The Mechanism and Function of Group II Chaperonins
Abstract
We report protein folding in the cell requires the assistance of enzymes collectively called chaperones. Among these, the chaperonins are 1-MDa ring-shaped oligomeric complexes that bind unfolded polypeptides and promote their folding within an isolated chamber in an ATP-dependent manner. Group II chaperonins, found in archaea and eukaryotes, contain a built-in lid that opens and closes over the central chamber. In eukaryotes, the chaperonin TRiC/CCT is hetero-oligomeric, consisting of two stacked rings of eight paralogous subunits each. TRiC facilitates folding of approximately 10% of the eukaryotic proteome, including many cytoskeletal components and cell cycle regulators. Folding of many cellular substrates of TRiC cannot be assisted by any other chaperone. A complete structural and mechanistic understanding of this highly conserved and essential chaperonin remains elusive. However, recent work is beginning to shed light on key aspects of chaperonin function and how their unique properties underlie their contribution to maintaining cellular proteostasis.
- Authors:
-
- Stanford Univ., CA (United States). Department of Biology
- Stanford Univ., CA (United States). Biophysics Program
- Stanford Univ., CA (United States). Department of Biology and Department of Genetics
- Publication Date:
- Research Org.:
- Stanford Univ., CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1440550
- Alternate Identifier(s):
- OSTI ID: 1246436
- Grant/Contract Number:
- SC0008504
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Molecular Biology
- Additional Journal Information:
- Journal Volume: 427; Journal Issue: 18; Journal ID: ISSN 0022-2836
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Lopez, Tom, Dalton, Kevin, and Frydman, Judith. The Mechanism and Function of Group II Chaperonins. United States: N. p., 2015.
Web. doi:10.1016/j.jmb.2015.04.013.
Lopez, Tom, Dalton, Kevin, & Frydman, Judith. The Mechanism and Function of Group II Chaperonins. United States. https://doi.org/10.1016/j.jmb.2015.04.013
Lopez, Tom, Dalton, Kevin, and Frydman, Judith. Thu .
"The Mechanism and Function of Group II Chaperonins". United States. https://doi.org/10.1016/j.jmb.2015.04.013. https://www.osti.gov/servlets/purl/1440550.
@article{osti_1440550,
title = {The Mechanism and Function of Group II Chaperonins},
author = {Lopez, Tom and Dalton, Kevin and Frydman, Judith},
abstractNote = {We report protein folding in the cell requires the assistance of enzymes collectively called chaperones. Among these, the chaperonins are 1-MDa ring-shaped oligomeric complexes that bind unfolded polypeptides and promote their folding within an isolated chamber in an ATP-dependent manner. Group II chaperonins, found in archaea and eukaryotes, contain a built-in lid that opens and closes over the central chamber. In eukaryotes, the chaperonin TRiC/CCT is hetero-oligomeric, consisting of two stacked rings of eight paralogous subunits each. TRiC facilitates folding of approximately 10% of the eukaryotic proteome, including many cytoskeletal components and cell cycle regulators. Folding of many cellular substrates of TRiC cannot be assisted by any other chaperone. A complete structural and mechanistic understanding of this highly conserved and essential chaperonin remains elusive. However, recent work is beginning to shed light on key aspects of chaperonin function and how their unique properties underlie their contribution to maintaining cellular proteostasis.},
doi = {10.1016/j.jmb.2015.04.013},
journal = {Journal of Molecular Biology},
number = 18,
volume = 427,
place = {United States},
year = {2015},
month = {4}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 111 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
The Kinetics of Formation of Native Ribonuclease During Oxidation of the Reduced Polypeptide Chain
journal, September 1961
- Anfinsen, C. B.; Haber, E.; Sela, M.
- Proceedings of the National Academy of Sciences, Vol. 47, Issue 9
The Search for Folding Intermediates and the Mechanism of Protein Folding
journal, June 2008
- Baldwin, Robert L.
- Annual Review of Biophysics, Vol. 37, Issue 1
The folding of single domain proteins—have we reached a consensus?
journal, February 2011
- Sosnick, Tobin R.; Barrick, Doug
- Current Opinion in Structural Biology, Vol. 21, Issue 1
Effects of macromolecular crowding on protein folding and aggregation
journal, December 1999
- van den Berg, B.
- The EMBO Journal, Vol. 18, Issue 24
Folding of Newly Translated Proteins In Vivo: The Role of Molecular Chaperones
journal, June 2001
- Frydman, Judith
- Annual Review of Biochemistry, Vol. 70, Issue 1
Folding the proteome
journal, July 2013
- Braselmann, Esther; Chaney, Julie L.; Clark, Patricia L.
