nitrogen Monoxide (·NO(g)) with a Ferric-Superoxide Species

Abstract

Peroxynitrite (–OON=O, PN) is a reactive nitrogen species (RNS) which can effect deleterious nitrative or oxidative (bio)chemistry. It may derive from reaction of superoxide anion (O2•–) with nitric oxide (·NO) and has been suggested to form an as-yet unobserved bound heme-iron-PN intermediate in the catalytic cycle of nitric oxide dioxygenase (NOD) enzymes, which facilitate a ·NO homeostatic process, i.e., its oxidation to the nitrate anion. Here, a discrete six-coordinate low-spin porphyrinate-FeIII complex [(PIm)FeIII(–OON=O)] (PIm; a porphyrin moiety with a covalently tethered imidazole axial “base” donor ligand) has been identified and characterized by various spectroscopies (UV–vis, NMR, EPR, XAS, resonance Raman) and DFT calculations, following its formation at –80 °C by addition of ·NO(g) to the heme-superoxo species, [(PIm)FeIII(O2•–)]. DFT calculations confirm that is a six-coordinate low-spin species with the PN ligand coordinated to iron via its terminal peroxidic anionic O atom with the overall geometry being in a cis-configuration. Complex thermally transforms to its isomeric low-spin nitrato form [(PIm)FeIII(NO3–)]. While previous (bio)chemical studies show that phenolic substrates undergo nitration in the presence of PN or PN-metal complexes, in the present system, addition of 2,4-di-tert-butylphenol (2,4DTBP) to complex does not lead to nitrated phenol; the nitrate complex still forms. Furthermore, DFTmore » calculations reveal that the phenolic H atom approaches the terminal PN O atom (farthest from the metal center and ring core), effecting O–O cleavage, giving nitrogen dioxide (·NO2) plus a ferryl compound [(PIm)FeIV=O] (7); this rebounds to give [(PIm)FeIII(NO3–)].The generation and characterization of the long sought after ferriheme peroxynitrite complex has been accomplished.« less

