Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting
Abstract
Multifunctional zinc oxide (ZnO) nanoparticles (NPs) with well-integrated multimodality imaging capacities have generated increasing research interest in the past decade. However, limited progress has been made in developing ZnO NP-based multimodality tumor-imaging agents. Here we developed novel red fluorescent ZnO NPs and described the successful conjugation of 64Cu (t1/2 = 12.7 h) and TRC105, a chimeric monoclonal antibody against CD105, to these ZnO NPs via well-developed surface engineering procedures. The produced dual-modality ZnO NPs were readily applicable for positron emission tomography (PET) imaging and fluorescence imaging of the tumor vasculature. Their pharmacokinetics and tumor-targeting efficacy/specificity in mice bearing murine breast 4T1 tumor were thoroughly investigated. ZnO NPs with dual-modality imaging properties can serve as an attractive candidate for future cancer theranostics.
- Authors:
-
- Univ. of Wisconsin, Madison, WI (United States)
- Univ. of Wisconsin, Madison, WI (United States); American Univ. of Beirut, Beirut (Lebanon)
- TRACON Pharmaceuticals, San Diego, CA (United States)
- Univ. of Wisconsin, Madison, WI (United States); Univ. of Wisconsin Carbone Cancer Center, Madison, WI (United States)
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); USDOE Advanced Research Projects Agency - Energy (ARPA-E); National Institutes of Health (NIH); US Air Force Office of Scientific Research (AFOSR); American Cancer Society
- OSTI Identifier:
- 1345171
- Alternate Identifier(s):
- OSTI ID: 1441140
- Grant/Contract Number:
- SC0008384; SC0008391; 1R01CA169365; P30CA014520; W81XWH-11-1-0644; W81XWH- 11-1-0648; 125246-RSG-13-099-01-CCE
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Applied Materials and Interfaces
- Additional Journal Information:
- Journal Volume: 7; Journal Issue: 5; Journal ID: ISSN 1944-8244
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES; angiogenesis; CD105; drug delivery; imaging; positron emission tomography; zinc oxide; 77 NANOSCIENCE AND NANOTECHNOLOGY
Citation Formats
Hong, Hao, Wang, Fei, Zhang, Yin, Graves, Stephen A., Eddine, Savo Bou Zein, Yang, Yunan, Theuer, Charles P., Nickles, Robert J., Wang, Xudong, and Cai, Weibo. Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting. United States: N. p., 2015.
Web. doi:10.1021/am508440j.
Hong, Hao, Wang, Fei, Zhang, Yin, Graves, Stephen A., Eddine, Savo Bou Zein, Yang, Yunan, Theuer, Charles P., Nickles, Robert J., Wang, Xudong, & Cai, Weibo. Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting. United States. https://doi.org/10.1021/am508440j
Hong, Hao, Wang, Fei, Zhang, Yin, Graves, Stephen A., Eddine, Savo Bou Zein, Yang, Yunan, Theuer, Charles P., Nickles, Robert J., Wang, Xudong, and Cai, Weibo. Wed .
"Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting". United States. https://doi.org/10.1021/am508440j. https://www.osti.gov/servlets/purl/1345171.