- Trends in Biochemical Sciences, Vol. 38, Issue 7
Molecular Chaperone Functions in Protein Folding and Proteostasis
journal, June 2013
- Kim, Yujin E.; Hipp, Mark S.; Bracher, Andreas
- Annual Review of Biochemistry, Vol. 82, Issue 1
Systems Analyses Reveal Two Chaperone Networks with Distinct Functions in Eukaryotic Cells
journal, January 2006
- Albanèse, Véronique; Yam, Alice Yen-Wen; Baughman, Joshua
- Cell, Vol. 124, Issue 1
A cradle for new proteins: trigger factor at the ribosome
journal, April 2005
- Maier, Timm; Ferbitz, Lars; Deuerling, Elke
- Current Opinion in Structural Biology, Vol. 15, Issue 2
Two Families of Chaperonin: Physiology and Mechanism
journal, November 2007
- Horwich, Arthur L.; Fenton, Wayne A.; Chapman, Eli
- Annual Review of Cell and Developmental Biology, Vol. 23, Issue 1
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
journal, March 2002
- Hartl, F. U.
- Science, Vol. 295, Issue 5561
Multiple chaperonins in bacteria – why so many?
journal, July 2009
- Lund, Peter A.
- FEMS Microbiology Reviews, Vol. 33, Issue 4
Differential substrate specificity of group I and group II chaperonins in the archaeon Methanosarcina mazei
journal, December 2009
- Hirtreiter, Angela M.; Calloni, Giulia; Forner, Francesca
- Molecular Microbiology, Vol. 74, Issue 5
The crystal structure of the asymmetric GroEL–GroES–(ADP)7 chaperonin complex
journal, August 1997
- Xu, Zhaohui; Horwich, Arthur L.; Sigler, Paul B.
- Nature, Vol. 388, Issue 6644
Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones
journal, July 1994
- Frydman, Judith; Nimmesgern, Elmar; Ohtsuka, Kenzo
- Nature, Vol. 370, Issue 6485
PhLP3 Modulates CCT-mediated Actin and Tubulin Folding via Ternary Complexes with Substrates
journal, March 2006
- Stirling, Peter C.; Cuéllar, Jorge; Alfaro, Gabriel A.
- Journal of Biological Chemistry, Vol. 281, Issue 11
Structure of the Molecular Chaperone Prefoldin
journal, November 2000
- Siegert, Ralf; Leroux, Michel R.; Scheufler, Clemens
- Cell, Vol. 103, Issue 4
Structures of the Gβ-CCT and PhLP1–Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly
journal, February 2015
- Plimpton, Rebecca L.; Cuéllar, Jorge; Lai, Chun Wan J.
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 8
Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex
journal, June 2002
- McLaughlin, J. N.; Thulin, C. D.; Hart, S. J.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 12
Compartmentation of protein folding invivo: sequestration of non-native polypeptide by the chaperonin-GimC system
journal, January 1999
- Siegers, K.
- The EMBO Journal, Vol. 18, Issue 1
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin
journal, December 1999
- Leroux, M. R.
- The EMBO Journal, Vol. 18, Issue 23
Yeast Phosducin-Like Protein 2 Acts as a Stimulatory Co-Factor for the Folding of Actin by the Chaperonin CCT via a Ternary Complex
journal, August 2009
- McCormack, Elizabeth A.; Altschuler, Gabriel M.; Dekker, Carien
- Journal of Molecular Biology, Vol. 391, Issue 1
TCP1 complex is a molecular chaperone in tubulin biogenesis
journal, July 1992
- Yaffe, Michael B.; Farr, George W.; Miklos, David
- Nature, Vol. 358, Issue 6383
The CCT Chaperonin Promotes Activation of the Anaphase-Promoting Complex through the Generation of Functional Cdc20
journal, July 2003
- Camasses, Alain; Bogdanova, Aliona; Shevchenko, Andrej
- Molecular Cell, Vol. 12, Issue 1
A yeast TCP-1-like protein is required for actin function in vivo.
journal, September 1994
- Vinh, D. B.; Drubin, D. G.
- Proceedings of the National Academy of Sciences, Vol. 91, Issue 19
Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies
journal, November 2008
- Yam, Alice Y.; Xia, Yu; Lin, Hen-Tzu Jill
- Nature Structural & Molecular Biology, Vol. 15, Issue 12
Conformational variability in the refined structure of the chaperonin GroEL at 2.8 Å resolution
journal, December 1995
- Braig, Kerstin; Adams, Paul D.; Brünger, Axel T.
- Nature Structural & Molecular Biology, Vol. 2, Issue 12
The crystal structure of the bacterial chaperonln GroEL at 2.8 Å
journal, October 1994
- Braig, Kerstin; Otwinowski, Zbyszek; Hegde, Rashmi
- Nature, Vol. 371, Issue 6498
Crystal Structure of Group II Chaperonin in the Open State
journal, October 2010
- Huo, Yanwu; Hu, Zhongjun; Zhang, Kai
- Structure, Vol. 18, Issue 10
The molecular chaperone TF55: Assesment of symmetry
journal, March 1994
- Marco, Sergio; Ureña, Dionisio; Carrascosa, José L.
- FEBS Letters, Vol. 341, Issue 2-3
Three conformations of an archaeal chaperonin, TF55 from Sulfolobus shibatae
journal, February 2000
- Schoehn, Guy; Quaite-Randall, Elsie; Jiménez, José L.