Authors:
 [1];  [2];  [2];  [3]; ORCiD logo [3];  [4];  [5]; ORCiD logo [5]; ORCiD logo [1]
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  1. Johns Hopkins Univ., Baltimore, MD (United States)
  2. Stanford Univ., Stanford, CA (United States)
  3. Oregon Health & Science Univ., Portland, OR (United States)
  4. SLAC National Accelerator Lab., Menlo Park, CA (United States)
  5. Stanford Univ., Stanford, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States)
Publication Date:
Research Org.:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1457149
Grant/Contract Number:  
24221005; GM118030; GM40392; AC02-76SF00515
Resource Type:
Accepted Manuscript
Journal Name:
Journal of the American Chemical Society
Additional Journal Information:
Journal Volume: 139; Journal Issue: 48; Journal ID: ISSN 0002-7863
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Sharma, Savita K., Schaefer, Andrew W., Lim, Hyeongtaek, Matsumura, Hirotoshi, Moenne-Loccoz, Pierre, Hedman, Britt, Hodgson, Keith O., Solomon, Edward I., and Karlin, Kenneth D.. A Six-Coordinate Peroxynitrite Low-Spin Iron(III) Porphyrinate Complex—The Product of the Reaction of Nitrogen Monoxide (·NO(g)) with a Ferric-Superoxide Species. United States: N. p., 2017. Web. doi:10.1021/jacs.7b08468.
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Sharma, Savita K., Schaefer, Andrew W., Lim, Hyeongtaek, Matsumura, Hirotoshi, Moenne-Loccoz, Pierre, Hedman, Britt, Hodgson, Keith O., Solomon, Edward I., & Karlin, Kenneth D.. A Six-Coordinate Peroxynitrite Low-Spin Iron(III) Porphyrinate Complex—The Product of the Reaction of Nitrogen Monoxide (·NO(g)) with a Ferric-Superoxide Species. United States. https://doi.org/10.1021/jacs.7b08468
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Sharma, Savita K., Schaefer, Andrew W., Lim, Hyeongtaek, Matsumura, Hirotoshi, Moenne-Loccoz, Pierre, Hedman, Britt, Hodgson, Keith O., Solomon, Edward I., and Karlin, Kenneth D.. Wed . "A Six-Coordinate Peroxynitrite Low-Spin Iron(III) Porphyrinate Complex—The Product of the Reaction of Nitrogen Monoxide (·NO(g)) with a Ferric-Superoxide Species". United States. https://doi.org/10.1021/jacs.7b08468. https://www.osti.gov/servlets/purl/1457149.
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@article{osti_1457149,
title = {A Six-Coordinate Peroxynitrite Low-Spin Iron(III) Porphyrinate Complex—The Product of the Reaction of Nitrogen Monoxide (·NO(g)) with a Ferric-Superoxide Species},
author = {Sharma, Savita K. and Schaefer, Andrew W. and Lim, Hyeongtaek and Matsumura, Hirotoshi and Moenne-Loccoz, Pierre and Hedman, Britt and Hodgson, Keith O. and Solomon, Edward I. and Karlin, Kenneth D.},
abstractNote = {Peroxynitrite (–OON=O, PN) is a reactive nitrogen species (RNS) which can effect deleterious nitrative or oxidative (bio)chemistry. It may derive from reaction of superoxide anion (O2•–) with nitric oxide (·NO) and has been suggested to form an as-yet unobserved bound heme-iron-PN intermediate in the catalytic cycle of nitric oxide dioxygenase (NOD) enzymes, which facilitate a ·NO homeostatic process, i.e., its oxidation to the nitrate anion. Here, a discrete six-coordinate low-spin porphyrinate-FeIII complex [(PIm)FeIII(–OON=O)] (PIm; a porphyrin moiety with a covalently tethered imidazole axial “base” donor ligand) has been identified and characterized by various spectroscopies (UV–vis, NMR, EPR, XAS, resonance Raman) and DFT calculations, following its formation at –80 °C by addition of ·NO(g) to the heme-superoxo species, [(PIm)FeIII(O2•–)]. DFT calculations confirm that is a six-coordinate low-spin species with the PN ligand coordinated to iron via its terminal peroxidic anionic O atom with the overall geometry being in a cis-configuration. Complex thermally transforms to its isomeric low-spin nitrato form [(PIm)FeIII(NO3–)]. While previous (bio)chemical studies show that phenolic substrates undergo nitration in the presence of PN or PN-metal complexes, in the present system, addition of 2,4-di-tert-butylphenol (2,4DTBP) to complex does not lead to nitrated phenol; the nitrate complex still forms. Furthermore, DFT calculations reveal that the phenolic H atom approaches the terminal PN O atom (farthest from the metal center and ring core), effecting O–O cleavage, giving nitrogen dioxide (·NO2) plus a ferryl compound [(PIm)FeIV=O] (7); this rebounds to give [(PIm)FeIII(NO3–)].The generation and characterization of the long sought after ferriheme peroxynitrite complex has been accomplished.},
doi = {10.1021/jacs.7b08468},
journal = {Journal of the American Chemical Society},
number = 48,
volume = 139,
place = {United States},
year = {2017},
month = {11}
}
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Works referenced in this record:

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide
journal, April 1990

Generation, Translocation, and Action of Nitric Oxide in Living Systems
journal, October 2011

Connecting the Chemical and Biological Properties of Nitric Oxide
journal, April 2012

  • Toledo, Jose Carlos; Augusto, Ohara
  • Chemical Research in Toxicology, Vol. 25, Issue 5
  • DOI: 10.1021/tx300042g

Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution
journal, October 1985

  • Blough, Neil V.; Zafiriou, Oliver C.
  • Inorganic Chemistry, Vol. 24, Issue 22
  • DOI: 10.1021/ic00216a003

The Rate Constant of the Reaction of Superoxide with Nitrogen Monoxide:  Approaching the Diffusion Limit
journal, April 2002