@article{osti_1345171,
title = {Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting},
author = {Hong, Hao and Wang, Fei and Zhang, Yin and Graves, Stephen A. and Eddine, Savo Bou Zein and Yang, Yunan and Theuer, Charles P. and Nickles, Robert J. and Wang, Xudong and Cai, Weibo},
abstractNote = {Multifunctional zinc oxide (ZnO) nanoparticles (NPs) with well-integrated multimodality imaging capacities have generated increasing research interest in the past decade. However, limited progress has been made in developing ZnO NP-based multimodality tumor-imaging agents. Here we developed novel red fluorescent ZnO NPs and described the successful conjugation of 64Cu (t1/2 = 12.7 h) and TRC105, a chimeric monoclonal antibody against CD105, to these ZnO NPs via well-developed surface engineering procedures. The produced dual-modality ZnO NPs were readily applicable for positron emission tomography (PET) imaging and fluorescence imaging of the tumor vasculature. Their pharmacokinetics and tumor-targeting efficacy/specificity in mice bearing murine breast 4T1 tumor were thoroughly investigated. ZnO NPs with dual-modality imaging properties can serve as an attractive candidate for future cancer theranostics.},
doi = {10.1021/am508440j},
journal = {ACS Applied Materials and Interfaces},
number = 5,
volume = 7,
place = {United States},
year = {Wed Jan 21 00:00:00 EST 2015},
month = {Wed Jan 21 00:00:00 EST 2015}
}
Web of Science
Works referenced in this record:
ZnO Nanoparticles Applied to Bioimaging and Drug Delivery
journal, June 2013
- Xiong, Huan-Ming
- Advanced Materials, Vol. 25, Issue 37
Biomedical Applications of Zinc Oxide Nanomaterials
journal, November 2013
- Zhang, Y.; Nayak, T.; Hong, H.
- Current Molecular Medicine, Vol. 13, Issue 10
Electronic Nose Based on Multipatterns of ZnO Nanorods on a Quartz Resonator with Remote Electrodes
journal, July 2013
- Ko, Wooree; Jung, Namchul; Lee, Moonchan
- ACS Nano, Vol. 7, Issue 8
Surface Functionalization of ZnO Nanotetrapods with Photoactive and Electroactive Organic Monolayers
journal, March 2008
- Liu, Dongfang; Wu, Wei; Qiu, Yongfu
- Langmuir, Vol. 24, Issue 9
Optical Molecular Imaging: From Single Cell to Patient
journal, April 2008
- Moriyama, Eh; Zheng, G.; Wilson, Bc
- Clinical Pharmacology & Therapeutics, Vol. 84, Issue 2
Multimodality Molecular Imaging of Tumor Angiogenesis
journal, June 2008
- Cai, W.; Chen, X.
- Journal of Nuclear Medicine, Vol. 49, Issue Suppl_2
Endoglin (CD105): A Marker of Tumor Vasculature and Potential Target for Therapy
journal, April 2008
- Dallas, Nikolaos A.; Samuel, Shaija; Xia, Ling
- Clinical Cancer Research, Vol. 14, Issue 7
Endoglin-Targeted Cancer Therapy
journal, January 2011
- K. Seon, Ben; Haba, Akinao; Matsuno, Fumihiko
- Current Drug Delivery, Vol. 8, Issue 1
Positron Emission Tomography Imaging of Tumor Angiogenesis with a 66 Ga-Labeled Monoclonal Antibody
journal, April 2012
- Engle, Jonathan W.; Hong, Hao; Zhang, Yin
- Molecular Pharmaceutics, Vol. 9, Issue 5
In Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene
journal, February 2012
- Hong, Hao; Yang, Kai; Zhang, Yin
- ACS Nano, Vol. 6, Issue 3
In vivo targeting and positron emission tomography imaging of tumor vasculature with 66Ga-labeled nano-graphene
journal, June 2012
- Hong, Hao; Zhang, Yin; Engle, Jonathan W.
- Biomaterials, Vol. 33, Issue 16
Positron Emission Tomography Imaging of CD105 Expression with a 64Cu-Labeled Monoclonal Antibody: NOTA Is Superior to DOTA
journal, December 2011
- Zhang, Yin; Hong, Hao; Engle, Jonathan W.
- PLoS ONE, Vol. 6, Issue 12
Image-guided and tumor-targeted drug delivery with radiolabeled unimolecular micelles
journal, November 2013
- Guo, Jintang; Hong, Hao; Chen, Guojun
- Biomaterials, Vol. 34, Issue 33
Multimodality Imaging of Breast Cancer Experimental Lung Metastasis with Bioluminescence and a Monoclonal Antibody Dual-Labeled with 89 Zr and IRDye 800CW
journal, July 2012
- Hong, Hao; Zhang, Yin; Severin, Gregory W.