- Journal of Molecular Biology, Vol. 296, Issue 3
Flexible interwoven termini determine the thermal stability of thermosomes
journal, May 2013
- Zhang, Kai; Wang, Li; Liu, Yanxin
- Protein & Cell, Vol. 4, Issue 6
Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.
journal, December 1992
- Frydman, J.; Nimmesgern, E.; Erdjument-Bromage, H.
- The EMBO Journal, Vol. 11, Issue 13
The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1
journal, January 1995
- Kubota, Hiroshi; Hynes, Gillian; Willison, Keith
- Gene, Vol. 154, Issue 2
Structure of the Substrate Binding Domain of the Thermosome, an Archaeal Group II Chaperonin
journal, October 1997
- Klumpp, Martin; Baumeister, Wolfgang; Essen, Lars-Oliver
- Cell, Vol. 91, Issue 2
Crystal structure of the β-apical domain of the thermosome reveals structural plasticity in the protrusion region 1 1Edited by D. Rees
journal, August 2000
- Bosch, Gundula; Baumeister, Wolfgang; Essen, Lars-Oliver
- Journal of Molecular Biology, Vol. 301, Issue 1
Mechanism of nucleotide sensing in group II chaperonins: Nucleotide sensing in group II chaperonins
journal, December 2011
- Pereira, Jose H.; Ralston, Corie Y.; Douglas, Nicholai R.
- The EMBO Journal, Vol. 31, Issue 3
Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT
journal, April 1998
- Ditzel, Lars; Löwe, Jan; Stock, Daniela
- Cell, Vol. 93, Issue 1
Programmed Cell Death Protein 5 Interacts with the Cytosolic Chaperonin Containing Tailless Complex Polypeptide 1 (CCT) to Regulate β-Tubulin Folding
journal, February 2014
- Tracy, Christopher M.; Gray, Amy J.; Cuéllar, Jorge
- Journal of Biological Chemistry, Vol. 289, Issue 7
Analysis of the Interaction between the Eukaryotic Chaperonin CCT and Its Substrates Actin and Tubulin
journal, August 2001
- Llorca, Oscar; Martín-Benito, Jaime; Gómez-Puertas, Paulino
- Journal of Structural Biology, Vol. 135, Issue 2
Eukaryotic type II chaperonin CCT interacts with actin through specific subunits
journal, December 1999
- Llorca, Oscar; McCormack, Elizabeth A.; Hynes, Gillian
- Nature, Vol. 402, Issue 6762
Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations
journal, November 2000
- Llorca, O.
- The EMBO Journal, Vol. 19, Issue 22
Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin
journal, December 2010
- Muñoz, Inés G.; Yébenes, Hugo; Zhou, Min
- Nature Structural & Molecular Biology, Vol. 18, Issue 1
Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT
journal, December 2002
- Martin-Benito, J.
- The EMBO Journal, Vol. 21, Issue 23
Structure of the complex between the cytosolic chaperonin CCT and phosducin-like protein
journal, December 2004
- Martin-Benito, J.; Bertrand, S.; Hu, T.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 50
The structure of CCT–Hsc70NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin
journal, July 2008
- Cuéllar, Jorge; Martín-Benito, Jaime; Scheres, Sjors H. W.
- Nature Structural & Molecular Biology, Vol. 15, Issue 8
Chaperonins: two rings for folding
journal, August 2011
- Yébenes, Hugo; Mesa, Pablo; Muñoz, Inés G.
- Trends in Biochemical Sciences, Vol. 36, Issue 8
Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT
journal, June 2008
- Booth, Christopher R.; Meyer, Anne S.; Cong, Yao
- Nature Structural & Molecular Biology, Vol. 15, Issue 7
4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement
journal, March 2010
- Cong, Y.; Baker, M. L.; Jakana, J.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 11
Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle: Symmetry-free Cryo-EM structures of the chaperonin TRiC
journal, November 2011
- Cong, Yao; Schröder, Gunnar F.; Meyer, Anne S.
- The EMBO Journal, Vol. 31, Issue 3
Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
journal, March 2003
- Meyer, Philippe; Prodromou, Chrisostomos; Hu, Bin
- Molecular Cell, Vol. 11, Issue 3
The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins
journal, June 2011
- Dekker, Carien; Roe, S. Mark; McCormack, Elizabeth A.
- The EMBO Journal, Vol. 30, Issue 15
The inter-ring arrangement of the cytosolic chaperonin CCT
journal, February 2007
- Martín-Benito, Jaime; Grantham, Julie; Boskovic, Jasminka
- EMBO reports, Vol. 8, Issue 3
The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT
journal, May 2012
- Leitner, Alexander; Joachimiak, Lukasz A.; Bracher, Andreas
- Structure, Vol. 20, Issue 5
Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling
journal, February 2012
- Kalisman, N.; Adams, C. M.; Levitt, M.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 8
A Gradient of ATP Affinities Generates an Asymmetric Power Stroke Driving the Chaperonin TRIC/CCT Folding Cycle
journal, October 2012
- Reissmann, Stefanie; Joachimiak, Lukasz A.; Chen, Bryan
- Cell Reports, Vol. 2, Issue 4
Specificity in chaperonin-mediated protein folding
journal, May 1995
- Tian, Guoling; Vainberg, Irina E.; Tap, William D.