  • Nauser, T.; Koppenol, W. H.
  • The Journal of Physical Chemistry A, Vol. 106, Issue 16
  • DOI: 10.1021/jp025518z

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
journal, February 1990

  • Beckman, J. S.; Beckman, T. W.; Chen, J.
  • Proceedings of the National Academy of Sciences, Vol. 87, Issue 4
  • DOI: 10.1073/pnas.87.4.1620

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
journal, November 1992

  • Koppenol, W. H.; Moreno, J. J.; Pryor, William A.
  • Chemical Research in Toxicology, Vol. 5, Issue 6
  • DOI: 10.1021/tx00030a017

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
journal, August 2007

  • Szabó, Csaba; Ischiropoulos, Harry; Radi, Rafael
  • Nature Reviews Drug Discovery, Vol. 6, Issue 8
  • DOI: 10.1038/nrd2222

Direct and Indirect Oxidations by Peroxynitrite
journal, August 1995

  • Goldstein, Sara; Czapski, Gidon
  • Inorganic Chemistry, Vol. 34, Issue 16
  • DOI: 10.1021/ic00120a006

The Yield of Hydroxyl Radical from the Decomposition of Peroxynitrous Acid
journal, August 1999

  • Gerasimov, Oleg V.; Lymar, Sergei V.
  • Inorganic Chemistry, Vol. 38, Issue 19
  • DOI: 10.1021/ic990384y

Protein Tyrosine Nitration: Biochemical Mechanisms and Structural Basis of Functional Effects
journal, November 2012

  • Radi, Rafael
  • Accounts of Chemical Research, Vol. 46, Issue 2
  • DOI: 10.1021/ar300234c

Metal-catalyzed protein tyrosine nitration in biological systems
journal, June 2014

Nitric oxide, oxidants, and protein tyrosine nitration
journal, March 2004

Nitric Oxide and Peroxynitrite in Health and Disease
journal, January 2007

NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?
journal, December 2003

Reactive nitrogen species in the chemical biology of inflammation
journal, March 2004

  • Dedon, Peter C.; Tannenbaum, Steven R.
  • Archives of Biochemistry and Biophysics, Vol. 423, Issue 1
  • DOI: 10.1016/j.abb.2003.12.017

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
journal, November 1996

Time Course and Site(s) of Cytochrome c Tyrosine Nitration by Peroxynitrite
journal, May 2005

  • Batthyány, Carlos; Souza, José M.; Durán, Rosario
  • Biochemistry, Vol. 44, Issue 22
  • DOI: 10.1021/bi0474620

Inactivation and nitration of human superoxide dismutase (SOD) by fluxes of nitric oxide and superoxide
journal, May 2007

Nitration in Neurodegeneration:  Deciphering the “Hows” “nYs”
journal, June 2007

  • Reynolds, Matthew R.; Berry, Robert W.; Binder, Lester I.
  • Biochemistry, Vol. 46, Issue 25
  • DOI: 10.1021/bi700430y

Crystal structure of nitrated human manganese superoxide dismutase: Mechanism of inactivation
journal, February 2006

3-Nitrotyrosine Modification of SERCA2a in the Aging Heart:  A Distinct Signature of the Cellular Redox Environment
journal, September 2005

  • Knyushko, Tatyana V.; Sharov, Victor S.; Williams, Todd D.
  • Biochemistry, Vol. 44, Issue 39
  • DOI: 10.1021/bi051226n

Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues †
journal, February 1998

  • MacMillan-Crow, Lee Ann; Crow, John P.; Thompson, John A.
  • Biochemistry, Vol. 37, Issue 6
  • DOI: 10.1021/bi971894b

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.
journal, October 1996

  • MacMillan-Crow, L. A.; Crow, J. P.; Kerby, J. D.
  • Proceedings of the National Academy of Sciences, Vol. 93, Issue 21
  • DOI: 10.1073/pnas.93.21.11853

