Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway

Khabibullin, Artem R.; Karolak, Aleksandra; Budzevich, Mikalai M.; McLaughlin, Mark L.; Morse, David L.; Woods, Lilia M.

doi:10.1039/C8MD00170G

Title: Structure and properties of DOTA-chelated radiopharmaceuticals within the ²²⁵ Ac decay pathway

Abstract

The stability of DOTA-chelated complexes coordinated with H ₂ O has a strong correlation between the opening angle of DOTA and the atomic mass of the radioactive isotope.

Authors:

Khabibullin, Artem R. ^[1]; Karolak, Aleksandra ^[2];

^[3]; McLaughlin, Mark L. ^[4];

^[5];

^[1]

Department of Physics, University of South Florida, Tampa, USA
Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
Small Animal Imaging Laboratory Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
Department of Pharmaceutical Sciences, West Virginia University, Health Sciences Center, Morgantown, USA
Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA, Department of Oncologic Sciences

Publication Date:: Mon Jan 01 00:00:00 EST 2018

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:: 1454630

Grant/Contract Number:: DE FG02-06ER46297

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: MedChemComm

Additional Journal Information:: Journal Name: MedChemComm Journal Volume: 9 Journal Issue: 7; Journal ID: ISSN 2040-2503

Publisher:: Royal Society of Chemistry (RSC)

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Khabibullin, Artem R., Karolak, Aleksandra, Budzevich, Mikalai M., McLaughlin, Mark L., Morse, David L., and Woods, Lilia M. Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway.  United Kingdom: N. p., 2018. 
Web.  doi:10.1039/C8MD00170G.

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                    Khabibullin, Artem R., Karolak, Aleksandra, Budzevich, Mikalai M., McLaughlin, Mark L., Morse, David L., & Woods, Lilia M. Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway.  United Kingdom.  https://doi.org/10.1039/C8MD00170G

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                    Khabibullin, Artem R., Karolak, Aleksandra, Budzevich, Mikalai M., McLaughlin, Mark L., Morse, David L., and Woods, Lilia M. Mon .  
"Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway".  United Kingdom.  https://doi.org/10.1039/C8MD00170G.

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@article{osti_1454630,

  title        = {Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway},

  author       = {Khabibullin, Artem R. and Karolak, Aleksandra and Budzevich, Mikalai M. and McLaughlin, Mark L. and Morse, David L. and Woods, Lilia M.},

  abstractNote = {The stability of DOTA-chelated complexes coordinated with H 2 O has a strong correlation between the opening angle of DOTA and the atomic mass of the radioactive isotope.},

  doi          = {10.1039/C8MD00170G},

  journal      = {MedChemComm},

  number       = 7,

  volume       = 9,

  place        = {United Kingdom},

  year         = {Mon Jan 01 00:00:00 EST 2018},

  month        = {Mon Jan 01 00:00:00 EST 2018}

}

Copy to clipboard

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Title: Structure and properties of DOTA-chelated radiopharmaceuticals within the ²²⁵ Ac decay pathway

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Efficiency of ab-initio total energy calculations for metals and semiconductors using a plane-wave basis set
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journal, September 2011

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Structural and Dynamic Parameters Obtained from ¹⁷ O NMR, EPR, and NMRD Studies of Monomeric and Dimeric Gd ³⁺ Complexes of Interest in Magnetic Resonance Imaging: An Integrated and Theoretically Self-Consistent Approach ¹
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Phase I Trial of the Targeted Alpha-Particle Nano-Generator Actinium-225 (225Ac)-Lintuzumab (Anti-CD33; HuM195) in Acute Myeloid Leukemia (AML)
journal, November 2011

In vitro and preclinical targeted alpha therapy of human prostate cancer with Bi-213 labeled J591 antibody against the prostate specific membrane antigen
journal, March 2002

Cancer Drug Delivery: Considerations in the Rational Design of Nanosized Bioconjugates
journal, November 2014

Radioimmunotherapy with alpha-emitting nuclides
journal, September 1998

Molecular Pathways: Targeted -Particle Radiation Therapy
journal, December 2012

Radioimmunotherapy of Breast Cancer Metastases with -Particle Emitter 225Ac: Comparing Efficacy with 213Bi and 90Y
journal, November 2009

Radium-223 Therapy of Bone Metastases in Prostate Cancer
journal, November 2016

Van der Waals density functional theory with applications: Van Der Waals DFT
journal, October 2004

Evaluation of nitrogen-rich macrocyclic ligands for the chelation of therapeutic bismuth radioisotopes
journal, May 2015

Active actinium
journal, October 2016

Equilibrium, ¹ H and ¹³ C NMR Spectroscopy, and X-ray Diffraction Studies on the Complexes Bi(DOTA) ^- and Bi(DO3A-Bu)
journal, April 2003

Stacking effects on the electronic and optical properties of bilayer transition metal dichalcogenides ${MoS}_{2}$ , ${MoSe}_{2}$ , ${WS}_{2}$ , and ${WSe}_{2}$
journal, February 2014

Conformational and Coordination Equilibria on DOTA Complexes of Lanthanide Metal Ions in Aqueous Solution Studied by ¹ H-NMR Spectroscopy
journal, May 1997

Treatment of Neuroblastoma Meningeal Carcinomatosis with Intrathecal Application of -Emitting Atomic Nanogenerators Targeting Disialo-Ganglioside GD2
journal, October 2004

Tumor Therapy with Targeted Atomic Nanogenerators
journal, November 2001

Breakthrough of 225Ac and its radionuclide daughters from an 225Ac/213Bi generator: development of new methods, quantitative characterization, and implications for clinical use
journal, November 2001

Therapeutic efficacy and toxicity of 225Ac-labelled vs. 213Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis
journal, January 2012

Zur Quantentheorie des Atomkernes
journal, March 1928

Gadolinium(iii) complexes as MRI contrast agents: ligand design and properties of the complexes
journal, January 2008

Self-Consistent Equations Including Exchange and Correlation Effects
journal, November 1965

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
journal, May 2009