- Nature, Vol. 375, Issue 6528
Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets
journal, November 2004
- Spiess, Christoph; Meyer, Anne S.; Reissmann, Stefanie
- Trends in Cell Biology, Vol. 14, Issue 11
Chaperonins: The hunt for the Group II mechanism
journal, June 2008
- Bigotti, Maria Giulia; Clarke, Anthony R.
- Archives of Biochemistry and Biophysics, Vol. 474, Issue 2
Crystal Structures of a Group II Chaperonin Reveal the Open and Closed States Associated with the Protein Folding Cycle
journal, June 2010
- Pereira, Jose H.; Ralston, Corie Y.; Douglas, Nicholai R.
- Journal of Biological Chemistry, Vol. 285, Issue 36
Mechanism of folding chamber closure in a group II chaperonin
journal, January 2010
- Zhang, Junjie; Baker, Matthew L.; Schröder, Gunnar F.
- Nature, Vol. 463, Issue 7279
Cryo-EM Structure of a Group II Chaperonin in the Prehydrolysis ATP-Bound State Leading to Lid Closure
journal, May 2011
- Zhang, Junjie; Ma, Boxue; DiMaio, Frank
- Structure, Vol. 19, Issue 5
Chaperonins from an Antarctic archaeon are predominantly monomeric: crystal structure of an open state monomer: Monomeric open state group II chaperonin structure
journal, April 2011
- Pilak, Oliver; Harrop, Stephen J.; Siddiqui, Khawar S.
- Environmental Microbiology, Vol. 13, Issue 8
Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins
journal, April 2007
- Reissmann, Stefanie; Parnot, Charles; Booth, Christopher R.
- Nature Structural & Molecular Biology, Vol. 14, Issue 5
ATP Dependent Rotational Motion of Group II Chaperonin Observed by X-ray Single Molecule Tracking
journal, May 2013
- Sekiguchi, Hiroshi; Nakagawa, Ayumi; Moriya, Kazuki
- PLoS ONE, Vol. 8, Issue 5
The Asymmetric ATPase Cycle of the Thermosome: Elucidation of the Binding, Hydrolysis and Product-release Steps
journal, September 2006
- Bigotti, Maria Giulia; Bellamy, Stuart R. W.; Clarke, Anthony R.
- Journal of Molecular Biology, Vol. 362, Issue 4
Reconstitution of the human chaperonin CCT by co-expression of the eight distinct subunits in mammalian cells
journal, March 2012
- Machida, Kodai; Masutani, Mamiko; Kobayashi, Tominari
- Protein Expression and Purification, Vol. 82, Issue 1
Closing the Folding Chamber of the Eukaryotic Chaperonin Requires the Transition State of ATP Hydrolysis
journal, May 2003
- Meyer, Anne S.; Gillespie, Joel R.; Walther, Dirk
- Cell, Vol. 113, Issue 3
Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber
journal, January 2011
- Douglas, Nicholai R.; Reissmann, Stefanie; Zhang, Junjie
- Cell, Vol. 144, Issue 2
Characterization of Archaeal Group II Chaperonin-ADP-Metal Fluoride Complexes
journal, December 2005
- Iizuka, Ryo; Yoshida, Takao; Ishii, Noriyuki
- Journal of Biological Chemistry, Vol. 280, Issue 48
Mechanism of GroEL action: Productive release of polypeptide from a sequestered position under groes
journal, November 1995
- Weissman, Jonathan S.; Hohl, Corinne M.; Kovalenko, Oleg
- Cell, Vol. 83, Issue 4
Thermodynamics of nucleotide binding to the chaperonin GroEL studied by isothermal titration calorimetry: evidence for noncooperative nucleotide binding
journal, May 1999
- Terada, Tomoki P.; Kuwajima, Kunihiro
- Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1431, Issue 2
ATPase cycle of an archaeal chaperonin
journal, June 2000
- Gutsche, Irina; Mihalache, Oana; Baumeister, Wolfgang
- Journal of Molecular Biology, Vol. 300, Issue 1
Sensing cooperativity in ATP hydrolysis for single multisubunit enzymes in solution
journal, September 2011
- Jiang, Y.; Douglas, N. R.; Conley, N. R.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 41
Dynamics of the chaperonin ATPase cycle: implications for facilitated protein folding
journal, July 1994
- Todd, M.; Viitanen, P.; Lorimer, G.
- Science, Vol. 265, Issue 5172
Elucidation of Steps in the Capture of a Protein Substrate for Efficient Encapsulation by GroE
journal, July 2006
- Cliff, Matthew J.; Limpkin, Claire; Cameron, Angus
- Journal of Biological Chemistry, Vol. 281, Issue 30
GroES in the asymmetric GroEL14-GroES7 complex exchanges via an associative mechanism
journal, March 1999
- Horowitz, P. M.; Lorimer, G. H.; Ybarra, J.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 6
Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4 ) gene
journal, July 2003
- Lee, M. -J.; Stephenson, D. A.; Groves, M. J.
- Human Molecular Genetics, Vol. 12, Issue 15
Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia
journal, September 2005
- Bouhouche, A.