Peroxynitrite, a potent macrophage-derived oxidizing cytotoxin to combat invading pathogens: Peroxynitrite in Pathogen Invasion
journal, November 2013

  • Prolo, Carolina; Álvarez, María Noel; Radi, Rafael
  • BioFactors, Vol. 40, Issue 2
  • DOI: 10.1002/biof.1150

Theoretical Calculations on the Torsion Potential of Peroxynitrite Anion in Aqueous Solution
journal, February 2002

  • Nagy, Peter I.
  • The Journal of Physical Chemistry A, Vol. 106, Issue 11
  • DOI: 10.1021/jp013416n

Ab Initio and NMR Study of Peroxynitrite and Peroxynitrous Acid:  Important Biological Oxidants
journal, January 1996

  • Tsai, Hui-Hsu; Hamilton, Tracy P.; Tsai, Jyh-Hsin M.
  • The Journal of Physical Chemistry, Vol. 100, Issue 37
  • DOI: 10.1021/jp961091i

A theoretical study on the reaction pathways of peroxynitrite formation and decay at nonheme iron centers
journal, February 2014

  • Attia, Amr Ali; Silaghi-Dumitrescu, Radu
  • International Journal of Quantum Chemistry, Vol. 114, Issue 10
  • DOI: 10.1002/qua.24650

A density functional study of heme–peroxynitrite adducts
journal, May 2005

No scavenging and the hypertensive effect of hemoglobin-based blood substitutes
journal, March 2004

Hemoglobins dioxygenate nitric oxide with high fidelity
journal, April 2006

Nitric oxide dioxygenase: An enzymic function for flavohemoglobin
journal, September 1998

  • Gardner, P. R.; Gardner, A. M.; Martin, L. A.
  • Proceedings of the National Academy of Sciences, Vol. 95, Issue 18
  • DOI: 10.1073/pnas.95.18.10378

Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide
journal, April 2002

  • Ouellet, H.; Ouellet, Y.; Richard, C.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 9
  • DOI: 10.1073/pnas.092017799

Peroxynitrite Isomerization Catalyzed by His64 Myoglobin Mutants
journal, May 2001

  • Herold, Susanna; Matsui, Toshitaka; Watanabe, Yoshihito
  • Journal of the American Chemical Society, Vol. 123, Issue 17
  • DOI: 10.1021/ja010111d

Kinetic and Mechanistic Studies of the NO • -Mediated Oxidation of Oxymyoglobin and Oxyhemoglobin †
journal, March 2001

  • Herold, Susanna; Exner, Michael; Nauser, Thomas
  • Biochemistry, Vol. 40, Issue 11
  • DOI: 10.1021/bi002407m

The Millisecond Intermediate in the Reaction of Nitric Oxide with Oxymyoglobin is an Iron(III)−Nitrato Complex, Not a Peroxynitrite
journal, May 2009

  • Yukl, Erik T.; de Vries, Simon; Moënne-Loccoz, Pierre
  • Journal of the American Chemical Society, Vol. 131, Issue 21
  • DOI: 10.1021/ja9026924

Hexacoordinate oxy-globin models Fe(Por)(NH3)(O2) react with NO to form only the nitrato analogs Fe(Por)(NH3)(η1-ONO2), even at ∼100 K
journal, January 2010

  • Kurtikyan, Tigran S.; Ford, Peter C.
  • Chemical Communications, Vol. 46, Issue 45
  • DOI: 10.1039/c0cc02665d

Nitric Oxide Dioxygenation Reaction by Oxy-Coboglobin Models: In-situ Low-Temperature FTIR Characterization of Coordinated Peroxynitrite
journal, August 2012

  • Kurtikyan, Tigran S.; Eksuzyan, Shahane R.; Hayrapetyan, Vardan A.
  • Journal of the American Chemical Society, Vol. 134, Issue 33
  • DOI: 10.1021/ja305774v

Nitric Oxide Interaction with Oxy–Coboglobin Models Containing trans -Pyridine Ligand: Two Reaction Pathways
journal, September 2013

