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Title: DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication

Abstract

Complex-shaped microparticles can enhance applications in drug delivery, tissue engineering, and structural materials, although techniques to fabricate these particles remain limited. A microfluidics-based process called optofluidic fabrication that utilizes inertial flows and ultraviolet polymerization has shown great potential for creating highly 3D-shaped particles in a high-throughput manner, but the particle dimensions are mainly at the millimeter scale. Here, a next generation optofluidic fabrication process is presented that utilizes on-the-fly fabricated multiscale fluidic channels producing customized sub-100 µm 3D-shaped microparticles. This flexible design scheme offers a user-friendly platform for rapid prototyping of new 3D particle shapes, providing greater potential for creating impactful engineered microparticles.

Authors:
ORCiD logo [1];  [2]; ORCiD logo [3]
  1. Rensselaer Polytechnic Inst., Troy, NY (United States). Dept. of Mechanical, Aerospace, and Nuclear Engineering; Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Engineering Directorate
  2. Rensselaer Polytechnic Inst., Troy, NY (United States). Dept. of Mechanical, Aerospace, and Nuclear Engineering
  3. Rensselaer Polytechnic Inst., Troy, NY (United States). Dept. of Mechanical, Aerospace, and Nuclear Engineering; Korea Univ., Seoul (Korea, Republic of). School of Biomedical Engineering
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Rensselaer Polytechnic Inst., Troy, NY (United States); Korea Univ., Seoul (Korea, Republic of)
Sponsoring Org.:
USDOE; National Science Foundation (NSF); Rensselaer Polytechnic Inst. (United States); Korea Univ. (Korea, Republic of)
OSTI Identifier:
1440257
Alternate Identifier(s):
OSTI ID: 1440258; OSTI ID: 1465317
Report Number(s):
LLNL-JRNL-749963
Journal ID: ISSN 2198-3844; 935419
Grant/Contract Number:  
AC52-07NA27344; IIA-1444104
Resource Type:
Published Article
Journal Name:
Advanced Science
Additional Journal Information:
Journal Volume: 5; Journal Issue: 7; Journal ID: ISSN 2198-3844
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING; 3D microparticles; inertial microfluidics; optofluidic fabrication; optofluidics

Citation Formats

Paulsen, Kevin S., Deng, Yanxiang, and Chung, Aram J. DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication. United States: N. p., 2018. Web. doi:10.1002/advs.201800252.
Paulsen, Kevin S., Deng, Yanxiang, & Chung, Aram J. DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication. United States. doi:10.1002/advs.201800252.
Paulsen, Kevin S., Deng, Yanxiang, and Chung, Aram J. Fri . "DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication". United States. doi:10.1002/advs.201800252.
@article{osti_1440257,
title = {DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication},
author = {Paulsen, Kevin S. and Deng, Yanxiang and Chung, Aram J.},
abstractNote = {Complex-shaped microparticles can enhance applications in drug delivery, tissue engineering, and structural materials, although techniques to fabricate these particles remain limited. A microfluidics-based process called optofluidic fabrication that utilizes inertial flows and ultraviolet polymerization has shown great potential for creating highly 3D-shaped particles in a high-throughput manner, but the particle dimensions are mainly at the millimeter scale. Here, a next generation optofluidic fabrication process is presented that utilizes on-the-fly fabricated multiscale fluidic channels producing customized sub-100 µm 3D-shaped microparticles. This flexible design scheme offers a user-friendly platform for rapid prototyping of new 3D particle shapes, providing greater potential for creating impactful engineered microparticles.},
doi = {10.1002/advs.201800252},
journal = {Advanced Science},
number = 7,
volume = 5,
place = {United States},
year = {2018},
month = {6}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1002/advs.201800252

Citation Metrics:
Cited by: 3 works
Citation information provided by
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