- Journal of Medical Genetics, Vol. 43, Issue 5
Protein folding in vivo: the importance of molecular chaperones
journal, February 2000
- Feldman, Douglas E.; Frydman, Judith
- Current Opinion in Structural Biology, Vol. 10, Issue 1
Tumorigenic Mutations in VHL Disrupt Folding In Vivo by Interfering with Chaperonin Binding
journal, November 2003
- Feldman, Douglas E.; Spiess, Christoph; Howard, Daniel E.
- Molecular Cell, Vol. 12, Issue 5
Formation of the VHL–Elongin BC Tumor Suppressor Complex Is Mediated by the Chaperonin TRiC
journal, December 1999
- Feldman, Douglas E.; Thulasiraman, Vanitha; Ferreyra, Raul G.
- Molecular Cell, Vol. 4, Issue 6
Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity
journal, June 2013
- Trinidad, Antonio Garcia; Muller, Patricia A. J.; Cuellar, Jorge
- Molecular Cell, Vol. 50, Issue 6
Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin
journal, April 2014
- Kasembeli, Moses; Lau, Wilson Chun Yu; Roh, Soung-Hun
- PLoS Biology, Vol. 12, Issue 4
Proteostatic Control of Telomerase Function through TRiC-Mediated Folding of TCAB1
journal, December 2014
- Freund, Adam; Zhong, Franklin L.; Venteicher, Andrew S.
- Cell, Vol. 159, Issue 6
Cytosolic chaperonin protects folding intermediates of Gbeta from aggregation by recognizing hydrophobic beta-strands
journal, May 2006
- Kubota, S.; Kubota, H.; Nagata, K.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 22
The Molecular Chaperone TRiC/CCT Binds to the Trp-Asp 40 (WD40) Repeat Protein WDR68 and Promotes Its Folding, Protein Kinase DYRK1A Binding, and Nuclear Accumulation
journal, November 2014
- Miyata, Yoshihiko; Shibata, Takeshi; Aoshima, Masato
- Journal of Biological Chemistry, Vol. 289, Issue 48
Function of phosducin-like proteins in G protein signaling and chaperone-assisted protein folding
journal, December 2007
- Willardson, Barry M.; Howlett, Alyson C.
- Cellular Signalling, Vol. 19, Issue 12
Affinity purification reveals the association of WD40 protein constitutive photomorphogenic 1 with the hetero-oligomeric TCP-1 chaperonin complex in mammalian cells
journal, January 2006
- Yi, Chunling; Li, Shuting; Wang, Jian
- The International Journal of Biochemistry & Cell Biology, Vol. 38, Issue 7
Chaperonin TRiC Promotes the Assembly of polyQ Expansion Proteins into Nontoxic Oligomers
journal, September 2006
- Behrends, Christian; Langer, Carola A.; Boteva, Raina
- Molecular Cell, Vol. 23, Issue 6
Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state
journal, September 2006
- Kitamura, Akira; Kubota, Hiroshi; Pack, Chan-Gi
- Nature Cell Biology, Vol. 8, Issue 10
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions
journal, September 2006
- Tam, Stephen; Geller, Ron; Spiess, Christoph
- Nature Cell Biology, Vol. 8, Issue 10
The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation
journal, November 2009
- Tam, Stephen; Spiess, Christoph; Auyeung, William
- Nature Structural & Molecular Biology, Vol. 16, Issue 12
The TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in Aβ-Expressing Caenorhabditis elegans
journal, July 2014
- Khabirova, Eleonora; Moloney, Aileen; Marciniak, Stefan J.
- PLoS ONE, Vol. 9, Issue 7
Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein
journal, February 2011
- Inoue, Yasushi; Aizaki, Hideki; Hara, Hiromichi
- Virology, Vol. 410, Issue 1
A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle.
journal, April 1994
- Lingappa, J. R.; Martin, R. L.; Wong, M. L.
- Journal of Cell Biology, Vol. 125, Issue 1
Cellular Chaperonin CCT Contributes to Rabies Virus Replication during Infection
journal, May 2013
- Zhang, J.; Wu, X.; Zan, J.
- Journal of Virology, Vol. 87, Issue 13
Genome-Scale RNAi Screen for Host Factors Required for HIV Replication
journal, November 2008
- Zhou, Honglin; Xu, Min; Huang, Qian
- Cell Host & Microbe, Vol. 4, Issue 5
Global landscape of HIV–human protein complexes
journal, December 2011
- Jäger, Stefanie; Cimermancic, Peter; Gulbahce, Natali
- Nature, Vol. 481, Issue 7381
Type D Retrovirus Gag Polyprotein Interacts with the Cytosolic Chaperonin TRiC
journal, March 2001
- Hong, Suntaek; Choi, Gyu; Park, Sunyoung
- Journal of Virology, Vol. 75, Issue 6
In vivo newly translated polypeptides are sequestered in a protected folding environment
journal, January 1999
- Thulasiraman, V.
- The EMBO Journal, Vol. 18, Issue 1
A structural model for GroEL-polypeptide recognition
journal, April 1997
- Buckle, A. M.; Zahn, R.; Fersht, A. R.