  • Kurtikyan, Tigran S.; Eksuzyan, Shahane R.; Goodwin, John A.
  • Inorganic Chemistry, Vol. 52, Issue 20
  • DOI: 10.1021/ic4018689

Heme/O 2 /•NO Nitric Oxide Dioxygenase (NOD) Reactivity: Phenolic Nitration via a Putative Heme-Peroxynitrite Intermediate
journal, July 2009

  • Schopfer, Mark P.; Mondal, Biplab; Lee, Dong-Heon
  • Journal of the American Chemical Society, Vol. 131, Issue 32
  • DOI: 10.1021/ja904832j

Reactions of a heme-superoxo complex toward a cuprous chelate and •NO (g) : C c O and NOD chemistry
journal, January 2015

  • Sharma, Savita K.; Rogler, Patrick J.; Karlin, Kenneth D.
  • Journal of Porphyrins and Phthalocyanines, Vol. 19, Issue 01-03
  • DOI: 10.1142/S108842461550025X

New heme–dioxygen and carbon monoxide adducts using pyridyl or imidazolyl tailed porphyrins
journal, July 2013

A Selective Stepwise Heme Oxygenase Model System: An Iron(IV)-Oxo Porphyrin π-Cation Radical Leads to a Verdoheme-Type Compound via an Isoporphyrin Intermediate
journal, October 2013

  • Garcia-Bosch, Isaac; Sharma, Savita K.; Karlin, Kenneth D.
  • Journal of the American Chemical Society, Vol. 135, Issue 44
  • DOI: 10.1021/ja405739m

Various approaches to analysis of difficult sample matrices of anions using capillary ion electrophoresis
journal, September 1992

Ultra-rapid analysis of nitrate and nitrite by capillary electrophoresis
journal, July 2000

Resonance Raman spectra of heme proteins. Effects of oxidation and spin state
journal, January 1974

  • Spiro, Thomas G.; Strekas, Thomas C.
  • Journal of the American Chemical Society, Vol. 96, Issue 2
  • DOI: 10.1021/ja00809a004

A Multiplet Analysis of Fe K-Edge 1s → 3d Pre-Edge Features of Iron Complexes
journal, July 1997

  • Westre, Tami E.; Kennepohl, Pierre; DeWitt, Jane G.
  • Journal of the American Chemical Society, Vol. 119, Issue 27
  • DOI: 10.1021/ja964352a

X-ray absorption spectroscopic investigation of the electronic structure differences in solution and crystalline oxyhemoglobin
journal, September 2013

  • Wilson, S. A.; Green, E.; Mathews, I. I.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 41
  • DOI: 10.1073/pnas.1315734110

Isocyanide or nitrosyl complexation to hemes with varying tethered axial base ligand donors: synthesis and characterization
journal, June 2016

  • Sharma, Savita K.; Kim, Hyun; Rogler, Patrick J.
  • JBIC Journal of Biological Inorganic Chemistry, Vol. 21, Issue 5-6
  • DOI: 10.1007/s00775-016-1369-4

Chromium(IV)–Peroxo Complex Formation and Its Nitric Oxide Dioxygenase Reactivity
journal, September 2012

  • Yokoyama, Atsutoshi; Han, Jung Eun; Cho, Jaeheung
  • Journal of the American Chemical Society, Vol. 134, Issue 37
  • DOI: 10.1021/ja307384e

Reactions of a Chromium(III)-Superoxo Complex and Nitric Oxide That Lead to the Formation of Chromium(IV)-Oxo and Chromium(III)-Nitrito Complexes
journal, September 2013

  • Yokoyama, Atsutoshi; Cho, Kyung-Bin; Karlin, Kenneth D.
  • Journal of the American Chemical Society, Vol. 135, Issue 40
  • DOI: 10.1021/ja405891n

Reactions of Co(III)–Nitrosyl Complexes with Superoxide and Their Mechanistic Insights
journal, March 2015

