Transcriptomic analysis of skin pigmentation variation in the Virginia opossum ( Didelphis virginiana )
Abstract
Abstract Skin pigmentation and coat pigmentation are two of the best‐studied examples of traits under natural selection given their quantifiable fitness interactions with the environment (e.g., camouflage) and signalling with other organisms (e.g., warning coloration). Previous morphological studies have found that skin pigmentation variation in the Virginia opossum ( Didelphis virginiana ) is associated with variation in precipitation and temperatures across its distribution range following Gloger's rule (lighter pigmentation in temperate environments). To investigate the molecular mechanism associated with skin pigmentation variation, we used RNA‐Seq and quantified gene expression of wild opossums from tropical and temperate populations. Using differential expression analysis and a co‐expression network approach, we found that expression variation in genes with melanocytic and immune functions is significantly associated with the degree of skin pigmentation variation and may be underlying this phenotypic difference. We also found evidence suggesting that the Wnt/β‐catenin signalling pathway might be regulating the depigmentation observed in temperate populations. Based on our study results, we present several alternative hypotheses that may explain Gloger's rule pattern of skin pigmentation variation in opossum, including changes in pathogen diversity supporting a pathogen‐resistant hypothesis, thermal stress associated with temperate environments, and pleiotropic and epistatic interactions between melanocytic and immunemore »
- Authors:
-
[1];
- Department of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California
- Key Lab of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Chaoyang, Beijing China
- Savannah River Ecology Lab Warnell School of Forestry and Natural Resources University of Georgia Aiken South Carolina
- Centro de Investigaciones Regionales “Dr. Hideyo Noguchi” Universidad Autónoma de Yucatán Mérida Yucatán Mexico
- Departamento de Ecología Evolutiva Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de Morelos Cuernavaca Morelos Mexico
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1440263
- Grant/Contract Number:
- DE‐FC09‐07SR22506
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Molecular Ecology
- Additional Journal Information:
- Journal Name: Molecular Ecology Journal Volume: 27 Journal Issue: 12; Journal ID: ISSN 0962-1083
- Publisher:
- Wiley-Blackwell
- Country of Publication:
- United Kingdom
- Language:
- English
Citation Formats
Nigenda‐Morales, Sergio F., Hu, Yibo, Beasley, James C., Ruiz‐Piña, Hugo A., Valenzuela‐Galván, David, and Wayne, Robert K. Transcriptomic analysis of skin pigmentation variation in the Virginia opossum ( Didelphis virginiana ). United Kingdom: N. p., 2018.
Web. doi:10.1111/mec.14712.
Nigenda‐Morales, Sergio F., Hu, Yibo, Beasley, James C., Ruiz‐Piña, Hugo A., Valenzuela‐Galván, David, & Wayne, Robert K. Transcriptomic analysis of skin pigmentation variation in the Virginia opossum ( Didelphis virginiana ). United Kingdom. https://doi.org/10.1111/mec.14712
Nigenda‐Morales, Sergio F., Hu, Yibo, Beasley, James C., Ruiz‐Piña, Hugo A., Valenzuela‐Galván, David, and Wayne, Robert K. Mon .
"Transcriptomic analysis of skin pigmentation variation in the Virginia opossum ( Didelphis virginiana )". United Kingdom. https://doi.org/10.1111/mec.14712.
@article{osti_1440263,
title = {Transcriptomic analysis of skin pigmentation variation in the Virginia opossum ( Didelphis virginiana )},
author = {Nigenda‐Morales, Sergio F. and Hu, Yibo and Beasley, James C. and Ruiz‐Piña, Hugo A. and Valenzuela‐Galván, David and Wayne, Robert K.},
abstractNote = {Abstract Skin pigmentation and coat pigmentation are two of the best‐studied examples of traits under natural selection given their quantifiable fitness interactions with the environment (e.g., camouflage) and signalling with other organisms (e.g., warning coloration). Previous morphological studies have found that skin pigmentation variation in the Virginia opossum ( Didelphis virginiana ) is associated with variation in precipitation and temperatures across its distribution range following Gloger's rule (lighter pigmentation in temperate environments). To investigate the molecular mechanism associated with skin pigmentation variation, we used RNA‐Seq and quantified gene expression of wild opossums from tropical and temperate populations. Using differential expression analysis and a co‐expression network approach, we found that expression variation in genes with melanocytic and immune functions is significantly associated with the degree of skin pigmentation variation and may be underlying this phenotypic difference. We also found evidence suggesting that the Wnt/β‐catenin signalling pathway might be regulating the depigmentation observed in temperate populations. Based on our study results, we present several alternative hypotheses that may explain Gloger's rule pattern of skin pigmentation variation in opossum, including changes in pathogen diversity supporting a pathogen‐resistant hypothesis, thermal stress associated with temperate environments, and pleiotropic and epistatic interactions between melanocytic and immune genes.},
doi = {10.1111/mec.14712},
journal = {Molecular Ecology},
number = 12,
volume = 27,
place = {United Kingdom},
year = {Mon Jun 04 00:00:00 EDT 2018},
month = {Mon Jun 04 00:00:00 EDT 2018}
}
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