- Proceedings of the National Academy of Sciences, Vol. 94, Issue 8
The Structural Basis of Substrate Recognition by the Eukaryotic Chaperonin TRiC/CCT
journal, November 2014
- Joachimiak, Lukasz A.; Walzthoeni, Thomas; Liu, Corey W.
- Cell, Vol. 159, Issue 5
Domain-Specific Chaperone-Induced Expansion Is Required for β-Actin Folding: A Comparison of β-Actin Conformations upon Interactions with GroEL and Tail-less Complex Polypeptide 1 Ring Complex (TRiC)
journal, October 2007
- Villebeck, Laila; Moparthi, Satish Babu; Lindgren, Mikael
- Biochemistry, Vol. 46, Issue 44
Conformational Rearrangements of Tail-less Complex Polypeptide 1 (TCP-1) Ring Complex (TRiC)-Bound Actin
journal, April 2007
- Villebeck, Laila; Persson, Malin; Luan, Shi-Lu
- Biochemistry, Vol. 46, Issue 17
Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT
journal, November 2012
- Russmann, F.; Stemp, M. J.; Monkemeyer, L.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 52
EMBOSS: The European Molecular Biology Open Software Suite
journal, June 2000
- Rice, Peter; Longden, Ian; Bleasby, Alan
- Trends in Genetics, Vol. 16, Issue 6
Electrostatics of nanosystems: Application to microtubules and the ribosome
journal, August 2001
- Baker, N. A.; Sept, D.; Joseph, S.
- Proceedings of the National Academy of Sciences, Vol. 98, Issue 18, p. 10037-10041
OpenMM 4: A Reusable, Extensible, Hardware Independent Library for High Performance Molecular Simulation
journal, November 2012
- Eastman, Peter; Friedrichs, Mark S.; Chodera, John D.
- Journal of Chemical Theory and Computation, Vol. 9, Issue 1
Works referencing / citing this record:
Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly
journal, December 2018
- Antonova, Simona V.; Haffke, Matthias; Corradini, Eleonora
- Nature Structural & Molecular Biology, Vol. 25, Issue 12
On the nature of the optimal form of the holdase‐type chaperone stress response
journal, August 2019
- Hall, Damien
- FEBS Letters, Vol. 594, Issue 1
Large-scale aggregation analysis of eukaryotic proteins reveals an involvement of intrinsically disordered regions in protein folding
journal, January 2018
- Uemura, Eri; Niwa, Tatsuya; Minami, Shintaro
- Scientific Reports, Vol. 8, Issue 1
Insights into the ubiquitin-proteasome system of human embryonic stem cells
journal, March 2018
- Saez, Isabel; Koyuncu, Seda; Gutierrez-Garcia, Ricardo
- Scientific Reports, Vol. 8, Issue 1
Vacuolar ATPase as a possible therapeutic target in human acute myeloid leukemia
journal, November 2017
- Aasebø, Elise; Bartaula-Brevik, Sushma; Hernandez-Valladares, Maria
- Expert Review of Hematology, Vol. 11, Issue 1
Chaperone-client interactions: Non-specificity engenders multifunctionality
journal, June 2017
- Koldewey, Philipp; Horowitz, Scott; Bardwell, James C. A.
- Journal of Biological Chemistry, Vol. 292, Issue 29
Identification of key sites controlling protein functional motions by using elastic network model combined with internal coordinates
journal, July 2019
- Zhang, Peng Fei; Su, Ji Guo
- The Journal of Chemical Physics, Vol. 151, Issue 4
Cellular Proteomes Drive Tissue-Specific Regulation of the Heat Shock Response
journal, January 2017
- Ma, Jian; Grant, Christopher E.; Plagens, Rosemary N.
- G3: Genes|Genomes|Genetics, Vol. 7, Issue 3
Expression and diagnostic value of CCT3 and IQGAP3 in hepatocellular carcinoma
journal, July 2016
- Qian, E-Na; Han, Shuang-Yin; Ding, Song-Ze
- Cancer Cell International, Vol. 16, Issue 1
Chloroplast Chaperonin: An Intricate Protein Folding Machine for Photosynthesis
journal, January 2018
- Zhao, Qian; Liu, Cuimin
- Frontiers in Molecular Biosciences, Vol. 4
The proteostasis network provides targets for neurodegeneration
journal, May 2019
- Newton, Timothy Mark; Duce, James Alex; Bayle, Elliott David
- British Journal of Pharmacology, Vol. 176, Issue 18
Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly
journal, June 2019
- Cuéllar, Jorge; Ludlam, W. Grant; Tensmeyer, Nicole C.