  • Kumar, Pankaj; Lee, Yong-Min; Park, Young Jun
  • Journal of the American Chemical Society, Vol. 137, Issue 13
  • DOI: 10.1021/ja513234b

Phenol Nitration Induced by an {Fe(NO) 2 } 10 Dinitrosyl Iron Complex
journal, February 2011

  • Tran, Nhut Giuc; Kalyvas, Harris; Skodje, Kelsey M.
  • Journal of the American Chemical Society, Vol. 133, Issue 5
  • DOI: 10.1021/ja108313u

Conversion of {Fe(NO)2}10 dinitrosyl iron to nitrato iron(iii) species by molecular oxygen
journal, January 2012

  • Skodje, Kelsey M.; Williard, Paul G.; Kim, Eunsuk
  • Dalton Transactions, Vol. 41, Issue 26
  • DOI: 10.1039/c2dt30443k

Reaction of a copper(ii)–nitrosyl complex with hydrogen peroxide: putative formation of a copper(i)–peroxynitrite intermediate
journal, January 2012

  • Kalita, Apurba; Kumar, Pankaj; Mondal, Biplab
  • Chemical Communications, Vol. 48, Issue 38
  • DOI: 10.1039/c2cc31117h

Reaction of a Copper(II)–Nitrosyl Complex with Hydrogen Peroxide: Phenol Ring Nitration through a Putative Peroxynitrite Intermediate
journal, September 2013

  • Kalita, Apurba; Deka, Ramesh C.; Mondal, Biplab
  • Inorganic Chemistry, Vol. 52, Issue 19
  • DOI: 10.1021/ic400890f

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
journal, November 1992

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite
journal, November 1992

  • Beckman, Joseph S.; Ischiropoulos, Harry; Zhu, Ling
  • Archives of Biochemistry and Biophysics, Vol. 298, Issue 2
  • DOI: 10.1016/0003-9861(92)90432-V

Mechanisms of Peroxynitrite-Mediated Nitration of Tyrosine
journal, April 2009

  • Gunaydin, Hakan; Houk, K. N.
  • Chemical Research in Toxicology, Vol. 22, Issue 5
  • DOI: 10.1021/tx800463y

Oxidative Damage and Tyrosine Nitration from Peroxynitrite
journal, January 1996

  • Beckman, Joseph S.
  • Chemical Research in Toxicology, Vol. 9, Issue 5
  • DOI: 10.1021/tx9501445

Nitration of Unsaturated Fatty Acids by Nitric Oxide-Derived Reactive Nitrogen Species Peroxynitrite, Nitrous Acid, Nitrogen Dioxide, and Nitronium Ion
journal, December 1998

  • O'Donnell, Valerie B.; Eiserich, Jason P.; Chumley, Phillip H.
  • Chemical Research in Toxicology, Vol. 12, Issue 1
  • DOI: 10.1021/tx980207u

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis
journal, September 2012

  • Barry, Sarah M.; Kers, Johan A.; Johnson, Evan G.
  • Nature Chemical Biology, Vol. 8, Issue 10
  • DOI: 10.1038/nchembio.1048

Heme-Nitrosyls: Electronic Structure Implications for Function in Biology
journal, June 2015

A peroxynitrite complex of copper: formation from a copper–nitrosyl complex, transformation to nitrite and exogenous phenol oxidative coupling or nitration
journal, August 2009

  • Park, Ga Young; Deepalatha, Subramanian; Puiu, Simona C.
  • JBIC Journal of Biological Inorganic Chemistry, Vol. 14, Issue 8
  • DOI: 10.1007/s00775-009-0575-8

Reaction of a Copper−Dioxygen Complex with Nitrogen Monoxide (•NO) Leads to a Copper(II)−Peroxynitrite Species
journal, May 2008

  • Maiti, Debabrata; Lee, Dong-Heon; Narducci Sarjeant, Amy A.
  • Journal of the American Chemical Society, Vol. 130, Issue 21
  • DOI: 10.1021/ja801540e
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