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Title: Nano-Enabled Approaches to Chemical Imaging in Biosystems

Abstract

Understanding and predicting how biosystems function require knowledge about the dynamic physicochemical environments with which they interact and alter by their presence. Yet, identifying specific components, tracking the dynamics of the system, and monitoring local environmental conditions without disrupting biosystem function present significant challenges for analytical measurements. Nanomaterials, by their very size and nature, can act as probes and interfaces to biosystems and offer solutions to some of these challenges. At the nanoscale, material properties emerge that can be exploited for localizing biomolecules and making chemical measurements at cellular and subcellular scales. Here, we review advances in chemical imaging enabled by nanoscale structures, in the use of nanoparticles as chemical and environmental probes, and in the development of micro- and nanoscale fluidic devices to define and manipulate local environments and facilitate chemical measurements of complex biosystems. As a result, integration of these nano-enabled methods will lead to an unprecedented understanding of biosystem function.

Authors:
ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1456812
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Annual Review of Analytical Chemistry
Additional Journal Information:
Journal Volume: 11; Journal Issue: 1; Journal ID: ISSN 1936-1327
Publisher:
Annual Reviews
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; nanoparticles; microfluidics; chemical imaging; multimodal imaging; metamaterials; super-resolution

Citation Formats

Retterer, Scott T., Morrell-Falvey, Jennifer L., and Doktycz, Mitchel John. Nano-Enabled Approaches to Chemical Imaging in Biosystems. United States: N. p., 2018. Web. doi:10.1146/annurev-anchem-061417-125635.
Retterer, Scott T., Morrell-Falvey, Jennifer L., & Doktycz, Mitchel John. Nano-Enabled Approaches to Chemical Imaging in Biosystems. United States. doi:10.1146/annurev-anchem-061417-125635.
Retterer, Scott T., Morrell-Falvey, Jennifer L., and Doktycz, Mitchel John. Wed . "Nano-Enabled Approaches to Chemical Imaging in Biosystems". United States. doi:10.1146/annurev-anchem-061417-125635. https://www.osti.gov/servlets/purl/1456812.
@article{osti_1456812,
title = {Nano-Enabled Approaches to Chemical Imaging in Biosystems},
author = {Retterer, Scott T. and Morrell-Falvey, Jennifer L. and Doktycz, Mitchel John},
abstractNote = {Understanding and predicting how biosystems function require knowledge about the dynamic physicochemical environments with which they interact and alter by their presence. Yet, identifying specific components, tracking the dynamics of the system, and monitoring local environmental conditions without disrupting biosystem function present significant challenges for analytical measurements. Nanomaterials, by their very size and nature, can act as probes and interfaces to biosystems and offer solutions to some of these challenges. At the nanoscale, material properties emerge that can be exploited for localizing biomolecules and making chemical measurements at cellular and subcellular scales. Here, we review advances in chemical imaging enabled by nanoscale structures, in the use of nanoparticles as chemical and environmental probes, and in the development of micro- and nanoscale fluidic devices to define and manipulate local environments and facilitate chemical measurements of complex biosystems. As a result, integration of these nano-enabled methods will lead to an unprecedented understanding of biosystem function.},
doi = {10.1146/annurev-anchem-061417-125635},
journal = {Annual Review of Analytical Chemistry},
number = 1,
volume = 11,
place = {United States},
year = {2018},
month = {2}
}

Journal Article:
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