DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication
Abstract
Abstract Complex‐shaped microparticles can enhance applications in drug delivery, tissue engineering, and structural materials, although techniques to fabricate these particles remain limited. A microfluidics‐based process called optofluidic fabrication that utilizes inertial flows and ultraviolet polymerization has shown great potential for creating highly 3D‐shaped particles in a high‐throughput manner, but the particle dimensions are mainly at the millimeter scale. Here, a next generation optofluidic fabrication process is presented that utilizes on‐the‐fly fabricated multiscale fluidic channels producing customized sub‐100 µm 3D‐shaped microparticles. This flexible design scheme offers a user‐friendly platform for rapid prototyping of new 3D particle shapes, providing greater potential for creating impactful engineered microparticles.
- Authors:
-
[1];
[3]
- Department of Mechanical, Aerospace, and Nuclear Engineering Rensselaer Polytechnic Institute (RPI) Troy NY 12180 USA, Engineering Directorate Lawrence Livermore National Laboratory (LLNL) Livermore CA 94550 USA
- Department of Mechanical, Aerospace, and Nuclear Engineering Rensselaer Polytechnic Institute (RPI) Troy NY 12180 USA
- Department of Mechanical, Aerospace, and Nuclear Engineering Rensselaer Polytechnic Institute (RPI) Troy NY 12180 USA, School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea
- Publication Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); Rensselaer Polytechnic Inst., Troy, NY (United States); Korea Univ., Seoul (Korea, Republic of)
- Sponsoring Org.:
- USDOE; National Science Foundation (NSF); Rensselaer Polytechnic Inst. (United States); Korea Univ. (Korea, Republic of)
- OSTI Identifier:
- 1440257
- Alternate Identifier(s):
- OSTI ID: 1440258; OSTI ID: 1465317
- Report Number(s):
- LLNL-JRNL-749963
Journal ID: ISSN 2198-3844; 1800252
- Grant/Contract Number:
- DE‐AC52‐07NA27344; AC52-07NA27344; IIA-1444104
- Resource Type:
- Published Article
- Journal Name:
- Advanced Science
- Additional Journal Information:
- Journal Name: Advanced Science Journal Volume: 5 Journal Issue: 7; Journal ID: ISSN 2198-3844
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Germany
- Language:
- English
- Subject:
- 42 ENGINEERING; 3D microparticles; inertial microfluidics; optofluidic fabrication; optofluidics
Citation Formats
Paulsen, Kevin S., Deng, Yanxiang, and Chung, Aram J. DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication. Germany: N. p., 2018.
Web. doi:10.1002/advs.201800252.
Paulsen, Kevin S., Deng, Yanxiang, & Chung, Aram J. DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication. Germany. https://doi.org/10.1002/advs.201800252
Paulsen, Kevin S., Deng, Yanxiang, and Chung, Aram J. Fri .
"DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication". Germany. https://doi.org/10.1002/advs.201800252.
@article{osti_1440257,
title = {DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication},
author = {Paulsen, Kevin S. and Deng, Yanxiang and Chung, Aram J.},
abstractNote = {Abstract Complex‐shaped microparticles can enhance applications in drug delivery, tissue engineering, and structural materials, although techniques to fabricate these particles remain limited. A microfluidics‐based process called optofluidic fabrication that utilizes inertial flows and ultraviolet polymerization has shown great potential for creating highly 3D‐shaped particles in a high‐throughput manner, but the particle dimensions are mainly at the millimeter scale. Here, a next generation optofluidic fabrication process is presented that utilizes on‐the‐fly fabricated multiscale fluidic channels producing customized sub‐100 µm 3D‐shaped microparticles. This flexible design scheme offers a user‐friendly platform for rapid prototyping of new 3D particle shapes, providing greater potential for creating impactful engineered microparticles.},
doi = {10.1002/advs.201800252},
journal = {Advanced Science},
number = 7,
volume = 5,
place = {Germany},
year = {Fri Jun 01 00:00:00 EDT 2018},
month = {Fri Jun 01 00:00:00 EDT 2018}
}
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1002/advs.201800252
https://doi.org/10.1002/advs.201800252
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 16 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Freestanding loadbearing structures with Z-shaped particles
journal, April 2016
- Murphy, Kieran A.; Reiser, Nikolaj; Choksy, Darius
- Granular Matter, Vol. 18, Issue 2
Multiplexed Detection of mRNA Using Porosity-Tuned Hydrogel Microparticles
journal, September 2012
- Choi, Nak Won; Kim, Jungwook; Chapin, Stephen C.
- Analytical Chemistry, Vol. 84, Issue 21
Recent advances in engineering microparticles and their nascent utilization in biomedical delivery and diagnostic applications
journal, January 2017
- Choi, Andrew; Seo, Kyoung Duck; Kim, Do Wan
- Lab on a Chip, Vol. 17, Issue 4
Hydrogel microparticles for biosensing
journal, November 2015
- Le Goff, Gaelle C.; Srinivas, Rathi L.; Hill, W. Adam
- European Polymer Journal, Vol. 72
Lithographically Designed Conical Microcarriers for Programed Release of Multiple Actives
journal, December 2017
- Je, Kwanghwi; Kim, Ju Hyeon; Shim, Tae Soup
- Advanced Materials Interfaces, Vol. 5, Issue 1
Temporal response of an initially deflected PDMS channel
journal, November 2009
- Panda, Priyadarshi; Yuet, Kai P.; Dendukuri, Dhananjay
- New Journal of Physics, Vol. 11, Issue 11
Microarchitecture for a Three-Dimensional Wrinkled Surface Platform
journal, February 2015
- Li, Minggan; Hakimi, Navid; Perez, Roman
- Advanced Materials, Vol. 27, Issue 11
Guided and fluidic self-assembly of microstructures using railed microfluidic channels
journal, June 2008
- Chung, Su Eun; Park, Wook; Shin, Sunghwan
- Nature Materials, Vol. 7, Issue 7
Fabricating Shaped Microfibers with Inertial Microfluidics
journal, March 2014
- Nunes, Janine K.; Wu, Chueh-Yu; Amini, Hamed
- Advanced Materials, Vol. 26, Issue 22
The effect of Brownian motion on the rheological properties of a suspension of non-spherical particles
journal, April 1972
- Hinch, E. J.; Leal, L. G.
