Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids
Abstract
An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development of biomimetic membranes. Here we report the assembly of lipid-like peptoids into highly stable, crystalline, free-standing and self-repairing membrane-mimetic 2D nanomaterials through a facile crystallization process. Both experimental and molecular dynamics simulation results show that peptoids assemble into membranes through an anisotropic formation process. We further demonstrated the use of peptoid membranes as a robust platform to incorporate and pattern functional objects through large side-chain diversity and/or co-crystallization approaches. Similar to lipid membranes, peptoid membranes exhibit changes in thickness upon exposure to external stimuli; they can coat surfaces in single layers and self-repair. We anticipate that this new class of membrane-mimetic 2D nanomaterials will provide a robust matrix for development of biomimetic membranes tailored to specific applications.
- Authors:
-
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Division of Physical Sciences
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Division of Physical Sciences; East China Normal Univ. (ECNU), Shanghai (China). School of Chemistry and Molecular Engineering
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Division of Physical Sciences; Linyi Univ., Linyi (China). College of Chemistry and Chemical Engineering
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Division of Physical Sciences; Xiangtan Univ., Xiantan (China). Inst. of Rheology Mechanics
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1267592
- Alternate Identifier(s):
- OSTI ID: 1439997
- Report Number(s):
- PNNL-SA-112006
Journal ID: ISSN 2041-1723
- Grant/Contract Number:
- AC05-76RL01830; AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Communications
- Additional Journal Information:
- Journal Volume: 7; Journal ID: ISSN 2041-1723
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE
Citation Formats
Jin, Haibao, Jiao, Fang, Daily, Michael D., Chen, Yulin, Yan, Feng, Ding, Yan-Huai, Zhang, Xin, Robertson, Ellen J., Baer, Marcel D., and Chen, Chun-Long. Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids. United States: N. p., 2016.
Web. doi:10.1038/ncomms12252.
Jin, Haibao, Jiao, Fang, Daily, Michael D., Chen, Yulin, Yan, Feng, Ding, Yan-Huai, Zhang, Xin, Robertson, Ellen J., Baer, Marcel D., & Chen, Chun-Long. Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids. United States. https://doi.org/10.1038/ncomms12252
Jin, Haibao, Jiao, Fang, Daily, Michael D., Chen, Yulin, Yan, Feng, Ding, Yan-Huai, Zhang, Xin, Robertson, Ellen J., Baer, Marcel D., and Chen, Chun-Long. Tue .
"Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids". United States. https://doi.org/10.1038/ncomms12252. https://www.osti.gov/servlets/purl/1267592.
@article{osti_1267592,
title = {Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids},
author = {Jin, Haibao and Jiao, Fang and Daily, Michael D. and Chen, Yulin and Yan, Feng and Ding, Yan-Huai and Zhang, Xin and Robertson, Ellen J. and Baer, Marcel D. and Chen, Chun-Long},
abstractNote = {An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development of biomimetic membranes. Here we report the assembly of lipid-like peptoids into highly stable, crystalline, free-standing and self-repairing membrane-mimetic 2D nanomaterials through a facile crystallization process. Both experimental and molecular dynamics simulation results show that peptoids assemble into membranes through an anisotropic formation process. We further demonstrated the use of peptoid membranes as a robust platform to incorporate and pattern functional objects through large side-chain diversity and/or co-crystallization approaches. Similar to lipid membranes, peptoid membranes exhibit changes in thickness upon exposure to external stimuli; they can coat surfaces in single layers and self-repair. We anticipate that this new class of membrane-mimetic 2D nanomaterials will provide a robust matrix for development of biomimetic membranes tailored to specific applications.},
doi = {10.1038/ncomms12252},
journal = {Nature Communications},
number = ,
volume = 7,
place = {United States},
year = {Tue Jul 12 00:00:00 EDT 2016},
month = {Tue Jul 12 00:00:00 EDT 2016}
}
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