- Molecular Pharmaceutics, Vol. 9, Issue 8
A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer
journal, July 2012
- Rosen, Lee S.; Hurwitz, Herbert I.; Wong, Michael K.
- Clinical Cancer Research, Vol. 18, Issue 17
Synthesis of zinc oxide nanoparticles with strong, tunable and stable visible light emission by solid-state transformation of Zn(ii)–organic coordination polymers
journal, January 2011
- Shi, Hong-Yan; Deng, Bin; Zhong, Sheng-Liang
- Journal of Materials Chemistry, Vol. 21, Issue 33
Cancer-Targeted Optical Imaging with Fluorescent Zinc Oxide Nanowires
journal, September 2011
- Hong, Hao; Shi, Jian; Yang, Yunan
- Nano Letters, Vol. 11, Issue 9
Evolution of zinc oxide nanostructures through kinetics control
journal, January 2011
- Shi, Jian; Hong, Hao; Ding, Yong
- Journal of Materials Chemistry, Vol. 21, Issue 25
Positron emission tomography imaging of CD105 expression during tumor angiogenesis
journal, March 2011
- Hong, Hao; Yang, Yunan; Zhang, Yin
- European Journal of Nuclear Medicine and Molecular Imaging, Vol. 38, Issue 7
Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging
journal, April 2012
- Xiao, Yuling; Hong, Hao; Javadi, Alireza
- Biomaterials, Vol. 33, Issue 11
Tumor vasculature targeting and imaging in living mice with reduced graphene oxide
journal, April 2013
- Shi, Sixiang; Yang, Kai; Hong, Hao
- Biomaterials, Vol. 34, Issue 12
cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging
journal, June 2011
- Yang, Xiaoqiang; Hong, Hao; Grailer, Jamison J.
- Biomaterials, Vol. 32, Issue 17
Dissolving Behavior and Stability of ZnO Wires in Biofluids: A Study on Biodegradability and Biocompatibility of ZnO Nanostructures
journal, September 2006
- Zhou, J.; Xu, N. S.; Wang, Z. L.
- Advanced Materials, Vol. 18, Issue 18, p. 2432-2435
Binding Studies of Molecular Linkers to ZnO and MgZnO Nanotip Films
journal, April 2006
- Taratula, Olena; Galoppini, Elena; Wang, Dong
- The Journal of Physical Chemistry B, Vol. 110, Issue 13
Enhancement of band gap emission stimulated by defect loss
journal, January 2006
- Lin, H. Y.; Cheng, C. L.; Chou, Y. Y.
- Optics Express, Vol. 14, Issue 6
Origin of defect-related green emission from ZnO nanoparticles: effect of surface modification
journal, June 2007
- Gong, Yinyan; Andelman, Tamar; Neumark, Gertrude F.
- Nanoscale Research Letters, Vol. 2, Issue 6
Synthesis of ZnO Nanoparticles with Tunable Emission Colors and Their Cell Labeling Applications
journal, June 2010
- Tang, Xiaosheng; Choo, Eugene Shi Guang; Li, Ling
- Chemistry of Materials, Vol. 22, Issue 11
Molecular imaging of cancer with positron emission tomography
journal, September 2002
- Gambhir, Sanjiv Sam
- Nature Reviews Cancer, Vol. 2, Issue 9
Toxicological mode of action of ZnO nanoparticles: Impact on immune cells
journal, February 2015
- Roy, Ruchi; Das, Mukul; Dwivedi, Premendra D.