- Journal of Fluid Mechanics, Vol. 52, Issue 4
Role of target geometry in phagocytosis
journal, March 2006
- Champion, J. A.; Mitragotri, S.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 13
Non-spherical particle generation from 4D optofluidic fabrication
journal, January 2016
- Paulsen, Kevin S.; Chung, Aram J.
- Lab Chip, Vol. 16, Issue 16
Optofluidic fabrication for 3D-shaped particles
journal, April 2015
- Paulsen, Kevin S.; Di Carlo, Dino; Chung, Aram J.
- Nature Communications, Vol. 6, Issue 1
Engineering fluid flow using sequenced microstructures
journal, May 2013
- Amini, Hamed; Sollier, Elodie; Masaeli, Mahdokht
- Nature Communications, Vol. 4, Issue 1
Anisotropy in Shape and Ligand-Conjugation of Hybrid Nanoparticulates Manipulates the Mode of Bio-Nano Interaction and Its Outcome
journal, May 2017
- Wang, Xiaoyou; Lin, Li; Liu, Renfa
- Advanced Functional Materials, Vol. 27, Issue 31
Optofluidic maskless lithography system for real-time synthesis of photopolymerized microstructures in microfluidic channels
journal, July 2007
- Chung, Su Eun; Park, Wook; Park, Hyunsung
- Applied Physics Letters, Vol. 91, Issue 4
Rapid Software-Based Design and Optical Transient Liquid Molding of Microparticles
journal, October 2015
- Wu, Chueh-Yu; Owsley, Keegan; Di Carlo, Dino
- Advanced Materials, Vol. 27, Issue 48
The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation
journal, June 2017
- Lebre, Filipa; Sridharan, Rukmani; Sawkins, Michael J.
- Scientific Reports, Vol. 7, Issue 1
Optimization of micropillar sequences for fluid flow sculpting
journal, January 2016
- Stoecklein, Daniel; Wu, Chueh-Yu; Kim, Donghyuk
- Physics of Fluids, Vol. 28, Issue 1
Celebrating Soft Matter’s 10th Anniversary: Toward jamming by design
journal, January 2015
- Jaeger, Heinrich M.
- Soft Matter, Vol. 11, Issue 1
Stop-flow lithography in a microfluidic device
journal, January 2007
- Dendukuri, Dhananjay; Gu, Shelley S.; Pregibon, Daniel C.
- Lab on a Chip, Vol. 7, Issue 7
Multifunctional Hydrogel Microparticles by Polymer-Assisted Photolithography
journal, September 2015
- Li, Bin; He, Muhan; Ramirez, Lisa
- ACS Applied Materials & Interfaces, Vol. 8, Issue 6
Non-polydimethylsiloxane devices for oxygen-free flow lithography
journal, January 2012
- Bong, Ki Wan; Xu, Jingjing; Kim, Jong-Ho
- Nature Communications, Vol. 3, Issue 1
Micropillar sequence designs for fundamental inertial flow transformations
journal, January 2014
- Stoecklein, Daniel; Wu, Chueh-Yu; Owsley, Keegan
- Lab Chip, Vol. 14, Issue 21
Engineering particle trajectories in microfluidic flows using particle shape
journal, November 2013
- Uspal, William E.; Burak Eral, H.; Doyle, Patrick S.
- Nature Communications, Vol. 4, Issue 1
Modeling of Oxygen-Inhibited Free Radical Photopolymerization in a PDMS Microfluidic Device
journal, November 2008
- Dendukuri, Dhananjay; Panda, Priyadarshi; Haghgooie, Ramin
- Macromolecules, Vol. 41, Issue 22
Fabrication and applications of complex-shaped microparticles via microfluidics
journal, January 2015
- Seo, K. D.; Kim, D. S.; Sánchez, S.
- Lab on a Chip, Vol. 15, Issue 18
3D printing of self-assembling thermoresponsive nanoemulsions into hierarchical mesostructured hydrogels
journal, January 2017
- Hsiao, Lilian C.; Badruddoza, Abu Zayed Md; Cheng, Li-Chiun
- Soft Matter, Vol. 13, Issue 5
Automated Design for Microfluid Flow Sculpting: Multiresolution Approaches, Efficient Encoding, and CUDA Implementation
journal, January 2017
- Stoecklein, Daniel; Davies, Michael; Wubshet, Nadab
- Journal of Fluids Engineering, Vol. 139, Issue 3
Shape-Controlled Hollow Mesoporous Silica Nanoparticles with Multifunctional Capping for In Vitro Cancer Treatment
journal, July 2017
- Geng, Hongya; Chen, Weiyu; Xu, Zhi Ping
- Chemistry - A European Journal, Vol. 23, Issue 45