- Nature Communications, Vol. 10, Issue 1
Protein Quality Control by Molecular Chaperones in Neurodegeneration
journal, April 2017
- Ciechanover, Aaron; Kwon, Yong Tae
- Frontiers in Neuroscience, Vol. 11
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis
journal, January 2020
- Showalter, Anne E.; Martini, Ana C.; Nierenberg, Daniel
- Scientific Reports, Vol. 10, Issue 1
Structural investigation of a chaperonin in action reveals how nucleotide binding regulates the functional cycle
journal, September 2018
- Mas, Guillaume; Guan, Jia-Ying; Crublet, Elodie
- Science Advances, Vol. 4, Issue 9
Pathways of cellular proteostasis in aging and disease
journal, November 2017
- Klaips, Courtney L.; Jayaraj, Gopal Gunanathan; Hartl, F. Ulrich
- The Journal of Cell Biology, Vol. 217, Issue 1
Structural insight into the cooperation of chloroplast chaperonin subunits
journal, April 2016
- Zhang, Shijia; Zhou, Huan; Yu, Feng
- BMC Biology, Vol. 14, Issue 1
Chaperones in sporadic inclusion body myositis—Validation of proteomic data
journal, November 2019
- Güttsches, Anne‐Katrin; Jacobsen, Frank; Schreiner, Anja
- Muscle & Nerve, Vol. 61, Issue 1
Chaperoning the Mononegavirales: Current Knowledge and Future Directions
journal, December 2018
- Latorre, Victor; Mattenberger, Florian; Geller, Ron
- Viruses, Vol. 10, Issue 12
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
journal, July 2018
- Koyuncu, Seda; Saez, Isabel; Lee, Hyun Ju
- Nature Communications, Vol. 9, Issue 1
The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B
journal, September 2018
- Steinemann, Marcus; Schlosser, Andreas; Jank, Thomas
- Proceedings of the National Academy of Sciences, Vol. 115, Issue 38
The CCT chaperonin is a novel regulator of Ca 2+ signaling through modulation of Orai1 trafficking
journal, September 2018
- Hodeify, Rawad; Nandakumar, Manjula; Own, Maryam
- Science Advances, Vol. 4, Issue 9
Functional characterization of chaperonin containing T-complex polypeptide-1 and its conserved and novel substrates in Arabidopsis
journal, March 2019
- Ahn, Hee-Kyung; Yoon, Joong-Tak; Choi, Ilyeong
- Journal of Experimental Botany, Vol. 70, Issue 10
Heat shock response in archaea
journal, November 2018
- Lemmens, Liesbeth; Baes, Rani; Peeters, Eveline
- Emerging Topics in Life Sciences, Vol. 2, Issue 4
E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response
journal, September 2016
- Li, Jian; Chauve, Laetitia; Phelps, Grace
- Genes & Development, Vol. 30, Issue 18
In vivo aspects of protein folding and quality control
journal, June 2016
- Balchin, David; Hayer-Hartl, Manajit; Hartl, F. Ulrich
- Science, Vol. 353, Issue 6294
A systematic atlas of chaperome deregulation topologies across the human cancer landscape
journal, January 2018
- Hadizadeh Esfahani, Ali; Sverchkova, Angelina; Saez-Rodriguez, Julio
- PLOS Computational Biology, Vol. 14, Issue 1
Protein cages and synthetic polymers: a fruitful symbiosis for drug delivery applications, bionanotechnology and materials science
journal, January 2016
- Rother, Martin; Nussbaumer, Martin G.; Renggli, Kasper
- Chemical Society Reviews, Vol. 45, Issue 22
T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation
journal, September 2018
- Chen, Xu-Qiao; Fang, Fang; Florio, Jazmin B.
- Traffic, Vol. 19, Issue 11
A cytosolic chaperone complex controls folding and degradation of type III CD38
journal, January 2019
- Wu, Yang; Zhang, Jingzi; Fang, Lei
- Journal of Biological Chemistry, Vol. 294, Issue 11
An information theoretic framework reveals a tunable allosteric network in group II chaperonins
journal, July 2017
- Lopez, Tom; Dalton, Kevin; Tomlinson, Anthony
- Nature Structural & Molecular Biology, Vol. 24, Issue 9
Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells
journal, July 2017
- Noormohammadi, Alireza; Calculli, Giuseppe; Gutierrez-Garcia, Ricardo
- Cellular and Molecular Life Sciences, Vol. 75, Issue 2
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis
journal, November 2015
- Roh, Soung-Hun; Kasembeli, Moses; Bakthavatsalam, Deenadayalan
- International Journal of Molecular Sciences, Vol. 16, Issue 11
Characterization of group II chaperonins from an acidothermophilic archaeon Picrophilus torridus
journal, June 2016
- Yamamoto, Yohei Y.; Tsuchida, Kanako; Noguchi, Keiichi
- FEBS Open Bio, Vol. 6, Issue 7
REP-X: An Evolution-guided Strategy for the Rational Design of Cysteine-less Protein Variants
journal, February 2020
- Dalton, Kevin; Lopez, Tom; Pande, Vijay
- Scientific Reports, Vol. 10, Issue 1
A systematic atlas of chaperome deregulation topologies across the human cancer landscape
text, January 2018
- Hadizadeh Esfahani, Ali; Sverchkova, Angelina; Sáez Rodríguez, Julio
- RWTH Aachen University
Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis
journal, July 2017
- Kevei, Éva; Pokrzywa, Wojciech; Hoppe, Thorsten
- FEBS Letters, Vol. 591, Issue 17
Characterization of group II chaperonins from an acidothermophilic archaeon Picrophilus torridus
journal, June 2016
- Yamamoto, Yohei Y.; Tsuchida, Kanako; Noguchi, Keiichi
- FEBS Open Bio, Vol. 6, Issue 7
In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly
journal, January 2018
- Berger, Joachim; Berger, Silke; Li, Mei
- Cell Reports, Vol. 22, Issue 2
An information theoretic framework reveals a tunable allosteric network in group II chaperonins
journal, July 2017
- Lopez, Tom; Dalton, Kevin; Tomlinson, Anthony
- Nature Structural & Molecular Biology, Vol. 24, Issue 9
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
journal, July 2018
- Koyuncu, Seda; Saez, Isabel; Lee, Hyun Ju
- Nature Communications, Vol. 9, Issue 1
Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly
journal, June 2019
- Cuéllar, Jorge; Ludlam, W. Grant; Tensmeyer, Nicole C.
