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Title: Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering

Abstract

In nature, specific biomolecules interacting with mineral precursors are responsible for the precise production of nanostructured inorganic materials that exhibit complex morphologies and superior performance. Despite advances in developing biomimetic approaches, the design rules for creating sequence-defined molecules that lead to the synthesis of inorganic nanomaterials with predictable complex morphologies are unknown. Herein we report the design of sequence-defined peptoids for controlled synthesis of highly branched plasmonic gold particles. By engineering peptoid sequences and investigating the resulting particle formation mechanisms, we develop a rule of thumb for designing peptoids that predictively enabled the morphological evolution from spherical to coral-shaped nanoparticles. Through a combination of hyperspectral UV-Vis extinction microscopy and three-photon photoemission electron microscopy, we demonstrate that the individual coral-shaped gold nanoparticles exhibit a plasmonic enhancement as high as 10 5-fold. This research significantly advances our ultimate vision of predictive bio-inspired materials synthesis using sequence-defined synthetic molecules that mimic proteins and peptides.

Authors:
; ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo; ; ORCiD logo; ; ORCiD logo; ORCiD logo; ORCiD logo
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); PNNL Laboratory Directed Research and Development (LDRD) Program
OSTI Identifier:
1441047
Alternate Identifier(s):
OSTI ID: 1457772
Report Number(s):
PNNL-SA-118537
Journal ID: ISSN 2041-1723; 2327; PII: 4789
Grant/Contract Number:  
AC05-76RL01830
Resource Type:
Published Article
Journal Name:
Nature Communications
Additional Journal Information:
Journal Name: Nature Communications Journal Volume: 9 Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United Kingdom
Language:
English
Subject:
36 MATERIALS SCIENCE; bioinspired materials; biomimetic synthesis; biomineralization; nanophotonics and plasmonics

Citation Formats

Yan, Feng, Liu, Lili, Walsh, Tiffany R., Gong, Yu, El-Khoury, Patrick Z., Zhang, Yanyan, Zhu, Zihua, De Yoreo, James J., Engelhard, Mark H., Zhang, Xin, and Chen, Chun-Long. Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering. United Kingdom: N. p., 2018. Web. doi:10.1038/s41467-018-04789-2.
Yan, Feng, Liu, Lili, Walsh, Tiffany R., Gong, Yu, El-Khoury, Patrick Z., Zhang, Yanyan, Zhu, Zihua, De Yoreo, James J., Engelhard, Mark H., Zhang, Xin, & Chen, Chun-Long. Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering. United Kingdom. doi:10.1038/s41467-018-04789-2.
Yan, Feng, Liu, Lili, Walsh, Tiffany R., Gong, Yu, El-Khoury, Patrick Z., Zhang, Yanyan, Zhu, Zihua, De Yoreo, James J., Engelhard, Mark H., Zhang, Xin, and Chen, Chun-Long. Wed . "Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering". United Kingdom. doi:10.1038/s41467-018-04789-2.
@article{osti_1441047,
title = {Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering},
author = {Yan, Feng and Liu, Lili and Walsh, Tiffany R. and Gong, Yu and El-Khoury, Patrick Z. and Zhang, Yanyan and Zhu, Zihua and De Yoreo, James J. and Engelhard, Mark H. and Zhang, Xin and Chen, Chun-Long},
abstractNote = {In nature, specific biomolecules interacting with mineral precursors are responsible for the precise production of nanostructured inorganic materials that exhibit complex morphologies and superior performance. Despite advances in developing biomimetic approaches, the design rules for creating sequence-defined molecules that lead to the synthesis of inorganic nanomaterials with predictable complex morphologies are unknown. Herein we report the design of sequence-defined peptoids for controlled synthesis of highly branched plasmonic gold particles. By engineering peptoid sequences and investigating the resulting particle formation mechanisms, we develop a rule of thumb for designing peptoids that predictively enabled the morphological evolution from spherical to coral-shaped nanoparticles. Through a combination of hyperspectral UV-Vis extinction microscopy and three-photon photoemission electron microscopy, we demonstrate that the individual coral-shaped gold nanoparticles exhibit a plasmonic enhancement as high as 105-fold. This research significantly advances our ultimate vision of predictive bio-inspired materials synthesis using sequence-defined synthetic molecules that mimic proteins and peptides.},
doi = {10.1038/s41467-018-04789-2},
journal = {Nature Communications},
number = 1,
volume = 9,
place = {United Kingdom},
year = {2018},
month = {6}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1038/s41467-018-04789-2

Citation Metrics:
Cited by: 4 works
Citation information provided by
Web of Science

Figures / Tables:

Figure 1 Figure 1: Structures of peptoids Pep-1–Pep-10. Nce=N-(2-carboxyethl)glycine, Nab=N-(4-aminobutyl)glycine, NXpe=N-[2-(4-X-phenyl)ethyl]glycines, Ndc=N-[2-(2,4-dichlorophenyl)ethyl]glycines, and Nae=N-(4-aminoethyl)glycine

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