- Molecular Immunology, Vol. 63, Issue 2
I G G F C R ECEPTORS
journal, April 2001
- Ravetch, Jeffrey V.; Bolland, Silvia
- Annual Review of Immunology, Vol. 19, Issue 1
Works referencing / citing this record:
Multimodale Kontrastmittel für die kombinierte Positronenemissionstomographie
journal, December 2018
- Ni, Dalong; Ehlerding, Emily B.; Cai, Weibo
- Angewandte Chemie, Vol. 131, Issue 9
Subchronic intravenous toxicity study of biofunctional ZnO and its application as a fluorescence probe for cell‐specific targeting
journal, December 2018
- Nakamura, Morihiko; Watanabe, Natsuko
- Journal of Biochemical and Molecular Toxicology, Vol. 33, Issue 4
Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer
journal, October 2019
- Liu, Mei; Anderson, Redmond‐Craig; Lan, Xiaoli
- Medicinal Research Reviews, Vol. 40, Issue 3
Multimodality Imaging Agents with PET as the Fundamental Pillar
journal, February 2019
- Ni, Dalong; Ehlerding, Emily B.; Cai, Weibo
- Angewandte Chemie International Edition, Vol. 58, Issue 9
Evaluation of 2-week repeated oral dose toxicity of 100 nm zinc oxide nanoparticles in rats
journal, January 2015
- Ko, Je-Won; Hong, Eun-Taek; Lee, In-Chul
- Laboratory Animal Research, Vol. 31, Issue 3
Interfacial Zinc Phosphate is the Key to Controlling Biocompatibility of Metallic Zinc Implants
journal, May 2019
- Su, Yingchao; Yang, Hongtao; Gao, Julia
- Advanced Science, Vol. 6, Issue 14
How can nanotechnology help the fight against breast cancer?
journal, January 2018
- Avitabile, Elisabetta; Bedognetti, Davide; Ciofani, Gianni
- Nanoscale, Vol. 10, Issue 25
Effect of orally administered zinc oxide nanoparticles on albino rat thymus and spleen: Effect of Orally Administered ZO NPs on Albino Rats
journal, June 2017
- Abass, Marwa A.; Selim, Sally A.; Selim, Assmaa O.
- IUBMB Life, Vol. 69, Issue 7
Enhanced Red Emission in Ultrasound-Assisted Sol-Gel Derived ZnO/PMMA Nanocomposite
journal, January 2018
- Mai, Van-Tuan; Hoang, Quang-Bac; Mai, Xuan-Dung
- Advances in Materials Science and Engineering, Vol. 2018
Biomedical Applications of Functionalized ZnO Nanomaterials: from Biosensors to Bioimaging
journal, October 2015
- Zhu, Ping; Weng, Zhengyang; Li, Xia
- Advanced Materials Interfaces, Vol. 3, Issue 1
Translating Nanomedicine to Comparative Oncology—the Case for Combining Zinc Oxide Nanomaterials with Nucleic Acid Therapeutic and Protein Delivery for Treating Metastatic Cancer
journal, April 2019
- DeLong, R. K.; Cheng, Yi-Hsien; Pearson, Paige
- Journal of Pharmacology and Experimental Therapeutics, Vol. 370, Issue 3
Near-Infrared Fluorescent Nanomaterials for Bioimaging and Sensing
journal, October 2016
- Reineck, Philipp; Gibson, Brant C.
- Advanced Optical Materials, Vol. 5, Issue 2
Growth Mechanism of Sea Urchin ZnO Nanostructures in Aqueous Solutions and Their Photocatalytic Activity for the Degradation of Organic Dyes
journal, August 2019
- Kiriarachchi, Hiran D.; Abouzeid, Khaled M.; Bo, Longli
- ACS Omega, Vol. 4, Issue 9
Radioactive Nanomaterials for Multimodality Imaging
journal, March 2016
- Chen, Daiqin; Dougherty, Casey A.; Yang, Dongzhi
- Tomography, Vol. 2, Issue 1
Versatile Nanosystem-Based Cancer Theranostics: Design Inspiration and Predetermined Routing
journal, January 2016
- Opoku-Damoah, Yaw; Wang, Ruoning; Zhou, Jianping
- Theranostics, Vol. 6, Issue 7