- Nature Communications, Vol. 10, Issue 1
Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly
journal, December 2018
- Antonova, Simona V.; Haffke, Matthias; Corradini, Eleonora
- Nature Structural & Molecular Biology, Vol. 25, Issue 12
Large-scale aggregation analysis of eukaryotic proteins reveals an involvement of intrinsically disordered regions in protein folding
journal, January 2018
- Uemura, Eri; Niwa, Tatsuya; Minami, Shintaro
- Scientific Reports, Vol. 8, Issue 1
Insights into the ubiquitin-proteasome system of human embryonic stem cells
journal, March 2018
- Saez, Isabel; Koyuncu, Seda; Gutierrez-Garcia, Ricardo
- Scientific Reports, Vol. 8, Issue 1
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis
journal, January 2020
- Showalter, Anne E.; Martini, Ana C.; Nierenberg, Daniel
- Scientific Reports, Vol. 10, Issue 1
Differential conformational modulations of MreB folding upon interactions with GroEL/ES and TRiC chaperonin components
journal, June 2016
- Moparthi, Satish Babu; Carlsson, Uno; Vincentelli, Renaud
- Scientific Reports, Vol. 6, Issue 1
Functional characterization of chaperonin containing T-complex polypeptide-1 and its conserved and novel substrates in Arabidopsis
journal, March 2019
- Ahn, Hee-Kyung; Yoon, Joong-Tak; Choi, Ilyeong
- Journal of Experimental Botany, Vol. 70, Issue 10
Replacement of GroEL in Escherichia coli by the Group II Chaperonin from the Archaeon Methanococcus maripaludis
journal, July 2016
- Shah, Riddhi; Large, Andrew T.; Ursinus, Astrid
- Journal of Bacteriology, Vol. 198, Issue 19
Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis
journal, February 2018
- Minegishi, Yuriko; Nakaya, Naoki; Tomarev, Stanislav I.
- Investigative Opthalmology & Visual Science, Vol. 59, Issue 2
Structural insight into the cooperation of chloroplast chaperonin subunits
journal, April 2016
- Zhang, Shijia; Zhou, Huan; Yu, Feng
- BMC Biology, Vol. 14, Issue 1
Expression and diagnostic value of CCT3 and IQGAP3 in hepatocellular carcinoma
journal, July 2016
- Qian, E-Na; Han, Shuang-Yin; Ding, Song-Ze
- Cancer Cell International, Vol. 16, Issue 1
Molecular chaperones: guardians of the proteome in normal and disease states
journal, January 2015
- Jeng, Wilson; Lee, Sukyeong; Sung, Nuri
- F1000Research, Vol. 4
Asymmetry in the function and dynamics of the cytosolic group II chaperonin CCT/TRiC
journal, May 2017
- Yamamoto, Yohei Y.; Uno, Yuko; Sha, Eiryo
- PLOS ONE, Vol. 12, Issue 5
Cellular Proteomes Drive Tissue-Specific Regulation of the Heat Shock Response
journal, January 2017
- Ma, Jian; Grant, Christopher E.; Plagens, Rosemary N.
- G3: Genes|Genomes|Genetics, Vol. 7, Issue 3
Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth
journal, December 2017
- Li, Li-Juan; Zhang, Lian-Sheng; Han, Zhi-Jian
- Oncotarget, Vol. 8, Issue 67
Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity
journal, March 2016
- Mack, Korrie L.; Shorter, James
- Frontiers in Molecular Biosciences, Vol. 3
Chloroplast Chaperonin: An Intricate Protein Folding Machine for Photosynthesis
journal, January 2018
- Zhao, Qian; Liu, Cuimin
- Frontiers in Molecular Biosciences, Vol. 4
Single-Ring Intermediates Are Essential for Some Chaperonins
journal, April 2018
- Bhatt, Jay M.; Enriquez, Adrian S.; Wang, Jinliang
- Frontiers in Molecular Biosciences, Vol. 5
Protein Quality Control by Molecular Chaperones in Neurodegeneration
journal, April 2017
- Ciechanover, Aaron; Kwon, Yong Tae
- Frontiers in Neuroscience, Vol. 11
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis
journal, November 2015
- Roh, Soung-Hun; Kasembeli, Moses; Bakthavatsalam, Deenadayalan
- International Journal of Molecular Sciences, Vol. 16, Issue 11